Project

GSE80451: E.coli grown aerobically and anaerobically

Navigation
Downloads

Results for Fur

Z-value: 1.33

Transcription factors associated with Fur

Gene Symbol Gene ID Gene Info
fur
fur Fur transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
fur-0.847.6e-02Click!

Activity profile of Fur motif

Sorted Z-values of Fur motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
feoABC 3.66
feoB
feoC
feoA
Fe2+ transporter FeoB
predicted DNA-binding transcriptional regulator
ferrous iron transport protein A
ompF 3.05
ompF
outer membrane porin F
gdhA 2.90
gdhA
glutamate dehydrogenase
tonB 2.73
tonB
TonB energy transducing system - TonB subunit
aspC 2.41
aspC
aspartate aminotransferase, PLP-dependent
nrdHIEF 2.25
nrdH
nrdI
nrdE
nrdF
glutaredoxin-like protein
flavodoxin involved in dimanganese-tyrosyl radical cofactor maintenance for ribonucleotide reductase
ribonucleoside-diphosphate reductase 2, α subunit
ribonucleoside-diphosphate reductase 2, β subunit
pyrC 2.23
pyrC
dihydroorotase
sdhCDAB-sucABCD 2.18
sucA
sucC
sucB
sucD
sdhA
sdhC
sdhB
sdhD
subunit of E1(0) component of 2-oxoglutarate dehydrogenase
succinyl-CoA synthetase, β subunit
dihydrolipoyltranssuccinylase
succinyl-CoA synthetase, α subunit
succinate:quinone oxidoreductase, FAD binding protein
succinate:quinone oxidoreductase, membrane protein SdhC
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein
succinate:quinone oxidoreductase, membrane protein SdhD
cyoABCDE 1.98
cyoA
cyoC
cyoB
cyoE
cyoD
cytochrome bo terminal oxidase subunit II
cytochrome bo terminal oxidase subunit III
cytochrome bo terminal oxidase subunit I
heme O synthase
cytochrome bo terminal oxidase subunit IV
metH 1.95
metH
cobalamin-dependent methionine synthase
mntP 1.86
mntP
manganese export protein
flhDC 1.57
flhC
flhD
FlhC transcriptional dual regulator
FlhD transcriptional dual regulator
yjjZ 1.26
yjjZ
predicted protein
katG 1.19
katG
hydroperoxidase I
fecIR 1.17
fecR
fecI
regulator for fec operon, periplasmic
RNA polymerase, sigma 19 factor
yhhY 1.17
yhhY
N-acetyltransferase
exbD 1.07
exbD
tonB energy transducing system - ExbD subunit
gltBDF 1.06
gltB
gltD
gltF
glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein
hmp 0.97
hmp
nitric oxide dioxygenase
nohA-ydfN-tfaQ 0.85
nohA
tfaQ
ydfN
Qin prophage; predicted packaging protein
Qin prophage; predicted tail fibre assembly protein
Qin prophage; predicted side tail fibre assembly protein
fepB 0.83
fepB
ferric enterobactin ABC transporter - periplasmic binding protein
fhuF 0.80
fhuF
hydroxamate siderophore iron reductase
entS 0.75
entS
enterobactin exporter EntS
rpoS 0.68
rpoS
RNA polymerase, sigma S (sigma 38) factor
exbBD 0.68
exbB
exbD
TonB energy transducing system - ExbB subunit
tonB energy transducing system - ExbD subunit
crl 0.68
crl
RNA polymerase holoenzyme assembly factor Crl
lpd 0.66
lpd
lipoamide dehydrogenase
grcA 0.56
grcA
stress-induced alternate pyruvate formate-lyase subunit
fiu 0.45
fiu
putative outer membrane receptor for iron transport
gnd 0.36
gnd
6-phosphogluconate dehydrogenase, decarboxylating
nac 0.24
nac
Nac DNA-binding transcriptional dual regulator
fepA-entD 0.23
fepA
entD
ferric enterobactin / colicin B / colicin D outer membrane porin FepA
phosphopantetheinyl transferase/phosphopantetheinyl transferase
purR 0.23
purR
PurR transcriptional repressor
zwf 0.19
zwf
glucose-6-phosphate dehydrogenase (NADP+)
glnD 0.19
glnD
PII uridylyltransferase / uridylyl removing enzyme
entCEBAH 0.15
entA
entH
entC
entB
entE
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
proofreading thioesterase in enterobactin biosynthesis
isochorismate synthase 1
EntB
2,3-dihydroxybenzoate-AMP ligase
glnK-amtB 0.15
glnK
amtB
nitrogen regulatory protein GlnK
ammonia / ammonium transporter
fur 0.07
fur
Fur transcriptional dual regulator
fes-ybdZ-entF-fepE 0.02
ybdZ
fes
fepE
entF
MbtH-like protein that enhances the catalytic function of EntF
enterochelin esterase
ferric enterobactin (enterochelin) transport
apo-serine activating enzyme

Network of associatons between targets according to the STRING database.

First level regulatory network of Fur

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.4 GO:0015889 cobalamin transport(GO:0015889)
0.8 2.4 GO:0046417 chorismate metabolic process(GO:0046417)
0.7 2.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.7 7.5 GO:0098662 inorganic cation transmembrane transport(GO:0098662)
0.7 2.0 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.4 2.2 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleotide biosynthetic process(GO:0006221) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.4 4.0 GO:0043650 glutamate metabolic process(GO:0006536) dicarboxylic acid biosynthetic process(GO:0043650)
0.4 2.2 GO:0017004 cytochrome complex assembly(GO:0017004)
0.4 1.2 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.3 3.0 GO:0006855 drug transmembrane transport(GO:0006855)
0.3 1.0 GO:0046210 nitric oxide metabolic process(GO:0046209) nitric oxide catabolic process(GO:0046210)
0.2 1.2 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.2 0.9 GO:0015685 ferric-enterobactin transport(GO:0015685)
0.2 0.7 GO:0001121 transcription from bacterial-type RNA polymerase promoter(GO:0001121)
0.2 0.7 GO:0019464 glycine decarboxylation via glycine cleavage system(GO:0019464)
0.2 1.1 GO:0050821 protein stabilization(GO:0050821)
0.2 0.2 GO:0046189 siderophore metabolic process(GO:0009237) enterobactin metabolic process(GO:0009238) enterobactin biosynthetic process(GO:0009239) catechol-containing compound metabolic process(GO:0009712) catechol-containing compound biosynthetic process(GO:0009713) nonribosomal peptide biosynthetic process(GO:0019184) siderophore biosynthetic process(GO:0019290) siderophore biosynthetic process from catechol(GO:0019540) phenol-containing compound biosynthetic process(GO:0046189)
0.1 0.4 GO:0042884 microcin transport(GO:0042884)
0.1 0.6 GO:0006567 threonine catabolic process(GO:0006567)
0.1 0.3 GO:0006808 regulation of nitrogen utilization(GO:0006808)
0.1 0.2 GO:0048874 homeostasis of number of cells(GO:0048872) homeostasis of number of cells in a free-living population(GO:0048874)
0.1 0.7 GO:0043623 cellular protein complex assembly(GO:0043623)
0.1 0.4 GO:0046177 D-gluconate metabolic process(GO:0019521) D-gluconate catabolic process(GO:0046177)
0.1 0.7 GO:0015850 organic hydroxy compound transport(GO:0015850)
0.0 0.2 GO:0045936 negative regulation of phosphorus metabolic process(GO:0010563) negative regulation of phosphate metabolic process(GO:0045936)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0045252 tricarboxylic acid cycle enzyme complex(GO:0045239) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252) respiratory chain complex II(GO:0045273) plasma membrane respiratory chain complex II(GO:0045274)
0.7 2.0 GO:0070069 cytochrome complex(GO:0070069)
0.6 3.0 GO:0046930 pore complex(GO:0046930)
0.3 1.2 GO:0005576 extracellular region(GO:0005576)
0.3 2.7 GO:0071575 integral component of external side of plasma membrane(GO:0071575)
0.1 1.2 GO:1990234 transferase complex(GO:1990234)
0.1 2.2 GO:0044445 cytosolic part(GO:0044445)
0.0 0.2 GO:0045203 integral component of cell outer membrane(GO:0045203)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0031992 energy transducer activity(GO:0031992)
1.0 4.2 GO:0048039 ubiquinone binding(GO:0048039)
0.7 2.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.7 4.0 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.6 2.2 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.5 2.0 GO:0008172 S-methyltransferase activity(GO:0008172)
0.5 2.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.5 1.4 GO:0022885 bacteriocin transmembrane transporter activity(GO:0022885) colicin transmembrane transporter activity(GO:0042912)
0.2 1.0 GO:0032843 hydroperoxide reductase activity(GO:0032843) dioxygenase activity(GO:0051213)
0.2 0.6 GO:0004096 catalase activity(GO:0004096)
0.2 1.2 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.2 0.7 GO:0001000 bacterial-type RNA polymerase core enzyme binding(GO:0001000)
0.2 2.4 GO:0008483 transaminase activity(GO:0008483)
0.1 0.6 GO:0008861 formate C-acetyltransferase activity(GO:0008861)
0.1 0.7 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.2 GO:0001217 transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding(GO:0001141) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 0.2 GO:0016289 CoA hydrolase activity(GO:0016289) thiolester hydrolase activity(GO:0016790) phosphopantetheine binding(GO:0031177)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle