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GSE67402: E.coli regulatory changes under long-term starvation

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Results for FadR

Z-value: 1.34

Transcription factors associated with FadR

Gene Symbol Gene ID Gene Info
fadR
fadR FadR DNA-binding transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
fadR0.748.6e-06Click!

Activity profile of FadR motif

Sorted Z-values of FadR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
fabI 16.12
fabI
enoyl-[acyl-carrier-protein] reductase subunit
accBC 13.85
accC
accB
biotin carboxylase
biotin carboxyl carrier protein
fabHDG 13.16
fabD
fabG
fabH
malonyl-CoA-ACP transacylase
3-oxoacyl-[acyl-carrier-protein] reductase subunit
β-ketoacyl-ACP synthase III
accA 11.51
accA
acetyl-CoA carboxyltransferase, α subunit
fabB 5.92
fabB
β-ketoacyl-ACP synthase I
fadBA 5.47
fadB
fadA
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase
3-ketoacyl-CoA thiolase
uspA 5.43
uspA
universal stress global stress response regulator
fadIJ 5.15
fadJ
fadI
FadJ component of anaerobic fatty acid oxidation complex
FadI component of anaerobic fatty acid oxidation complex
accD 5.02
accD
acetyl-CoA carboxyltransferase, β subunit
fabA 4.33
fabA
β-hydroxyacyl-ACP dehydratase/isomerase
fadR 3.55
fadR
FadR DNA-binding transcriptional dual regulator
iclR 3.10
iclR
IclR transcriptional repressor
fadH 2.00
fadH
2,4-dienoyl-CoA reductase
fadL 1.75
fadL
long-chain fatty acid outer membrane porin; bacteriophage T2 receptor

Network of associatons between targets according to the STRING database.

First level regulatory network of FadR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.8 29.3 GO:0030497 fatty acid elongation(GO:0030497)
5.8 17.4 GO:0046890 regulation of lipid metabolic process(GO:0019216) regulation of fatty acid metabolic process(GO:0019217) regulation of fatty acid biosynthetic process(GO:0042304) regulation of lipid biosynthetic process(GO:0046890)
2.4 26.8 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.2 1.7 GO:0006869 lipid transport(GO:0006869)
0.0 3.1 GO:0045892 negative regulation of transcription, DNA-templated(GO:0045892) negative regulation of RNA biosynthetic process(GO:1902679) negative regulation of nucleic acid-templated transcription(GO:1903507)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 16.5 GO:1990234 transferase complex(GO:1990234)
0.1 55.1 GO:0005829 cytosol(GO:0005829)
0.0 1.7 GO:0009279 cell outer membrane(GO:0009279)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 35.2 GO:0004312 fatty acid synthase activity(GO:0004312)
3.5 10.6 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
1.4 4.3 GO:0019171 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity(GO:0008693) 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity(GO:0019171) 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity(GO:0047451)
0.6 1.7 GO:0022836 gated channel activity(GO:0022836) transmembrane receptor activity(GO:0099600)
0.5 13.8 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.3 5.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3 2.0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 6.7 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 16.9 GO:0042802 identical protein binding(GO:0042802)