Project

GSE67402: E.coli regulatory changes under long-term starvation

Navigation
Downloads

Results for Fur

Z-value: 2.50

Transcription factors associated with Fur

Gene Symbol Gene ID Gene Info
fur
fur Fur transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
fur0.471.3e-02Click!

Activity profile of Fur motif

Sorted Z-values of Fur motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
cirA 36.29
cirA
outer membrane receptor involved in uptake of ferric dihyroxybenzoylserine
fepA-entD 22.12
fepA
entD
ferric enterobactin / colicin B / colicin D outer membrane porin FepA
phosphopantetheinyl transferase/phosphopantetheinyl transferase
entCEBAH 21.95
entA
entH
entC
entB
entE
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
proofreading thioesterase in enterobactin biosynthesis
isochorismate synthase 1
EntB
2,3-dihydroxybenzoate-AMP ligase
fes-ybdZ-entF-fepE 17.28
ybdZ
fes
fepE
entF
MbtH-like protein that enhances the catalytic function of EntF
enterochelin esterase
ferric enterobactin (enterochelin) transport
apo-serine activating enzyme
ompF 16.41
ompF
outer membrane porin F
aspC 16.01
aspC
aspartate aminotransferase, PLP-dependent
yjjZ 15.48
yjjZ
predicted protein
ryhB 14.73
ryhB
RyhB
fhuE 14.44
fhuE
ferric coprogen outer membrane porin FhuE
fecABCDE 12.77
fecD
fecE
fecB
fecC
fecA
ferric citrate ABC transporter - membrane subunit
ferric citrate ABC transporter - ATP binding subunit
ferric citrate ABC transporter - periplasmic binding protein
ferric citrate ABC transporter - membrane subunit
ferric citrate outer membrane porin FecA
fhuACDB 12.61
fhuD
fhuA
fhuC
fhuB
iron (III) hydroxamate ABC transporter - periplasmic binding protein
ferrichrome / phage / antibiotic outer membrane porin FhuA
iron (III) hydroxamate ABC transporter - ATP binding subunit
iron (III) hydroxamate ABC transporter - membrane subunit
flhDC 10.45
flhC
flhD
FlhC transcriptional dual regulator
FlhD transcriptional dual regulator
gltBDF 9.55
gltB
gltD
gltF
glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein
fhuF 9.28
fhuF
hydroxamate siderophore iron reductase
exbBD 9.16
exbB
exbD
TonB energy transducing system - ExbB subunit
tonB energy transducing system - ExbD subunit
sodA 9.03
sodA
superoxide dismutase (Mn)
exbD 8.97
exbD
tonB energy transducing system - ExbD subunit
fecIR 7.95
fecR
fecI
regulator for fec operon, periplasmic
RNA polymerase, sigma 19 factor
ndh 7.48
ndh
NADH:quinone oxidoreductase II
lpd 6.55
lpd
lipoamide dehydrogenase
oppABCDF 6.33
oppA
oppC
oppB
oppD
oppF
peptide ABC transporter - periplasmic binding protein
murein tripeptide ABC transporter / peptide ABC transporter - putative membrane subunit
murein tripeptide ABC transporter / peptide ABC transporter - putative membrane subunit
murein tripeptide ABC transporter / peptide ABC transporter - putative ATP binding subunit
murein tripeptide ABC transporter / peptide ABC transporter - putative ATP binding subunit
gdhA 5.87
gdhA
glutamate dehydrogenase
nrdHIEF 5.70
nrdH
nrdI
nrdE
nrdF
glutaredoxin-like protein
flavodoxin involved in dimanganese-tyrosyl radical cofactor maintenance for ribonucleotide reductase
ribonucleoside-diphosphate reductase 2, α subunit
ribonucleoside-diphosphate reductase 2, β subunit
sdhCDAB-sucABCD 5.35
sucA
sucC
sucB
sucD
sdhA
sdhC
sdhB
sdhD
subunit of E1(0) component of 2-oxoglutarate dehydrogenase
succinyl-CoA synthetase, β subunit
dihydrolipoyltranssuccinylase
succinyl-CoA synthetase, α subunit
succinate:quinone oxidoreductase, FAD binding protein
succinate:quinone oxidoreductase, membrane protein SdhC
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein
succinate:quinone oxidoreductase, membrane protein SdhD
cyoABCDE 4.39
cyoA
cyoC
cyoB
cyoE
cyoD
cytochrome bo terminal oxidase subunit II
cytochrome bo terminal oxidase subunit III
cytochrome bo terminal oxidase subunit I
heme O synthase
cytochrome bo terminal oxidase subunit IV
crl 3.91
crl
RNA polymerase holoenzyme assembly factor Crl
metH 3.87
metH
cobalamin-dependent methionine synthase
sufABCDSE 3.53
sufB
sufC
sufA
sufD
sufE
sufS
SufB component of SufBCD Fe-S cluster scaffold complex
SufC component of SufBCD Fe-S cluster scaffold complex
Fe-S transport protein in Fe-S cluster assembly
SufD component of SufBCD Fe-S cluster scaffold complex
sulfur acceptor for SufS cysteine desulfurase
L-cysteine desulfurase
gpmA 3.44
gpmA
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
fepDGC 3.43
fepC
fepG
fepD
ferric enterobactin ABC transporter - ATP binding subunit
ferric enterobactin ABC transporter - membrane subunit
ferric enterobactin ABC transporter - membrane subunit
gnd 3.19
gnd
6-phosphogluconate dehydrogenase, decarboxylating
zwf 2.05
zwf
glucose-6-phosphate dehydrogenase (NADP+)
katG 1.89
katG
hydroperoxidase I
yqjH 1.88
yqjH
ferric reductase, NADPH-dependent
grcA 1.69
grcA
stress-induced alternate pyruvate formate-lyase subunit
tonB 1.58
tonB
TonB energy transducing system - TonB subunit
fepB 1.54
fepB
ferric enterobactin ABC transporter - periplasmic binding protein
rpoS 1.08
rpoS
RNA polymerase, sigma S (sigma 38) factor

Network of associatons between targets according to the STRING database.

First level regulatory network of Fur

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
20.5 61.4 GO:0009712 siderophore metabolic process(GO:0009237) enterobactin metabolic process(GO:0009238) enterobactin biosynthetic process(GO:0009239) catechol-containing compound metabolic process(GO:0009712) catechol-containing compound biosynthetic process(GO:0009713) nonribosomal peptide biosynthetic process(GO:0019184) siderophore biosynthetic process(GO:0019290) siderophore biosynthetic process from catechol(GO:0019540) phenol-containing compound biosynthetic process(GO:0046189)
11.9 47.4 GO:0033212 iron assimilation(GO:0033212)
7.9 39.5 GO:0072512 ferric iron transport(GO:0015682) trivalent inorganic cation transport(GO:0072512)
5.3 16.0 GO:0046417 chorismate metabolic process(GO:0046417)
3.2 9.6 GO:0019676 ammonia assimilation cycle(GO:0019676)
3.0 9.0 GO:0006801 response to superoxide(GO:0000303) superoxide metabolic process(GO:0006801)
3.0 11.9 GO:0019646 aerobic electron transport chain(GO:0019646)
2.2 6.6 GO:0019464 glycine decarboxylation via glycine cleavage system(GO:0019464)
1.8 16.4 GO:0006855 drug transmembrane transport(GO:0006855)
1.8 9.0 GO:0050821 protein stabilization(GO:0050821)
1.6 6.3 GO:0035672 oligopeptide transport(GO:0006857) oligopeptide transmembrane transport(GO:0035672)
1.3 3.9 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
1.1 3.4 GO:0010906 regulation of glucose metabolic process(GO:0010906) regulation of cellular catabolic process(GO:0031329) regulation of cellular carbohydrate catabolic process(GO:0043471)
1.1 5.7 GO:0045454 cell redox homeostasis(GO:0045454)
1.1 5.4 GO:0017004 cytochrome complex assembly(GO:0017004)
1.0 5.9 GO:0006536 glutamate metabolic process(GO:0006536)
0.7 2.1 GO:0009372 quorum sensing(GO:0009372) homeostasis of number of cells(GO:0048872) homeostasis of number of cells in a free-living population(GO:0048874)
0.6 3.2 GO:0019521 D-gluconate metabolic process(GO:0019521) D-gluconate catabolic process(GO:0046177)
0.6 3.5 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.5 1.6 GO:0015889 cobalamin transport(GO:0015889)
0.5 3.9 GO:0043623 cellular protein complex assembly(GO:0043623)
0.4 1.9 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.3 1.7 GO:0006567 threonine catabolic process(GO:0006567)
0.3 1.1 GO:0001121 transcription from bacterial-type RNA polymerase promoter(GO:0001121)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 16.4 GO:0046930 pore complex(GO:0046930)
3.2 22.1 GO:0045203 integral component of cell outer membrane(GO:0045203)
2.2 4.4 GO:0070069 cytochrome complex(GO:0070069)
1.8 5.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252) respiratory chain complex II(GO:0045273) plasma membrane respiratory chain complex II(GO:0045274)
1.6 73.6 GO:0009279 cell outer membrane(GO:0009279)
0.8 13.2 GO:1990204 oxidoreductase complex(GO:1990204)
0.7 29.5 GO:0098797 plasma membrane protein complex(GO:0098797)
0.5 1.9 GO:0005576 extracellular region(GO:0005576)
0.2 11.8 GO:0043234 protein complex(GO:0043234)
0.1 51.9 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
24.9 74.8 GO:0022885 bacteriocin transmembrane transporter activity(GO:0022885) colicin transmembrane transporter activity(GO:0042912)
10.4 20.7 GO:0015620 ferric-enterobactin transmembrane transporter activity(GO:0015620)
9.1 18.1 GO:0031992 energy transducer activity(GO:0031992)
9.0 27.0 GO:0015603 iron chelate transmembrane transporter activity(GO:0015603)
7.3 22.0 GO:0016803 CoA hydrolase activity(GO:0016289) thiolester hydrolase activity(GO:0016790) hydrolase activity, acting on ether bonds(GO:0016801) ether hydrolase activity(GO:0016803)
3.2 9.7 GO:0048039 quinone binding(GO:0048038) ubiquinone binding(GO:0048039)
3.0 9.0 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
2.6 15.4 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
2.5 7.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
2.1 6.3 GO:0015647 oligopeptide transporter activity(GO:0015198) peptidoglycan transporter activity(GO:0015647) oligopeptide transmembrane transporter activity(GO:0035673)
1.9 5.7 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.0 3.9 GO:0008172 S-methyltransferase activity(GO:0008172)
0.9 6.6 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.9 16.0 GO:0008483 transaminase activity(GO:0008483)
0.8 10.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.7 3.4 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.6 1.8 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
0.4 1.7 GO:0008861 formate C-acetyltransferase activity(GO:0008861)
0.3 1.1 GO:0001000 bacterial-type RNA polymerase core enzyme binding(GO:0001000)
0.0 0.5 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.3 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology
1.8 5.4 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle