Project
GSE80451: E.coli grown aerobically and anaerobically
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Results for CRP
Z-value: 0.75
Transcription factors associated with CRP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| crp | -0.61 | 2.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| glnA Show fit | 0.45 |
glutamine synthetase |
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| spf Show fit | 0.45 |
Spot42 |
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| glpABC Show fit | 0.30 |
anaerobic glycerol-3-phosphate dehydrogenase subunit A anaerobic glycerol-3-phosphate dehydrogenase subunit C anaerobic glycerol-3-phosphate dehydrogenase subunit B |
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| ykgR Show fit | 0.24 |
small membrane protein |
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| tnaC Show fit | 0.23 |
tryptophanase operon leader peptide |
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| ppiA Show fit | 0.22 |
peptidyl-prolyl cis-trans isomerase A (rotamase A) |
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| bglG Show fit | 0.21 |
BglG transcriptional antiterminator |
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| dctA Show fit | 0.21 |
C4 dicarboxylate / orotate:H+ symporter |
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| rhaSR Show fit | 0.20 |
RhaS transcriptional activator RhaR transcriptional activator |
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| hofMNOP Show fit | 0.20 |
protein involved in utilization of DNA as a carbon source protein involved in utilization of DNA as a carbon source protein involved in utilization of DNA as a carbon source protein involved in utilization of DNA as a carbon source |
Network of associatons between targets according to the STRING database.
First level regulatory network of CRP
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.2 | 0.6 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 0.1 | 0.3 | GO:0019566 | arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568) |
| 0.1 | 0.3 | GO:0090357 | regulation of cellular amino acid metabolic process(GO:0006521) regulation of cellular amine metabolic process(GO:0033238) regulation of tryptophan metabolic process(GO:0090357) |
| 0.0 | 0.3 | GO:0031669 | cellular response to nutrient levels(GO:0031669) |
| 0.1 | 0.2 | GO:0015976 | carbon utilization(GO:0015976) |
| 0.1 | 0.2 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.1 | 0.2 | GO:0071941 | nitrogen cycle metabolic process(GO:0071941) |
| 0.1 | 0.2 | GO:0042873 | aldonate transport(GO:0042873) |
| 0.1 | 0.2 | GO:0015748 | organophosphate ester transport(GO:0015748) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:1990204 | oxidoreductase complex(GO:1990204) |
| 0.1 | 0.3 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 0.2 | GO:0045273 | respiratory chain complex II(GO:0045273) plasma membrane respiratory chain complex II(GO:0045274) |
| 0.0 | 0.1 | GO:0070069 | cytochrome complex(GO:0070069) |
| 0.0 | 0.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 0.1 | GO:0031246 | intrinsic component of periplasmic side of cell outer membrane(GO:0031246) |
| 0.0 | 0.0 | GO:0009295 | nucleoid(GO:0009295) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0016211 | ammonia ligase activity(GO:0016211) |
| 0.0 | 0.4 | GO:0003700 | transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 0.3 | GO:0042879 | gluconate transmembrane transporter activity(GO:0015128) aldonate transmembrane transporter activity(GO:0042879) |
| 0.0 | 0.3 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.1 | 0.2 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) |
| 0.1 | 0.2 | GO:0016901 | oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901) |
| 0.1 | 0.2 | GO:0000104 | succinate dehydrogenase activity(GO:0000104) |
| 0.1 | 0.2 | GO:0016208 | AMP binding(GO:0016208) |
| 0.1 | 0.2 | GO:0015150 | fucose transmembrane transporter activity(GO:0015150) |
| 0.0 | 0.2 | GO:0015556 | dicarboxylic acid transmembrane transporter activity(GO:0005310) fumarate transmembrane transporter activity(GO:0015138) succinate transmembrane transporter activity(GO:0015141) C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 0.1 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | Genes involved in Platelet activation, signaling and aggregation |
| 0.1 | 0.2 | REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | Genes involved in The citric acid (TCA) cycle and respiratory electron transport |
| 0.0 | 0.1 | REACTOME DEVELOPMENTAL BIOLOGY | Genes involved in Developmental Biology |