ISMARA results: FhlA

Project

GSE67402: E.coli regulatory changes under long-term starvation

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Results for FhlA

Z-value: 0.39

Transcription factors associated with FhlA

Gene Symbol	Gene ID	Gene Info
fhlA RegulonDB EcoCyc	fhlA	FhlA transcriptional activator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
fhlA		0.33	9.1e-02	Click!

Activity profile of FhlA motif

Sorted Z-values of FhlA motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
hycABCDEFGHI Show fit	2.72		hycD RegulonDB EcoCyc Show fit hycE RegulonDB EcoCyc Show fit hycF RegulonDB EcoCyc Show fit hycG RegulonDB EcoCyc Show fit hycA RegulonDB EcoCyc Show fit hycB RegulonDB EcoCyc Show fit hycC RegulonDB EcoCyc Show fit hycH RegulonDB EcoCyc Show fit hycI RegulonDB EcoCyc Show fit	hydrogenase 3, membrane subunit hydrogenase 3, large subunit formate hydrogenlyase complex iron-sulfur protein hydrogenase 3 and formate hydrogenlyase complex, HycG subunit regulator of the transcriptional regulator FhlA hydrogenase 3, Fe-S subunit hydrogenase 3, membrane subunit protein required for maturation of hydrogenase 3 hydrogenase 3 maturation protease
hypABCDE Show fit	1.75		hypE RegulonDB EcoCyc Show fit hypD RegulonDB EcoCyc Show fit hypA RegulonDB EcoCyc Show fit hypC RegulonDB EcoCyc Show fit hypB RegulonDB EcoCyc Show fit	hydrogenase maturation protein, carbamoyl dehydratase HypD, scaffold protein for assembly of the Fe-(CN)₂CO cofactor accessory protein for nickel incorporation into hydrogenase 3 HypC, protein involved in hydrogenase 3 maturation accessory protein for nickel incorporation into hydrogenase isoenzymes
fdhF Show fit	1.64		fdhF RegulonDB EcoCyc Show fit	formate dehydrogenase H
hypABCDE-fhlA Show fit	1.32		fhlA RegulonDB EcoCyc Show fit hypE RegulonDB EcoCyc Show fit hypD RegulonDB EcoCyc Show fit hypA RegulonDB EcoCyc Show fit hypC RegulonDB EcoCyc Show fit hypB RegulonDB EcoCyc Show fit	FhlA transcriptional activator hydrogenase maturation protein, carbamoyl dehydratase HypD, scaffold protein for assembly of the Fe-(CN)₂CO cofactor accessory protein for nickel incorporation into hydrogenase 3 HypC, protein involved in hydrogenase 3 maturation accessory protein for nickel incorporation into hydrogenase isoenzymes

Network of associatons between targets according to the STRING database.

First level regulatory network of FhlA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.1	GO:0046892	protein dehydration(GO:0018249) peptidyl-S-carbamoyl-L-cysteine dehydration(GO:0046892)
0.5	2.7	GO:0016485	protein processing(GO:0016485)
0.4	1.6	GO:0015942	formate metabolic process(GO:0015942)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.1	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1	2.7	GO:1990204	oxidoreductase complex(GO:1990204)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.1	GO:0070025	carbon monoxide binding(GO:0070025)
0.3	2.7	GO:0016151	nickel cation binding(GO:0016151)
0.3	1.6	GO:0030151	molybdenum ion binding(GO:0030151)