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GSE67402: E.coli regulatory changes under long-term starvation

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Results for Sigma70

Z-value: 3.87

Transcription factors associated with Sigma70

Gene Symbol Gene ID Gene Info
rpoD
rpoD RNA polymerase sigma factor RpoD

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rpoD0.946.8e-13Click!

Activity profile of Sigma70 motif

Sorted Z-values of Sigma70 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
ilvIH 47.73
ilvI
ilvH
acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit
acetolactate synthase / acetohydroxybutanoate synthase, regulatory subunit
tufA 44.87
tufA
elongation factor Tu
topA 44.16
topA
DNA topoisomerase I
cspA 41.49
cspA
CspA DNA-binding transcriptional activator
hupB 38.79
hupB
transcriptional dual regulator HU-β, NS1 (HU-1)
rpsA-ihfB 35.73
ihfB
rpsA
integration host factor (IHF), β subunit
30S ribosomal subunit protein S1
ahpCF 32.77
ahpF
ahpC
alkyl hydroperoxide reductase, AhpF component
alkyl hydroperoxide reductase, AhpC component
pgk-fbaA 31.54
pgk
fbaA
phosphoglycerate kinase
fructose bisphosphate aldolase class II
gltX 29.61
gltX
glutamate-tRNA ligase
serA 28.84

rne 28.83
rne
RNase E
yjeF-tsaE-amiB-mutL-miaA-hfq-hflXKC 28.70
miaA
tsaE
hfq
hflK
mutL
amiB
yjeF
hflX
hflC
tRNA(i6A37) synthase
N6-L-threonylcarbamoyladenine synthase, TsaE subunit
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
MutL
N-acetylmuramoyl-L-alanine amidase B
NAD(P)HX epimerase / NAD(P)HX dehydratase
ribosome-dissociating factor, GTPase
regulator of FtsH protease
flgBCDEFGHIJ 28.07
flgC
flgB
flgG
flgF
flgE
flgD
flgJ
flgI
flgH
flagellar basal-body rod protein FlgC
flagellar basal-body rod protein FlgB
flagellar basal-body rod protein FlgG
flagellar basal-body rod protein FlgF
flagellar hook protein FlgE
flagellar biosynthesis, initiation of hook assembly
FlgJ
flagellar P-ring protein FlgI
flagellar L-ring protein FlgH; basal-body outer-membrane L (lipopolysaccharide layer) ring protein
rpsF-priB-rpsR-rplI 27.74
rpsF
priB
rpsR
rplI
30S ribosomal subunit protein S6
primosomal replication protein N
30S ribosomal subunit protein S18
50S ribosomal subunit protein L9
rpsMKD-rpoA-rplQ 27.63
rpsD
rpsM
rpsK
rplQ
rpoA
30S ribosomal subunit protein S4
30S ribosomal subunit protein S13
30S ribosomal subunit protein S11
50S ribosomal subunit protein L17
RNA polymerase, α subunit
rpsJ-rplCDWB-rpsS-rplV-rpsC-rplP-rpmC-rpsQ 26.28
rpsC
rplV
rplW
rpsJ
rplP
rpsS
rpsQ
rpmC
rplD
rplB
rplC
30S ribosomal subunit protein S3
50S ribosomal subunit protein L22
50S ribosomal subunit protein L23
30S ribosomal subunit protein S10
50S ribosomal subunit protein L16
30S ribosomal subunit protein S19
30S ribosomal subunit protein S17
50S ribosomal subunit protein L29
50S ribosomal subunit protein L4
50S ribosomal subunit protein L2
50S ribosomal subunit protein L3
aroKB-damX-dam-rpe-gph-trpS 26.25
damX
gph
dam
aroB
rpe
trpS
aroK
cell division protein DamX
phosphoglycolate phosphatase
DNA adenine methyltransferase
3-dehydroquinate synthase
ribulose-5-phosphate 3-epimerase
tryptophan-tRNA ligase
shikimate kinase I
tff-rpsB-tsf 25.82
tsf
tff
rpsB
protein chain elongation factor EF-Ts
Tff
30S ribosomal subunit protein S2
icd 24.49
icd
isocitrate dehydrogenase
atpIBEFHAGDC 24.46
atpI
atpH
atpC
atpB
atpA
atpG
atpF
atpE
atpD
AtpI
ATP synthase F1 complex - delta subunit
ATP synthase F1 complex - epsilon subunit
ATP synthase F0 complex - a subunit
ATP synthase F1 complex - alpha subunit
ATP synthase F1 complex - gamma subunit
ATP synthase F0 complex - b subunit
ATP synthase F0 complex - subunit c
ATP synthase F1 complex - beta subunit
rplM-rpsI 24.36
rplM
rpsI
50S ribosomal subunit protein L13
30S ribosomal subunit protein S9
gapA 24.21
gapA
glyceraldehyde 3-phosphate dehydrogenase
kdsC-lptCAB 23.57
kdsC
lptA
lptB
lptC
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
LptA
LptB
LptC
rpsP-rimM-trmD-rplS 23.50
rplS
rimM
trmD
rpsP
50S ribosomal subunit protein L19
ribosome maturation protein
tRNA m1G37 methyltransferase
30S ribosomal subunit protein S16
rpsU-dnaG-rpoD 23.19
rpsU
dnaG
rpoD
30S ribosomal subunit protein S21
DNA primase
RNA polymerase, sigma 70 (sigma D) factor
lrp 22.48
lrp
Lrp transcriptional dual regulator
cmk-rpsA 21.05
cmk
rpsA
cytidylate kinase
30S ribosomal subunit protein S1
hfq-hflXKC 20.55
hflC
hfq
hflK
hflX
regulator of FtsH protease
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
ribosome-dissociating factor, GTPase
folE-yeiB 20.18
folE
yeiB
GTP cyclohydrolase I
conserved inner membrane protein
ilvC 19.25
ilvC
acetohydroxy acid isomeroreductase
metH 18.99
metH
cobalamin-dependent methionine synthase
pgk 18.83
pgk
phosphoglycerate kinase
rpmI-rplT 18.64
rpmI
rplT
50S ribosomal subunit protein L35
50S ribosomal subunit protein L20
pcnB-folK 18.14
pcnB
folK
poly(A) polymerase I
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
cysPUWAM 18.11
cysU
cysM
cysW
cysA
cysP
sulfate / thiosulfate ABC transporter - membrane subunit
cysteine synthase B
sulfate / thiosulfate ABC transporter - membrane subunit
sulfate / thiosulfate ABC transporter - ATP binding subunit
sulfate / thiosulfate ABC transporter - periplasmic binding protein CysP
dusB-fis 18.07
fis
dusB
Fis DNA-binding transcriptional dual regulator
tRNA-dihydrouridine synthase B
malPQ 18.00
malP
malQ
maltodextrin phosphorylase
amylomaltase/amylomaltase/amylomaltase
rplY 17.89
rplY
50S ribosomal subunit protein L25
infA 17.84
infA
protein chain initiation factor IF-1
nuoABCEFGHIJKLMN 17.82
nuoB
nuoC
nuoA
nuoF
nuoG
nuoE
nuoJ
nuoK
nuoH
nuoI
nuoN
nuoL
nuoM
NADH:ubiquinone oxidoreductase, chain B
NADH:ubiquinone oxidoreductase, chain CD
NADH:ubiquinone oxidoreductase, membrane subunit A
NADH:ubiquinone oxidoreductase, chain F
NADH:ubiquinone oxidoreductase, chain G
NADH:ubiquinone oxidoreductase, chain E
NADH:ubiquinone oxidoreductase, membrane subunit J
NADH:ubiquinone oxidoreductase, membrane subunit K
NADH:ubiquinone oxidoreductase, membrane subunit H
NADH:ubiquinone oxidoreductase, chain I
NADH:ubiquinone oxidoreductase, membrane subunit N
NADH:ubiquinone oxidoreductase, membrane subunit L
NADH:ubiquinone oxidoreductase, membrane subunit M
trxA 17.48
