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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for znf384l
Z-value: 0.87
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Transcription factors associated with znf384l
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| znf384l | dr11_v1_chr19_-_6983002_6983002 | 0.92 | 5.0e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_14143344 Show fit | 2.11 |
ENSDART00000152742
|
bucky ball 2-like |
|
| chr15_+_22394074 Show fit | 1.78 |
ENSDART00000109931
|
OAF homolog a (Drosophila) |
|
| chr23_+_28322986 Show fit | 1.75 |
ENSDART00000134710
|
baculoviral IAP repeat containing 5b |
|
| chr11_-_3613558 Show fit | 1.74 |
ENSDART00000163578
|
DnaJ (Hsp40) homolog, subfamily C, member 16 like |
|
| chr6_+_23809163 Show fit | 1.59 |
ENSDART00000170402
|
glutamate-ammonia ligase (glutamine synthase) b |
|
| chr2_-_17115256 Show fit | 1.54 |
ENSDART00000190488
|
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) |
|
| chr6_-_7109063 Show fit | 1.51 |
ENSDART00000148548
|
nonhomologous end-joining factor 1 |
|
| chr12_-_4249000 Show fit | 1.45 |
ENSDART00000059298
|
zgc:92313 |
|
| chr16_+_35924188 Show fit | 1.45 |
ENSDART00000165847
|
SH3 domain containing 21 |
|
| chr2_+_22416275 Show fit | 1.40 |
ENSDART00000185179
ENSDART00000172715 |
protein kinase N2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of znf384l
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0000377 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.0 | 2.6 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.5 | 2.3 | GO:0000741 | karyogamy(GO:0000741) pronuclear fusion(GO:0007344) |
| 0.1 | 2.0 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 1.9 | GO:0016575 | histone deacetylation(GO:0016575) |
| 0.6 | 1.7 | GO:0000212 | meiotic spindle organization(GO:0000212) |
| 0.2 | 1.7 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.1 | 1.7 | GO:0090309 | methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.1 | 1.5 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.1 | 1.5 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 2.1 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.3 | 2.0 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.0 | 1.9 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 1.9 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.8 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.3 | 1.5 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.1 | 1.5 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.0 | 1.5 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 1.4 | GO:0005681 | spliceosomal complex(GO:0005681) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.6 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.2 | 2.1 | GO:0043028 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028) |
| 0.2 | 1.7 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.1 | 1.6 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.2 | 1.4 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 1.4 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.4 | 1.3 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.1 | 1.3 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 1.3 | GO:0030170 | pyridoxal phosphate binding(GO:0030170) |
| 0.2 | 1.2 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 1.4 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 1.3 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.1 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.0 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 1.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.1 | 2.0 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 1.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.3 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.0 | 1.2 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 1.2 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.1 | 1.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 1.0 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |