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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for zic4+zic6

Z-value: 0.28

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Transcription factors associated with zic4+zic6

Gene Symbol Gene ID Gene Info
zic4
ENSDARG00000031307 zic family member 4
zic6
ENSDARG00000071496 zic family member 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zic4dr11_v1_chr24_+_4977862_4977862-0.814.3e-05Click!
zic6dr11_v1_chr14_+_32022272_320222720.097.3e-01Click!

Activity profile of zic4+zic6 motif

Sorted Z-values of zic4+zic6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_4245311 1.22 ENSDART00000055379
gdf3
growth differentiation factor 3
chr17_-_4245902 1.05 ENSDART00000151851
gdf3
growth differentiation factor 3
chr19_-_27550768 0.84 ENSDART00000142313
si:dkeyp-46h3.8
si:dkeyp-46h3.8
chr8_+_15269423 0.61 ENSDART00000020386
gclm
glutamate-cysteine ligase, modifier subunit
chr12_-_4243268 0.57 ENSDART00000131275
zgc:92313
zgc:92313
chr15_+_47746176 0.46 ENSDART00000154481
ENSDART00000160914
stard10
StAR-related lipid transfer (START) domain containing 10
chr24_-_34680956 0.45 ENSDART00000171009
ctnna1
catenin (cadherin-associated protein), alpha 1
chr1_-_34450784 0.45 ENSDART00000140515
lmo7b
LIM domain 7b
chr3_+_24094581 0.45 ENSDART00000138270
ENSDART00000131509
copz2
coatomer protein complex, subunit zeta 2
chr1_-_34450622 0.42 ENSDART00000083736
lmo7b
LIM domain 7b
chr5_-_15948833 0.40 ENSDART00000051649
ENSDART00000124467
xbp1
X-box binding protein 1
chr5_+_31811662 0.37 ENSDART00000023463
uap1l1
UDP-N-acetylglucosamine pyrophosphorylase 1, like 1
chr5_+_13521081 0.35 ENSDART00000171975
si:ch211-230g14.6
si:ch211-230g14.6
chr12_-_41619257 0.33 ENSDART00000162967
dpysl4
dihydropyrimidinase-like 4
chr1_+_40613297 0.33 ENSDART00000040798
ENSDART00000168067
ENSDART00000130490
naa15b
N(alpha)-acetyltransferase 15, NatA auxiliary subunit b
chr11_-_2504750 0.31 ENSDART00000173149
dgkab
diacylglycerol kinase, alpha b
chr19_-_81851 0.30 ENSDART00000172319
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr11_-_44999858 0.29 ENSDART00000167759
ENSDART00000126845
ldb1b
LIM-domain binding 1b
chr6_+_23026714 0.26 ENSDART00000124948
srp68
signal recognition particle 68
chr19_-_17996162 0.26 ENSDART00000150928
ENSDART00000104491
ints8
integrator complex subunit 8
chr5_+_37744625 0.26 ENSDART00000014031
dpf2
D4, zinc and double PHD fingers family 2
chr24_-_21172122 0.26 ENSDART00000154259
atp6v1ab
ATPase H+ transporting V1 subunit Ab
chr20_-_14781904 0.25 ENSDART00000187200
ENSDART00000179912
ENSDART00000160481
ENSDART00000026969
suco
SUN domain containing ossification factor
chr19_-_82504 0.24 ENSDART00000027864
ENSDART00000160560
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr18_+_31117136 0.24 ENSDART00000138403
tcf25
transcription factor 25 (basic helix-loop-helix)
chr8_-_4618653 0.23 ENSDART00000025535
sept5a
septin 5a
chr12_+_20627164 0.23 ENSDART00000190179
stx4
syntaxin 4
chr12_-_2800809 0.23 ENSDART00000152682
ENSDART00000083784
ubtd1b
ubiquitin domain containing 1b
chr25_-_1079417 0.23 ENSDART00000163134
FO907089.1

chr12_+_20627505 0.23 ENSDART00000074384
stx4
syntaxin 4
chr18_+_1615 0.23 ENSDART00000082450
homer2
homer scaffolding protein 2
chr8_-_1266181 0.23 ENSDART00000148654
ENSDART00000149924
cdc14b
cell division cycle 14B
chr19_-_17996336 0.22 ENSDART00000186143
ENSDART00000080751
ints8
integrator complex subunit 8
chr17_-_23895026 0.22 ENSDART00000122108
pdzd8
PDZ domain containing 8
chr18_-_20458412 0.21 ENSDART00000012241
kif23
kinesin family member 23
chr13_+_37653851 0.21 ENSDART00000141988
ENSDART00000126902
ENSDART00000100352
phf3
PHD finger protein 3
chr10_-_4961923 0.20 ENSDART00000050177
ENSDART00000146066
snx30
sorting nexin family member 30
chr18_+_20047374 0.19 ENSDART00000146957
uacaa
uveal autoantigen with coiled-coil domains and ankyrin repeats a
chr5_+_36611128 0.17 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr21_-_217589 0.17 ENSDART00000185017
CZQB01146713.1

chr21_+_5926777 0.16 ENSDART00000121769
rexo4
REX4 homolog, 3'-5' exonuclease
chr17_+_52300018 0.16 ENSDART00000190302
esrrb
estrogen-related receptor beta
chr1_-_58601636 0.16 ENSDART00000141143
si:ch73-236c18.8
si:ch73-236c18.8
chr21_-_14664445 0.15 ENSDART00000124223
ehmt1b
euchromatic histone-lysine N-methyltransferase 1b
chr20_-_28768109 0.14 ENSDART00000114611
ENSDART00000182443
sipa1l1
signal-induced proliferation-associated 1 like 1
chr21_+_3093419 0.14 ENSDART00000162520
SHC3
SHC adaptor protein 3
chr19_+_40122160 0.14 ENSDART00000143966
si:ch211-173p18.3
si:ch211-173p18.3
chr13_+_16521898 0.14 ENSDART00000122557
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr25_+_2776511 0.14 ENSDART00000115280
neo1b
neogenin 1b
chr21_-_21465111 0.13 ENSDART00000141487
nectin3b
nectin cell adhesion molecule 3b
chr11_+_34921492 0.13 ENSDART00000128070
gnai2a
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a
chr8_+_26859639 0.11 ENSDART00000133440
prdm2a
PR domain containing 2, with ZNF domain a
chr22_-_26558166 0.11 ENSDART00000111125
glis2a
GLIS family zinc finger 2a
chr5_+_30596822 0.10 ENSDART00000188375
hinfp
histone H4 transcription factor
chr11_+_31558006 0.10 ENSDART00000024296
egln1b
egl-9 family hypoxia-inducible factor 1b
chr24_-_20599781 0.09 ENSDART00000179664
ENSDART00000141823
zbtb47b
zinc finger and BTB domain containing 47b
chr16_-_7228276 0.09 ENSDART00000149030
nt5c3a
5'-nucleotidase, cytosolic IIIA
chr3_-_40162843 0.08 ENSDART00000129664
ENSDART00000025285
drg2
developmentally regulated GTP binding protein 2
chr14_+_40852497 0.07 ENSDART00000128588
ENSDART00000166065
taf7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr25_-_27729046 0.07 ENSDART00000131437
zgc:153935
zgc:153935
chr15_-_33495048 0.07 ENSDART00000159882
stard13b
StAR-related lipid transfer (START) domain containing 13b
chr5_-_67750907 0.07 ENSDART00000172097
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr20_-_28642061 0.07 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr3_-_19561058 0.06 ENSDART00000079323
zgc:163079
zgc:163079
chr23_-_27547931 0.06 ENSDART00000144419
larp4aa
La ribonucleoprotein domain family, member 4Aa
chr19_+_9790806 0.06 ENSDART00000155948
cacng6a
calcium channel, voltage-dependent, gamma subunit 6a
chr17_+_34215886 0.06 ENSDART00000186775
mpp5a
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr2_-_42628028 0.05 ENSDART00000179866
myo10
myosin X
chr15_-_26844591 0.05 ENSDART00000077582
pitpnm3
PITPNM family member 3
chr24_-_10897511 0.05 ENSDART00000145593
ENSDART00000102484
ENSDART00000066784
fam49bb
family with sequence similarity 49, member Bb
chr5_-_68927728 0.05 ENSDART00000132838
ank1a
ankyrin 1, erythrocytic a
chr3_-_37588855 0.05 ENSDART00000149258
arf2a
ADP-ribosylation factor 2a
chr14_-_21097574 0.04 ENSDART00000186803
rnf20
ring finger protein 20, E3 ubiquitin protein ligase
chr24_-_21587335 0.04 ENSDART00000091528
gpr12
G protein-coupled receptor 12
chr11_+_31558207 0.04 ENSDART00000140204
egln1b
egl-9 family hypoxia-inducible factor 1b
chr22_-_18116635 0.04 ENSDART00000005724
ncanb
neurocan b
chr4_+_76349919 0.04 ENSDART00000174194
si:ch73-158p21.2
si:ch73-158p21.2
chr1_-_54191626 0.04 ENSDART00000062941
nthl1
nth-like DNA glycosylase 1
chr5_-_23725480 0.04 ENSDART00000137063
si:dkey-110k5.10
si:dkey-110k5.10
chr17_+_28670132 0.04 ENSDART00000076344
ENSDART00000164981
ENSDART00000182851
hectd1
HECT domain containing 1
chr5_+_31944270 0.03 ENSDART00000147850
ungb
uracil DNA glycosylase b
chr15_-_38202630 0.03 ENSDART00000183772
rhoga
ras homolog family member Ga
chr12_-_4206869 0.03 ENSDART00000106572
si:dkey-32n7.9
si:dkey-32n7.9
chr17_-_14523722 0.03 ENSDART00000024726
daam1a
dishevelled associated activator of morphogenesis 1a
chr24_-_13566015 0.03 ENSDART00000123450
KCNB2
si:dkey-192j17.1
chr2_-_14987282 0.03 ENSDART00000143057
hccsa.2
holocytochrome c synthase a, tandem duplicate 2
chr16_-_55028740 0.02 ENSDART00000156368
ENSDART00000161704
zgc:114181
zgc:114181
chr5_-_61588998 0.02 ENSDART00000050912
pex12
peroxisomal biogenesis factor 12
chr21_-_33995213 0.02 ENSDART00000140184
EBF1 (1 of many)
si:ch211-51e8.2
chr18_-_50947868 0.02 ENSDART00000174276
st7
suppression of tumorigenicity 7
chr8_+_40210398 0.02 ENSDART00000167612
rnf34a
ring finger protein 34a
chr17_+_132555 0.02 ENSDART00000158159
zgc:77287
zgc:77287
chr10_+_10677697 0.01 ENSDART00000188705
fam163b
family with sequence similarity 163, member B
chr16_-_46567344 0.01 ENSDART00000127721
si:dkey-152b24.7
si:dkey-152b24.7
chr25_-_18730697 0.01 ENSDART00000182475
si:dkeyp-93a5.2
si:dkeyp-93a5.2
chr6_-_7438584 0.01 ENSDART00000053776
fkbp11
FK506 binding protein 11
chr9_-_32191620 0.01 ENSDART00000139426
pimr143
Pim proto-oncogene, serine/threonine kinase, related 143
chr4_+_64562090 0.01 ENSDART00000188810
si:ch211-223a21.3
si:ch211-223a21.3
chr10_+_21786656 0.01 ENSDART00000185851
ENSDART00000167219
pcdh1g26
protocadherin 1 gamma 26
chr9_-_37748513 0.01 ENSDART00000188967
ENSDART00000187886
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr23_-_29824146 0.00 ENSDART00000020616
zgc:194189
zgc:194189
chr3_+_46724528 0.00 ENSDART00000181358
pde4a
phosphodiesterase 4A, cAMP-specific
chr18_-_15559817 0.00 ENSDART00000061681
si:ch211-245j22.3
si:ch211-245j22.3
chr3_-_19899914 0.00 ENSDART00000134969
rnd2
Rho family GTPase 2
chr13_-_32648382 0.00 ENSDART00000138571
ENSDART00000132820
bend3
BEN domain containing 3

Network of associatons between targets according to the STRING database.

First level regulatory network of zic4+zic6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.2 0.6 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 0.3 GO:0048785 hatching gland development(GO:0048785)
0.1 0.2 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.0 0.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.2 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.2 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.0 0.4 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.2 GO:0046850 regulation of bone remodeling(GO:0046850)
0.0 0.2 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.2 GO:0006203 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.0 0.3 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.5 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.5 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.1 GO:0035587 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.1 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.0 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031415 NatA complex(GO:0031415)
0.1 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.1 0.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0008832 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.0 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 2.1 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation