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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for TrpR

Z-value: 1.38

Transcription factors associated with TrpR

Gene Symbol Gene ID Gene Info
trpR
trpR TrpR transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
trpR0.962.1e-04Click!

Activity profile of TrpR motif

Sorted Z-values of TrpR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
trpL 7.83
trpL
trp operon leader peptide
trpR 6.79
trpR
TrpR transcriptional repressor
trpLEDCBA 4.20
trpL
trpB
trpC
trpA
trpD
trpE
trp operon leader peptide
tryptophan synthase, β subunit
indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
tryptophan synthase, α subunit
anthranilate synthase component II
anthranilate synthase component I
mtr 2.87
mtr
tryptohan / indole:H+ symporter Mtr
aroL-yaiA-aroM 1.03
yaiA
aroL
aroM
predicted protein
shikimate kinase II
conserved protein
aroH 0.35
aroH
2-dehydro-3-deoxyphosphoheptonate aldolase

Network of associatons between targets according to the STRING database.

First level regulatory network of TrpR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 12.0 GO:0033238 regulation of cellular amino acid metabolic process(GO:0006521) regulation of cellular amine metabolic process(GO:0033238) regulation of tryptophan metabolic process(GO:0090357)
1.0 2.9 GO:0015827 tryptophan transport(GO:0015827)
0.1 1.4 GO:0009073 aromatic amino acid family metabolic process(GO:0009072) aromatic amino acid family biosynthetic process(GO:0009073)
0.0 6.8 GO:1903506 regulation of transcription, DNA-templated(GO:0006355) regulation of nucleic acid-templated transcription(GO:1903506) regulation of RNA biosynthetic process(GO:2001141)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0005950 anthranilate synthase complex(GO:0005950)
0.0 2.9 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0015196 L-tryptophan transmembrane transporter activity(GO:0015196)
0.5 4.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.4 GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity(GO:0003849)
0.1 6.8 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 1.0 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)