ISMARA results: MetJ

Project

GSE80451: E.coli grown aerobically and anaerobically

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Results for MetJ

Z-value: 0.65

Transcription factors associated with MetJ

Gene Symbol	Gene ID	Gene Info
metJ RegulonDB EcoCyc	metJ	MetJ transcriptional repressor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
metJ		-0.97	7.2e-03	Click!

Activity profile of MetJ motif

Sorted Z-values of MetJ motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
folE-yeiB Show fit	2.16		folE RegulonDB EcoCyc Show fit yeiB RegulonDB EcoCyc Show fit	GTP cyclohydrolase I conserved inner membrane protein
metBL Show fit	1.62		metB RegulonDB EcoCyc Show fit metL RegulonDB EcoCyc Show fit	O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase aspartate kinase / homoserine dehydrogenase
metR Show fit	1.05		metR RegulonDB EcoCyc Show fit	MetR DNA-binding transcriptional dual regulator
ahpCF Show fit	0.84		ahpF RegulonDB EcoCyc Show fit ahpC RegulonDB EcoCyc Show fit	alkyl hydroperoxide reductase, AhpF component alkyl hydroperoxide reductase, AhpC component
metC Show fit	0.49		metC RegulonDB EcoCyc Show fit	cystathionine-β-lyase / L-cysteine desulfhydrase
metNIQ Show fit	0.38		metI RegulonDB EcoCyc Show fit metN RegulonDB EcoCyc Show fit metQ RegulonDB EcoCyc Show fit	L-methionine / D-methionine ABC transporter - membrane subunit L-methionine / D-methionine ABC transporter - ATP binding subunit L-methionine / D-methionine ABC transporter - periplasmic binding protein
metA Show fit	0.18		metA RegulonDB EcoCyc Show fit	homoserine O-succinyltransferase

Network of associatons between targets according to the STRING database.

First level regulatory network of MetJ

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.6	GO:0009092	homoserine biosynthetic process(GO:0009090) homoserine metabolic process(GO:0009092)
0.3	0.8	GO:0009970	cellular response to sulfate starvation(GO:0009970)
0.2	0.5	GO:0044273	sulfur compound catabolic process(GO:0044273)
0.1	0.9	GO:0042455	ribonucleoside biosynthetic process(GO:0042455)
0.1	0.4	GO:0000101	sulfur amino acid transport(GO:0000101)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0009274	peptidoglycan-based cell wall(GO:0009274) anchored component of membrane(GO:0031225)
0.0	0.8	GO:1990204	oxidoreductase complex(GO:1990204)
0.0	2.2	GO:0043234	protein complex(GO:0043234)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.2	GO:0019238	cyclohydrolase activity(GO:0019238)
0.5	1.6	GO:0019202	aspartate kinase activity(GO:0004072) amino acid kinase activity(GO:0019202)
0.3	0.8	GO:0070402	NADPH binding(GO:0070402)
0.1	0.5	GO:0080146	L-cysteine desulfhydrase activity(GO:0080146)
0.1	1.1	GO:0016597	amino acid binding(GO:0016597)
0.1	0.4	GO:1901682	sulfur compound transmembrane transporter activity(GO:1901682)
0.0	0.2	GO:0016748	succinyltransferase activity(GO:0016748)