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GSE80451: E.coli grown aerobically and anaerobically

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Results for Sigma70

Z-value: 0.41

Transcription factors associated with Sigma70

Gene Symbol Gene ID Gene Info
rpoD
rpoD RNA polymerase sigma factor RpoD

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rpoD0.941.6e-02Click!

Activity profile of Sigma70 motif

Sorted Z-values of Sigma70 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
arcA 2.02
arcA
ArcA transcriptional dual regulator
cydAB 1.05
cydA
cydB
cytochrome bd-I terminal oxidase subunit I
cytochrome bd-I terminal oxidase subunit II
dadAX 1.00
dadA
dadX
D-amino acid dehydrogenase
alanine racemase 2, PLP-binding
csrA 0.73
csrA
carbon storage regulator; pleiotropic regulatory protein for carbon source metabolism
narK 0.71
narK
nitrate:nitrite antiporter NarK
dksA-gluQ 0.70
gluQ
dksA
glutamyl-Q tRNAAsp synthetase
RNA polymerase-binding transcription factor DksA
gpmA 0.68
gpmA
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
bssS 0.60
bssS
regulator of biofilm formation
astCADBE 0.59
astA
astB
astC
astD
astE
arginine succinyltransferase
succinylarginine dihydrolase
succinylornithine transaminase
aldehyde dehydrogenase
succinylglutamate desuccinylase
pykF 0.57
pykF
pyruvate kinase I
eno 0.56
eno
enolase
ssb 0.55
ssb
ssDNA-binding protein
osmB 0.52
osmB
OsmB osmotically inducible lipoprotein
metJ 0.51
metJ
MetJ transcriptional repressor
osmY 0.50
osmY
periplasmic chaperone, osmotically induced
hns 0.48
hns
H-NS DNA-binding transcriptional dual regulator
deoCABD 0.47
deoA
deoB
deoC
deoD
thymidine phosphorylase / uracil phosphorylase
phosphopentomutase
deoxyribose-phosphate aldolase
purine nucleoside phosphorylase
yjeF-tsaE-amiB-mutL-miaA-hfq-hflXKC 0.47
miaA
tsaE
hfq
hflK
mutL
amiB
yjeF
hflX
hflC
tRNA(i6A37) synthase
N6-L-threonylcarbamoyladenine synthase, TsaE subunit
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
MutL
N-acetylmuramoyl-L-alanine amidase B
NAD(P)HX epimerase / NAD(P)HX dehydratase
ribosome-dissociating factor, GTPase
regulator of FtsH protease
phoH 0.46
phoH
ATP-binding protein
bolA 0.46
bolA
BolA DNA-binding transcriptional dual regulator
bhsA 0.44
bhsA
outer membrane protein involved in copper permeability, stress resistance and biofilm formation
phoA-psiF 0.44
phoA
psiF
alkaline phosphatase
conserved protein
pepA 0.44
pepA
aminopeptidase A/I
gapA 0.43
gapA
glyceraldehyde 3-phosphate dehydrogenase
glnB 0.43
glnB
regulatory protein P-II; regulation of nitrogen metabolism and fatty acid biosynthesis
decR 0.42
decR
DecR DNA-binding transcriptional activator
mqsRA 0.42
mqsR
mqsA
mRNA interferase, toxin of the MqsR-MqsA toxin-antitoxin system
MqsA antitoxin of the MqsRA toxin-antitoxin system and DNA-binding transcriptional repressor
mntH 0.42
mntH
Mn2+ / Fe2+: H+ symporter MntH
metY-rimP-nusA-infB-rbfA-truB-rpsO-pnp 0.42
metY
rimP
rpsO
pnp
rbfA
infB
nusA
truB
tRNAfMet2
ribosome maturation factor RimP
30S ribosomal subunit protein S15
polynucleotide phosphorylase
30S ribosome binding factor
protein chain initiation factor IF2
transcription termination/antitermination L factor
tRNA pseudouridine 55 synthase
pfkA 0.41
pfkA
6-phosphofructokinase I
ydeI 0.40
ydeI
stress response protein
speAB 0.40
speB
speA
agmatinase
arginine decarboxylase, biosynthetic
def-fmt 0.40
fmt
def
10-formyltetrahydrofolate:L-methionyl-tRNAfMet N-formyltransferase
peptide deformylase
rpoD 0.38
rpoD
RNA polymerase, sigma 70 (sigma D) factor
pabA 0.38
pabA
aminodeoxychorismate synthase component 2
argX-hisR-leuT-proM 0.37
argX
leuT
proM
hisR
tRNAargX
tRNAleuT
tRNAproM
tRNAhisR
hfq-hflXKC 0.37
hflC
hfq
hflK
hflX
regulator of FtsH protease
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
ribosome-dissociating factor, GTPase
focA-pflB 0.37
focA
pflB
formate channel FocA
pyruvate formate-lyase (inactive)
deoBD 0.34
deoB
deoD
phosphopentomutase
purine nucleoside phosphorylase
nanA 0.34
nanA
N-acetylneuraminate lyase
sodA 0.34
sodA
superoxide dismutase (Mn)
lptD 0.33
lptD
outer membrane lipopolysaccharide transport and assembly complex - LptD subunit
sibD 0.32
sibD
SibD
fadD-sroD 0.32
sroD
fadD
SroD
fatty acyl-CoA synthetase
cpxPQ 0.32
cpxQ
cpxP
CpxQ small regulatory RNA
CpxP
fruBKA 0.32
fruK
fruB
fruA
1-phosphofructokinase
fructose PTS permease - FruB subunit
fructose PTS permease - FruA subunit
pykA 0.32
pykA
pyruvate kinase II
aidB 0.31
aidB
isovaleryl-CoA dehydrogenase and DNA-binding transcriptional repressor
cbpAM 0.31
cbpM
cbpA
chaperone modulator protein CbpM
chaperone with DnaK; curved DNA-binding protein
stpA 0.31
stpA
H-NS-like DNA-binding transcriptional repressor with RNA chaperone activity
ybhL 0.30
ybhL
inner membrane protein
osmE 0.30
osmE
osmotically inducible protein OsmE
garPLRK-rnpB 0.30
garL
rnpB
garR
garK
garP
α-dehydro-β-deoxy-D-glucarate aldolase
RnpB
tartronate semialdehyde reductase
glycerate kinase I
galactarate / glucarate / glycerate transporter GarP
aroL-yaiA-aroM 0.29
yaiA
aroL
aroM
predicted protein
shikimate kinase II
conserved protein
trxA 0.29
trxA
thioredoxin 1
ompR-envZ 0.29
envZ
ompR
EnvZ
OmpR transcriptional dual regulator
clpPX 0.29
clpP
clpX
ClpP
ClpX
csiE 0.29
csiE
stationary phase inducible protein
mcbA 0.29
mcbA
protein involved in colanic acid production
mtr 0.29
mtr
tryptohan / indole:H+ symporter Mtr
pflA 0.29
pflA
pyruvate formate-lyase activating enzyme
dps 0.28
dps
stationary phase nucleoid protein that sequesters iron and protects DNA from damage
sfsA-dksA 0.28
dksA
sfsA
RNA polymerase-binding transcription factor DksA
predicted DNA-binding transcriptional regulator of maltose metabolism
topA 0.28
topA
DNA topoisomerase I
pgk-fbaA 0.28
pgk
fbaA
phosphoglycerate kinase
fructose bisphosphate aldolase class II
rraB 0.28
rraB
ribonuclease E inhibitor protein B
sufABCDSE 0.28
sufB
sufC
sufA
sufD
sufE
sufS
SufB component of SufBCD Fe-S cluster scaffold complex
SufC component of SufBCD Fe-S cluster scaffold complex
Fe-S transport protein in Fe-S cluster assembly
SufD component of SufBCD Fe-S cluster scaffold complex
sulfur acceptor for SufS cysteine desulfurase
L-cysteine desulfurase
grxB 0.28
grxB
reduced glutaredoxin 2
pgk 0.28
pgk
phosphoglycerate kinase
ugpBAECQ 0.28
ugpE
ugpA
ugpB
ugpC
ugpQ
glycerol-3-phosphate ABC transporter - membrane subunit
glycerol-3-phosphate ABC transporter - membrane subunit
glycerol-3-phosphate ABC transporter - periplasmic binding protein
glycerol-3-phosphate ABC transporter - ATP binding subunit
glycerophosphodiester phosphodiesterase, cytosolic
secB-gpsA 0.27
gpsA
secB
glycerol-3-phosphate dehydrogenase
SecB chaperone
trxC 0.27
trxC
reduced thioredoxin 2
cirA 0.27
cirA
outer membrane receptor involved in uptake of ferric dihyroxybenzoylserine
frr 0.26
frr
ribosome recycling factor
ribA 0.26
ribA
GTP cyclohydrolase II
pntAB 0.26
pntB
pntA
pyridine nucleotide transhydrogenase, β subunit
pyridine nucleotide transhydrogenase, α subunit
dacC 0.26
dacC
penicillin-binding protein 6
gfcA 0.26
gfcA
predicted protein
proS 0.26
proS
proline-tRNA ligase
ptsG 0.25
ptsG
glucose PTS permease - PtsG subunit
slp-dctR 0.25
slp
dctR
starvation lipoprotein
predicted DNA-binding transcriptional regulator
sixA 0.25
sixA
phosphohistidine phosphatase
cmk-rpsA 0.25
cmk
rpsA
cytidylate kinase
30S ribosomal subunit protein S1
kbl-tdh 0.25
tdh
kbl
threonine dehydrogenase
2-amino-3-ketobutyrate CoA ligase
feaB 0.25
feaB
phenylacetaldehyde dehydrogenase
bcsBZ 0.25
bcsB
bcsZ
cellulose synthase, periplasmic subunit
endo-1,4-D-glucanase
yjbEFGH 0.25
yjbG
yjbF
yjbE
yjbH
conserved protein
predicted lipoprotein
predicted protein
predicted porin
dapE-ypfN 0.25
dapE
ypfN
N-succinyl-L-diaminopimelate desuccinylase subunit
predicted protein
mtlADR 0.24
mtlR
mtlA
mtlD
MtlR DNA-binding transcriptional repressor
mannitol PTS permease
mannitol-1-phosphate 5-dehydrogenase
yihI 0.24
yihI
GAP-like protein that activates GTPase activity of Der
tomB-hha 0.24
tomB
hha
protein that modulates Hha toxicity
haemolysin expression modulating protein
nagE 0.24
nagE
N-acetylglucosamine PTS permease
sulA 0.24
sulA
SOS cell division inhibitor
yibN-grxC-secB-gpsA 0.24
grxC
gpsA
secB
yibN
reduced glutaredoxin 3
glycerol-3-phosphate dehydrogenase
SecB chaperone
predicted rhodanese-related sulfurtransferase
ompX 0.23
ompX
outer membrane protein X
serT 0.23
serT
tRNASer1
soxS 0.23
soxS
SoxS DNA-binding transcriptional dual regulator
hemH 0.22
hemH
ferrochelatase
lysU 0.22
lysU
lysine-tRNA ligase / Ap4A synthetase / Ap3A synthetase
gloA 0.22
gloA
glyoxalase I
uxuR 0.22
uxuR
UxuR DNA-binding transcriptional repressor
acpP 0.22
acpP
apo-[acyl carrier protein]
metF 0.22
metF
5,10-methylenetetrahydrofolate reductase
cspE 0.22
cspE
transcription antiterminator and regulator of RNA stability
metK 0.22
metK
methionine adenosyltransferase
ompC 0.21
ompC
outer membrane protein C
cspD 0.21
cspD
DNA replication inhibitor
rybA-mntS 0.21
rybA
mntS
RybA
small protein MntS
acpP-fabF 0.21
fabF
acpP
β-ketoacyl-ACP synthase II
apo-[acyl carrier protein]
nupC 0.21
nupC
nucleoside:H+ symporter NupC
gcd 0.21
gcd
quinoprotein glucose dehydrogenase
add 0.21
add
adenosine deaminase
fnr 0.21
fnr
FNR DNA-binding transcriptional dual regulator
mlrA 0.20
mlrA
MlrA DNA binding transcriptional activator
yjbE 0.20
yjbE
predicted protein
spy 0.20
spy
ATP-independent periplasmic chaperone
osmC 0.19
osmC
osmotically inducible peroxiredoxin
narGHJI 0.19
narG
narI
narH
narJ
nitrate reductase A, α subunit
nitrate reductase A, γ subunit
nitrate reductase A, β subunit
molybdenum cofactor assembly chaperone subunit (δ subunit) of nitrate reductase 1
gatYZABCD 0.19
gatY
gatZ
gatD
gatA
gatB
gatC
tagatose-1,6-bisphosphate aldolase 2 subunit GatY
tagatose-1,6-bisphosphate aldolase 2 subunit GatZ
L-galactitol-1-phosphate 5-dehydrogenase
galactitol PTS permease - GatA subunit
galactitol PTS permease - GatB subunit
galactitol PTS permease - GatC subunit
glmUS 0.19
glmU
glmS
fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
L-glutamine:D-fructose-6-phosphate aminotransferase
loiP 0.19
loiP
outer membrane metallopeptidase
miaA-hfq-hflXKC 0.19
miaA
hflC
hfq
hflK
hflX
tRNA(i6A37) synthase
regulator of FtsH protease
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
ribosome-dissociating factor, GTPase
yqhD-dkgA 0.19
yqhD
dkgA
NADPH-dependent aldehyde reductase
methylglyoxal reductase/isobutyraldehyde reductase/β-keto ester reductase/2,5-diketo-D-gluconate reductase
feaR 0.18
feaR
FeaR DNA-binding transcriptional activator
galET 0.18
galT
galE
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
nupG 0.18
nupG
