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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for Cra

Z-value: 2.67

Transcription factors associated with Cra

Gene Symbol Gene ID Gene Info
cra Cra DNA-binding transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cra0.696.0e-02Click!

Activity profile of Cra motif

Sorted Z-values of Cra motif

Promoter Log-likelihood Transcript Gene Gene Info
gapA 28.25 glyceraldehyde 3-phosphate dehydrogenase
eno 15.72 enolase
pck 12.05 phosphoenolpyruvate carboxykinase (ATP)
icd 9.65 isocitrate dehydrogenase
gapA-yeaD 9.04 glyceraldehyde 3-phosphate dehydrogenase
conserved protein
tpiA 8.08 triosephosphate isomerase
epd-pgk-fbaA 7.64 erythrose 4-phosphate dehydrogenase
phosphoglycerate kinase
fructose bisphosphate aldolase class II
manXYZ 7.35 mannose PTS permease - ManX subunit
mannose PTS permease - ManY subunit
mannose PTS permease - ManZ subunit
ptsHI-crr 7.29 PTS enzyme I
HPr
Enzyme IIAGlc; Crr
epd-pgk 7.09 erythrose 4-phosphate dehydrogenase
phosphoglycerate kinase
ppsA 5.21 phosphoenolpyruvate synthetase
adhE 3.94 aldehyde-alcohol dehydrogenase
zwf 3.21 glucose-6-phosphate dehydrogenase (NADP+)
pykF 3.21 pyruvate kinase I
pfkA 2.12 6-phosphofructokinase I
pdhR-aceEF-lpd 1.62 PdhR DNA-binding transcriptional dual regulator
lipoamide dehydrogenase
pyruvate dehydrogenase, E2 subunit
subunit of E1p component of pyruvate dehydrogenase complex
glk 1.55 glucosamine kinase/glucokinase
aceBAK 1.41 isocitrate dehydrogenase phosphatase / isocitrate dehydrogenase kinase
malate synthase A
isocitrate lyase
prpBCDE 0.94 2-methylcitrate dehydratase
propionyl-CoA synthetase
2-methylisocitrate lyase
2-methylcitrate synthase
acnB 0.72 bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase
poxB 0.29 pyruvate oxidase
crp 0.21 CRP transcriptional dual regulator
edd-eda 0.17 multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase
phosphogluconate dehydratase

Network of associatons between targets according to the STRING database.

First level regulatory network of Cra

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.3 GO:0019319 gluconeogenesis(GO:0006094) hexose biosynthetic process(GO:0019319)
4.9 82.7 GO:0006096 glycolytic process(GO:0006096)
3.6 7.3 GO:0043471 regulation of glucose metabolic process(GO:0010906) regulation of cellular catabolic process(GO:0031329) regulation of cellular carbohydrate catabolic process(GO:0043471)
1.7 6.7 GO:0046323 glucose transport(GO:0015758) glucose import(GO:0046323)
1.3 3.9 GO:0006067 ethanol metabolic process(GO:0006067)
1.1 3.2 GO:0009372 quorum sensing(GO:0009372)
0.8 1.6 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.6 1.7 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.5 5.6 GO:0022900 electron transport chain(GO:0022900)
0.2 1.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.1 0.2 GO:0007584 response to nutrient(GO:0007584)
0.0 0.2 GO:0046177 D-gluconate metabolic process(GO:0019521) D-gluconate catabolic process(GO:0046177)
0.0 0.3 GO:0006090 pyruvate metabolic process(GO:0006090)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.7 GO:0005856 cytoskeleton(GO:0005856)
1.0 7.6 GO:0005618 cell wall(GO:0005618)
0.6 7.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 2.1 GO:0061695 transferase complex, transferring phosphorus-containing groups(GO:0061695)
0.2 82.2 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
13.0 52.0 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.5 12.0 GO:0005509 calcium ion binding(GO:0005509)
1.1 2.1 GO:0008443 phosphofructokinase activity(GO:0008443)
1.0 7.3 GO:0008047 enzyme activator activity(GO:0008047)
0.6 9.7 GO:0051287 NAD binding(GO:0051287)
0.6 2.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.5 4.9 GO:0015149 hexose transmembrane transporter activity(GO:0015149)
0.5 1.6 GO:0031405 lipoic acid binding(GO:0031405)
0.5 8.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4 21.2 GO:0000287 magnesium ion binding(GO:0000287)
0.3 1.6 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 2.2 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.1 3.2 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.0 0.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 NABA MATRISOME Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System