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GSE67402: E.coli regulatory changes under long-term starvation

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Results for CpxR

Z-value: 0.93

Transcription factors associated with CpxR

Gene Symbol Gene ID Gene Info
cpxR
cpxR CpxR transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cpxR-0.203.1e-01Click!

Activity profile of CpxR motif

Sorted Z-values of CpxR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
cpxPQ 9.20
cpxQ
cpxP
CpxQ small regulatory RNA
CpxP
cyaR 8.72
cyaR
CyaR
spy 8.71
spy
ATP-independent periplasmic chaperone
tomB-hha 7.91
tomB
hha
protein that modulates Hha toxicity
haemolysin expression modulating protein
yebE 6.95
yebE
conserved inner membrane protein
bamE 6.06
bamE
Outer Membrane Protein Assembly Complex - BamE subunit
ftnB 4.87
ftnB
predicted ferritin-like protein
ldtD 4.35
ldtD
L,D-transpeptidase LdtD
ldtC 3.20
ldtC
L,D-transpeptidase YcfS
yidQ 3.07
yidQ
conserved outer membrane protein
rpoH 2.95
rpoH
RNA polymerase, sigma 32 (sigma H) factor
yqjA-mzrA 2.84
yqjA
mzrA
membrane transport protein; required for proton-motive force (PMF) dependent drug efflux
MzrA
rpoE-rseABC 2.54
rpoE
rseB
rseC
rseA
RNA polymerase, sigma 24 (sigma E) factor
rseB
protein RseC
anti-sigma factor
yqaE 2.33
yqaE
predicted membrane protein
marRAB 2.21
marB
marA
marR
multiple antibiotic resistance protein
MarA DNA-binding transcriptional dual regulator
MarR DNA-binding transcriptional repressor
dgcZ 1.76
dgcZ
diguanylate cyclase
ompC 1.62
ompC
outer membrane protein C
ppiA 1.31
ppiA
peptidyl-prolyl cis-trans isomerase A (rotamase A)
yccA 0.22
yccA
putative carrier/transport protein; substrate or modulator of FtsH-mediated proteolysis

Network of associatons between targets according to the STRING database.

First level regulatory network of CpxR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0043164 Gram-negative-bacterium-type cell wall biogenesis(GO:0043164)
1.6 9.4 GO:0030162 regulation of proteolysis(GO:0030162)
0.7 2.9 GO:0001121 transcription from bacterial-type RNA polymerase promoter(GO:0001121)
0.7 1.3 GO:0006457 protein folding(GO:0006457)
0.6 4.9 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.6 1.8 GO:0031345 negative regulation of organelle organization(GO:0010639) negative regulation of cell projection organization(GO:0031345) negative regulation of organelle assembly(GO:1902116) negative regulation of bacterial-type flagellum assembly(GO:1902209)
0.4 1.6 GO:0015748 organophosphate ester transport(GO:0015748)
0.4 2.7 GO:0051205 protein insertion into membrane(GO:0051205)
0.4 6.4 GO:0044010 single-species biofilm formation(GO:0044010)
0.3 5.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 2.8 GO:0022414 reproduction(GO:0000003) asexual reproduction(GO:0019954) reproductive process(GO:0022414) reproduction of a single-celled organism(GO:0032505) FtsZ-dependent cytokinesis(GO:0043093) single organism reproductive process(GO:0044702)
0.1 2.2 GO:0009408 response to heat(GO:0009408)
0.1 0.9 GO:0009266 response to temperature stimulus(GO:0009266)
0.0 3.1 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.7 GO:0045203 integral component of cell outer membrane(GO:0045203)
0.1 11.5 GO:0030288 outer membrane-bounded periplasmic space(GO:0030288)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0016807 cysteine-type peptidase activity(GO:0008234) cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) peptidoglycan L,D-transpeptidase activity(GO:0071972)
1.2 14.5 GO:0051082 unfolded protein binding(GO:0051082)
0.8 2.5 GO:0045152 antisigma factor binding(GO:0045152)
0.6 2.9 GO:0016987 transcription factor activity, core RNA polymerase binding(GO:0000990) core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) sigma factor activity(GO:0016987)
0.4 1.8 GO:0052621 diguanylate cyclase activity(GO:0052621)
0.3 1.3 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.3 2.8 GO:0019899 enzyme binding(GO:0019899)
0.1 4.9 GO:0005506 iron ion binding(GO:0005506)
0.1 7.8 GO:0003677 DNA binding(GO:0003677)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 REACTOME HEMOSTASIS Genes involved in Hemostasis