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GSE67402: E.coli regulatory changes under long-term starvation

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Results for MetJ

Z-value: 1.67

Transcription factors associated with MetJ

Gene Symbol Gene ID Gene Info
metJ
metJ MetJ transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
metJ0.875.1e-09Click!

Activity profile of MetJ motif

Sorted Z-values of MetJ motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
metE 48.48
metE
cobalamin-independent homocysteine transmethylase
folE-yeiB 43.97
folE
yeiB
GTP cyclohydrolase I
conserved inner membrane protein
ahpCF 32.35
ahpF
ahpC
alkyl hydroperoxide reductase, AhpF component
alkyl hydroperoxide reductase, AhpC component
metNIQ 20.01
metI
metN
metQ
L-methionine / D-methionine ABC transporter - membrane subunit
L-methionine / D-methionine ABC transporter - ATP binding subunit
L-methionine / D-methionine ABC transporter - periplasmic binding protein
metK 5.11
metK
methionine adenosyltransferase
metC 3.66
metC
cystathionine-β-lyase / L-cysteine desulfhydrase

Network of associatons between targets according to the STRING database.

First level regulatory network of MetJ

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
16.2 48.5 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
10.8 32.3 GO:0009970 cellular response to sulfate starvation(GO:0009970)
5.5 49.1 GO:0042455 ribonucleoside biosynthetic process(GO:0042455)
5.0 20.0 GO:0000101 sulfur amino acid transport(GO:0000101)
1.2 3.7 GO:0044273 sulfur compound catabolic process(GO:0044273)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 48.5 GO:0005576 extracellular region(GO:0005576)
6.7 20.0 GO:0009274 peptidoglycan-based cell wall(GO:0009274)
1.5 32.3 GO:1990204 oxidoreductase complex(GO:1990204)
0.4 44.0 GO:0043234 protein complex(GO:0043234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 48.5 GO:0008172 S-methyltransferase activity(GO:0008172)
11.0 44.0 GO:0019238 cyclohydrolase activity(GO:0019238)
10.8 32.3 GO:0070402 NADPH binding(GO:0070402)
2.9 20.0 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.9 3.7 GO:0080146 L-cysteine desulfhydrase activity(GO:0080146)
0.7 5.1 GO:0030955 potassium ion binding(GO:0030955)