ISMARA results: TrpR

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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for TrpR

Z-value: 1.38

Transcription factors associated with TrpR

Gene Symbol	Gene ID	Gene Info
trpR RegulonDB EcoCyc	trpR	TrpR transcriptional repressor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
trpR		0.96	2.1e-04	Click!

Activity profile of TrpR motif

Sorted Z-values of TrpR motif

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Promoter	Log-likelihood	Gene	Gene Info
trpL Show fit	7.83	trpL RegulonDB EcoCyc Show fit	trp operon leader peptide
trpR Show fit	6.79	trpR RegulonDB EcoCyc Show fit	TrpR transcriptional repressor
trpLEDCBA Show fit	4.20	trpL RegulonDB EcoCyc Show fit trpB RegulonDB EcoCyc Show fit trpC RegulonDB EcoCyc Show fit trpA RegulonDB EcoCyc Show fit trpD RegulonDB EcoCyc Show fit trpE RegulonDB EcoCyc Show fit	trp operon leader peptide tryptophan synthase, β subunit indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase tryptophan synthase, α subunit anthranilate synthase component II anthranilate synthase component I
mtr Show fit	2.87	mtr RegulonDB EcoCyc Show fit	tryptohan / indole:H+ symporter Mtr
aroL-yaiA-aroM Show fit	1.03	yaiA RegulonDB EcoCyc Show fit aroL RegulonDB EcoCyc Show fit aroM RegulonDB EcoCyc Show fit	predicted protein shikimate kinase II conserved protein
aroH Show fit	0.35	aroH RegulonDB EcoCyc Show fit	2-dehydro-3-deoxyphosphoheptonate aldolase

Showing 1 to 6 of 6 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TrpR

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.0	12.0	GO:0033238	regulation of cellular amino acid metabolic process(GO:0006521) regulation of cellular amine metabolic process(GO:0033238) regulation of tryptophan metabolic process(GO:0090357)
0.0	6.8	GO:1903506	regulation of transcription, DNA-templated(GO:0006355) regulation of nucleic acid-templated transcription(GO:1903506) regulation of RNA biosynthetic process(GO:2001141)
1.0	2.9	GO:0015827	tryptophan transport(GO:0015827)
0.1	1.4	GO:0009073	aromatic amino acid family metabolic process(GO:0009072) aromatic amino acid family biosynthetic process(GO:0009073)

Showing 1 to 4 of 4 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	4.2	GO:0005950	anthranilate synthase complex(GO:0005950)
0.0	2.9	GO:0005887	integral component of plasma membrane(GO:0005887)

Showing 1 to 2 of 2 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.8	GO:0043565	sequence-specific DNA binding(GO:0043565)
0.5	4.2	GO:0016833	oxo-acid-lyase activity(GO:0016833)
1.0	2.9	GO:0015196	L-tryptophan transmembrane transporter activity(GO:0015196)
0.0	1.0	GO:0016773	phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.1	0.4	GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity(GO:0003849)

Showing 1 to 5 of 5 entries

Results for TrpR

Z-value: 1.38

Transcription factors associated with TrpR

Activity-expression correlation:

Activity profile of TrpR motif

Sorted Z-values of TrpR motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TrpR

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category: