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GSE67402: E.coli regulatory changes under long-term starvation
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Results for CRP
Z-value: 1.49
Transcription factors associated with CRP
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
crp
|
crp | CRP transcriptional dual regulator |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| crp | 0.09 | 6.7e-01 | Click! |
Activity profile of CRP motif
Sorted Z-values of CRP motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| cyaR | 6.97 |
cyaR
|
CyaR |
|
| raiA | 5.77 |
raiA
|
stationary phase translation inhibitor and ribosome stability factor |
|
| mglBAC | 5.47 |
mglA
mglB
mglC
|
D-galactose / D-galactoside ABC transporter - ATP binding subunit D-galactose / D-galactoside ABC transporter - periplasmic binding protein D-galactose / D-galactoside ABC transporter - membrane subunit |
|
| dadAX | 5.02 |
dadA
dadX
|
D-amino acid dehydrogenase alanine racemase 2, PLP-binding |
|
| nanATEK-yhcH | 4.37 |
nanA
nanK
nanE
nanT
yhcH
|
N-acetylneuraminate lyase N-acetylmannosamine kinase predicted N-acetylmannosamine-6-phosphate epimerase N-acetylneuraminate:H+ symporter conserved protein |
|
| pck | 4.34 |
pck
|
phosphoenolpyruvate carboxykinase (ATP) |
|
| dctA | 4.11 |
dctA
|
C4 dicarboxylate / orotate:H+ symporter |
|
| rpoH | 4.03 |
rpoH
|
RNA polymerase, sigma 32 (sigma H) factor |
|
| glpABC | 4.00 |
glpA
glpC
glpB
|
anaerobic glycerol-3-phosphate dehydrogenase subunit A anaerobic glycerol-3-phosphate dehydrogenase subunit C anaerobic glycerol-3-phosphate dehydrogenase subunit B |
|
| cstA | 3.96 |
cstA
|
peptide transporter induced by carbon starvation |
|
| ompR-envZ | 3.85 |
envZ
ompR
|
EnvZ OmpR transcriptional dual regulator |
|
| mhpR-lacI | 3.81 |
mhpR
lacI
|
MhpR transcriptional activator LacI DNA-binding transcriptional repressor |
|
| cspD | 3.65 |
cspD
|
DNA replication inhibitor |
|
| glpTQ | 3.58 |
glpT
glpQ
|
glycerol-3-phosphate:phosphate antiporter glycerophosphoryl diester phosphodiesterase, periplasmic |
|
| acs-yjcH-actP | 3.46 |
acs
actP
yjcH
|
acetyl-CoA synthetase (AMP-forming) acetate / glycolate : cation symporter conserved inner membrane protein |
|
| nanA | 3.34 |
nanA
|
N-acetylneuraminate lyase |
|
| aceBAK | 3.29 |
aceK
aceB
aceA
|
isocitrate dehydrogenase phosphatase / isocitrate dehydrogenase kinase malate synthase A isocitrate lyase |
|
| fucPIKUR | 3.19 |
fucU
fucR
fucK
fucP
fucI
|
L-fucose mutarotase FucR transcriptional activator L-fuculokinase fucose:H+ symporter L-fucose isomerase |
|
| glcC | 3.07 |
glcC
|
GlcC transcriptional dual regulator |
|
| ychH | 3.04 |
ychH
|
stress-induced protein |
|
| ompW | 3.01 |
ompW
|
outer membrane protein W |
|
| sbmC | 2.97 |
sbmC
|
DNA gyrase inhibitor |
|
| malT | 2.92 |
malT
|
MalT transcriptional activator |
|
| fadD-sroD | 2.84 |
sroD
fadD
|
SroD fatty acyl-CoA synthetase |
|
| aldA | 2.81 |
aldA
|
aldehyde dehydrogenase A |
|
| agp | 2.71 |
agp
|
glucose-1-phosphatase |
|
| preTA | 2.68 |
preT
preA
|
NADH-dependent dihydropyrimidine dehydrogenase subunit NADH-dependent dihydropyrimidine dehydrogenase subunit |
|
| glpFKX | 2.66 |
glpF
glpX
glpK
|
glycerol channel GlpF fructose 1,6-bisphosphatase II glycerol kinase |
|
| glgS | 2.66 |
glgS
|
surface composition regulator |
|
| glpD | 2.56 |
glpD
|
glycerol-3-phosphate dehydrogenase, aerobic |
|
| araC | 2.51 |
araC
|
AraC DNA-binding transcriptional dual regulator |
|
| yaeP-rof | 2.44 |
yaeP
rof
|
conserved protein modulator of Rho-dependent transcription termination |
|
| rbsDACBKR | 2.33 |
rbsK
rbsA
rbsC
rbsB
rbsD
rbsR
|
ribokinase ribose ABC transporter - putative ATP binding subunit ribose ABC transporter - membrane subunit ribose ABC transporter - putative periplasmic binding protein ribose pyranase RbsR DNA-binding transcriptional dual regulator |
|
| ivbL | 2.32 |
ivbL
|
ilvB operon leader peptide |
|
| aldB | 2.30 |
aldB
|
acetaldehyde dehydrogenase |
|
| ivbL-ilvBN | 2.26 |
ilvB
ilvN
ivbL
|
acetohydroxy acid synthase I, large subunit acetohydroxy acid synthase I, small subunit ilvB operon leader peptide |
|
| bhsA | 2.25 |
bhsA
|
outer membrane protein involved in copper permeability, stress resistance and biofilm formation |
|
| araBAD | 2.23 |
araB
araA
araD
|
L-ribulokinase L-arabinose isomerase L-ribulose 5-phosphate 4-epimerase |
|
| gntP | 2.19 |
gntP
|
gluconate / fructuronate transporter GntP |
|
| araFGH | 2.00 |
araF
araG
araH
|
arabinose ABC transporter - periplasmic binding protein arabinose ABC transporter - ATP binding subunit arabinose ABC transporter - membrane subunit |
|
| aspA-dcuA | 1.96 |
aspA
dcuA
|
aspartate ammonia-lyase dicarboxylate transporter DcuA |
|
| ascFB | 1.94 |
ascF
ascB
|
β-glucoside PTS permease AscF (cryptic) 6-phospho-β-glucosidase AscB |
|
| fadH | 1.93 |
fadH
|
2,4-dienoyl-CoA reductase |
|
| aspA | 1.88 |
aspA
|
aspartate ammonia-lyase |
|
| manXYZ | 1.83 |
manX
manY
manZ
|
mannose PTS permease - ManX subunit mannose PTS permease - ManY subunit mannose PTS permease - ManZ subunit |
|
| csiE | 1.81 |
csiE
|
stationary phase inducible protein |
|
| mtlADR | 1.77 |
mtlR
mtlA
mtlD
|
MtlR DNA-binding transcriptional repressor mannitol PTS permease mannitol-1-phosphate 5-dehydrogenase |
|
| fumAC | 1.75 |
fumA
fumC
|
fumarase A fumarase C |
|
| mdh | 1.74 |
mdh
|
malate dehydrogenase |
|
| srlAEBD-gutM-srlR-gutQ | 1.73 |
srlB
srlA
srlE
srlD
gutQ
srlR
gutM
|
sorbitol PTS permease - SrlB subunit sorbitol PTS permease - SrlA subunit sorbitol PTS permease - SrlE subunit sorbitol-6-phosphate dehydrogenase D-arabinose 5-phosphate isomerase GutR DNA-binding transcriptional repressor GutM DNA-binding transcriptional activator |
|
| tdcABCDEFG | 1.66 |
tdcE
tdcD
tdcG
tdcF
tdcA
tdcC
tdcB
|
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4, inactive propionate kinase L-serine deaminase III predicted enamine/imine deaminase TdcA DNA-binding transcriptional activator serine / threonine:H+ symporter TdcC catabolic threonine dehydratase |
|
| ykgR | 1.59 |
ykgR
|
small membrane protein |
|
| fumA | 1.59 |
fumA
|
fumarase A |
|
| sfsA-dksA | 1.58 |
dksA
sfsA
|
RNA polymerase-binding transcription factor DksA predicted DNA-binding transcriptional regulator of maltose metabolism |
|
| ugpBAECQ | 1.55 |
ugpE
ugpA
ugpB
ugpC
ugpQ
|
glycerol-3-phosphate ABC transporter - membrane subunit glycerol-3-phosphate ABC transporter - membrane subunit glycerol-3-phosphate ABC transporter - periplasmic binding protein glycerol-3-phosphate ABC transporter - ATP binding subunit glycerophosphodiester phosphodiesterase, cytosolic |
|
| rmf | 1.55 |
rmf
|
ribosome modulation factor |
|
| fur | 1.53 |
fur
|
Fur transcriptional dual regulator |
|
| lsrACDBFG-tam | 1.44 |
lsrA
lsrC
lsrB
lsrD
lsrG
lsrF
tam
|
AI-2 ABC transporter - ATP binding subunit Autoinducer-2 ABC transporter - membrane subunit autoinducer-2 ABC transporter - periplasmic binding protein Autoinducer-2 ABC transporter - membrane subunit phospho-AI-2 isomerase 3-hydroxy-2,4-pentadione 5-phosphate thiolase trans-aconitate 2-methyltransferase |
|
| uidABC | 1.43 |
uidB
uidC
uidA
|
glucuronide:H+ symporter outer membrane-associated protein β-D-glucuronidase |
|
| galS | 1.38 |
galS
|
GalS DNA-binding transcriptional dual regulator |
|
| gltA | 1.38 |
gltA
|
citrate synthase |
|
| feaR | 1.38 |
feaR
|
FeaR DNA-binding transcriptional activator |
|
| uxuAB | 1.36 |
uxuA
uxuB
|
D-mannonate dehydratase D-mannonate oxidoreductase |
|
| patZ | 1.36 |
patZ
|
peptidyl-lysine acetyltransferase |
|
| malK-lamB-malM | 1.29 |
lamB
malM
malK
|
maltose outer membrane porin / phage lambda receptor protein maltose regulon periplasmic protein maltose ABC transporter - ATP binding subunit |
|
| nupG | 1.28 |
nupG
|
nucleoside:H+ symporter NupG |
|
| crp | 1.24 |
crp
|
CRP transcriptional dual regulator |
|
| nagE | 1.22 |
nagE
|
N-acetylglucosamine PTS permease |
|
| csiD-lhgO-gabDTP | 1.17 |
gabD
lhgO
gabP
csiD
gabT
|
succinate-semialdehyde dehydrogenase (NADP+) L-2-hydroxyglutarate oxidase 4-aminobutyrate:H+ symporter predicted protein 4-aminobutyrate aminotransferase |
|
| narQ | 1.14 |
narQ
|
NarQ |
|
| chiP-ybfN | 1.13 |
chiP
ybfN
|
chitobiose outer membrane channel predicted lipoprotein |
|
| fixABCX | 1.09 |
fixC
fixB
fixA
fixX
|
flavoprotein (electron transport), possibly involved in anaerobic carnitine metabolism predicted electron transfer flavoprotein, NAD/FAD-binding domain and ETFP adenine nucleotide-binding domain-like predicted elecron transfer flavoprotein subunit, ETFP adenine nucleotide-binding domain putative ferredoxin possibly involved in anaerobic carnitine metabolism |
|
| exuT | 1.09 |
exuT
|
hexuronate transporter |
|
| rhaSR | 1.08 |
rhaS
rhaR
|
RhaS transcriptional activator RhaR transcriptional activator |
|
| gntX-nfuA | 1.07 |
gntX
nfuA
|
protein involved in utilization of DNA as a carbon source iron-sulfur cluster scaffold protein |
|
| yhfA | 1.04 |
yhfA
|
conserved protein |
|
| prpR | 0.99 |
prpR
|
PrpR DNA-binding transcriptional dual regulator |
|
| fepA-entD | 0.97 |
fepA
entD
|
ferric enterobactin / colicin B / colicin D outer membrane porin FepA phosphopantetheinyl transferase/phosphopantetheinyl transferase |
|
| malEFG | 0.96 |
malF
malG
malE
|
maltose ABC transporter - membrane subunit maltose ABC transporter - membrane subunit maltose ABC transporter - periplasmic binding protein |
|
| idnK | 0.96 |
idnK
|
D-gluconate kinase, thermosensitive |
|
| mlc-ynfK | 0.96 |
mlc
ynfK
|
Mlc DNA-binding transcriptional repressor predicted dethiobiotin synthetase |
|
| sxy | 0.93 |
sxy
|
transcriptional coactivator for CRP |
|
| melR | 0.93 |
melR
|
MelR DNA-binding transcriptional dual regulator |
|
| mhpABCDFE | 0.91 |
mhpC
mhpB
mhpA
mhpF
mhpE
mhpD
|
2-hydroxy-6-ketonona-2,4-dienedioate hydrolase 2,3-dihydroxyphenylpropionate 1,2-dioxygenase 3-(3-hydroxyphenyl)propionate 2-hydroxylase acetaldehyde dehydrogenase (acylating) 4-hydroxy-2-ketovalerate aldolase 2-hydroxypentadienoate hydratase |
|
| dcuR | 0.90 |
dcuR
|
DcuR transcriptional activator |
|
| rhaBAD | 0.86 |
rhaD
rhaA
rhaB
|
rhamnulose-1-phosphate aldolase L-rhamnose isomerase L-rhamnulose kinase |
|
| uxaCA | 0.84 |
uxaA
uxaC
|
D-altronate dehydratase D-glucuronate isomerase/D-galacturonate isomerase |
|
| hyfABCDEFGHIJR-focB | 0.84 |
hyfJ
hyfI
hyfH
hyfC
hyfB
hyfA
hyfG
hyfF
hyfE
hyfD
hyfR
focB
|
hydrogenase 4 component J, putative protein processing element hydrogenase 4, small subunit hydrogenase 4, component H hydrogenase 4, component C hydrogenase 4, component B hydrogenase 4, component A hydrogenase 4, large subunit hydrogenase 4, component F hydrogenase 4, component E hydrogenase 4, component D HyfR DNA-binding transcriptional activator FocB formate FNT transporter |
|
| fumC | 0.82 |
fumC
|
fumarase C |
|
| mlc | 0.81 |
mlc
|
Mlc DNA-binding transcriptional repressor |
|
| trg | 0.80 |
|
|
|
| gadBC | 0.80 |
gadB
gadC
|
glutamate decarboxylase B subunit glutamic acid:4-aminobutyrate antiporter |
|
| tnaCAB | 0.78 |
tnaA
tnaC
tnaB
|
tryptophanase tryptophanase operon leader peptide tryptophan:H+ symporter TnaB |
|
| osmY | 0.74 |
osmY
|
periplasmic chaperone, osmotically induced |
|
| cspE | 0.69 |
cspE
|
transcription antiterminator and regulator of RNA stability |
|
| metK | 0.69 |
metK
|
methionine adenosyltransferase |
|
| chbBCARFG | 0.66 |
chbG
chbF
chbC
chbB
chbA
chbR
|
chito-oligosaccharide mono-deacetylase monoacetylchitobiose-6-phosphate hydrolase chitobiose PTS permease - ChbC subunit chitobiose PTS permease - ChbB subunit chitobiose PTS permease - ChbA subunit ChbR DNA-binding transcriptional dual regulator |
|
| glgCAP | 0.65 |
glgP
glgA
glgC
|
glycogen phosphorylase glycogen synthase glucose-1-phosphate adenylyltransferase |
|
| malXY | 0.63 |
malX
malY
|
MalX PTS permease bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon |
|
| sdhDAB | 0.63 |
sdhA
sdhB
sdhD
|
succinate:quinone oxidoreductase, FAD binding protein succinate:quinone oxidoreductase, iron-sulfur cluster binding protein succinate:quinone oxidoreductase, membrane protein SdhD |
|
| sdhCDAB-sucABCD | 0.61 |
sucA
sucC
sucB
sucD
sdhA
sdhC
sdhB
sdhD
|
subunit of E1(0) component of 2-oxoglutarate dehydrogenase succinyl-CoA synthetase, β subunit dihydrolipoyltranssuccinylase succinyl-CoA synthetase, α subunit succinate:quinone oxidoreductase, FAD binding protein succinate:quinone oxidoreductase, membrane protein SdhC succinate:quinone oxidoreductase, iron-sulfur cluster binding protein succinate:quinone oxidoreductase, membrane protein SdhD |
|
| xylFGHR | 0.59 |
xylH
xylR
xylG
xylF
|
xylose ABC transporter - membrane subunit XylR transcriptional dual regulator xylose ABC transporter - ATP binding subunit xylose ABC transporter - periplasmic binding protein |
|
| idnDOTR | 0.58 |
idnD
idnO
idnR
idnT
|
L-idonate 5-dehydrogenase 5-keto-D-gluconate 5-reductase IdnR transcriptional regulator L-idonate / 5-ketogluconate / gluconate transporter IdnT |
|
| kbaZ-agaVWA | 0.57 |
agaA
agaW
agaV
kbaZ
|
predicted truncated N-acetylgalactosamine-6-phosphate deacetylase N-acetyl-D-galactosamine PTS permease (cryptic) - AgaW subunit (pseudogene) N-acetyl-D-galactosamine PTS permease (cryptic) - AgaV subunit tagatose-1,6-bisphosphate aldolase 1 subunit KbaZ |
|
| metY | 0.54 |
metY
|
tRNAfMet2 |
|
| prpBCDE | 0.53 |
prpD
prpE
prpB
prpC
|
2-methylcitrate dehydratase propionyl-CoA synthetase 2-methylisocitrate lyase 2-methylcitrate synthase |
|
| rpoS | 0.53 |
rpoS
|
RNA polymerase, sigma S (sigma 38) factor |
|
| marRAB | 0.52 |
marB
marA
marR
|
multiple antibiotic resistance protein MarA DNA-binding transcriptional dual regulator MarR DNA-binding transcriptional repressor |
|
| dsdXA | 0.49 |
dsdA
dsdX
|
D-serine ammonia-lyase D-serine transporter |
|
| lacZYA | 0.48 |
lacA
lacY
lacZ
|
galactoside O-acetyltransferase lactose / melibiose:H+ symporter LacY β-galactosidase |
|
| gatYZABCD | 0.47 |
gatY
gatZ
gatD
gatA
gatB
gatC
|
tagatose-1,6-bisphosphate aldolase 2 subunit GatY tagatose-1,6-bisphosphate aldolase 2 subunit GatZ L-galactitol-1-phosphate 5-dehydrogenase galactitol PTS permease - GatA subunit galactitol PTS permease - GatB subunit galactitol PTS permease - GatC subunit |
|
| mcaS | 0.42 |
mcaS
|
IsrA |
|
| ppdD-hofBC | 0.42 |
ppdD
hofC
hofB
|
prepilin peptidase dependent protein inner membrane protein HofC T2SSE family protein |
|
| melAB | 0.41 |
melB
melA
|
melibiose:H+/Na+/Li+ symporter α-galactosidase |
|
| entCEBAH | 0.40 |
entA
entH
entC
entB
entE
|
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase proofreading thioesterase in enterobactin biosynthesis isochorismate synthase 1 EntB 2,3-dihydroxybenzoate-AMP ligase |
|
| yiaKLMNO-lyxK-sgbHUE | 0.39 |
lyxK
sgbH
sgbE
sgbU
yiaK
yiaM
yiaL
yiaO
yiaN
|
L-xylulose kinase 3-keto-L-gulonate 6-phosphate decarboxylase L-ribulose-5-phosphate 4-epimerase predicted L-xylulose 5-phosphate 3-epimerase 2,3-diketo-L-gulonate reductase 2,3-diketo-L-gulonate:Na+ symporter - membrane subunit conserved protein 2,3-diketo-L-gulonate:Na+ symporter - periplasmic binding protein 2,3-diketo-L-gulonate:Na+ symporter - membrane subunit |
|
| pdhR-aceEF-lpd | 0.39 |
pdhR
lpd
aceF
aceE
|
PdhR DNA-binding transcriptional dual regulator lipoamide dehydrogenase pyruvate dehydrogenase, E2 subunit subunit of E1p component of pyruvate dehydrogenase complex |
|
| deoCABD | 0.38 |
deoA
deoB
deoC
deoD
|
thymidine phosphorylase / uracil phosphorylase phosphopentomutase deoxyribose-phosphate aldolase purine nucleoside phosphorylase |
|
| ulaABCDEF | 0.38 |
ulaD
ulaE
ulaF
ulaA
ulaB
ulaC
|
3-keto-L-gulonate 6-phosphate decarboxylase L-xylulose 5-phosphate 3-epimerase L-ribulose 5-phosphate 4-epimerase L-ascorbate PTS permease - UlaA subunit L-ascorbate PTS permease - UlaB subunit L-ascorbate PTS permease - UlaC subunit |
|
| comR | 0.38 |
comR
|
ComR DNA-binding transcriptional repressor |
|
| aer | 0.37 |
aer
|
aerotaxis sensor receptor, flavoprotein |
|
| caiTABCDE | 0.35 |
caiT
caiE
caiD
caiC
caiB
caiA
|
L-carnitine : γ-butyrobetaine antiporter predicted acyl transferase crotonobetainyl-CoA hydratase carnitine-CoA ligase γ-butyrobetainyl-CoA:carnitine CoA transferase crotonobetainyl-CoA reductase |
|
| uxaB | 0.33 |
uxaB
|
altronate oxidoreductase |
|
| caiF | 0.33 |
caiF
|
CaiF transcriptional activator |
|
| metY-rimP-nusA-infB-rbfA-truB-rpsO-pnp | 0.33 |
metY
rimP
rpsO
pnp
rbfA
infB
nusA
truB
|
tRNAfMet2 ribosome maturation factor RimP 30S ribosomal subunit protein S15 polynucleotide phosphorylase 30S ribosome binding factor protein chain initiation factor IF2 transcription termination/antitermination L factor tRNA pseudouridine 55 synthase |
|
| feaB | 0.32 |
feaB
|
phenylacetaldehyde dehydrogenase |
|
| rhaT | 0.31 |
rhaT
|
rhamnose / lyxose:H+ symporter |
|
| putP | 0.28 |
putP
|
proline:Na+ symporter |
|
| murQP | 0.24 |
murP
murQ
|
N-acetylmuramic acid PTS permease / anhydro-N-acetylmuramic acid permease N-acetylmuramic acid 6-phosphate etherase |
|
| hupA | 0.24 |
hupA
|
transcriptional dual regulator HU-α (HU-2) |
|
| fiu | 0.21 |
fiu
|
putative outer membrane receptor for iron transport |
|
| tsx | 0.20 |
tsx
|
nucleoside channel; receptor of phage T6 and colicin K |
|
| galETKM | 0.18 |
galT
galE
galM
galK
|
galactose-1-phosphate uridylyltransferase UDP-glucose 4-epimerase galactose-1-epimerase galactokinase |
|
| gadE-mdtEF | 0.17 |
mdtF
mdtE
gadE
|
MdtEF-TolC multidrug efflux pump - permease subunit MdtEF-TolC multidrug efflux pump - membrane fusion protein GadE DNA-binding transcriptional activator |
|
| ebgAC | 0.16 |
ebgA
ebgC
|
evolved β-D-galactosidase, α subunit; cryptic gene evolved β-D-galactosidase, β subunit; cryptic gene |
|
| udp | 0.14 |
udp
|
uridine phosphorylase |
|
| paaABCDEFGHIJK | 0.13 |
paaB
paaC
paaA
paaF
paaG
paaD
paaE
paaJ
paaK
paaH
paaI
|
ring 1,2-phenylacetyl-CoA epoxidase subunit ring 1,2-phenylacetyl-CoA epoxidase, structural subunit ring 1,2-phenylacetyl-CoA epoxidase, monooxygenase subunit predicted 2,3-dehydroadipyl-CoA hydratase predicted ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) phenylacetate degradation protein ring 1,2-phenylacetyl-CoA epoxidase, reductase subunit β-ketoadipyl-CoA thiolase phenylacetate-CoA ligase 3-hydroxyadipyl-CoA dehydrogenase (NAD+) phenylacetyl-CoA thioesterase |
|
| ampDE | 0.12 |
ampD
ampE
|
N-acetyl-anhydromuramyl-L-alanine amidase inner membrane protein |
|
| acnA | 0.11 |
acnA
|
aconitate hydratase 1 |
|
| dcuB-fumB | 0.11 |
fumB
dcuB
|
fumarase B dicarboxylate transporter DcuB |
|
| cyoABCDE | 0.09 |
cyoA
cyoC
cyoB
cyoE
cyoD
|
cytochrome bo terminal oxidase subunit II cytochrome bo terminal oxidase subunit III cytochrome bo terminal oxidase subunit I heme O synthase cytochrome bo terminal oxidase subunit IV |
|
| lsrRK | 0.08 |
lsrK
lsrR
|
autoinducer-2 kinase LsrR DNA-binding transcriptional repressor |
|
| treBC | 0.08 |
treC
treB
|
trehalose-6-phosphate hydrolase trehalose PTS permease - TreB subunit |
|
| aaeXAB | 0.05 |
aaeA
aaeX
aaeB
|
hydroxylated, aromatic carboxylic acid exporter - putative membrane fusion protein hypothetical protein hydroxylated, aromatic carboxylic acid exporter - putative membrane subunit |
|
| xylAB | 0.05 |
xylA
xylB
|
xylose isomerase xylulokinase |
|
| grpE | 0.04 |
grpE
|
nucleotide exchange factor |
|
| gntK | 0.03 |
gntK
|
D-gluconate kinase, thermostable |
|
| lpd | 0.01 |
lpd
|
lipoamide dehydrogenase |
|
| nanCMS | 0.01 |
nanC
nanM
nanS
|
N-acetylneuraminic acid outer membrane channel N-acetylneuraminate mutarotase probable 9-O-acetyl-N-acetylneuraminate esterase |
Network of associatons between targets according to the STRING database.
First level regulatory network of CRP
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 8.5 | GO:0015791 | polyol transport(GO:0015791) |
| 2.0 | 8.1 | GO:0015757 | galactose transport(GO:0015757) |
| 1.9 | 7.5 | GO:0019262 | N-acetylneuraminate metabolic process(GO:0006054) N-acetylneuraminate catabolic process(GO:0019262) |
| 1.8 | 5.5 | GO:0019478 | D-amino acid catabolic process(GO:0019478) |
| 1.7 | 1.7 | GO:0019407 | hexitol metabolic process(GO:0006059) hexitol catabolic process(GO:0019407) |
| 1.7 | 6.6 | GO:0051053 | negative regulation of DNA replication(GO:0008156) negative regulation of DNA metabolic process(GO:0051053) |
| 1.6 | 4.8 | GO:0018394 | peptidyl-lysine acetylation(GO:0018394) |
| 1.5 | 4.5 | GO:0019566 | arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568) |
| 1.4 | 5.8 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 1.4 | 4.3 | GO:0006108 | malate metabolic process(GO:0006108) |
| 1.4 | 2.8 | GO:0006004 | fucose metabolic process(GO:0006004) fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 1.3 | 3.8 | GO:0048583 | regulation of response to stimulus(GO:0048583) |
| 1.1 | 2.3 | GO:0097305 | response to alcohol(GO:0097305) |
| 1.1 | 4.6 | GO:0001121 | transcription from bacterial-type RNA polymerase promoter(GO:0001121) |
| 1.1 | 3.4 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 1.1 | 3.2 | GO:0006637 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
| 1.0 | 3.0 | GO:0046686 | response to cadmium ion(GO:0046686) |
| 1.0 | 2.9 | GO:0015768 | maltose transport(GO:0015768) |
| 0.9 | 1.8 | GO:0015755 | fructose transport(GO:0015755) |
| 0.9 | 2.7 | GO:0006208 | pyrimidine nucleobase catabolic process(GO:0006208) |
| 0.9 | 2.7 | GO:1900232 | regulation of single-species biofilm formation on inanimate substrate(GO:1900231) negative regulation of single-species biofilm formation on inanimate substrate(GO:1900232) |
| 0.9 | 6.2 | GO:0015740 | dicarboxylic acid transport(GO:0006835) C4-dicarboxylate transport(GO:0015740) |
| 0.9 | 2.6 | GO:0042873 | aldonate transport(GO:0042873) |
| 0.8 | 2.5 | GO:0006063 | uronic acid metabolic process(GO:0006063) |
| 0.8 | 4.1 | GO:0015750 | pentose transport(GO:0015750) |
| 0.7 | 2.2 | GO:0019541 | propionate metabolic process(GO:0019541) |
| 0.7 | 4.7 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101) |
| 0.7 | 4.6 | GO:0009099 | valine biosynthetic process(GO:0009099) |
| 0.6 | 7.0 | GO:0046434 | organophosphate catabolic process(GO:0046434) |
| 0.6 | 1.3 | GO:0019324 | L-lyxose metabolic process(GO:0019324) |
| 0.6 | 1.8 | GO:0009437 | carnitine metabolic process(GO:0009437) |
| 0.6 | 2.9 | GO:0015766 | disaccharide transport(GO:0015766) |
| 0.5 | 3.1 | GO:0019319 | gluconeogenesis(GO:0006094) hexose biosynthetic process(GO:0019319) |
| 0.5 | 1.5 | GO:0015748 | organophosphate ester transport(GO:0015748) |
| 0.5 | 0.9 | GO:0031346 | positive regulation of cell projection organization(GO:0031346) |
| 0.5 | 1.4 | GO:0009713 | siderophore metabolic process(GO:0009237) enterobactin metabolic process(GO:0009238) enterobactin biosynthetic process(GO:0009239) catechol-containing compound metabolic process(GO:0009712) catechol-containing compound biosynthetic process(GO:0009713) nonribosomal peptide biosynthetic process(GO:0019184) siderophore biosynthetic process(GO:0019290) siderophore biosynthetic process from catechol(GO:0019540) phenol-containing compound biosynthetic process(GO:0046189) |
| 0.5 | 0.9 | GO:0019748 | secondary metabolic process(GO:0019748) |
| 0.4 | 1.2 | GO:0007584 | response to nutrient(GO:0007584) |
| 0.4 | 2.8 | GO:0031564 | transcription antitermination(GO:0031564) |
| 0.4 | 1.6 | GO:0009254 | peptidoglycan turnover(GO:0009254) |
| 0.4 | 1.5 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 0.4 | 1.1 | GO:1902170 | cellular response to nitrogen compound(GO:1901699) cellular response to reactive nitrogen species(GO:1902170) |
| 0.4 | 1.1 | GO:0015772 | oligosaccharide transport(GO:0015772) |
| 0.3 | 0.3 | GO:0018958 | phenol-containing compound metabolic process(GO:0018958) |
| 0.3 | 2.1 | GO:0009062 | fatty acid beta-oxidation(GO:0006635) fatty acid catabolic process(GO:0009062) cellular lipid catabolic process(GO:0044242) |
| 0.3 | 2.6 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.3 | 1.4 | GO:1901658 | glycosyl compound catabolic process(GO:1901658) |
| 0.3 | 0.8 | GO:0030641 | regulation of pH(GO:0006885) cellular monovalent inorganic cation homeostasis(GO:0030004) regulation of cellular pH(GO:0030641) pH elevation(GO:0045852) regulation of intracellular pH(GO:0051453) intracellular pH elevation(GO:0051454) monovalent inorganic cation homeostasis(GO:0055067) |
| 0.2 | 1.0 | GO:0046177 | D-gluconate metabolic process(GO:0019521) D-gluconate catabolic process(GO:0046177) |
| 0.2 | 1.2 | GO:0006591 | ornithine metabolic process(GO:0006591) arginine biosynthetic process via ornithine(GO:0042450) |
| 0.2 | 0.7 | GO:0043242 | negative regulation of protein complex disassembly(GO:0043242) negative regulation of DNA-templated transcription, termination(GO:0060567) |
| 0.2 | 5.0 | GO:0009267 | cellular response to starvation(GO:0009267) |
| 0.2 | 0.7 | GO:0046498 | S-adenosylmethionine cycle(GO:0033353) S-adenosylhomocysteine metabolic process(GO:0046498) S-adenosylmethionine metabolic process(GO:0046500) |
| 0.2 | 0.7 | GO:0031556 | regulation of cellular amino acid metabolic process(GO:0006521) transcriptional attenuation by ribosome(GO:0031556) regulation of cellular amine metabolic process(GO:0033238) regulation of tryptophan metabolic process(GO:0090357) |
| 0.2 | 0.7 | GO:1901136 | carbohydrate derivative catabolic process(GO:1901136) |
| 0.2 | 0.7 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 0.1 | 0.4 | GO:0050918 | positive chemotaxis(GO:0050918) |
| 0.1 | 1.0 | GO:0006768 | biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102) |
| 0.1 | 0.5 | GO:0071236 | cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237) |
| 0.1 | 0.3 | GO:0015858 | nucleoside transport(GO:0015858) |
| 0.1 | 0.2 | GO:0042884 | microcin transport(GO:0042884) |
| 0.1 | 0.7 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.1 | 0.4 | GO:0051180 | vitamin transport(GO:0051180) |
| 0.0 | 0.1 | GO:0009372 | quorum sensing(GO:0009372) |
| 0.0 | 1.9 | GO:1903508 | positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA metabolic process(GO:0051254) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508) |
| 0.0 | 0.1 | GO:0019646 | aerobic electron transport chain(GO:0019646) |
| 0.0 | 0.0 | GO:0045117 | azole transport(GO:0045117) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.1 | GO:0043231 | membrane-bounded organelle(GO:0043227) intracellular membrane-bounded organelle(GO:0043231) |
| 0.4 | 1.2 | GO:0045274 | respiratory chain complex II(GO:0045273) plasma membrane respiratory chain complex II(GO:0045274) |
| 0.3 | 6.9 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) cytoplasmic side of membrane(GO:0098562) |
| 0.3 | 3.6 | GO:0055052 | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing(GO:0055052) |
| 0.3 | 1.7 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.3 | 7.6 | GO:1904949 | ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949) |
| 0.2 | 4.7 | GO:1990204 | oxidoreductase complex(GO:1990204) |
| 0.2 | 2.3 | GO:1990234 | transferase complex(GO:1990234) |
| 0.1 | 1.0 | GO:0045203 | integral component of cell outer membrane(GO:0045203) |
| 0.1 | 36.0 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.1 | 0.2 | GO:0009295 | nucleoid(GO:0009295) |
| 0.0 | 1.1 | GO:0044462 | cell outer membrane(GO:0009279) external encapsulating structure part(GO:0044462) |
| 0.0 | 1.0 | GO:0030288 | outer membrane-bounded periplasmic space(GO:0030288) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 7.8 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) |
| 2.0 | 8.1 | GO:0005354 | galactose transmembrane transporter activity(GO:0005354) |
| 1.7 | 3.4 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 1.6 | 6.6 | GO:0043211 | carbohydrate-transporting ATPase activity(GO:0043211) |
| 1.5 | 4.4 | GO:0015136 | sialic acid transmembrane transporter activity(GO:0015136) |
| 1.4 | 2.7 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 1.3 | 4.0 | GO:0004777 | succinate-semialdehyde dehydrogenase (NAD+) activity(GO:0004777) |
| 1.3 | 3.9 | GO:0016208 | AMP binding(GO:0016208) |
| 1.3 | 3.8 | GO:0016901 | oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901) |
| 1.2 | 6.2 | GO:0005310 | dicarboxylic acid transmembrane transporter activity(GO:0005310) fumarate transmembrane transporter activity(GO:0015138) succinate transmembrane transporter activity(GO:0015141) C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
| 1.2 | 3.5 | GO:0015118 | tellurite transmembrane transporter activity(GO:0015118) tellurite uptake transmembrane transporter activity(GO:0015654) |
| 1.1 | 2.2 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
| 1.0 | 4.2 | GO:0004333 | fumarate hydratase activity(GO:0004333) |
| 1.0 | 3.0 | GO:0060590 | ATPase regulator activity(GO:0060590) |
| 1.0 | 3.0 | GO:0008742 | L-ribulose-phosphate 4-epimerase activity(GO:0008742) |
| 0.9 | 4.6 | GO:0016987 | transcription factor activity, core RNA polymerase binding(GO:0000990) core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) sigma factor activity(GO:0016987) |
| 0.9 | 3.5 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.8 | 4.0 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.8 | 3.8 | GO:0001141 | transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding(GO:0001141) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217) |
| 0.8 | 2.3 | GO:0003984 | acetolactate synthase activity(GO:0003984) |
| 0.7 | 3.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.7 | 7.6 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.7 | 4.8 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.6 | 0.6 | GO:0005363 | maltose transmembrane transporter activity(GO:0005363) |
| 0.6 | 1.7 | GO:0019146 | arabinose-5-phosphate isomerase activity(GO:0019146) |
| 0.5 | 1.6 | GO:0008706 | 6-phospho-beta-glucosidase activity(GO:0008706) |
| 0.5 | 2.6 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.5 | 4.2 | GO:0015145 | monosaccharide transmembrane transporter activity(GO:0015145) |
| 0.5 | 3.1 | GO:0016877 | ligase activity, forming carbon-sulfur bonds(GO:0016877) |
| 0.5 | 1.0 | GO:0008897 | holo-[acyl-carrier-protein] synthase activity(GO:0008897) |
| 0.4 | 1.2 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.4 | 0.4 | GO:0015592 | methylgalactoside transmembrane transporter activity(GO:0015592) |
| 0.4 | 1.1 | GO:0022838 | substrate-specific channel activity(GO:0022838) |
| 0.3 | 1.0 | GO:0051119 | sugar transmembrane transporter activity(GO:0051119) |
| 0.3 | 0.6 | GO:0000104 | succinate dehydrogenase activity(GO:0000104) |
| 0.3 | 1.7 | GO:0000156 | phosphorelay response regulator activity(GO:0000156) |
| 0.3 | 1.6 | GO:0031420 | alkali metal ion binding(GO:0031420) |
| 0.3 | 0.8 | GO:0046316 | gluconokinase activity(GO:0046316) |
| 0.2 | 1.0 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.2 | 1.4 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.2 | 0.6 | GO:0016803 | hydrolase activity, acting on ether bonds(GO:0016801) ether hydrolase activity(GO:0016803) |
| 0.2 | 1.9 | GO:0071949 | FAD binding(GO:0071949) |
| 0.2 | 1.1 | GO:0016645 | oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645) |
| 0.2 | 0.7 | GO:0001072 | RNA binding transcription factor activity(GO:0001070) transcription antitermination factor activity, RNA binding(GO:0001072) |
| 0.1 | 0.3 | GO:0015081 | sodium ion transmembrane transporter activity(GO:0015081) |
| 0.1 | 1.7 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.1 | 0.7 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 0.1 | 1.3 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.1 | 0.4 | GO:0031405 | lipoic acid binding(GO:0031405) |
| 0.1 | 0.4 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.1 | 0.8 | GO:0015297 | antiporter activity(GO:0015297) |
| 0.1 | 0.1 | GO:0048039 | quinone binding(GO:0048038) ubiquinone binding(GO:0048039) |
| 0.1 | 2.8 | GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors(GO:0016614) |
| 0.1 | 0.3 | GO:0015932 | nucleoside transmembrane transporter activity(GO:0005337) nucleobase-containing compound transmembrane transporter activity(GO:0015932) |
| 0.0 | 1.2 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.1 | GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) |
| 0.0 | 1.5 | GO:0003700 | transcription factor activity, sequence-specific DNA binding(GO:0003700) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 4.0 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.8 | 2.4 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 3.6 | REACTOME INNATE IMMUNE SYSTEM | Genes involved in Innate Immune System |
| 0.4 | 1.2 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.1 | 0.3 | REACTOME PURINE METABOLISM | Genes involved in Purine metabolism |