trxA
thioredoxin 1
rnb 17.47
rnb
ribonuclease II
hisBHAFI 17.45
hisF
hisH
hisA
hisB
hisI
imidazole glycerol phosphate synthase, HisF subunit
imidazole glycerol phosphate synthase, HisH subunit
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase
imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase
phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase
cysDNC 17.36
cysD
cysN
cysC
sulfate adenylyltransferase, CysD subunit
sulfate adenylyltransferase, CysN subunit
adenylylsulfate kinase
glmUS 17.34
glmU
glmS
fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
L-glutamine:D-fructose-6-phosphate aminotransferase
serC-aroA 17.33
aroA
3-phosphoshikimate-1-carboxyvinyltransferase
flhBAE 17.28
flhB
flhA
flhE
flagellar biosynthesis protein FlhB
flagellar biosynthesis protein FlhA
flagellar protein
pepA 17.02
pepA
aminopeptidase A/I
opgGH 16.86
opgG
opgH
periplasmic protein associated with synthesis of osmoregulated periplasmic glucans (OPGs)
membrane glycosyltransferase; synthesis of osmoregulated periplasmic glucans (OPGs)
relA-mazEF 16.86
mazE
relA
mazF
MazE antitoxin of the MazF-MazE toxin-antitoxin system
GDP pyrophosphokinase/GTP pyrophosphokinase
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity
cysJIH 16.74
cysI
cysH
cysJ
sulfite reductase, hemoprotein subunit
3'-phospho-adenylylsulfate reductase
sulfite reductase, flavoprotein subunit
dadAX 16.66
dadA
dadX
D-amino acid dehydrogenase
alanine racemase 2, PLP-binding
focA-pflB 16.50
focA
pflB
formate channel FocA
pyruvate formate-lyase (inactive)
infC-rpmI-rplT 16.41
rpmI
rplT
infC
50S ribosomal subunit protein L35
50S ribosomal subunit protein L20
protein chain initiation factor IF-3
carAB 16.21
carB
carA
carbamoyl phosphate synthetase, β chain
carbamoyl phosphate synthetase, α chain
yrbN-deaD 15.98
yrbN
deaD
small protein
DeaD, DEAD-box RNA helicase
glyA 15.53
glyA
serine hydroxymethyltransferase
aceEF 15.38
aceF
aceE
pyruvate dehydrogenase, E2 subunit
subunit of E1p component of pyruvate dehydrogenase complex
rimP-nusA-infB 15.12
rimP
infB
nusA
ribosome maturation factor RimP
protein chain initiation factor IF2
transcription termination/antitermination L factor
dppABCDF 15.03
dppA
dppB
dppC
dppD
dppF
dipeptide ABC transporter - periplasmic binding protein
dipeptide ABC transporter - predicted membrane subunit
dipeptide ABC transporter - predicted membrane subunit
dipeptide ABC transporter - predicted ATP binding subunit
dipeptide ABC transporter - predicted ATP binding subunit
rplU-rpmA 14.94
rpmA
rplU
50S ribosomal subunit protein L27
50S ribosomal subunit protein L21
flgAMN 14.84
flgA
flgN
flgM
flagellar biosynthesis; assembly of basal-body periplasmic P ring
flagellar biosynthesis protein FlgN
anti-sigma factor for FliA (σ28)
pnp 14.83
pnp
polynucleotide phosphorylase
malEFG 14.82
malF
malG
malE
maltose ABC transporter - membrane subunit
maltose ABC transporter - membrane subunit
maltose ABC transporter - periplasmic binding protein
cydAB 14.70
cydA
cydB
cytochrome bd-I terminal oxidase subunit I
cytochrome bd-I terminal oxidase subunit II
cmoM-mukFEB 14.62
cmoM
mukB
mukF
mukE
tRNA cmo5U34 methyltransferase
cell division protein involved in chromosome partitioning
Ca2+-binding protein involved in chromosome partitioning
protein involved in chromosome partitioning
livJ 14.60
livJ
branched chain amino acid / phenylalanine ABC transporter - periplasmic binding protein
spf 14.52
spf
Spot42
asnA 14.51
asnA
asparagine synthetase A
yobF-cspC 14.45
yobF
cspC
small protein involved in stress responses
stress protein, member of the CspA family
pntAB 14.24
pntB
pntA
pyridine nucleotide transhydrogenase, β subunit
pyridine nucleotide transhydrogenase, α subunit
rfe-wzzE-wecBC-rffGHC-wecE-wzxE-rffT-wzyE-rffM 14.20
rffG
rffC
wecE
wzxE
rffM
wzyE
rffH
wecB
rffT
wzzE
wecC
rfe
dTDP-glucose 4,6-dehydratase 2
dTDP-fucosamine acetyltransferase
dTDP-4-dehydro-6-deoxy-D-glucose transaminase
lipid III flippase
UDP-N-acetyl-D-mannosaminuronic acid transferase
predicted Wzy protein involved in ECA polysaccharide chain elongation
dTDP-glucose pyrophosphorylase 2
UDP-N-acetylglucosamine 2-epimerase
4-acetamido-4,6-dideoxy-D-galactose transferase
Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein
UDP-N-acetyl-D-mannosamine dehydrogenase
undecaprenyl-phosphate α-N-acetylglucosaminyl transferase
rplU-rpmA-yhbE-obgE 14.17
rpmA
yhbE
rplU
obgE
50S ribosomal subunit protein L27
inner membrane protein YhbE
50S ribosomal subunit protein L21
GTPase involved in chromosome partitioning and ribosome assembly
dnaN-recF 14.11
recF
dnaN
ssDNA and dsDNA binding, ATP binding
DNA polymerase III, β subunit
udp 14.09
udp
uridine phosphorylase
mreBCD 14.08
mreB
mreC
mreD
dynamic cytoskeletal protein MreB
membrane protein required for maintenance of rod shape
membrane protein required for maintenance of rod shape
serC 14.05

artPIQM 14.04
artQ
artP
artI
artM
L-arginine ABC transporter - membrane subunit
L-arginine ABC transporter - ATP binding subunit
periplasmic binding protein ArtI
L-arginine ABC transporter - membrane subunit
cusCFBA 13.88
cusA
cusC
cusB
cusF
copper / silver exporter - membrane subunit
copper / silver exporter - outer membrane porin
copper / silver exporter - membrane fusion protein
copper / silver exporter - periplasmic binding protein and metallochaperone
ribF-ileS-lspA-fkpB-ispH 13.84
lspA
ileS
ispH
fkpB
ribF
prolipoprotein signal peptidase II
isoleucine-tRNA ligase
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
peptidyl-prolyl cis-trans isomerase
bifunctional riboflavin kinase / FMN adenylyltransferase
tatABC 13.66
tatA
tatC
tatB
twin arginine protein translocation system - TatA protein
twin arginine protein translocation system - TatC protein
twin arginine protein translocation system - TatB protein
ftsK 13.56
ftsK
essential cell division protein FtsK
rpoN-hpf-ptsN-rapZ-npr 13.53
rapZ
ptsN
rpoN
npr
hpf
RNase adaptor protein
phosphotransferase system enzyme IIA, regulation of potassium transport
RNA polymerase, sigma 54 (sigma N) factor
phosphorelay protein Npr
hibernation promoting factor
tatABCD 13.47
tatD
tatA
tatC
tatB
ssDNA/RNA exonuclease, 3' → 5' specific
twin arginine protein translocation system - TatA protein
twin arginine protein translocation system - TatC protein
twin arginine protein translocation system - TatB protein
dapA-bamC 13.39
dapA
bamC
4-hydroxy-tetrahydrodipicolinate synthase
Outer Membrane Protein Assembly Complex - BamC subunit
aroG 13.37
aroG
2-dehydro-3-deoxyphosphoheptonate aldolase
lptD 13.30
lptD
outer membrane lipopolysaccharide transport and assembly complex - LptD subunit
glyQS 13.26
glyS
glyQ
glycine-tRNA ligase, β subunit
glycine-tRNA ligase, α subunit
proP 13.16
proP
osmolyte:H+ symporter ProP
galETKM 13.07
galT
galE
galM
galK
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
galactose-1-epimerase
galactokinase
aroF-tyrA 13.05
tyrA
aroF
chorismate mutase / prephenate dehydrogenase
2-dehydro-3-deoxyphosphoheptonate aldolase
ileS-lspA-fkpB-ispH 12.90
ileS
ispH
fkpB
lspA
isoleucine-tRNA ligase
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
peptidyl-prolyl cis-trans isomerase
prolipoprotein signal peptidase II
livKHMGF 12.88
livG
livF
livM
livK
livH
branched chain amino acid / phenylalanine ABC transporter - ATP binding subunit
branched chain amino acid / phenylalanine ABC transporter - ATP binding subunit
branched chain amino acid / phenylalanine ABC transporter - membrane subunit
L-leucine / L-phenylalanine ABC transporter - periplasmic binding protein
branched chain amino acid / phenylalanine ABC transporter - membrane subunit
plsX-fabHDG 12.82
plsX
fabG
fabH
fabD
fatty acid/phospholipid synthesis protein
3-oxoacyl-[acyl-carrier-protein] reductase subunit
β-ketoacyl-ACP synthase III
malonyl-CoA-ACP transacylase
trpCBA 12.79
trpB
trpC
trpA
tryptophan synthase, β subunit
indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
tryptophan synthase, α subunit
mgtLA 12.74
mgtA
mgtL
Mg2+ / Ni2+ transporting ATPase
predicted leader peptide
copA 12.71
copA
Cu+ export ATPase
gyrA 12.67
gyrA
DNA gyrase, subunit A
bcp 12.63
bcp
thiol peroxidase
hisS 12.62
hisS
histidine-tRNA ligase
glnQ 12.46
glnQ
L-glutamine ABC transporter - ATP binding subunit
rpsU 12.44
rpsU
30S ribosomal subunit protein S21
sdhDAB 12.31
sdhA
sdhB
sdhD
succinate:quinone oxidoreductase, FAD binding protein
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein
succinate:quinone oxidoreductase, membrane protein SdhD
nudB-yebC-ruvC 12.28
ruvC
nudB
yebC
Holliday junction nuclease; resolution of structures; repair
dihydroneopterin triphosphate pyrophosphohydrolase
conserved protein
epd-pgk-fbaA 12.27
epd
pgk
fbaA
erythrose 4-phosphate dehydrogenase
phosphoglycerate kinase
fructose bisphosphate aldolase class II
glnA 12.25
glnA
glutamine synthetase
lspA-fkpB-ispH 12.15
lspA
ispH
fkpB
prolipoprotein signal peptidase II
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
peptidyl-prolyl cis-trans isomerase
ftsAZ 12.10
ftsZ
ftsA
essential cell division protein FtsZ
essential cell division protein FtsA
crp 12.09
crp
CRP transcriptional dual regulator
hpt 12.06
hpt
hypoxanthine-guanine phosphoribosyltransferase
acnB 12.05
acnB
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase
accBC 12.02
accC
accB
biotin carboxylase
biotin carboxyl carrier protein
evgAS 11.97
evgA
evgS
EvgA transcriptional activator
EvgS sensory histidine kinase
cysK 11.78
cysK
O-acetylserine sulfhydrylase A
flhDC 11.72
flhC
flhD
FlhC transcriptional dual regulator
FlhD transcriptional dual regulator
valS 11.69
valS
valine-tRNA ligase
thrLABC 11.40
thrL
thrB
thrC
thrA
thr operon leader peptide
homoserine kinase
threonine synthase
aspartate kinase / homoserine dehydrogenase
lpd 11.38
lpd
lipoamide dehydrogenase
gyrB 11.34
gyrB
DNA gyrase, subunit B
efp 11.29
efp
protein chain elongation factor EF-P
guaBA 11.14
guaB
guaA
IMP dehydrogenase
GMP synthetase
rdoA-dsbA 11.05
dsbA
rdoA
protein disulfide oxidoreductase - DsbAreduced
serine/threonine protein kinase
upp-uraA 11.04
upp
uraA
uracil phosphoribosyltransferase
uracil:H+ symporter UraA
hisJQMP 11.01
hisM
hisP
hisQ
hisJ
lysine/arginine/ornithine ABC transporter / histidine ABC transporter - membrane subunit
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - ATP binding subunit
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - membrane subunit
histidine ABC transporter - periplasmic binding protein
mutL-miaA-hfq-hflXKC 10.98
miaA
hflC
hfq
hflK
mutL
hflX
tRNA(i6A37) synthase
regulator of FtsH protease
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
MutL
ribosome-dissociating factor, GTPase
sdhCDAB-sucABCD 10.98
sucA
sucC
sucB
sucD
sdhA
sdhC
sdhB
sdhD
subunit of E1(0) component of 2-oxoglutarate dehydrogenase
succinyl-CoA synthetase, β subunit
dihydrolipoyltranssuccinylase
succinyl-CoA synthetase, α subunit
succinate:quinone oxidoreductase, FAD binding protein
succinate:quinone oxidoreductase, membrane protein SdhC
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein
succinate:quinone oxidoreductase, membrane protein SdhD
miaA-hfq-hflXKC 10.97
miaA
hflC
hfq
hflK
hflX
tRNA(i6A37) synthase
regulator of FtsH protease
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
ribosome-dissociating factor, GTPase
pheLA 10.95
pheA
pheL
chorismate mutase / prephenate dehydratase
leader peptide of chorismate mutase-P-prephenate dehydratase
accA 10.91
accA
acetyl-CoA carboxyltransferase, α subunit
damX-dam-rpe-gph-trpS 10.65
dam
damX
rpe
trpS
gph
DNA adenine methyltransferase
cell division protein DamX
ribulose-5-phosphate 3-epimerase
tryptophan-tRNA ligase
phosphoglycolate phosphatase
yibN-grxC-secB-gpsA 10.62
grxC
gpsA
secB
yibN
reduced glutaredoxin 3
glycerol-3-phosphate dehydrogenase
SecB chaperone
predicted rhodanese-related sulfurtransferase
trpLEDCBA 10.62
trpL
trpB
trpC
trpA
trpD
trpE
trp operon leader peptide
tryptophan synthase, β subunit
indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
tryptophan synthase, α subunit
anthranilate synthase component II
anthranilate synthase component I
glnALG 10.50
glnL
glnA
glnG
NtrB
glutamine synthetase
NtrC transcriptional dual regulator
gltBDF 10.45
gltB
gltD
gltF
glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein
yebC-ruvC 10.45
ruvC
yebC
Holliday junction nuclease; resolution of structures; repair
conserved protein
hscBA-fdx-iscX 10.44
hscB
fdx
hscA
iscX
co-chaperone for [Fe-S] cluster biosynthesis
reduced ferredoxin
chaperone for [Fe-S] cluster biosynthesis
regulator of iron-sulfur cluster assembly
proVWX 10.31
proX
proW
proV
glycine betaine / proline ABC transporter - periplasmic binding protein
glycine betaine / proline ABC transporter - membrane subunit
glycine betaine / proline ABC transporter - ATP binding subunit
lolA-rarA 10.27
rarA
lolA
recombination factor
periplasmic chaperone, effects translocation of lipoproteins from inner membrane to outer
ptsG 10.25
ptsG
glucose PTS permease - PtsG subunit
argCBH 10.22
argH
argB
argC
argininosuccinate lyase
acetylglutamate kinase
N-acetylglutamylphosphate reductase
nrdAB-yfaE 10.17
nrdA
nrdB
yfaE
ribonucleoside diphosphate reductase 1, α subunit
ribonucleoside diphosphate reductase 1, β subunit, ferritin-like
2Fe-2S cluster-containing protein involved in diferric-tyrosyl radical cofactor maintenance
mrp 10.11
mrp
P-loop NTPase family protein
yacC-speED 10.09
yacC
speD
speE
predicted protein
adenosylmethionine decarboxylase, proenzyme
spermidine synthase
ysgA 10.09
ysgA
predicted hydrolase
yrbG-kdsDC-lptCAB 10.03
kdsC
kdsD
yrbG
lptA
lptB
lptC
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
D-arabinose 5-phosphate isomerase
inner membrane protein YrbG
LptA
LptB
LptC
sohB 9.91
sohB
predicted inner membrane peptidase
pfkA 9.88
pfkA
6-phosphofructokinase I
acpP-fabF 9.83
fabF
acpP
β-ketoacyl-ACP synthase II
apo-[acyl carrier protein]
rpoZ-spoT-trmH-recG 9.83
rpoZ
spoT
recG
trmH
RNA polymerase, ω subunit
guanosine 3'-diphosphate 5'-triphosphate 3'-diphosphatase/GDP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase
RecG DNA helicase
tRNA (Gm18) 2'-O-methyltransferase
ftnA 9.72
ftnA
ferritin iron storage protein
lysC 9.63
lysC
aspartate kinase III
ppiD 9.58
ppiD
periplasmic folding chaperone
pepD 9.55
pepD
peptidase D
acpP 9.51
acpP
apo-[acyl carrier protein]
putP 9.48
putP
proline:Na+ symporter
sodA 9.39
sodA
superoxide dismutase (Mn)
dam-rpe-gph-trpS 9.38
gph
dam
rpe
trpS
phosphoglycolate phosphatase
DNA adenine methyltransferase
ribulose-5-phosphate 3-epimerase
tryptophan-tRNA ligase
sodB 9.34
sodB
superoxide dismutase (Fe)
ndh 9.26
ndh
NADH:quinone oxidoreductase II
ptrA-recBD 9.13
recB
recD
ptrA
RecB
RecD
protease III
deoCABD 9.02
deoA
deoB
deoC
deoD
thymidine phosphorylase / uracil phosphorylase
phosphopentomutase
deoxyribose-phosphate aldolase
purine nucleoside phosphorylase
shiA 8.99
shiA
shikimate:H+ symporter
ryfD 8.98
ryfD
RyfD
gcd 8.97
gcd
quinoprotein glucose dehydrogenase
greA 8.92
greA
transcription elongation factor GreA
frr 8.88
frr
ribosome recycling factor
symR 8.81
symR
SymR
menA-rraA 8.79
rraA
menA
ribonuclease E inhibitor protein A
1,4-dihydroxy-2-naphthoate octaprenyltransferase
pykA 8.77
pykA
pyruvate kinase II
stpA 8.76
stpA
H-NS-like DNA-binding transcriptional repressor with RNA chaperone activity
secB-gpsA 8.76
gpsA
secB
glycerol-3-phosphate dehydrogenase
SecB chaperone
malK-lamB-malM 8.73
lamB
malM
malK
maltose outer membrane porin / phage lambda receptor protein
maltose regulon periplasmic protein
maltose ABC transporter - ATP binding subunit
panD 8.67
panD
PanD proenzyme, π protein
btuB-murI 8.61
murI
btuB
glutamate racemase
vitamin B12 / E colicin / bacteriophage BF23 outer membrane porin BtuB
fepA-entD 8.57
fepA
entD
ferric enterobactin / colicin B / colicin D outer membrane porin FepA
phosphopantetheinyl transferase/phosphopantetheinyl transferase
mgrR 8.52
mgrR
MgrR
metG 8.43
metG
methionine-tRNA ligase
dsbA 8.39
dsbA
protein disulfide oxidoreductase - DsbAreduced
sgrR-sroA-tbpA-thiPQ 8.37
thiP
tbpA
thiQ
sgrR
sroA
thiamin ABC transporter - membrane subunit
thiamin ABC transporter - periplasmic binding protein
thiamin ABC transporter - ATP binding subunit
SgrR DNA-binding transcriptional dual regulator
SroA
cbpAM 8.14
cbpM
cbpA
chaperone modulator protein CbpM
chaperone with DnaK; curved DNA-binding protein
yccA 8.10
yccA
putative carrier/transport protein; substrate or modulator of FtsH-mediated proteolysis
eno 8.07
eno
enolase
tpiA 8.06
tpiA
triosephosphate isomerase
ynfEFGH-dmsD 8.03
ynfG
ynfF
ynfE
dmsD
ynfH
putative selenate reductase, predicted Fe-S subunit
putative selenate reductase, oxidoreductase subunit
putative selenate reductase, oxidoreductase subunit
DMS reductase maturation protein
putative selenate reductase, predicted membrane anchor subunit
ilvLXG_1G_2MEDA 8.03
ilvE
ilvX
ilvM
ilvL
ilvG_1
ilvD
ilvG_2
ilvA
branched-chain amino-acid aminotransferase
small protein
acetolactate synthase / acetohydroxybutanoate synthase, regulatory subunit
ilvGEDA operon leader peptide
acetolactate synthase II, large subunit, N-ter fragment (pseudogene)
dihydroxy acid dehydratase
acetolactate synthase II, large subunit, C-ter fragment (pseudogene)
threonine deaminase
metNIQ 7.98
metI
metN
metQ
L-methionine / D-methionine ABC transporter - membrane subunit
L-methionine / D-methionine ABC transporter - ATP binding subunit
L-methionine / D-methionine ABC transporter - periplasmic binding protein
rlmE-ftsH 7.92
rlmE
ftsH
23S rRNA 2'-O-ribose U2552 methyltransferase
ATP-dependent zinc metalloprotease FtsH
mdh 7.87
mdh
malate dehydrogenase
grxD 7.87
grxD
glutaredoxin 4
glgCAP 7.80
glgP
glgA
glgC
glycogen phosphorylase
glycogen synthase
glucose-1-phosphate adenylyltransferase
ygfB-pepP-ubiHI 7.79
ygfB
pepP
ubiH
ubiI
predicted protein
proline aminopeptidase P II
2-octaprenyl-6-methoxyphenol hydroxylase
2-octaprenylphenol hydroxylase
purC 7.71
purC
phosphoribosylaminoimidazole-succinocarboxamide synthase
prs 7.70
prs
ribose-phosphate diphosphokinase
nagBAC-umpH 7.68
nagB
nagC
umpH
nagA
glucosamine-6-phosphate deaminase
NagC DNA-binding transcriptional dual regulator
UMP phosphatase
N-acetylglucosamine-6-phosphate deacetylase
mreB 7.55
mreB
dynamic cytoskeletal protein MreB
tpx 7.55
tpx
lipid hydroperoxide peroxidase
nrdR-ribDE-nusB-thiL-pgpA 7.53
nusB
nrdR
thiL
pgpA
ribE
ribD
transcription antitermination protein NusB
NrdR transcriptional repressor
thiamine monophosphate kinase
phosphatidylglycerophosphatase A
6,7-dimethyl-8-ribityllumazine synthase
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase
pdhR-aceEF-lpd 7.53
pdhR
lpd
aceF
aceE
PdhR DNA-binding transcriptional dual regulator
lipoamide dehydrogenase
pyruvate dehydrogenase, E2 subunit
subunit of E1p component of pyruvate dehydrogenase complex
uvrA 7.48
uvrA
excision nuclease subunit A
fimB 7.47
fimB
regulator for fimA

Network of associatons between targets according to the STRING database.

First level regulatory network of Sigma70

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
22.7 68.2 GO:0006265 DNA topological change(GO:0006265)
21.5 107.4 GO:2000765 regulation of cytoplasmic translation(GO:2000765)
20.5 20.5 GO:0045975 viral latency(GO:0019042) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) positive regulation of translation, ncRNA-mediated(GO:0045975)
20.3 81.3 GO:0006549 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
16.4 16.4 GO:1903008 ribosome disassembly(GO:0032790) ribonucleoprotein complex disassembly(GO:0032988) organelle disassembly(GO:1903008)
15.4 46.3 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306) DNA methylation on adenine(GO:0032775) cell cycle DNA replication initiation(GO:1902292) bacterial-type DNA replication initiation(GO:1902328)
14.0 42.1 GO:0043242 negative regulation of protein complex disassembly(GO:0043242) negative regulation of DNA-templated transcription, termination(GO:0060567)
13.9 69.3 GO:0006276 plasmid maintenance(GO:0006276)
13.8 55.3 GO:0045727 positive regulation of cellular amide metabolic process(GO:0034250) positive regulation of translation(GO:0045727)
13.0 38.9 GO:0097304 lipoprotein biosynthetic process via signal peptide cleavage(GO:0097304)
11.7 35.1 GO:0032074 negative regulation of nuclease activity(GO:0032074) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702)
11.4 34.3 GO:0034661 ncRNA catabolic process(GO:0034661)
11.1 33.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
11.0 11.0 GO:0043174 nucleoside salvage(GO:0043174)
10.3 30.9 GO:0010272 response to silver ion(GO:0010272)
10.3 41.2 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
10.3 41.2 GO:0006544 glycine metabolic process(GO:0006544) glycine catabolic process(GO:0006546)
10.2 30.7 GO:0006570 tyrosine metabolic process(GO:0006570) tyrosine biosynthetic process(GO:0006571)
10.0 29.9 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
9.9 29.7 GO:0072321 chaperone-mediated protein transport(GO:0072321)
9.7 29.0 GO:0006551 leucine metabolic process(GO:0006551) leucine biosynthetic process(GO:0009098)
9.3 18.6 GO:0009225 nucleotide-sugar metabolic process(GO:0009225) nucleotide-sugar biosynthetic process(GO:0009226)
9.2 27.5 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
9.1 64.0 GO:0007059 chromosome segregation(GO:0007059)
8.8 26.4 GO:0046049 pyrimidine nucleotide catabolic process(GO:0006244) nucleoside monophosphate catabolic process(GO:0009125) pyrimidine nucleoside monophosphate catabolic process(GO:0009131) ribonucleoside monophosphate catabolic process(GO:0009158) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate catabolic process(GO:0009175) pyrimidine ribonucleotide metabolic process(GO:0009218) pyrimidine ribonucleotide catabolic process(GO:0009222) ribonucleotide catabolic process(GO:0009261) UMP metabolic process(GO:0046049) UMP catabolic process(GO:0046050)
8.7 52.3 GO:0015920 lipopolysaccharide transport(GO:0015920)
8.7 17.3 GO:0046417 chorismate metabolic process(GO:0046417)
8.6 25.9 GO:0009970 cellular response to sulfate starvation(GO:0009970)
8.5 144.9 GO:0006096 glycolytic process(GO:0006096)
8.4 25.3 GO:0019646 aerobic electron transport chain(GO:0019646)
8.3 24.8 GO:0045900 negative regulation of translational elongation(GO:0045900)
7.9 31.7 GO:0030490 maturation of SSU-rRNA(GO:0030490)
7.9 23.7 GO:1901070 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037) guanosine-containing compound biosynthetic process(GO:1901070)
7.7 23.0 GO:0015768 maltose transport(GO:0015768)
7.6 22.9 GO:0009651 response to salt stress(GO:0009651)
7.5 37.6 GO:0005980 glycogen catabolic process(GO:0005980)
7.5 22.5 GO:0071932 replication fork reversal(GO:0071932)
7.4 7.4 GO:0051181 cofactor transport(GO:0051181)
7.3 14.5 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
7.1 35.7 GO:0000162 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
7.1 14.2 GO:0006818 hydrogen transport(GO:0006818) proton transport(GO:0015992)
7.1 21.3 GO:0035672 oligopeptide transport(GO:0006857) oligopeptide transmembrane transport(GO:0035672)
7.0 7.0 GO:0046490 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299) isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway(GO:0019288) isopentenyl diphosphate metabolic process(GO:0046490)
6.5 19.6 GO:0000303 response to superoxide(GO:0000303)
6.5 25.9 GO:0006541 glutamine metabolic process(GO:0006541)
6.5 6.5 GO:0046040 IMP metabolic process(GO:0046040)
6.3 6.3 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
6.3 25.0 GO:1902837 amino acid import(GO:0043090) L-arginine import(GO:0043091) L-amino acid import(GO:0043092) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
6.2 30.9 GO:0017004 cytochrome complex assembly(GO:0017004)
6.2 6.2 GO:0009152 purine ribonucleotide biosynthetic process(GO:0009152) ribonucleotide biosynthetic process(GO:0009260)
6.1 73.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418) tRNA aminoacylation(GO:0043039)
6.1 18.4 GO:0019877 diaminopimelate biosynthetic process(GO:0019877)
6.0 36.1 GO:0006566 threonine metabolic process(GO:0006566)
5.9 17.6 GO:0019540 siderophore metabolic process(GO:0009237) enterobactin metabolic process(GO:0009238) enterobactin biosynthetic process(GO:0009239) catechol-containing compound metabolic process(GO:0009712) catechol-containing compound biosynthetic process(GO:0009713) nonribosomal peptide biosynthetic process(GO:0019184) siderophore biosynthetic process(GO:0019290) siderophore biosynthetic process from catechol(GO:0019540) secondary metabolite biosynthetic process(GO:0044550) phenol-containing compound biosynthetic process(GO:0046189)
5.7 28.4 GO:0046400 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process(GO:0019294) keto-3-deoxy-D-manno-octulosonic acid metabolic process(GO:0046400)
5.7 11.3 GO:0042181 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
5.5 22.1 GO:0009163 nucleoside biosynthetic process(GO:0009163) glycosyl compound biosynthetic process(GO:1901659)
5.4 10.9 GO:0006528 asparagine metabolic process(GO:0006528)
