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GSE80451: E.coli grown aerobically and anaerobically

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Results for HipAB

Z-value: 0.20

Transcription factors associated with HipAB

Gene Symbol Gene ID Gene Info
hipB
hipB antitoxin DNA-binding transcriptional repressor HipB
hipA
hipA serine threonine-protein kinase toxin HipA

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hipA-0.118.6e-01Click!
hipB-0.118.6e-01Click!

Activity profile of HipAB motif

Sorted Z-values of HipAB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
relA-mazEF 0.36
mazE
relA
mazF
MazE antitoxin of the MazF-MazE toxin-antitoxin system
GDP pyrophosphokinase/GTP pyrophosphokinase
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity
hipBA 0.14
hipA
hipB
serine/threonine kinase HipA
HipB antitoxin and DNA-binding transcriptional repressor

Network of associatons between targets according to the STRING database.

First level regulatory network of HipAB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034035 guanosine tetraphosphate metabolic process(GO:0015969) purine ribonucleoside bisphosphate metabolic process(GO:0034035) ncRNA catabolic process(GO:0034661)
0.0 0.1 GO:0036289 dormancy process(GO:0022611) peptidyl-serine autophosphorylation(GO:0036289)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0005618 cell wall(GO:0005618)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016794 GTP diphosphokinase activity(GO:0008728) guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(GO:0008893) diphosphoric monoester hydrolase activity(GO:0016794)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology