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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for TyrR

Z-value: 2.25

Transcription factors associated with TyrR

Gene Symbol Gene ID Gene Info
tyrR
tyrR TyrR DNA-binding transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tyrR0.944.3e-04Click!

Activity profile of TyrR motif

Sorted Z-values of TyrR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
aroP 27.50
aroP
aromatic amino acid:H+ symporter AroP
tyrP 9.24
tyrP
tyrosine:H+ symporter TyrP
tyrB 6.48
tyrB
tyrosine aminotransferase
tyrR 4.70
tyrR
TyrR DNA-binding transcriptional dual regulator
mtr 4.30
mtr
tryptohan / indole:H+ symporter Mtr
aroG 2.00
aroG
2-dehydro-3-deoxyphosphoheptonate aldolase
aroL-yaiA-aroM 1.72
yaiA
aroL
aroM
predicted protein
shikimate kinase II
conserved protein
aroF-tyrA 0.02
tyrA
aroF
chorismate mutase / prephenate dehydrogenase
2-dehydro-3-deoxyphosphoheptonate aldolase

Network of associatons between targets according to the STRING database.

First level regulatory network of TyrR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.6 31.8 GO:0015827 tryptophan transport(GO:0015827)
2.2 6.5 GO:0006570 tyrosine metabolic process(GO:0006570) tyrosine biosynthetic process(GO:0006571)
0.3 3.7 GO:0009073 aromatic amino acid family biosynthetic process(GO:0009073)
0.1 4.7 GO:0045892 negative regulation of transcription, DNA-templated(GO:0045892) negative regulation of RNA biosynthetic process(GO:1902679) negative regulation of nucleic acid-templated transcription(GO:1903507)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 41.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 12.3 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.6 31.8 GO:0015196 L-tryptophan transmembrane transporter activity(GO:0015196)
0.7 2.0 GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity(GO:0003849)
0.4 6.5 GO:0008483 transaminase activity(GO:0008483)
0.1 4.7 GO:0005524 ATP binding(GO:0005524)
0.0 1.7 GO:0000287 magnesium ion binding(GO:0000287)