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GSE55662: Plasticity of transcriptional regulation under antibiotic stress
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Results for CpxR
Z-value: 0.41
Transcription factors associated with CpxR
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| cpxR | 0.89 | 2.9e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| cyaR Show fit | 2.03 |
CyaR |
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| bamE Show fit | 1.63 |
Outer Membrane Protein Assembly Complex - BamE subunit |
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| yccA Show fit | 1.53 |
putative carrier/transport protein; substrate or modulator of FtsH-mediated proteolysis |
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| ompF Show fit | 1.14 |
outer membrane porin F |
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| degP Show fit | 0.92 |
serine protease Do |
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| ompC Show fit | 0.84 |
outer membrane protein C |
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| spy Show fit | 0.82 |
ATP-independent periplasmic chaperone |
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| rpoE-rseABC Show fit | 0.72 |
RNA polymerase, sigma 24 (sigma E) factor rseB protein RseC anti-sigma factor |
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| skp-lpxD-fabZ-lpxA Show fit | 0.66 |
UDP-N-acetylglucosamine acyltransferase UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase periplasmic chaperone 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase |
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| cpxRA Show fit | 0.65 |
CpxA sensory histidine kinase CpxR transcriptional dual regulator |
Network of associatons between targets according to the STRING database.
First level regulatory network of CpxR
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.3 | GO:0051205 | protein insertion into membrane(GO:0051205) |
| 0.3 | 2.0 | GO:0030162 | regulation of proteolysis(GO:0030162) |
| 0.1 | 1.3 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 1.1 | GO:0034220 | ion transmembrane transport(GO:0034220) |
| 0.2 | 0.9 | GO:0006515 | misfolded or incompletely synthesized protein catabolic process(GO:0006515) |
| 0.2 | 0.8 | GO:0015748 | organophosphate ester transport(GO:0015748) |
| 0.0 | 0.7 | GO:0006979 | response to oxidative stress(GO:0006979) |
| 0.0 | 0.7 | GO:0009314 | response to radiation(GO:0009314) |
| 0.0 | 0.2 | GO:0010038 | response to metal ion(GO:0010038) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.5 | GO:0045203 | integral component of cell outer membrane(GO:0045203) |
| 0.0 | 1.3 | GO:0030288 | outer membrane-bounded periplasmic space(GO:0030288) |
| 0.3 | 1.1 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.4 | GO:0071575 | integral component of external side of plasma membrane(GO:0071575) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.4 | 1.1 | GO:0022885 | bacteriocin transmembrane transporter activity(GO:0022885) colicin transmembrane transporter activity(GO:0042912) |
| 0.1 | 0.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 0.7 | GO:0045152 | antisigma factor binding(GO:0045152) |
| 0.2 | 0.7 | GO:0019171 | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity(GO:0008693) 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity(GO:0019171) 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity(GO:0047451) |
| 0.1 | 0.4 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.2 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.0 | 0.1 | GO:0003849 | 3-deoxy-7-phosphoheptulonate synthase activity(GO:0003849) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | PID CMYB PATHWAY | C-MYB transcription factor network |