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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Aire

Z-value: 0.47

Motif logo

Transcription factors associated with Aire

Gene Symbol Gene ID Gene Info
ENSRNOG00000001213 autoimmune regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Airern6_v1_chr20_+_11365697_11365697-0.296.4e-01Click!

Activity profile of Aire motif

Sorted Z-values of Aire motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_23135354 0.14 ENSRNOT00000011432
STEAP4 metalloreductase
chr2_+_209661244 0.12 ENSRNOT00000091973

chrM_+_9451 0.12 ENSRNOT00000041241
mitochondrially encoded NADH dehydrogenase 3
chrM_+_14136 0.11 ENSRNOT00000042098
mitochondrially encoded cytochrome b
chr8_+_52751854 0.09 ENSRNOT00000072518
neurexophilin and PC-esterase domain family, member 1
chr15_-_83494423 0.09 ENSRNOT00000037588
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
chrM_+_7006 0.09 ENSRNOT00000043693
mitochondrially encoded cytochrome c oxidase II
chr18_-_36513317 0.08 ENSRNOT00000025453
PLAC8-like 1
chr20_+_34633157 0.08 ENSRNOT00000000469
phospholamban
chr1_-_66212418 0.08 ENSRNOT00000026074
hypothetical protein LOC691722
chr3_-_161294125 0.08 ENSRNOT00000021143
spermatogenesis associated 25
chrM_+_11736 0.08 ENSRNOT00000048767
mitochondrially encoded NADH dehydrogenase 5
chr13_-_82129989 0.08 ENSRNOT00000078963

chrX_+_22285184 0.08 ENSRNOT00000086262
IQ motif and Sec7 domain 2
chr2_+_92573004 0.07 ENSRNOT00000065774
GTPase activating protein testicular GAP1
chr3_+_161413298 0.07 ENSRNOT00000023965
ENSRNOT00000088776
matrix metallopeptidase 9
chr1_+_141120166 0.07 ENSRNOT00000050759
Fanconi anemia, complementation group I
chr6_-_99843245 0.07 ENSRNOT00000080270
glutathione peroxidase 2
chr4_-_164123974 0.07 ENSRNOT00000082447
similar to immunoreceptor Ly49si1
chrM_+_8599 0.07 ENSRNOT00000049683
mitochondrially encoded cytochrome C oxidase III
chrM_-_14061 0.06 ENSRNOT00000051268
mitochondrially encoded NADH dehydrogenase 6
chr16_-_79671719 0.06 ENSRNOT00000015908
myomesin 2
chrX_-_915953 0.06 ENSRNOT00000075264
sperm acrosome associated 5
chr14_+_91557601 0.06 ENSRNOT00000038733
hypothetical LOC289778
chr17_+_16455026 0.05 ENSRNOT00000022932
zinc finger protein 169
chr1_-_146556171 0.05 ENSRNOT00000017636
aryl hydrocarbon receptor nuclear translocator 2
chr7_+_70445366 0.05 ENSRNOT00000045687
similar to 40S ribosomal protein S26
chr10_-_34242985 0.05 ENSRNOT00000046438
similar to novel protein
chr9_+_12475006 0.05 ENSRNOT00000079703
uncharacterized LOC100912293
chr5_+_122508388 0.05 ENSRNOT00000038410
Tctex1 domain containing 1
chrX_-_156270748 0.05 ENSRNOT00000078438
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr2_-_179704629 0.05 ENSRNOT00000083361
ENSRNOT00000077941
glutamate ionotropic receptor AMPA type subunit 2
chr19_+_15081590 0.05 ENSRNOT00000024187
carboxylesterase 1F
chr18_+_61377051 0.04 ENSRNOT00000066659
O-acyltransferase like
chr15_+_61879184 0.04 ENSRNOT00000042606
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr7_-_98804499 0.04 ENSRNOT00000070909
TatD DNase domain containing 1
chr8_-_52828134 0.04 ENSRNOT00000007736
RNA binding motif protein 7
chr2_-_21931720 0.04 ENSRNOT00000018449
mutS homolog 3
chr14_-_34561696 0.04 ENSRNOT00000059763
steroid 5 alpha-reductase 3
chr1_-_154165524 0.04 ENSRNOT00000023468
Hikeshi, heat shock protein nuclear import factor
chr7_-_11754508 0.04 ENSRNOT00000026341
ornithine decarboxylase antizyme 1
chr8_-_23282989 0.04 ENSRNOT00000019204
zinc finger protein 717
chr11_+_43521054 0.04 ENSRNOT00000041679
olfactory receptor 1551
chr10_-_88611105 0.04 ENSRNOT00000024718
DEXH-box helicase 58
chr1_+_101884276 0.04 ENSRNOT00000082917
transmembrane protein 143
chr1_+_78739930 0.04 ENSRNOT00000021976
striatin 4
chr4_+_123162086 0.04 ENSRNOT00000011557
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
chr2_+_182006242 0.04 ENSRNOT00000064091
fibrinogen alpha chain
chr4_+_88695590 0.04 ENSRNOT00000087835
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr5_+_118418799 0.04 ENSRNOT00000012052
ALG6, alpha-1,3-glucosyltransferase
chr20_+_22728208 0.04 ENSRNOT00000000794
nuclear receptor-binding factor 2-like
chr16_-_52127591 0.03 ENSRNOT00000033652
tripartite motif family-like 2
chr4_-_117575154 0.03 ENSRNOT00000075813
probable N-acetyltransferase CML2-like
chr13_-_78851600 0.03 ENSRNOT00000076985
zinc finger and BTB domain containing 37
chr11_-_4332255 0.03 ENSRNOT00000087133
cell adhesion molecule 2
chr11_+_84745904 0.03 ENSRNOT00000002617
kelch-like family member 6
chr1_+_101884019 0.03 ENSRNOT00000028650
transmembrane protein 143
chrX_-_29825439 0.03 ENSRNOT00000048155
gem (nuclear organelle) associated protein 8
chr16_-_62164135 0.03 ENSRNOT00000058872
general transcription factor IIE subunit 2
chr4_-_120559078 0.03 ENSRNOT00000085730
ENSRNOT00000079575
kelch repeat and BTB domain containing 12
chr10_-_52290657 0.03 ENSRNOT00000005293
mitogen activated protein kinase kinase 4
chr1_+_228142778 0.03 ENSRNOT00000028517
mitochondrial ribosomal protein L16
chr11_-_31772984 0.03 ENSRNOT00000002771
DnaJ heat shock protein family (Hsp40) member C28
chr13_-_42885440 0.03 ENSRNOT00000038020
NCK-associated protein 5
chr3_-_51612397 0.03 ENSRNOT00000081401
sodium voltage-gated channel alpha subunit 3
chr1_+_220096422 0.03 ENSRNOT00000034771
coiled-coil domain containing 87
chr15_-_52214616 0.03 ENSRNOT00000015035
surfactant protein C
chrX_-_45284341 0.03 ENSRNOT00000045436
odorant binding protein I f
chr8_-_58253688 0.02 ENSRNOT00000010956
cullin 5
chr8_-_36438730 0.02 ENSRNOT00000015366
family with sequence similarity 118, member B
chrX_+_83926513 0.02 ENSRNOT00000035274
similar to RIKEN cDNA 2010106E10
chr9_+_84410972 0.02 ENSRNOT00000019724
monoacylglycerol O-acyltransferase 1
chr3_-_13978224 0.02 ENSRNOT00000025528
PHD finger protein 19
chr7_-_123655896 0.02 ENSRNOT00000012413
cytochrome P450, family 2, subfamily d, polypeptide 2
chr11_+_45462345 0.02 ENSRNOT00000029420
nitrilase family, member 2
chr4_-_144620731 0.02 ENSRNOT00000066468
RAD18 E3 ubiquitin protein ligase
chr15_-_37830131 0.02 ENSRNOT00000075861
eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1
chr7_-_119712888 0.02 ENSRNOT00000077438
interleukin 2 receptor subunit beta
chr7_-_101138373 0.02 ENSRNOT00000043257
Ab1-152
chr9_+_93086012 0.02 ENSRNOT00000089470
proteasome 26S subunit, non-ATPase 1
chr10_-_107158997 0.02 ENSRNOT00000004047
dynein, axonemal, heavy chain 17
chr7_-_138483612 0.02 ENSRNOT00000085620
solute carrier family 38, member 4
chr3_+_2872031 0.02 ENSRNOT00000023062
lipocalin 8
chr18_-_36322320 0.02 ENSRNOT00000060260
glutaredoxin and cysteine rich domain containing 2
chr9_+_95285592 0.02 ENSRNOT00000063853
UDP glucuronosyltransferase family 1 member A5
chr11_+_54619129 0.02 ENSRNOT00000059924
T cell receptor associated transmembrane adaptor 1
chr17_-_15566332 0.02 ENSRNOT00000093743
extracellular matrix protein 2
chr10_-_70735742 0.02 ENSRNOT00000077035
HEAT repeat containing 9
chr14_+_79339258 0.02 ENSRNOT00000058414
TBC1 domain family, member 14
chr14_-_17436897 0.02 ENSRNOT00000003277
USO1 vesicle transport factor
chr13_+_60545635 0.02 ENSRNOT00000077153
ubiquitin C-terminal hydrolase L5
chr12_+_4248808 0.02 ENSRNOT00000042410

