ISMARA results: AcrR

Project

GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for AcrR

Z-value: 0.85

Transcription factors associated with AcrR

Gene Symbol	Gene ID	Gene Info
acrR RegulonDB EcoCyc	acrR	AcrR DNA-binding transcriptional repressor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
acrR		0.95	2.8e-04	Click!

Activity profile of AcrR motif

Sorted Z-values of AcrR motif

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Promoter	Log-likelihood	Gene	Gene Info
acrR Show fit	6.29	acrR RegulonDB EcoCyc Show fit	AcrR DNA-binding transcriptional repressor
soxR Show fit	4.63	soxR RegulonDB EcoCyc Show fit	SoxR DNA-binding transcriptional dual regulator
marRAB Show fit	4.50	marB RegulonDB EcoCyc Show fit marA RegulonDB EcoCyc Show fit marR RegulonDB EcoCyc Show fit	multiple antibiotic resistance protein MarA DNA-binding transcriptional dual regulator MarR DNA-binding transcriptional repressor
acrAB Show fit	0.03	acrB RegulonDB EcoCyc Show fit acrA RegulonDB EcoCyc Show fit	AcrAB-TolC multidrug efflux pump - permease subunit AcrAB-TolC multidrug efflux pump - membrane fusion protein

Showing 1 to 4 of 4 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of AcrR

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.3	GO:0042493	response to drug(GO:0042493)
0.1	4.6	GO:0006979	response to oxidative stress(GO:0006979)
0.5	4.5	GO:0071236	cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)

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Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	GO:0030288	outer membrane-bounded periplasmic space(GO:0030288)

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Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	6.3	GO:0008144	drug binding(GO:0008144)
0.3	4.6	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.9	GO:0000975	regulatory region DNA binding(GO:0000975) regulatory region nucleic acid binding(GO:0001067) transcription regulatory region DNA binding(GO:0044212)
0.0	0.0	GO:0015307	drug:proton antiporter activity(GO:0015307)

Showing 1 to 4 of 4 entries

Results for AcrR

Z-value: 0.85

Transcription factors associated with AcrR

Activity-expression correlation:

Activity profile of AcrR motif

Sorted Z-values of AcrR motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of AcrR

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category: