ISMARA results: Arntl_Tfe3_Mlx_Mitf_Mlxipl

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 0.48

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Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Gene Symbol	Gene ID	Gene Info
Arntl NCBI RGD Ensembl	ENSRNOG00000014448	aryl hydrocarbon receptor nuclear translocator-like
Tfe3 NCBI RGD Ensembl	ENSRNOG00000009605	transcription factor binding to IGHM enhancer 3
Mlx NCBI RGD Ensembl	ENSRNOG00000019983	MLX, MAX dimerization protein
Mitf NCBI RGD Ensembl	ENSRNOG00000008658	melanogenesis associated transcription factor
Mlxipl NCBI RGD Ensembl	ENSRNOG00000046171	Mlxipl
Tfec NCBI RGD Ensembl	ENSRNOG00000061595	transcription factor EC

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tfec	rn6_v1_chr4_-_44136815_44136815	-0.53	3.6e-01	Click!
Mitf	rn6_v1_chr4_+_130332076_130332076	0.28	6.4e-01	Click!
Tfe3	rn6_v1_chrX_-_15587419_15587419	0.18	7.7e-01	Click!
Mlx	rn6_v1_chr10_+_88997399_88997399	0.09	8.8e-01	Click!
Arntl	rn6_v1_chr1_+_178039063_178039063	0.09	8.8e-01	Click!

Activity profile of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

Sorted Z-values of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_56610051 Show fit	0.41	ENSRNOT00000024348	Dvl2 NCBI RGD Ensembl Show fit	dishevelled segment polarity protein 2
chr1_-_219450451 Show fit	0.41	ENSRNOT00000025317	Rad9a NCBI RGD Ensembl Show fit	RAD9 checkpoint clamp component A
chr11_+_61531416 Show fit	0.40	ENSRNOT00000093263	Atp6v1a NCBI RGD Ensembl Show fit	ATPase H+ transporting V1 subunit A
chr3_-_161299024 Show fit	0.34	ENSRNOT00000021216	Neurl2 NCBI RGD Ensembl Show fit	neuralized E3 ubiquitin protein ligase 2
chr9_+_94425252 Show fit	0.25	ENSRNOT00000064965 ENSRNOT00000076099	Gigyf2 NCBI RGD Ensembl Show fit	GRB10 interacting GYF protein 2
chr10_+_94988362 Show fit	0.24	ENSRNOT00000066525	Cep95 NCBI RGD Ensembl Show fit	centrosomal protein 95
chr1_-_222495382 Show fit	0.24	ENSRNOT00000028759	Naa40 NCBI RGD Ensembl Show fit	N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr3_+_155297566 Show fit	0.21	ENSRNOT00000021435 ENSRNOT00000084866	Dhx35 NCBI RGD Ensembl Show fit	DEAH-box helicase 35
chr13_+_41802697 Show fit	0.20	ENSRNOT00000046719	LOC100362110 NCBI RGD Ensembl Show fit	LRRGT00155-like
chr1_-_92119951 Show fit	0.20	ENSRNOT00000018153 ENSRNOT00000092121	Zfp507 NCBI RGD Ensembl Show fit	zinc finger protein 507

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0	0.5	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.1	0.2	GO:1905245	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1	0.2	GO:0051037	regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.0	0.2	GO:0090204	protein localization to nuclear pore(GO:0090204)
0.0	0.2	GO:1903564	regulation of protein localization to cilium(GO:1903564)
0.0	0.2	GO:1905150	regulation of voltage-gated sodium channel activity(GO:1905150)
0.0	0.2	GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.2	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)

Showing 1 to 10 of 113 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0030896	checkpoint clamp complex(GO:0030896)
0.0	0.4	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1	0.3	GO:0005927	muscle tendon junction(GO:0005927)
0.0	0.3	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.2	GO:0005879	axonemal microtubule(GO:0005879)
0.0	0.2	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.2	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.2	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.0	0.2	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.2	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.3	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1	0.2	GO:1990189	peptide-serine-N-acetyltransferase activity(GO:1990189)
0.1	0.2	GO:0004874	aryl hydrocarbon receptor activity(GO:0004874)
0.0	0.2	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.2	GO:0051373	FATZ binding(GO:0051373)
0.0	0.2	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.0	0.2	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)

Showing 1 to 10 of 61 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.7	PID ATM PATHWAY	ATM pathway
0.5	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway

Showing 1 to 3 of 3 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.5	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	REACTOME AQUAPORIN MEDIATED TRANSPORT	Genes involved in Aquaporin-mediated transport

Showing 1 to 9 of 9 entries

Results for Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 0.48

Motif logo

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Activity-expression correlation:

Activity profile of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

Sorted Z-values of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: