Project
GSE80451: E.coli grown aerobically and anaerobically
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Results for Sigma70
Z-value: 0.41
Transcription factors associated with Sigma70
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rpoD | 0.94 | 1.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| arcA Show fit | 2.02 |
ArcA transcriptional dual regulator |
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| cydAB Show fit | 1.05 |
cytochrome bd-I terminal oxidase subunit I cytochrome bd-I terminal oxidase subunit II |
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| dadAX Show fit | 1.00 |
D-amino acid dehydrogenase alanine racemase 2, PLP-binding |
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| csrA Show fit | 0.73 |
carbon storage regulator; pleiotropic regulatory protein for carbon source metabolism |
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| narK Show fit | 0.71 |
nitrate:nitrite antiporter NarK |
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| dksA-gluQ Show fit | 0.70 |
glutamyl-Q tRNAAsp synthetase RNA polymerase-binding transcription factor DksA |
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| gpmA Show fit | 0.68 |
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase |
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| bssS Show fit | 0.60 |
regulator of biofilm formation |
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| astCADBE Show fit | 0.59 |
arginine succinyltransferase succinylarginine dihydrolase succinylornithine transaminase aldehyde dehydrogenase succinylglutamate desuccinylase |
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| pykF Show fit | 0.57 |
pyruvate kinase I |
Network of associatons between targets according to the STRING database.
First level regulatory network of Sigma70
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.7 | GO:0006096 | glycolytic process(GO:0006096) |
| 0.5 | 1.4 | GO:0010906 | regulation of glucose metabolic process(GO:0010906) |
| 0.1 | 1.3 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.3 | 1.2 | GO:0040033 | negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) positive regulation of translation, ncRNA-mediated(GO:0045975) |
| 0.3 | 1.0 | GO:0019478 | D-amino acid catabolic process(GO:0019478) |
| 0.3 | 1.0 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.2 | 1.0 | GO:0019646 | aerobic electron transport chain(GO:0019646) |
| 0.1 | 1.0 | GO:0034599 | cellular response to oxidative stress(GO:0034599) |
| 0.2 | 0.9 | GO:1990748 | cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748) |
| 0.3 | 0.8 | GO:0009264 | deoxyribonucleotide catabolic process(GO:0009264) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0019867 | outer membrane(GO:0019867) |
| 0.3 | 0.8 | GO:0070069 | cytochrome complex(GO:0070069) |
| 0.2 | 0.6 | GO:0032300 | mismatch repair complex(GO:0032300) |
| 0.2 | 0.6 | GO:0005856 | cytoskeleton(GO:0005856) |
| 0.1 | 0.5 | GO:0061695 | transferase complex, transferring phosphorus-containing groups(GO:0061695) |
| 0.0 | 0.5 | GO:0022627 | small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 0.4 | GO:0045203 | integral component of cell outer membrane(GO:0045203) |
| 0.1 | 0.3 | GO:0005950 | anthranilate synthase complex(GO:0005950) |
| 0.1 | 0.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.2 | GO:0005840 | ribosome(GO:0005840) large ribosomal subunit(GO:0015934) cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626) intracellular ribonucleoprotein complex(GO:0030529) ribosomal subunit(GO:0044391) ribonucleoprotein complex(GO:1990904) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.3 | GO:0000156 | phosphorelay response regulator activity(GO:0000156) |
| 0.3 | 2.0 | GO:0003681 | bent DNA binding(GO:0003681) |
| 0.3 | 1.5 | GO:0016868 | intramolecular transferase activity, phosphotransferases(GO:0016868) |
| 0.3 | 1.0 | GO:0016682 | oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor(GO:0016682) |
| 0.1 | 1.0 | GO:0008047 | enzyme activator activity(GO:0008047) |
| 0.1 | 1.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 1.0 | GO:0090563 | protein-phosphocysteine-sugar phosphotransferase activity(GO:0090563) |
| 0.2 | 0.7 | GO:0008443 | phosphofructokinase activity(GO:0008443) |
| 0.2 | 0.7 | GO:0015113 | nitrite transmembrane transporter activity(GO:0015113) |
| 0.2 | 0.7 | GO:0004618 | phosphoglycerate kinase activity(GO:0004618) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 0.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.0 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 0.4 | REACTOME METABOLISM OF MRNA | Genes involved in Metabolism of mRNA |
| 0.1 | 0.1 | REACTOME METABOLISM OF RNA | Genes involved in Metabolism of RNA |
| 0.0 | 0.1 | REACTOME IMMUNE SYSTEM | Genes involved in Immune System |
| 0.0 | 0.0 | REACTOME DEVELOPMENTAL BIOLOGY | Genes involved in Developmental Biology |