chr1_+_266482858 0.01 ENSRNOT00000027223
arsenite methyltransferase
chr1_+_100059967 0.01 ENSRNOT00000081095
kallikrein 1
chr2_+_196608496 0.01 ENSRNOT00000091681
aryl hydrocarbon receptor nuclear translocator
chr10_-_87153982 0.01 ENSRNOT00000014414
keratin 222
chr17_+_68477446 0.01 ENSRNOT00000086236
ENSRNOT00000068174
pitrilysin metallopeptidase 1
chr3_-_11820549 0.01 ENSRNOT00000020660
cilia and flagella associated protein 157
chr4_-_99546905 0.01 ENSRNOT00000077447
lysine demethylase 3A
chr3_-_148493225 0.01 ENSRNOT00000012141
p53 and DNA damage regulated 1
chr6_+_104611026 0.01 ENSRNOT00000007583
serine and arginine rich splicing factor 5
chr1_+_59156251 0.01 ENSRNOT00000017442
limb and CNS expressed 1
chr2_-_100249811 0.01 ENSRNOT00000086760
hepatocyte nuclear factor 4, gamma
chr1_-_162713610 0.01 ENSRNOT00000018091
aquaporin 11
chr5_-_124403195 0.01 ENSRNOT00000067850
complement C8 alpha chain
chr13_-_98529040 0.01 ENSRNOT00000091715
presenilin 2
chr1_+_63842277 0.01 ENSRNOT00000087957
ENSRNOT00000080820
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3A
chr9_+_92618550 0.01 ENSRNOT00000078987
SP140 nuclear body protein
chr18_+_29506128 0.01 ENSRNOT00000003878
solute carrier family 35, member A4
chr8_+_82171497 0.01 ENSRNOT00000011768
myosin VC
chr1_+_143675985 0.01 ENSRNOT00000078500
transmembrane 6 superfamily member 1
chr15_+_62520953 0.01 ENSRNOT00000040851
similar to RIKEN cDNA 3100001N19
chr3_+_95233874 0.01 ENSRNOT00000079743
hypothetical protein LOC691083
chrX_+_26294066 0.01 ENSRNOT00000037862
holocytochrome c synthase
chr3_+_153398130 0.01 ENSRNOT00000068135
ribophorin II
chr2_-_209001895 0.01 ENSRNOT00000055960
similar to Hypothetical protein MGC58999
chr3_-_153246433 0.01 ENSRNOT00000067748
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
chr17_+_25228437 0.01 ENSRNOT00000072904

chr7_-_143738237 0.01 ENSRNOT00000055320
SPRY domain containing 3
chr5_+_60528997 0.01 ENSRNOT00000051445
glyoxylate and hydroxypyruvate reductase
chr12_-_19439977 0.01 ENSRNOT00000060035
neurexophilin and PC-esterase domain family, member 5
chr1_-_99135977 0.01 ENSRNOT00000056515
vomeronasal 2 receptor, 38
chr12_+_40417944 0.01 ENSRNOT00000073125
acyl-CoA dehydrogenase family, member 10
chr4_+_118160147 0.01 ENSRNOT00000022014
family with sequence similarity 136, member A
chrX_-_1704033 0.01 ENSRNOT00000051956
ubiquitin specific peptidase 11
chr5_+_15043955 0.01 ENSRNOT00000047093
retinitis pigmentosa 1
chrX_-_10218583 0.00 ENSRNOT00000013382
nyctalopin
chr9_+_7643533 0.00 ENSRNOT00000074923
vomeronasal 2 receptor, 76
chr11_+_83986230 0.00 ENSRNOT00000002331
ENSRNOT00000073703
ALG3, alpha-1,3- mannosyltransferase
chr8_-_16486419 0.00 ENSRNOT00000033223
similar to MAP/microtubule affinity-regulating kinase 4 (MAP/microtubule affinity-regulating kinase-like 1)
chr10_+_37594578 0.00 ENSRNOT00000007676
S-phase kinase-associated protein 1
chr1_+_142951094 0.00 ENSRNOT00000077441
solute carrier family 28 member 1
chr11_+_34101197 0.00 ENSRNOT00000002299
chromatin assembly factor 1 subunit B
chr8_-_32000378 0.00 ENSRNOT00000013341
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr10_-_56511583 0.00 ENSRNOT00000021402
similar to RIKEN cDNA 2810408A11
chr7_+_123482255 0.00 ENSRNOT00000064487
hypothetical protein LOC688613
chr6_+_44225233 0.00 ENSRNOT00000066593
kinase D-interacting substrate 220

Network of associatons between targets according to the STRING database.

First level regulatory network of Aire

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071283 response to high light intensity(GO:0009644) cellular response to iron(III) ion(GO:0071283)
0.0 0.1 GO:0009609 response to symbiotic bacterium(GO:0009609)
0.0 0.1 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.1 GO:0098706 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.0 GO:0052422 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0 0.1 GO:0033590 response to cobalamin(GO:0033590)
0.0 0.0 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.0 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.1 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.0 0.0 GO:0016095 polyprenol catabolic process(GO:0016095)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0090534 calcium ion-transporting ATPase complex(GO:0090534)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.0 GO:0032142 dinucleotide insertion or deletion binding(GO:0032139) single guanine insertion binding(GO:0032142)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.0 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.0 GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)