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GSE80451: E.coli grown aerobically and anaerobically

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Results for Lrp

Z-value: 4.08

Transcription factors associated with Lrp

Gene Symbol Gene ID Gene Info
lrp
lrp Lrp transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lrp-0.932.4e-02Click!

Activity profile of Lrp motif

Sorted Z-values of Lrp motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
rrsA-ileT-alaT-rrlA-rrfA 18.64
rrlA
ileT
alaT
rrsA
rrfA
23S ribosomal RNA (rrlA)
tRNAileT
tRNAalaT
16S ribosomal RNA (rrsA)
5S ribosomal RNA (rrfA)
rrsE-gltV-rrlE-rrfE 18.12
rrlE
gltV
rrsE
rrfE
rrlE 23S ribosomal RNA
tRNAgltV
rrsE 16S ribosomal RNA
rrfE 5S ribosomal RNA
rrsD-ileU-alaU-rrlD-rrfD-thrV-rrfF 17.82
rrlD
ileU
alaU
thrV
rrfF
rrsD
rrfD
rrlD 23S ribosomal RNA
tRNAileU
tRNAalaU
tRNAthrV
rrfF 5S ribosomal RNA
rrsD 16S ribosomal RNA
rrfD 5S ribosomal RNA
rrsB-gltT-rrlB-rrfB 17.79
rrlB
gltT
rrfB
rrsB
rrlB 23S ribosomal RNA
tRNAgltT
rrfB 5S ribosomal RNA
rrsB 16S ribosomal RNA
rrsC-gltU-rrlC-rrfC 17.75
rrlC
gltU
rrfC
rrsC
rrlC 23S ribosomal RNA
tRNAgltU
rrfC 5S ribosomal RNA
rrsC 16S ribosomal RNA
rrsG-gltW-rrlG-rrfG 17.64
rrlG
gltW
rrfG
rrsG
rrlG 23S ribosomal RNA
tRNAgltW
rrfG 5S ribosomal RNA
rrsG 16S ribosomal RNA
rrsH-ileV-alaV-rrlH-rrfH 16.92
rrlH
rrfH
rrsH
ileV
alaV
rrlH 23S ribosomal RNA
rrfH 5S ribosomal RNA
rrsH 16S ribosomal RNA
tRNAileV
tRNAalaV
ilvLXG_1G_2MEDA 11.97
ilvE
ilvX
ilvM
ilvL
ilvG_1
ilvD
ilvG_2
ilvA
branched-chain amino-acid aminotransferase
small protein
acetolactate synthase / acetohydroxybutanoate synthase, regulatory subunit
ilvGEDA operon leader peptide
acetolactate synthase II, large subunit, N-ter fragment (pseudogene)
dihydroxy acid dehydratase
acetolactate synthase II, large subunit, C-ter fragment (pseudogene)
threonine deaminase
avtA 8.91
avtA
valine-pyruvate aminotransferase
serA 8.28

fimE 5.69
fimE
regulator for fimA
ilvL 5.57
ilvL
ilvGEDA operon leader peptide
ilvIH 4.89
ilvI
ilvH
acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit
acetolactate synthase / acetohydroxybutanoate synthase, regulatory subunit
csiD-lhgO-gabDTP 4.27
gabD
lhgO
gabP
csiD
gabT
succinate-semialdehyde dehydrogenase (NADP+)
L-2-hydroxyglutarate oxidase
4-aminobutyrate:H+ symporter
predicted protein
4-aminobutyrate aminotransferase
serC-aroA 3.96
aroA
3-phosphoshikimate-1-carboxyvinyltransferase
gltBDF 3.85
gltB
gltD
gltF
glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein
livJ 3.22
livJ
branched chain amino acid / phenylalanine ABC transporter - periplasmic binding protein
gcvTHP 2.92
gcvH
gcvP
gcvT
glycine cleavage system H protein
glycine decarboxylase
aminomethyltransferase
serC 2.81

malT 2.73
malT
MalT transcriptional activator
hdeAB-yhiD 1.83
yhiD
hdeB
hdeA
inner membrane protein YhiD
HdeB monomer
HdeA monomer, chaperone active form
yeiL 1.72
yeiL
YeiL DNA-binding transcriptional activator
livKHMGF 1.35
livG
livF
livM
livK
livH
branched chain amino acid / phenylalanine ABC transporter - ATP binding subunit
branched chain amino acid / phenylalanine ABC transporter - ATP binding subunit
branched chain amino acid / phenylalanine ABC transporter - membrane subunit
L-leucine / L-phenylalanine ABC transporter - periplasmic binding protein
branched chain amino acid / phenylalanine ABC transporter - membrane subunit
cadBA 1.14
cadA
cadB
lysine decarboxylase 1
lysine:cadaverine antiporter
yojI 0.17
yojI
microcin J25 efflux protein, putative ABC superfamily: membrane component / ATP-binding component

Network of associatons between targets according to the STRING database.

First level regulatory network of Lrp

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 31.3 GO:0009099 valine biosynthetic process(GO:0009099)
1.9 5.7 GO:0015074 DNA integration(GO:0015074)
1.3 4.0 GO:0046417 chorismate metabolic process(GO:0046417)
1.3 3.8 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.0 2.9 GO:0019464 glycine decarboxylation via glycine cleavage system(GO:0019464)
0.9 2.7 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.9 4.3 GO:0042450 ornithine metabolic process(GO:0006591) arginine biosynthetic process via ornithine(GO:0042450)
0.6 3.0 GO:0071468 cellular response to acidic pH(GO:0071468)
0.1 0.2 GO:0042884 microcin transport(GO:0042884)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.9 GO:1990234 transferase complex(GO:1990234)
0.2 2.9 GO:1990204 oxidoreductase complex(GO:1990204)
0.1 1.3 GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing(GO:0055052)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.9 GO:0003984 acetolactate synthase activity(GO:0003984)
1.4 4.3 GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity(GO:0004777)
0.9 2.7 GO:0070492 oligosaccharide binding(GO:0070492)
0.6 1.8 GO:0051087 chaperone binding(GO:0051087)
0.6 8.5 GO:0008483 transaminase activity(GO:0008483)
0.5 2.9 GO:0031405 lipoic acid binding(GO:0031405)
0.4 1.3 GO:0015192 L-phenylalanine transmembrane transporter activity(GO:0015192)
0.3 1.1 GO:0015491 L-lysine transmembrane transporter activity(GO:0015189) cation:cation antiporter activity(GO:0015491)
0.2 4.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)