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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for AcrR

Z-value: 0.85

Transcription factors associated with AcrR

Gene Symbol Gene ID Gene Info
acrR AcrR DNA-binding transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
acrR0.952.8e-04Click!

Activity profile of AcrR motif

Sorted Z-values of AcrR motif

Promoter Log-likelihood Transcript Gene Gene Info
acrR 6.29 AcrR DNA-binding transcriptional repressor
soxR 4.63 SoxR DNA-binding transcriptional dual regulator
marRAB 4.50 multiple antibiotic resistance protein
MarA DNA-binding transcriptional dual regulator
MarR DNA-binding transcriptional repressor
acrAB 0.03 AcrAB-TolC multidrug efflux pump - permease subunit
AcrAB-TolC multidrug efflux pump - membrane fusion protein

Network of associatons between targets according to the STRING database.

First level regulatory network of AcrR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.5 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.2 6.3 GO:0042493 response to drug(GO:0042493)
0.1 4.6 GO:0006979 response to oxidative stress(GO:0006979)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.5 GO:0030288 outer membrane-bounded periplasmic space(GO:0030288)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.3 GO:0008144 drug binding(GO:0008144)
0.3 4.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.9 GO:0000975 regulatory region DNA binding(GO:0000975) regulatory region nucleic acid binding(GO:0001067) transcription regulatory region DNA binding(GO:0044212)
0.0 0.0 GO:0015307 drug:proton antiporter activity(GO:0015307)