5.3 37.4 GO:0051276 chromosome organization(GO:0051276)
5.3 26.6 GO:0042273 ribosomal large subunit assembly(GO:0000027) ribosomal large subunit biogenesis(GO:0042273)
5.3 15.9 GO:0009250 glucan biosynthetic process(GO:0009250)
5.2 10.3 GO:0072337 modified amino acid transport(GO:0072337)
5.1 15.2 GO:0006573 valine metabolic process(GO:0006573)
5.0 10.0 GO:0009264 deoxyribonucleotide catabolic process(GO:0009264)
4.8 14.5 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
4.6 18.3 GO:0046144 alanine metabolic process(GO:0006522) pyruvate family amino acid metabolic process(GO:0009078) L-alanine metabolic process(GO:0042851) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436)
4.5 9.0 GO:0006007 glucose catabolic process(GO:0006007)
4.5 17.9 GO:0015889 cobalamin transport(GO:0015889)
4.4 13.3 GO:0043687 post-translational protein modification(GO:0043687)
4.4 17.5 GO:0019388 galactose metabolic process(GO:0006012) galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
4.4 35.0 GO:0006261 DNA-dependent DNA replication(GO:0006261)
4.3 12.8 GO:0030497 fatty acid elongation(GO:0030497)
4.1 28.9 GO:0006364 rRNA processing(GO:0006364) rRNA metabolic process(GO:0016072)
4.1 12.3 GO:0009073 aromatic amino acid family biosynthetic process(GO:0009073)
4.1 16.4 GO:0007584 response to nutrient(GO:0007584)
4.0 4.0 GO:0002098 tRNA wobble uridine modification(GO:0002098)
4.0 12.0 GO:0019626 propionate metabolic process(GO:0019541) short-chain fatty acid catabolic process(GO:0019626)
4.0 8.0 GO:0000101 sulfur amino acid transport(GO:0000101)
4.0 19.8 GO:0051258 protein polymerization(GO:0051258)
3.9 7.8 GO:0001522 pseudouridine synthesis(GO:0001522) tRNA pseudouridine synthesis(GO:0031119)
3.8 7.5 GO:0006772 thiamine metabolic process(GO:0006772) thiamine biosynthetic process(GO:0009228) thiamine-containing compound metabolic process(GO:0042723) thiamine-containing compound biosynthetic process(GO:0042724)
3.8 18.8 GO:0015804 neutral amino acid transport(GO:0015804)
3.7 11.0 GO:1990748 cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
3.5 10.6 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
3.5 10.6 GO:0002181 cytoplasmic translation(GO:0002181)
3.5 10.4 GO:0070417 cellular response to cold(GO:0070417)
3.4 37.9 GO:0006633 fatty acid biosynthetic process(GO:0006633)
3.4 6.8 GO:0006479 protein methylation(GO:0006479) protein alkylation(GO:0008213)
3.4 16.8 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
3.3 3.3 GO:0043101 purine-containing compound salvage(GO:0043101)
3.3 43.3 GO:0006970 response to osmotic stress(GO:0006970)
3.3 6.6 GO:1902410 mitotic cell cycle(GO:0000278) mitotic cytokinesis(GO:0000281) barrier septum assembly(GO:0000917) cytokinetic process(GO:0032506) cytoskeleton-dependent cytokinesis(GO:0061640) cell septum assembly(GO:0090529) mitotic cytokinetic process(GO:1902410) mitotic cell cycle process(GO:1903047)
3.3 9.9 GO:0009129 pyrimidine nucleoside monophosphate metabolic process(GO:0009129) pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
3.2 9.7 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process to lactate(GO:0061727)
3.2 9.6 GO:0043171 peptide catabolic process(GO:0043171)
3.2 15.9 GO:0006090 pyruvate metabolic process(GO:0006090)
3.1 6.3 GO:0009092 homoserine biosynthetic process(GO:0009090) homoserine metabolic process(GO:0009092)
3.1 15.4 GO:0006098 pentose-phosphate shunt(GO:0006098) glucose 6-phosphate metabolic process(GO:0051156)
3.0 6.0 GO:0046039 GTP metabolic process(GO:0046039)
3.0 11.9 GO:0009309 amine biosynthetic process(GO:0009309) cellular biogenic amine biosynthetic process(GO:0042401)
2.9 5.9 GO:0051180 vitamin transport(GO:0051180)
2.8 8.4 GO:0098739 import across plasma membrane(GO:0098739)
2.4 14.5 GO:0030162 regulation of proteolysis(GO:0030162)
2.4 9.6 GO:0010043 response to zinc ion(GO:0010043)
2.2 6.7 GO:0006952 defense response(GO:0006952) clearance of foreign intracellular DNA(GO:0044355)
2.1 6.4 GO:0051828 entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
2.1 12.3 GO:0006531 aspartate metabolic process(GO:0006531)
2.1 4.1 GO:0015755 fructose transport(GO:0015755)
1.9 5.8 GO:0009263 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
1.9 5.8 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
1.9 14.9 GO:0097237 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
1.8 1.8 GO:0015835 peptidoglycan transport(GO:0015835)
1.8 9.1 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
1.8 5.3 GO:0046390 ribose phosphate biosynthetic process(GO:0046390)
1.8 7.1 GO:0015682 ferric iron transport(GO:0015682) trivalent inorganic cation transport(GO:0072512)
1.8 7.1 GO:0016485 protein processing(GO:0016485)
1.7 5.0 GO:0030091 protein repair(GO:0030091)
1.5 1.5 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231) flavin-containing compound metabolic process(GO:0042726) flavin-containing compound biosynthetic process(GO:0042727)
1.5 6.1 GO:0022900 electron transport chain(GO:0022900)
1.5 6.0 GO:0009254 peptidoglycan turnover(GO:0009254)
1.5 6.0 GO:0006536 glutamate metabolic process(GO:0006536)
1.4 4.1 GO:0006164 purine nucleotide biosynthetic process(GO:0006164)
1.3 2.6 GO:0043470 regulation of carbohydrate catabolic process(GO:0043470)
1.2 2.5 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
1.1 8.9 GO:0010212 response to ionizing radiation(GO:0010212)
0.9 0.9 GO:0007049 cell cycle(GO:0007049) cell cycle process(GO:0022402)
0.8 4.2 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.7 3.3 GO:0033014 tetrapyrrole metabolic process(GO:0033013) tetrapyrrole biosynthetic process(GO:0033014)
0.5 1.6 GO:0015976 carbon utilization(GO:0015976)
0.5 1.0 GO:0006298 mismatch repair(GO:0006298)
0.5 1.5 GO:0044042 glucan metabolic process(GO:0044042)
0.5 1.9 GO:0015801 aromatic amino acid transport(GO:0015801)
0.4 1.3 GO:0006650 glycerophospholipid metabolic process(GO:0006650) glycerolipid biosynthetic process(GO:0045017) glycerophospholipid biosynthetic process(GO:0046474) glycerolipid metabolic process(GO:0046486)
0.4 3.3 GO:0006855 drug transmembrane transport(GO:0006855)
0.4 1.1 GO:0033212 iron assimilation(GO:0033212)
0.3 4.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.3 1.2 GO:0051596 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process(GO:0051596)
