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GSE80451: E.coli grown aerobically and anaerobically

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Results for Cra

Z-value: 1.93

Transcription factors associated with Cra

Gene Symbol Gene ID Gene Info
cra
cra Cra DNA-binding transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cra-0.997.5e-04Click!

Activity profile of Cra motif

Sorted Z-values of Cra motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
eno 12.90
eno
enolase
gapA 7.05
gapA
glyceraldehyde 3-phosphate dehydrogenase
prpBCDE 6.40
prpD
prpE
prpB
prpC
2-methylcitrate dehydratase
propionyl-CoA synthetase
2-methylisocitrate lyase
2-methylcitrate synthase
fruBKA 4.36
fruK
fruB
fruA
1-phosphofructokinase
fructose PTS permease - FruB subunit
fructose PTS permease - FruA subunit
pykF 3.93
pykF
pyruvate kinase I
gapA-yeaD 3.27
gapA
yeaD
glyceraldehyde 3-phosphate dehydrogenase
conserved protein
mtlADR 3.21
mtlR
mtlA
mtlD
MtlR DNA-binding transcriptional repressor
mannitol PTS permease
mannitol-1-phosphate 5-dehydrogenase
cydAB 2.85
cydA
cydB
cytochrome bd-I terminal oxidase subunit I
cytochrome bd-I terminal oxidase subunit II
pfkA 2.84
pfkA
6-phosphofructokinase I
manXYZ 2.57
manX
manY
manZ
mannose PTS permease - ManX subunit
mannose PTS permease - ManY subunit
mannose PTS permease - ManZ subunit
acnA 1.97
acnA
aconitate hydratase 1
betIBA 1.87
betB
betI
betA
betaine aldehyde dehydrogenase
BetI DNA-binding transcriptional repressor
choline dehydrogenase
adhE 1.40
adhE
aldehyde-alcohol dehydrogenase
fbaB 1.38
fbaB
fructose bisphosphate aldolase class I
ptsHI-crr 1.35
ptsI
ptsH
crr
PTS enzyme I
HPr
Enzyme IIAGlc; Crr
betT 1.35
betT
choline:H+ symporter
tpiA 1.33
tpiA
triosephosphate isomerase
epd-pgk-fbaA 1.29
epd
pgk
fbaA
erythrose 4-phosphate dehydrogenase
phosphoglycerate kinase
fructose bisphosphate aldolase class II
epd-pgk 1.01
epd
pgk
erythrose 4-phosphate dehydrogenase
phosphoglycerate kinase
poxB 0.87
poxB
pyruvate oxidase
glk 0.24
glk
glucosamine kinase/glucokinase
zwf 0.20
zwf
glucose-6-phosphate dehydrogenase (NADP+)
nirBDC-cysG 0.07
nirD
cysG
nirC
nirB
nitrite reductase, small subunit
siroheme synthase subunit
nitrite transporter NirC
nitrite reductase, large subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of Cra

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0015755 fructose transport(GO:0015755)
2.0 33.9 GO:0006096 glycolytic process(GO:0006096)
1.1 3.2 GO:0006059 hexitol metabolic process(GO:0006059) hexitol catabolic process(GO:0019407)
1.0 3.0 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.7 1.4 GO:0043471 regulation of glucose metabolic process(GO:0010906) regulation of cellular catabolic process(GO:0031329) regulation of cellular carbohydrate catabolic process(GO:0043471)
0.5 1.9 GO:0006577 amino-acid betaine metabolic process(GO:0006577)
0.5 1.4 GO:0006067 ethanol metabolic process(GO:0006067)
0.2 1.3 GO:0015696 ammonium transport(GO:0015696)
0.1 0.5 GO:0019646 aerobic electron transport chain(GO:0019646)
0.1 2.0 GO:0009061 anaerobic respiration(GO:0009061)
0.1 0.2 GO:0048872 homeostasis of number of cells(GO:0048872) homeostasis of number of cells in a free-living population(GO:0048874)
0.0 0.9 GO:0051262 protein tetramerization(GO:0051262) protein homotetramerization(GO:0051289)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 12.9 GO:0005856 cytoskeleton(GO:0005856)
0.4 2.8 GO:0061695 transferase complex, transferring phosphorus-containing groups(GO:0061695)
0.3 5.7 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.2 1.3 GO:0005618 cell wall(GO:0005618)
0.2 0.5 GO:0070069 cytochrome complex(GO:0070069)
0.0 16.3 GO:0016020 membrane(GO:0016020)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 12.6 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
2.4 7.2 GO:0008443 phosphofructokinase activity(GO:0008443)
1.1 6.4 GO:0016878 acid-thiol ligase activity(GO:0016878)
0.9 2.8 GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor(GO:0016682)
0.7 1.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 1.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.3 10.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 2.6 GO:0015149 hexose transmembrane transporter activity(GO:0015149)
0.3 1.4 GO:0008047 enzyme activator activity(GO:0008047)
0.2 3.2 GO:0090563 protein-phosphocysteine-sugar phosphotransferase activity(GO:0090563)
0.2 1.4 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.2 1.3 GO:0008519 ammonium transmembrane transporter activity(GO:0008519) alcohol transmembrane transporter activity(GO:0015665)
0.1 0.9 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 1.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0015113 ferrochelatase activity(GO:0004325) nitrite transmembrane transporter activity(GO:0015113) uptake transmembrane transporter activity(GO:0015563)