ISMARA results: Nac

Project

GSE67402: E.coli regulatory changes under long-term starvation

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Results for Nac

Z-value: 0.74

Transcription factors associated with Nac

Gene Symbol	Gene ID	Gene Info
nac RegulonDB EcoCyc	nac	Nac DNA-binding transcriptional dual regulator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nac		0.73	1.5e-05	Click!

Activity profile of Nac motif

Sorted Z-values of Nac motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
serA Show fit	8.64
gltBDF Show fit	7.39		gltB RegulonDB EcoCyc Show fit gltD RegulonDB EcoCyc Show fit gltF RegulonDB EcoCyc Show fit	glutamate synthase, large subunit glutamate synthase, small subunit periplasmic protein
gdhA Show fit	6.50		gdhA RegulonDB EcoCyc Show fit	glutamate dehydrogenase
nupC Show fit	4.66		nupC RegulonDB EcoCyc Show fit	nucleoside:H⁺ symporter NupC
asnC-mioC-mnmG Show fit	2.88		mioC RegulonDB EcoCyc Show fit mnmG RegulonDB EcoCyc Show fit asnC RegulonDB EcoCyc Show fit	flavoprotein involved in biotin synthesis protein involved in modification of U34 in tRNA AsnC DNA-binding transcriptional dual regulator
asnC-mioC Show fit	1.44		mioC RegulonDB EcoCyc Show fit asnC RegulonDB EcoCyc Show fit	flavoprotein involved in biotin synthesis AsnC DNA-binding transcriptional dual regulator

Network of associatons between targets according to the STRING database.

First level regulatory network of Nac

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.5	7.4	GO:0019676	ammonia assimilation cycle(GO:0019676)
1.1	6.5	GO:0006536	glutamate metabolic process(GO:0006536)
1.0	2.9	GO:0002098	tRNA wobble uridine modification(GO:0002098)
0.9	4.7	GO:0015858	nucleoside transport(GO:0015858)
0.2	1.4	GO:0009102	biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.7	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	10.8	GO:0005829	cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.3	13.9	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.9	4.7	GO:0015932	nucleoside transmembrane transporter activity(GO:0005337) nucleobase-containing compound transmembrane transporter activity(GO:0015932)
0.2	4.3	GO:0010181	FMN binding(GO:0010181)