0.2 4.7 GO:0009314 response to radiation(GO:0009314)
0.2 3.7 GO:0006790 sulfur compound metabolic process(GO:0006790)
0.2 2.0 GO:0006508 proteolysis(GO:0006508)
0.2 0.5 GO:0001121 transcription from bacterial-type RNA polymerase promoter(GO:0001121)
0.2 0.3 GO:0036460 cellular response to cell envelope stress(GO:0036460)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
15.3 245.1 GO:0022627 small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627)
13.2 39.7 GO:0032300 mismatch repair complex(GO:0032300)
11.6 92.7 GO:0005618 cell wall(GO:0005618)
10.8 43.2 GO:0044427 chromosome(GO:0005694) chromosomal part(GO:0044427)
9.9 29.7 GO:0005856 cytoskeleton(GO:0005856)
9.1 82.1 GO:0044446 intracellular organelle part(GO:0044446)
8.2 24.5 GO:0031225 anchored component of membrane(GO:0031225)
7.2 21.7 GO:0045273 respiratory chain complex II(GO:0045273) plasma membrane respiratory chain complex II(GO:0045274)
6.9 13.7 GO:0070470 respiratory chain(GO:0070469) plasma membrane respiratory chain(GO:0070470) respiratory chain complex(GO:0098803)
6.8 20.4 GO:0070069 cytochrome complex(GO:0070069)
6.4 96.0 GO:1990234 transferase complex(GO:1990234)
6.1 18.3 GO:0009295 nucleoid(GO:0009295)
5.6 55.7 GO:0032153 cell division site(GO:0032153)
4.8 28.9 GO:0048476 Holliday junction resolvase complex(GO:0048476)
4.8 52.3 GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing(GO:0055052)
4.3 227.6 GO:0098796 membrane protein complex(GO:0098796)
4.0 8.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
3.9 15.6 GO:0044445 cytosolic part(GO:0044445)
2.9 11.5 GO:0005576 extracellular region(GO:0005576)
2.8 14.1 GO:0043228 non-membrane-bounded organelle(GO:0043228)
2.6 1106.9 GO:0005829 cytosol(GO:0005829)
2.2 6.7 GO:0009338 exodeoxyribonuclease V complex(GO:0009338)
0.8 2.3 GO:0098562 cytoplasmic side of plasma membrane(GO:0009898) cytoplasmic side of membrane(GO:0098562)
0.5 29.0 GO:0005737 cytoplasm(GO:0005737)
0.5 4.2 GO:0044424 intracellular part(GO:0044424)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
22.7 68.2 GO:0003916 DNA topoisomerase activity(GO:0003916)
20.7 62.1 GO:0003984 acetolactate synthase activity(GO:0003984)
18.4 276.3 GO:0003735 structural constituent of ribosome(GO:0003735)
17.9 17.9 GO:0019843 rRNA binding(GO:0019843)
17.5 70.0 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
16.9 50.6 GO:0052381 tRNA dimethylallyltransferase activity(GO:0052381)
15.4 46.3 GO:0008967 phosphoglycolate phosphatase activity(GO:0008967) site-specific DNA-methyltransferase (adenine-specific) activity(GO:0009007) DNA-methyltransferase activity(GO:0009008) chloride ion binding(GO:0031404) S-adenosyl-L-methionine binding(GO:1904047)
14.0 42.1 GO:0001072 RNA binding transcription factor activity(GO:0001070) transcription antitermination factor activity, RNA binding(GO:0001072)
13.2 52.9 GO:0032843 hydroperoxide reductase activity(GO:0032843)
13.0 39.0 GO:0017089 glycolipid transporter activity(GO:0017089)
13.0 38.9 GO:0042380 hydroxymethylbutenyl pyrophosphate reductase activity(GO:0042380)
12.7 12.7 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
12.1 24.2 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
11.6 46.5 GO:0019238 cyclohydrolase activity(GO:0019238)
11.0 33.0 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
10.5 42.1 GO:0048039 ubiquinone binding(GO:0048039)
10.5 21.0 GO:0004072 aspartate kinase activity(GO:0004072) amino acid kinase activity(GO:0019202)
9.3 37.3 GO:0016211 ammonia ligase activity(GO:0016211)
8.9 26.7 GO:0016794 GTP diphosphokinase activity(GO:0008728) guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(GO:0008893) diphosphoric monoester hydrolase activity(GO:0016794)
8.8 44.1 GO:0004645 phosphorylase activity(GO:0004645)
8.7 26.2 GO:0009977 proton motive force dependent protein transmembrane transporter activity(GO:0009977)
8.6 34.3 GO:0043566 bent DNA binding(GO:0003681) structure-specific DNA binding(GO:0043566)
8.4 50.5 GO:0070566 adenylyltransferase activity(GO:0070566)
8.3 24.8 GO:0004177 aminopeptidase activity(GO:0004177)
8.1 24.4 GO:0005275 amine transmembrane transporter activity(GO:0005275)
7.9 31.6 GO:0072341 modified amino acid binding(GO:0072341)
7.8 23.5 GO:0015616 DNA translocase activity(GO:0015616)
7.8 23.4 GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity(GO:0003849)
7.7 7.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
7.7 23.0 GO:0005363 maltose transmembrane transporter activity(GO:0005363)
7.6 37.8 GO:0008276 protein methyltransferase activity(GO:0008276)
7.5 22.6 GO:0005416 cation:amino acid symporter activity(GO:0005416)
7.3 14.6 GO:0008175 tRNA methyltransferase activity(GO:0008175)
7.2 36.0 GO:0019829 cation-transporting ATPase activity(GO:0019829)
7.2 35.9 GO:0070569 uridylyltransferase activity(GO:0070569)
6.8 6.8 GO:0004750 ribulose-phosphate 3-epimerase activity(GO:0004750)
6.7 33.3 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
6.7 6.7 GO:0070567 cytidylyltransferase activity(GO:0070567)
6.6 6.6 GO:0019842 vitamin binding(GO:0019842)
6.6 85.5 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
6.5 32.5 GO:0016987 transcription factor activity, core RNA polymerase binding(GO:0000990) core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) sigma factor activity(GO:0016987)
6.4 12.9 GO:0015192 L-phenylalanine transmembrane transporter activity(GO:0015192)
6.4 19.3 GO:0004659 prenyltransferase activity(GO:0004659)
6.3 6.3 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
6.2 18.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
6.2 55.9 GO:0050661 NADP binding(GO:0050661)
6.2 36.9 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
6.1 24.6 GO:0080146 L-cysteine desulfhydrase activity(GO:0080146)
6.1 12.2 GO:0015620 ferric-enterobactin transmembrane transporter activity(GO:0015620)
6.1 18.3 GO:0008171 O-methyltransferase activity(GO:0008171)
6.0 17.9 GO:0019205 nucleobase-containing compound kinase activity(GO:0019205)
5.8 5.8 GO:0005198 structural molecule activity(GO:0005198)
5.6 11.3 GO:0003746 translation elongation factor activity(GO:0003746)
5.5 22.1 GO:0031405 lipoic acid binding(GO:0031405)
5.4 21.8 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
