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GSE67402: E.coli regulatory changes under long-term starvation

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Results for PurR

Z-value: 3.14

Transcription factors associated with PurR

Gene Symbol Gene ID Gene Info
purR
purR PurR transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
purR0.831.2e-07Click!

Activity profile of PurR motif

Sorted Z-values of PurR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
glyA 53.32
glyA
serine hydroxymethyltransferase
guaBA 43.34
guaB
guaA
IMP dehydrogenase
GMP synthetase
purHD 36.61
purH
purD
AICAR transformylase/IMP cyclohydrolase
phosphoribosylamine-glycine ligase
purC 35.55
purC
phosphoribosylaminoimidazole-succinocarboxamide synthase
prs 34.31
prs
ribose-phosphate diphosphokinase
carAB 33.62
carB
carA
carbamoyl phosphate synthetase, β chain
carbamoyl phosphate synthetase, α chain
purL 30.29
purL
phosphoribosylformylglycinamide synthetase
gcvTHP 29.76
gcvH
gcvP
gcvT
glycine cleavage system H protein
glycine decarboxylase
aminomethyltransferase
purEK 27.37
purK
purE
N5-carboxyaminoimidazole ribonucleotide synthetase
N5-carboxyaminoimidazole ribonucleotide mutase
purA 23.80
purA
adenylosuccinate synthetase
cvpA-purF-ubiX 19.39
cvpA
purF
ubiX
membrane protein required for colicin V production
amidophosphoribosyl transferase
3-octaprenyl-4-hydroxybenzoate carboxy-lyase partner protein
hflD-purB 13.42
purB
hflD
adenylosuccinate lyase
lysogenization regulator
speAB 9.58
speB
speA
agmatinase
arginine decarboxylase, biosynthetic
purMN 9.57
purN
purM
phosphoribosylglycinamide formyltransferase 1
phosphoribosylformylglycinamide cyclo-ligase
codBA 3.41
codB
codA
cytosine transporter
cytosine deaminase

Network of associatons between targets according to the STRING database.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
30.3 30.3 GO:0006188 IMP biosynthetic process(GO:0006188)
23.8 23.8 GO:0046040 IMP metabolic process(GO:0046040)
20.8 83.1 GO:0006544 glycine metabolic process(GO:0006544) glycine catabolic process(GO:0006546)
14.4 43.3 GO:0046039 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037) GTP metabolic process(GO:0046039) guanosine-containing compound biosynthetic process(GO:1901070)
11.4 34.3 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
8.8 53.0 GO:0006541 glutamine metabolic process(GO:0006541)
5.9 35.2 GO:0006164 purine nucleotide biosynthetic process(GO:0006164)
3.2 9.6 GO:0006527 arginine catabolic process(GO:0006527)
2.5 35.5 GO:0033013 tetrapyrrole metabolic process(GO:0033013) tetrapyrrole biosynthetic process(GO:0033014)
1.1 3.4 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) pyrimidine nucleobase transport(GO:0015855)
0.3 13.4 GO:0009408 response to heat(GO:0009408)
0.1 9.6 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 29.8 GO:1990204 oxidoreductase complex(GO:1990204)
1.1 13.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6 283.9 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
26.8 107.3 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
19.9 99.5 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
6.9 34.3 GO:0042301 phosphate ion binding(GO:0042301)
5.0 29.8 GO:0031405 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) lipoic acid binding(GO:0031405)
4.5 13.4 GO:0016842 amidine-lyase activity(GO:0016842)
3.8 86.7 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
2.4 9.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.7 3.4 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
1.5 19.4 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)