nucleoside:H+ symporter NupG
ndh 0.18
ndh
NADH:quinone oxidoreductase II
manXYZ 0.18
manX
manY
manZ
mannose PTS permease - ManX subunit
mannose PTS permease - ManY subunit
mannose PTS permease - ManZ subunit
mutL-miaA-hfq-hflXKC 0.18
miaA
hflC
hfq
hflK
mutL
hflX
tRNA(i6A37) synthase
regulator of FtsH protease
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
MutL
ribosome-dissociating factor, GTPase
accA 0.18
accA
acetyl-CoA carboxyltransferase, α subunit
argR 0.18
argR
ArgR transcriptional dual regulator
gltI-sroC-gltJKL 0.18
sroC
gltI
gltK
gltJ
gltL
SroC
glutamate / aspartate ABC transporter - periplasmic binding protein
glutamate / aspartate ABC transporter - membrane subunit
glutamate / aspartate ABC transporter - membrane subunit
glutamate / aspartate ABC transporter - ATP binding subunit
tyrR 0.18
tyrR
TyrR DNA-binding transcriptional dual regulator
hslJ 0.18
hslJ
lipoprotein implicated in Novobiocin resistance
folA 0.18
folA
dihydrofolate reductase
yciCB 0.17
yciC
yciB
predicted inner membrane protein
inner membrane protein
rpsU-dnaG-rpoD 0.17
rpsU
dnaG
rpoD
30S ribosomal subunit protein S21
DNA primase
RNA polymerase, sigma 70 (sigma D) factor
nagBAC-umpH 0.17
nagB
nagC
umpH
nagA
glucosamine-6-phosphate deaminase
NagC DNA-binding transcriptional dual regulator
UMP phosphatase
N-acetylglucosamine-6-phosphate deacetylase
kdsC-lptCAB 0.17
kdsC
lptA
lptB
lptC
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
LptA
LptB
LptC
rpoE-rseABC 0.17
rpoE
rseB
rseC
rseA
RNA polymerase, sigma 24 (sigma E) factor
rseB
protein RseC
anti-sigma factor
rlmE-ftsH 0.17
rlmE
ftsH
23S rRNA 2'-O-ribose U2552 methyltransferase
ATP-dependent zinc metalloprotease FtsH
lysP 0.17
lysP
lysine:H+ symporter
ydeJ 0.17
ydeJ
conserved protein
preTA 0.17
preT
preA
NADH-dependent dihydropyrimidine dehydrogenase subunit
NADH-dependent dihydropyrimidine dehydrogenase subunit
rnd 0.17
rnd
RNase D
ychH 0.16
ychH
stress-induced protein
glmZ 0.16
glmZ
GlmZ
iraD 0.16
iraD
inhibitor of σS proteolysis
ssrS 0.16
ssrS
6S RNA
pyrD 0.15
pyrD
dihydroorotate dehydrogenase, type 2
nemRA-gloA 0.15
gloA
nemA
nemR
glyoxalase I
N-ethylmaleimide reductase, FMN-linked
NemR DNA-binding transcriptional repressor
rplY 0.15
rplY
50S ribosomal subunit protein L25
iraP 0.15
iraP
anti-adaptor protein for σS stabilization
fadIJ 0.15
fadJ
fadI
FadJ component of anaerobic fatty acid oxidation complex
FadI component of anaerobic fatty acid oxidation complex
lexA-dinF 0.14
dinF
lexA
putative transport protein, multi antimicrobial extrusion (MATE) family
LexA DNA-binding transcriptional repressor
plsX-fabHDG 0.14
plsX
fabG
fabH
fabD
fatty acid/phospholipid synthesis protein
3-oxoacyl-[acyl-carrier-protein] reductase subunit
β-ketoacyl-ACP synthase III
malonyl-CoA-ACP transacylase
ssrS-fau 0.14
ssrS
fau
6S RNA
5-formyltetrahydrofolate cyclo-ligase
mreBCD 0.14
mreB
mreC
mreD
dynamic cytoskeletal protein MreB
membrane protein required for maintenance of rod shape
membrane protein required for maintenance of rod shape
fumC 0.14
fumC
fumarase C
galR 0.14
galR
GalR DNA-binding transcriptional dual regulator
cadC 0.14
cadC
CadC DNA-binding transcriptional activator
proP 0.14
proP
osmolyte:H+ symporter ProP
ivbL 0.13
ivbL
ilvB operon leader peptide
yqjH 0.13
yqjH
ferric reductase, NADPH-dependent
torCAD 0.13
torD
torA
torC
chaperone protein for trimethylamine-N-oxide oxidoreductase I
trimethylamine N-oxide reductase, catalytic subunit
trimethylamine N-oxide reductase, cytochrome c-type subunit
rutR 0.13
rutR
RutR DNA-binding transcriptional dual regulator
ysgA 0.13
ysgA
predicted hydrolase
srlAEBD-gutM-srlR-gutQ 0.13
srlB
srlA
srlE
srlD
gutQ
srlR
gutM
sorbitol PTS permease - SrlB subunit
sorbitol PTS permease - SrlA subunit
sorbitol PTS permease - SrlE subunit
sorbitol-6-phosphate dehydrogenase
D-arabinose 5-phosphate isomerase
GutR DNA-binding transcriptional repressor
GutM DNA-binding transcriptional activator
fadR 0.13
fadR
FadR DNA-binding transcriptional dual regulator
hemN 0.13
hemN
coproporphyrinogen III dehydrogenase
acnA 0.13
acnA
aconitate hydratase 1
hdeD 0.13
hdeD
acid-resistance membrane protein
gpt 0.13
gpt
xanthine-guanine phsophoribosyltransferase
xseA 0.13
xseA
exonuclease VII, large subunit
galE 0.13
galE
UDP-glucose 4-epimerase
yebE 0.13
yebE
conserved inner membrane protein
fadBA 0.13
fadB
fadA
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase
3-ketoacyl-CoA thiolase
yhdT-panF-prmA 0.13
prmA
panF
yhdT
methyltransferase for 50S ribosomal subunit protein L11
pantothenate:Na+ symporter
conserved inner membrane protein
ilvY 0.13
ilvY
IlvY DNA-binding transcriptional dual regulator
uxaB 0.13
uxaB
altronate oxidoreductase
cbl 0.13
cbl
Cbl DNA-binding transcriptional activator
fldB 0.13
fldB
flavodoxin 2
rfaD-waaFCL 0.12
waaC
waaF
waaL
rfaD
ADP-heptose:LPS heptosyltransferase I
ADP-heptose:LPS heptosyltransferase II
O-antigen ligase
ADP-L-glycero-D-mannoheptose-6-epimerase
glmY 0.12
glmY
GlmY
betIBA 0.12
betB
betI
betA
betaine aldehyde dehydrogenase
BetI DNA-binding transcriptional repressor
choline dehydrogenase
alkB 0.12
alkB
AlkB repair system for alkylated DNA and RNA
metY 0.12
metY
tRNAfMet2
dgcZ 0.12
dgcZ
diguanylate cyclase
gntK 0.12
gntK
D-gluconate kinase, thermostable
aspA 0.12
aspA
aspartate ammonia-lyase
kbaZ-agaVWA 0.11
agaA
agaW
agaV
kbaZ
predicted truncated N-acetylgalactosamine-6-phosphate deacetylase
N-acetyl-D-galactosamine PTS permease (cryptic) - AgaW subunit (pseudogene)
N-acetyl-D-galactosamine PTS permease (cryptic) - AgaV subunit
tagatose-1,6-bisphosphate aldolase 1 subunit KbaZ
degS 0.11
degS
serine endoprotease
lysO 0.11
lysO
L-lysine exporter
glcDEFGBA 0.11
glcD
glcE
glcF
glcG
glcA
glcB
glycolate oxidase, predicted FAD-linked subunit
glycolate oxidase, predicted FAD-binding subunit
glycolate oxidase, predicted iron-sulfur subunit
conserved protein
glycolate / lactate:H+ symporter
malate synthase G
znuCB 0.11
znuC
znuB
Zn2+ ABC transporter - ATP binding subunit
Zn2+ ABC transporter - membrane subunit
phnCDE_1E_2FGHIJKLMNOP 0.11
phnP
phnL
phnF
phnG
phnD
phnC
phnO
phnN
phnE_1
phnE_2
phnM
phnJ
phnK
phnH
phnI
5-phospho-α-D-ribosyl 1,2-cyclic phosphate phosphodiesterase
PhnL subunit of methylphosphonate degradation complex
PhnF predicted transcriptional regulator
carbon-phosphorus lyase core complex, PhnG subunit
phosphonate ABC transporter - periplasmic binding protein
phosphonate ABC transporter - ATP binding subunit
aminoalkylphosphonate N-acetyltransferase
ribose 1,5-bisphosphokinase
phosphonate ABC transporter - membrane subunit
phosphonate/organophosphate ester transporter (pseudogene)
RPnTP hydrolase
carbon-phosphorus lyase core complex, PhnJ subunit
predicted carbon-phosphorus lyase subunit
carbon-phosphorus lyase core complex, PhnH subunit
carbon-phosphorus lyase core complex, PhnI subunit
aspA-dcuA 0.11
aspA
dcuA
aspartate ammonia-lyase
dicarboxylate transporter DcuA
pqiAB 0.11
pqiB
pqiA
paraquat-inducible protein B
paraquat-inducible protein A
serX 0.11
serX
tRNASer5
clpA 0.11
clpA
ClpA

Network of associatons between targets according to the STRING database.

