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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for RcsAB

Z-value: 1.14

Transcription factors associated with RcsAB

Gene Symbol Gene ID Gene Info
rcsB DNA-binding transcriptional activator RcsB
rcsA DNA-binding transcriptional activator RcsA

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rcsA0.981.5e-05Click!
rcsB-0.952.5e-04Click!

Activity profile of RcsAB motif

Sorted Z-values of RcsAB motif

Promoter Log-likelihood Transcript Gene Gene Info
rcsA 6.57 positive DNA-binding transcriptional regulator of capsular polysaccharide synthesis, activates its own expression
yjbEFGH 5.23 conserved protein
predicted lipoprotein
predicted protein
predicted porin
csgDEFG 4.67 curli secretion channel
curli assembly component
curli transport specificity factor
CsgD DNA-binding transcriptional dual regulator
wza-wzb-wzc-wcaAB 3.99 predicted colanic acid biosynthesis glycosyl transferase
predicted colanic acid biosynthesis acyl transferase
protein-tyrosine phosphatase
protein-tyrosine kinase
lipoprotein required for capsular polysaccharide translocation through the outer membrane

Network of associatons between targets according to the STRING database.

First level regulatory network of RcsAB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
1.0 4.0 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.7 4.7 GO:0043900 regulation of multi-organism process(GO:0043900) regulation of single-species biofilm formation(GO:1900190)
0.0 3.7 GO:0006351 transcription, DNA-templated(GO:0006351) nucleic acid-templated transcription(GO:0097659)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.2 GO:0045203 integral component of cell outer membrane(GO:0045203)
0.6 4.7 GO:0031246 intrinsic component of periplasmic side of cell outer membrane(GO:0031246)
0.0 4.0 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 4.7 GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding(GO:0000986) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)