5.4 10.7 GO:0000104 succinate dehydrogenase activity(GO:0000104)
5.4 16.1 GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor(GO:0016682)
5.3 16.0 GO:0003727 single-stranded RNA binding(GO:0003727)
5.1 25.6 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
5.1 10.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
5.0 20.1 GO:0008861 formate C-acetyltransferase activity(GO:0008861)
5.0 9.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
4.9 19.7 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
4.9 9.8 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
4.9 9.8 GO:0016530 metallochaperone activity(GO:0016530)
4.8 14.5 GO:0047661 racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
4.8 19.3 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
4.8 14.3 GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity(GO:0008963)
4.7 14.1 GO:0008443 phosphofructokinase activity(GO:0008443)
4.7 14.1 GO:0030955 potassium ion binding(GO:0030955)
4.6 9.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
4.4 4.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
4.0 8.0 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
3.9 19.4 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
3.7 7.4 GO:0016453 C-acetyltransferase activity(GO:0016453)
3.7 3.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
3.6 7.2 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
3.5 7.0 GO:0008135 translation factor activity, RNA binding(GO:0008135)
3.5 10.4 GO:0060590 ATPase regulator activity(GO:0060590)
3.3 3.3 GO:0051920 peroxiredoxin activity(GO:0051920)
3.2 19.4 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
3.2 12.9 GO:0015299 solute:proton antiporter activity(GO:0015299)
3.2 9.6 GO:0015198 oligopeptide transporter activity(GO:0015198) oligopeptide transmembrane transporter activity(GO:0035673)
3.2 9.6 GO:0008235 metalloexopeptidase activity(GO:0008235)
3.2 38.0 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
3.2 6.3 GO:0005319 lipid transporter activity(GO:0005319)
3.1 6.1 GO:0008144 drug binding(GO:0008144)
3.0 33.3 GO:0043022 ribosome binding(GO:0043022)
3.0 9.0 GO:0009927 histidine phosphotransfer kinase activity(GO:0009927)
2.9 23.6 GO:0016989 sigma factor antagonist activity(GO:0016989)
2.9 8.8 GO:0001098 basal transcription machinery binding(GO:0001098) bacterial-type RNA polymerase holo enzyme binding(GO:0001108)
2.9 5.8 GO:0008134 transcription factor binding(GO:0008134)
2.9 2.9 GO:0019146 arabinose-5-phosphate isomerase activity(GO:0019146)
2.7 21.5 GO:0016866 intramolecular transferase activity(GO:0016866)
2.6 7.7 GO:0016778 diphosphotransferase activity(GO:0016778)
2.5 4.9 GO:0031992 energy transducer activity(GO:0031992)
2.4 7.1 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) siderophore transporter activity(GO:0042927)
2.4 7.1 GO:0015654 tellurite transmembrane transporter activity(GO:0015118) tellurite uptake transmembrane transporter activity(GO:0015654)
2.3 21.0 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
2.3 9.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
2.3 4.7 GO:0019171 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity(GO:0008693) 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity(GO:0019171) 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity(GO:0047451)
2.2 6.7 GO:0008854 exodeoxyribonuclease V activity(GO:0008854)
2.2 6.5 GO:0003678 DNA helicase activity(GO:0003678) ATP-dependent DNA helicase activity(GO:0004003)
2.2 17.4 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
2.2 15.1 GO:0008408 3'-5' exonuclease activity(GO:0008408)
2.1 4.3 GO:0016803 hydrolase activity, acting on ether bonds(GO:0016801) ether hydrolase activity(GO:0016803)
2.1 8.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337) nucleobase-containing compound transmembrane transporter activity(GO:0015932)
2.1 8.2 GO:0005525 GTP binding(GO:0005525)
1.9 5.8 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.7 10.4 GO:0051287 NAD binding(GO:0051287)
1.6 8.1 GO:0003697 single-stranded DNA binding(GO:0003697)
1.6 1.6 GO:0015099 nickel cation transmembrane transporter activity(GO:0015099)
1.5 6.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.5 4.6 GO:0005048 signal sequence binding(GO:0005048)
1.3 2.7 GO:0030551 cyclic nucleotide binding(GO:0030551) cyclic-di-GMP binding(GO:0035438)
1.2 2.4 GO:0019534 toxin transporter activity(GO:0019534)
1.2 2.4 GO:0004312 fatty acid synthase activity(GO:0004312)
1.1 3.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821) endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
1.1 3.2 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.9 2.8 GO:0050897 cobalt ion binding(GO:0050897)
0.9 3.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.8 3.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.7 0.7 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.7 1.4 GO:0016842 amidine-lyase activity(GO:0016842)
0.6 1.3 GO:0008962 phosphatidylglycerophosphatase activity(GO:0008962)
0.6 6.9 GO:0008168 methyltransferase activity(GO:0008168)
0.6 1.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.4 2.1 GO:0042625 ATPase coupled ion transmembrane transporter activity(GO:0042625)
0.2 0.7 GO:0004096 catalase activity(GO:0004096)
0.2 2.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 2.9 GO:0000287 magnesium ion binding(GO:0000287)
0.1 0.9 GO:1901618 organic hydroxy compound transmembrane transporter activity(GO:1901618)
0.1 1.3 GO:0016887 ATPase activity(GO:0016887)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 16.9 PID P73PATHWAY p73 transcription factor network
7.4 22.3 PID CMYB PATHWAY C-MYB transcription factor network
2.6 7.8 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
1.6 1.6 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
17.4 52.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
10.4 10.4 REACTOME METABOLISM OF PROTEINS Genes involved in Metabolism of proteins
7.8 23.3 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
6.2 18.5 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology
4.5 44.5 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
1.4 5.6 REACTOME METABOLISM OF NUCLEOTIDES Genes involved in Metabolism of nucleotides