ISMARA results: CysB

Project

GSE80451: E.coli grown aerobically and anaerobically

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Results for CysB

Z-value: 0.28

Transcription factors associated with CysB

Gene Symbol	Gene ID	Gene Info
cysB RegulonDB EcoCyc	cysB	CysB transcriptional dual regulator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
cysB		0.69	2.0e-01	Click!

Activity profile of CysB motif

Sorted Z-values of CysB motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
yoaC Show fit	0.76		yoaC RegulonDB EcoCyc Show fit	predicted protein
hslJ Show fit	0.45		hslJ RegulonDB EcoCyc Show fit	lipoprotein implicated in Novobiocin resistance
dgcZ Show fit	0.38		dgcZ RegulonDB EcoCyc Show fit	diguanylate cyclase
ybdN Show fit	0.25		ybdN RegulonDB EcoCyc Show fit	conserved protein
cbl Show fit	0.24		cbl RegulonDB EcoCyc Show fit	Cbl DNA-binding transcriptional activator
cysJIH Show fit	0.18		cysI RegulonDB EcoCyc Show fit cysH RegulonDB EcoCyc Show fit cysJ RegulonDB EcoCyc Show fit	sulfite reductase, hemoprotein subunit 3'-phospho-adenylylsulfate reductase sulfite reductase, flavoprotein subunit
yfbR Show fit	0.04		yfbR RegulonDB EcoCyc Show fit	dCMP phosphohydrolase
tauABCD Show fit	0.02		tauB RegulonDB EcoCyc Show fit tauC RegulonDB EcoCyc Show fit tauA RegulonDB EcoCyc Show fit tauD RegulonDB EcoCyc Show fit	taurine ABC transporter - ATP binding subunit taurine ABC transporter - membrane subunit taurine ABC transporter - periplasmic binding protein taurine dioxygenase

Network of associatons between targets according to the STRING database.

First level regulatory network of CysB

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0010639	negative regulation of organelle organization(GO:0010639) negative regulation of cell projection organization(GO:0031345) cell adhesion involved in biofilm formation(GO:0043708) negative regulation of organelle assembly(GO:1902116) negative regulation of bacterial-type flagellum assembly(GO:1902209)
0.0	0.0	GO:0009177	pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0052621	diguanylate cyclase activity(GO:0052621)
0.0	0.2	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.0	GO:0050897	cobalt ion binding(GO:0050897)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	REACTOME ADAPTIVE IMMUNE SYSTEM	Genes involved in Adaptive Immune System