First level regulatory network of Sigma70

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.3 1.0 GO:0019478 D-amino acid catabolic process(GO:0019478)
0.3 1.0 GO:0006527 arginine catabolic process(GO:0006527)
0.3 1.2 GO:0040033 negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) positive regulation of translation, ncRNA-mediated(GO:0045975)
0.3 0.8 GO:0009264 deoxyribonucleotide catabolic process(GO:0009264)
0.3 0.3 GO:0031329 regulation of cellular catabolic process(GO:0031329) regulation of cellular carbohydrate catabolic process(GO:0043471)
0.2 1.0 GO:0019646 aerobic electron transport chain(GO:0019646)
0.2 0.7 GO:0015707 nitrite transport(GO:0015707)
0.2 0.6 GO:0006007 glucose catabolic process(GO:0006007)
0.2 0.6 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.2 0.6 GO:0006059 hexitol metabolic process(GO:0006059) hexitol catabolic process(GO:0019407)
0.2 0.9 GO:1990748 cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.2 2.7 GO:0006096 glycolytic process(GO:0006096)
0.2 0.5 GO:0042150 plasmid recombination(GO:0042150)
0.1 0.4 GO:0006808 regulation of nitrogen utilization(GO:0006808)
0.1 0.8 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.1 0.5 GO:0019262 N-acetylneuraminate metabolic process(GO:0006054) N-acetylneuraminate catabolic process(GO:0019262)
0.1 0.4 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 0.4 GO:0031119 pseudouridine synthesis(GO:0001522) tRNA pseudouridine synthesis(GO:0031119)
0.1 0.4 GO:0015755 fructose transport(GO:0015755)
0.1 0.4 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.1 0.1 GO:1902116 negative regulation of organelle organization(GO:0010639) negative regulation of cell projection organization(GO:0031345) negative regulation of organelle assembly(GO:1902116) negative regulation of bacterial-type flagellum assembly(GO:1902209)
0.1 0.2 GO:0051346 negative regulation of hydrolase activity(GO:0051346)
0.1 0.6 GO:0006567 threonine catabolic process(GO:0006567)
0.1 0.2 GO:0006152 purine nucleoside catabolic process(GO:0006152)
0.1 0.2 GO:2000765 regulation of cytoplasmic translation(GO:2000765)
0.1 0.3 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.2 GO:0009225 nucleotide-sugar metabolic process(GO:0009225) nucleotide-sugar biosynthetic process(GO:0009226)
0.1 1.0 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.1 0.5 GO:0002097 tRNA wobble base modification(GO:0002097)
0.1 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.4 GO:0043335 protein unfolding(GO:0043335)
0.1 0.3 GO:0019579 aldaric acid metabolic process(GO:0019577) aldaric acid catabolic process(GO:0019579)
0.1 0.5 GO:0043200 response to amino acid(GO:0043200)
0.1 0.3 GO:0048583 regulation of response to stimulus(GO:0048583)
0.1 0.6 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.1 0.6 GO:1900190 regulation of multi-organism process(GO:0043900) regulation of single-species biofilm formation(GO:1900190)
0.1 0.3 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231) flavin-containing compound metabolic process(GO:0042726) flavin-containing compound biosynthetic process(GO:0042727)
0.1 0.2 GO:0060699 regulation of nuclease activity(GO:0032069) regulation of endoribonuclease activity(GO:0060699) regulation of ribonuclease activity(GO:0060700)
0.1 0.2 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.3 GO:0015748 organophosphate ester transport(GO:0015748)
0.1 0.1 GO:0010272 response to silver ion(GO:0010272)
0.1 0.1 GO:0006577 amino-acid betaine metabolic process(GO:0006577)
0.1 0.2 GO:0046500 S-adenosylmethionine cycle(GO:0033353) S-adenosylhomocysteine metabolic process(GO:0046498) S-adenosylmethionine metabolic process(GO:0046500)
0.1 0.2 GO:0008156 negative regulation of DNA replication(GO:0008156) negative regulation of DNA metabolic process(GO:0051053)
0.1 0.4 GO:1901998 toxin transport(GO:1901998)
0.1 0.3 GO:1901698 response to nitrogen compound(GO:1901698)
0.1 0.1 GO:0000303 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305)
0.1 0.4 GO:0030162 regulation of proteolysis(GO:0030162)
0.1 0.1 GO:0015697 quaternary ammonium group transport(GO:0015697) amino-acid betaine transport(GO:0015838)
0.1 0.2 GO:2001057 reactive nitrogen species metabolic process(GO:2001057)
0.1 1.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.6 GO:0006972 hyperosmotic response(GO:0006972)
0.1 0.2 GO:0018958 phenol-containing compound metabolic process(GO:0018958)
0.1 0.2 GO:1902022 lysine transport(GO:0015819) L-lysine transport(GO:1902022)
0.1 0.2 GO:0015992 hydrogen transport(GO:0006818) proton transport(GO:0015992)
0.1 0.2 GO:0042177 negative regulation of catabolic process(GO:0009895) regulation of protein catabolic process(GO:0042176) negative regulation of protein catabolic process(GO:0042177)
0.1 0.2 GO:0009438 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process(GO:0051596)
0.1 0.4 GO:0046377 colanic acid biosynthetic process(GO:0009242) colanic acid metabolic process(GO:0046377)
0.1 0.2 GO:0009297 pilus assembly(GO:0009297)
0.1 0.6 GO:0019395 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.1 0.1 GO:0071310 cellular response to organic substance(GO:0071310)
0.1 0.1 GO:0010043 response to zinc ion(GO:0010043)
0.1 0.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.1 GO:0043649 dicarboxylic acid catabolic process(GO:0043649)
0.1 0.3 GO:0071248 cellular response to metal ion(GO:0071248)
0.1 0.3 GO:0030163 protein catabolic process(GO:0030163)
0.1 0.1 GO:0046100 hypoxanthine metabolic process(GO:0046100)
0.0 0.1 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.1 GO:0046474 glycerophospholipid metabolic process(GO:0006650) glycerolipid biosynthetic process(GO:0045017) glycerophospholipid biosynthetic process(GO:0046474) glycerolipid metabolic process(GO:0046486)
0.0 0.4 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.1 GO:0042873 aldonate transport(GO:0042873)
0.0 0.2 GO:0000725 recombinational repair(GO:0000725)
0.0 0.2 GO:0009653 cell morphogenesis(GO:0000902) regulation of cell shape(GO:0008360) anatomical structure morphogenesis(GO:0009653) regulation of anatomical structure morphogenesis(GO:0022603) regulation of cell morphogenesis(GO:0022604) cellular component morphogenesis(GO:0032989) single-organism developmental process(GO:0044767) anatomical structure development(GO:0048856) cellular developmental process(GO:0048869) regulation of developmental process(GO:0050793)
0.0 0.1 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.5 GO:0042710 biofilm formation(GO:0042710)
0.0 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.1 GO:0035510 DNA dealkylation involved in DNA repair(GO:0006307) DNA dealkylation(GO:0035510) RNA repair(GO:0042245)
0.0 0.1 GO:0022611 dormancy process(GO:0022611)
0.0 0.1 GO:0051707 response to biotic stimulus(GO:0009607) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) response to other organism(GO:0051707)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.1 GO:0045117 azole transport(GO:0045117)
0.0 0.1 GO:0006275 regulation of DNA replication(GO:0006275)
0.0 0.2 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.2 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0009164 nucleoside catabolic process(GO:0009164)
0.0 0.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.1 GO:0009250 glucan biosynthetic process(GO:0009250)
0.0 0.1 GO:0051715 cell killing(GO:0001906) cytolysis(GO:0019835) killing of cells of other organism(GO:0031640) modification of morphology or physiology of other organism(GO:0035821) disruption of cells of other organism(GO:0044364) cytolysis in other organism(GO:0051715)
0.0 0.1 GO:0015696 ammonium transport(GO:0015696)
0.0 0.1 GO:0070201 regulation of protein localization(GO:0032880) regulation of protein transport(GO:0051223) regulation of establishment of protein localization(GO:0070201)
0.0 0.0 GO:0015685 ferric-enterobactin transport(GO:0015685)
0.0 0.0 GO:0071229 cellular response to acid chemical(GO:0071229)
0.0 0.0 GO:0051189 prosthetic group metabolic process(GO:0051189)
0.0 0.0 GO:0072512 ferric iron transport(GO:0015682) trivalent inorganic cation transport(GO:0072512)
0.0 0.0 GO:0009068 aspartate family amino acid catabolic process(GO:0009068)
0.0 0.0 GO:0006805 xenobiotic metabolic process(GO:0006805) response to xenobiotic stimulus(GO:0009410) cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.0 GO:0043086 negative regulation of catalytic activity(GO:0043086)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0070069 cytochrome complex(GO:0070069)
0.2 0.6 GO:0032300 mismatch repair complex(GO:0032300)
0.2 0.6 GO:0005856 cytoskeleton(GO:0005856)
0.1 0.3 GO:0005950 anthranilate synthase complex(GO:0005950)
0.1 0.5 GO:0061695 transferase complex, transferring phosphorus-containing groups(GO:0061695)
0.1 0.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.4 GO:0045203 integral component of cell outer membrane(GO:0045203)
0.0 0.1 GO:0005576 extracellular region(GO:0005576)
0.0 0.5 GO:0022627 small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627)
0.0 0.2 GO:0005840 ribosome(GO:0005840) large ribosomal subunit(GO:0015934) cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626) intracellular ribonucleoprotein complex(GO:0030529) ribosomal subunit(GO:0044391) ribonucleoprotein complex(GO:1990904)
0.0 1.0 GO:0019867 outer membrane(GO:0019867)
0.0 0.1 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0071575 integral component of external side of plasma membrane(GO:0071575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.3 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.3 1.0 GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor(GO:0016682)
