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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for znf740b
Z-value: 1.04
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Transcription factors associated with znf740b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| znf740b | dr11_v1_chr23_-_36418059_36418059 | 0.70 | 1.2e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_1732838 Show fit | 4.39 |
ENSDART00000159555
ENSDART00000168161 |
fibulin 1 |
|
| chr2_+_22694382 Show fit | 4.10 |
ENSDART00000139196
|
kinesin family member 1Ab |
|
| chr3_-_16289826 Show fit | 3.52 |
ENSDART00000131972
|
branched chain keto acid dehydrogenase E1, beta polypeptide, like |
|
| chr2_-_44183613 Show fit | 3.13 |
ENSDART00000079596
|
cell adhesion molecule 3 |
|
| chr17_-_4395373 Show fit | 3.07 |
ENSDART00000015923
|
kelch-like family member 10a |
|
| chr3_+_62126981 Show fit | 2.95 |
ENSDART00000060527
|
dynein regulatory complex subunit 3 |
|
| chr14_-_9522364 Show fit | 2.92 |
ENSDART00000054689
|
atonal bHLH transcription factor 8 |
|
| chr2_-_44183451 Show fit | 2.89 |
ENSDART00000111246
|
cell adhesion molecule 3 |
|
| chr10_-_5857548 Show fit | 2.83 |
ENSDART00000166933
|
si:ch211-281k19.2 |
|
| chr21_-_43117327 Show fit | 2.74 |
ENSDART00000122352
|
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of znf740b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.1 | 5.9 | GO:0045732 | positive regulation of protein catabolic process(GO:0045732) |
| 0.4 | 5.7 | GO:0051127 | positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 1.0 | 2.9 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.0 | 2.8 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
| 0.1 | 2.7 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) |
| 0.2 | 2.4 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.1 | 2.3 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.0 | 2.3 | GO:0009250 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.1 | 2.0 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.7 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 3.7 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 3.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.8 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 2.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 2.3 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 2.3 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 2.0 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
| 0.1 | 2.0 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.1 | 1.8 | GO:1990246 | uniplex complex(GO:1990246) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.4 | 3.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 3.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 3.5 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 3.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.3 | 2.8 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.2 | 2.7 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 0.1 | 2.4 | GO:0048185 | activin binding(GO:0048185) |
| 0.5 | 2.3 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.0 | 2.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.4 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 2.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 1.3 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 1.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.5 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | REACTOME SIGNALING BY ERBB4 | Genes involved in Signaling by ERBB4 |
| 0.1 | 2.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.6 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 1.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 1.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.0 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.0 | 0.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 0.6 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.6 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.4 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |