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GSE55662: Plasticity of transcriptional regulation under antibiotic stress
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Results for Sigma32
Z-value: 2.67
Transcription factors associated with Sigma32
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rpoH | 0.93 | 9.1e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| dnaK-tpke11-dnaJ Show fit | 14.21 |
chaperone protein DnaK chaperone protein DnaJ Tpke11 |
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| htpG Show fit | 13.89 |
molecular chaperone, HSP90 family |
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| rrsD-ileU-alaU-rrlD-rrfD-thrV-rrfF Show fit | 9.12 |
rrlD 23S ribosomal RNA tRNAileU tRNAalaU tRNAthrV rrfF 5S ribosomal RNA rrsD 16S ribosomal RNA rrfD 5S ribosomal RNA |
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| rrsC-gltU-rrlC-rrfC Show fit | 9.07 |
rrlC 23S ribosomal RNA tRNAgltU rrfC 5S ribosomal RNA rrsC 16S ribosomal RNA |
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| groSL Show fit | 8.66 |
GroES cochaperonin GroEL chaperonin |
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| rrsG-gltW-rrlG-rrfG Show fit | 8.52 |
rrlG 23S ribosomal RNA tRNAgltW rrfG 5S ribosomal RNA rrsG 16S ribosomal RNA |
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| raiA Show fit | 8.20 |
stationary phase translation inhibitor and ribosome stability factor |
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| rrsE-gltV-rrlE-rrfE Show fit | 7.85 |
rrlE 23S ribosomal RNA tRNAgltV rrsE 16S ribosomal RNA rrfE 5S ribosomal RNA |
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| bssS Show fit | 7.75 |
regulator of biofilm formation |
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| rrsH-ileV-alaV-rrlH-rrfH Show fit | 7.54 |
rrlH 23S ribosomal RNA rrfH 5S ribosomal RNA rrsH 16S ribosomal RNA tRNAileV tRNAalaV |
Network of associatons between targets according to the STRING database.
First level regulatory network of Sigma32
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.0 | 30.0 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 1.1 | 24.9 | GO:0006457 | protein folding(GO:0006457) |
| 2.6 | 10.3 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 2.3 | 9.1 | GO:0043335 | protein unfolding(GO:0043335) |
| 0.5 | 8.4 | GO:0006096 | glycolytic process(GO:0006096) |
| 2.0 | 8.2 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 1.1 | 7.8 | GO:0043900 | regulation of multi-organism process(GO:0043900) regulation of single-species biofilm formation(GO:1900190) |
| 1.9 | 7.6 | GO:0040033 | negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) positive regulation of translation, ncRNA-mediated(GO:0045975) |
| 1.5 | 4.4 | GO:0015976 | carbon utilization(GO:0015976) |
| 0.8 | 4.2 | GO:0030163 | protein catabolic process(GO:0030163) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 91.5 | GO:0005829 | cytosol(GO:0005829) |
| 0.8 | 23.7 | GO:0044445 | cytosolic part(GO:0044445) |
| 0.9 | 10.1 | GO:0071575 | integral component of external side of plasma membrane(GO:0071575) |
| 0.8 | 2.5 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.3 | 2.1 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 24.1 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.4 | 19.2 | GO:0016887 | ATPase activity(GO:0016887) |
| 2.4 | 12.2 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.7 | 7.9 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 1.6 | 6.5 | GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 1.9 | 5.7 | GO:0060590 | ATPase regulator activity(GO:0060590) |
| 1.8 | 5.4 | GO:0052381 | tRNA dimethylallyltransferase activity(GO:0052381) |
| 0.7 | 5.3 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 0.5 | 5.1 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.3 | 5.0 | GO:0051287 | NAD binding(GO:0051287) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.0 | REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | Genes involved in The citric acid (TCA) cycle and respiratory electron transport |