0.3 1.5 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.3 2.0 GO:0003681 bent DNA binding(GO:0003681)
0.3 0.3 GO:0008658 penicillin binding(GO:0008658)
0.2 0.7 GO:0008443 phosphofructokinase activity(GO:0008443)
0.2 0.7 GO:0015113 nitrite transmembrane transporter activity(GO:0015113)
0.2 0.4 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 0.7 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.2 0.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.4 GO:0051192 prosthetic group binding(GO:0051192)
0.1 0.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.0 GO:0008047 enzyme activator activity(GO:0008047)
0.1 0.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.1 GO:0003978 UDP-glucose 4-epimerase activity(GO:0003978)
0.1 0.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.2 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
0.1 0.6 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 0.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.4 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.1 0.3 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 0.2 GO:0004325 ferrochelatase activity(GO:0004325)
0.1 1.0 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.3 GO:0008861 formate C-acetyltransferase activity(GO:0008861)
0.1 1.0 GO:0090563 protein-phosphocysteine-sugar phosphotransferase activity(GO:0090563)
0.1 0.3 GO:0042912 bacteriocin transmembrane transporter activity(GO:0022885) colicin transmembrane transporter activity(GO:0042912)
0.1 0.3 GO:0016662 oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662)
0.1 0.2 GO:0015437 lipopolysaccharide transmembrane transporter activity(GO:0015221) lipopolysaccharide-transporting ATPase activity(GO:0015437) glycolipid transporter activity(GO:0017089) protein complex binding(GO:0032403)
0.1 0.4 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 0.3 GO:0016408 C-acyltransferase activity(GO:0016408)
0.1 0.2 GO:0046316 gluconokinase activity(GO:0046316)
0.1 0.2 GO:0051920 peroxiredoxin activity(GO:0051920)
0.1 0.5 GO:0019239 deaminase activity(GO:0019239)
0.1 0.2 GO:0015651 amino-acid betaine transmembrane transporter activity(GO:0015199) quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.1 0.1 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.1 0.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 0.2 GO:0008940 nitrate reductase activity(GO:0008940)
0.1 0.2 GO:0043856 anti-sigma factor antagonist activity(GO:0043856)
0.1 0.1 GO:0005416 cation:amino acid symporter activity(GO:0005416)
0.1 0.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 0.1 GO:0015620 ferric-enterobactin transmembrane transporter activity(GO:0015620)
0.1 0.2 GO:0046857 oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor(GO:0046857)
0.1 0.2 GO:0045152 antisigma factor binding(GO:0045152)
0.1 0.1 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 0.5 GO:0030234 enzyme regulator activity(GO:0030234)
0.1 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.0 GO:0047451 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity(GO:0008693) 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity(GO:0019171) 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity(GO:0047451)
0.0 0.1 GO:0008962 phosphatidylglycerophosphatase activity(GO:0008962)
0.0 0.2 GO:0005469 succinate:fumarate antiporter activity(GO:0005469)
0.0 0.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.1 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.0 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0004333 fumarate hydratase activity(GO:0004333)
0.0 0.1 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.1 GO:0001217 transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding(GO:0001141) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.1 GO:0043531 ADP binding(GO:0043531)
0.0 0.1 GO:0043211 carbohydrate-transporting ATPase activity(GO:0043211)
0.0 0.3 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.0 0.4 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0000987 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding(GO:0000986) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.0 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.0 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.0 GO:0015136 sialic acid transmembrane transporter activity(GO:0015136)
0.0 0.0 GO:0008477 purine nucleosidase activity(GO:0008477)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 0.1 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 0.4 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.1 0.1 REACTOME METABOLISM OF RNA Genes involved in Metabolism of RNA
0.0 0.1 REACTOME IMMUNE SYSTEM Genes involved in Immune System
0.0 0.0 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology