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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for LeuO

Z-value: 2.02

Transcription factors associated with LeuO

Gene Symbol Gene ID Gene Info
leuO
leuO LeuO DNA-binding transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
leuO0.902.6e-03Click!

Activity profile of LeuO motif

Sorted Z-values of LeuO motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
yjjQ-bglJ 12.46
bglJ
yjjQ
BglJ DNA-binding transcriptional regulator
YjjQ DNA-binding transcriptional repressor
dsrA 11.27
dsrA
DsrA
cadC 10.26
cadC
CadC DNA-binding transcriptional activator
casABCDE12 8.87
casE
casD
casA
casC
casB
cas1
cas2
crRNA endonuclease
Cascade subunit D
Cascade subunit A
Cascade subunit C
Cascade subunit B
multifunctional nuclease Cas1
Cas2 protein
leuLABCD 6.51
leuD
leuB
leuC
leuA
leuL
LeuD
3-isopropylmalate dehydrogenase
LeuC
2-isopropylmalate synthase
leu operon leader peptide
bglGFB 6.22
bglB
bglG
bglF
6-phospho-β-glucosidase B; cryptic
BglG transcriptional antiterminator
BglF
bglG 3.74
bglG
BglG transcriptional antiterminator
leuL 0.32
leuL
leu operon leader peptide

Network of associatons between targets according to the STRING database.

First level regulatory network of LeuO

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.5 GO:0051595 response to methylglyoxal(GO:0051595) response to ketone(GO:1901654)
3.0 8.9 GO:0043571 maintenance of DNA repeat elements(GO:0043570) maintenance of CRISPR repeat elements(GO:0043571) RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
1.4 6.8 GO:0009098 leucine metabolic process(GO:0006551) leucine biosynthetic process(GO:0009098) transcriptional attenuation by ribosome(GO:0031556)
0.4 6.2 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.2 10.3 GO:1902680 positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA metabolic process(GO:0051254) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.5 GO:0044445 cytosolic part(GO:0044445)
0.1 8.9 GO:0043234 protein complex(GO:0043234)
0.1 16.5 GO:0005886 plasma membrane(GO:0005886)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0008706 6-phospho-beta-glucosidase activity(GO:0008706)
1.8 8.9 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821) endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
1.6 6.5 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 12.5 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 3.7 GO:0003723 RNA binding(GO:0003723)
0.0 10.3 GO:0005515 protein binding(GO:0005515)