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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for LexA

Z-value: 3.26

Transcription factors associated with LexA

Gene Symbol Gene ID Gene Info
lexA
lexA LexA DNA-binding transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lexA0.961.7e-04Click!

Activity profile of LexA motif

Sorted Z-values of LexA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
sulA 20.69
sulA
SOS cell division inhibitor
recA 20.03
recA
DNA strand exchange and recombination protein with protease and nuclease activity
recN 14.21
recN
protein used in recombination and DNA repair
sbmC 12.95
sbmC
DNA gyrase inhibitor
dinI 12.01
dinI
DNA damage-inducible protein I
ruvAB 11.32
ruvA
ruvB
branch migration of Holliday structures; repair
branch migration of Holliday structures; repair helicase
dinQ 10.12
dinQ
toxic inner membrane peptide DinQ
yebG 10.05
yebG
conserved protein regulated by LexA
uvrB 9.24
uvrB
DNA repair; excision nuclease subunit B
recAX 8.09
recX
recA
regulatory protein RecX; inhibitor of RecA
DNA strand exchange and recombination protein with protease and nuclease activity
ftsK 7.76
ftsK
essential cell division protein FtsK
uvrA 6.28
uvrA
excision nuclease subunit A
polB 6.01
polB
DNA polymerase II
lexA-dinF 5.08
dinF
lexA
putative transport protein, multi antimicrobial extrusion (MATE) family
LexA DNA-binding transcriptional repressor
umuDC 4.93
umuD
umuC
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC
SOS mutagenesis and repair
uvrD 4.78
uvrD
ssDNA translocase and dsDNA helicase - DNA helicase II
dinG 4.36
dinG
ATP-dependent helicase
rpsU-dnaG-rpoD 2.59
rpsU
dnaG
rpoD
30S ribosomal subunit protein S21
DNA primase
RNA polymerase, sigma 70 (sigma D) factor
uvrYC 2.56
uvrC
uvrY
excinuclease ABC, subunit C; repair of UV damage to DNA
UvrY transcriptional regulator
cho 1.84
cho
endonuclease of nucleotide excision repair
ssb 1.67
ssb
ssDNA-binding protein
dinD 1.41
dinD
DNA-damage-inducible protein
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC 1.02
ftsL
murF
ddlB
ftsA
mraY
murC
murD
murE
ftsI
murG
ftsW
ftsQ
lpxC
ftsZ
essential cell division protein FtsL
D-alanyl-D-alanine-adding enzyme
D-alanine-D-alanine ligase B
essential cell division protein FtsA
phospho-N-acetylmuramoyl-pentapeptide transferase
UDP-N-acetylmuramate-alanine ligase
UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase
essential cell division protein FtsI; penicillin-binding protein 3
N-acetylglucosaminyl transferase
essential cell division protein FtsW; lipid II flippase
essential cell division protein FtsQ
UDP-3-O-acyl-N-acetylglucosamine deacetylase
essential cell division protein FtsZ

Network of associatons between targets according to the STRING database.

First level regulatory network of LexA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 20.7 GO:0051726 regulation of cell cycle process(GO:0010564) regulation of cytokinesis(GO:0032465) regulation of GTPase activity(GO:0043087) regulation of cell cycle(GO:0051726)
4.8 91.2 GO:0009432 SOS response(GO:0009432)
4.3 12.9 GO:2000104 regulation of ATPase activity(GO:0043462) negative regulation of DNA-dependent DNA replication(GO:2000104)
2.6 7.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.3 1.0 GO:0015835 peptidoglycan transport(GO:0015835)
0.3 2.5 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.2 2.6 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.1 7.2 GO:0009314 response to radiation(GO:0009314)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 19.9 GO:0009380 excinuclease repair complex(GO:0009380)
1.6 4.9 GO:0042575 DNA polymerase complex(GO:0042575)
1.6 11.3 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 2.6 GO:0015935 small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627)
0.1 50.7 GO:0005829 cytosol(GO:0005829)
0.0 8.7 GO:0016020 membrane(GO:0016020)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 12.9 GO:0060590 ATPase regulator activity(GO:0060590)
4.2 12.5 GO:0015616 DNA translocase activity(GO:0015616)
3.2 34.7 GO:0003697 single-stranded DNA binding(GO:0003697)
2.0 6.0 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
1.5 12.0 GO:0019899 enzyme binding(GO:0019899)
1.1 7.4 GO:0003678 DNA helicase activity(GO:0003678) ATP-dependent DNA helicase activity(GO:0004003)
0.9 2.6 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990) core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) sigma factor activity(GO:0016987)
0.4 2.6 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.3 1.0 GO:0008963 penicillin binding(GO:0008658) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) phospho-N-acetylmuramoyl-pentapeptide-transferase activity(GO:0008963) peptidoglycan transporter activity(GO:0015647)
0.2 1.8 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 6.3 GO:0016887 ATPase activity(GO:0016887)
0.1 5.1 GO:0003677 DNA binding(GO:0003677)
0.1 34.2 GO:0005515 protein binding(GO:0005515)