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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for zfhx3+zfhx3a+zfhx4

Z-value: 0.58

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Transcription factors associated with zfhx3+zfhx3a+zfhx4

Gene Symbol Gene ID Gene Info
zfhx3a
ENSDARG00000073944 si_ch73-386h18.1
zfhx4
ENSDARG00000075542 zinc finger homeobox 4
zfhx3
ENSDARG00000103057 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zfhx4dr11_v1_chr24_-_23320223_233202230.931.6e-08Click!
si:ch73-386h18.1dr11_v1_chr18_+_6054816_60548160.858.4e-06Click!
zfhx3dr11_v1_chr7_-_68373495_683734950.832.3e-05Click!

Activity profile of zfhx3+zfhx3a+zfhx4 motif

Sorted Z-values of zfhx3+zfhx3a+zfhx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_31075972 1.74 ENSDART00000122927
si:ch211-198b3.4
si:ch211-198b3.4
chr7_+_20587506 1.67 ENSDART00000172416
ENSDART00000170633
si:dkey-19b23.7
si:dkey-19b23.7
chr15_+_34988148 1.58 ENSDART00000076269
ccdc105
coiled-coil domain containing 105
chr9_+_52613820 1.53 ENSDART00000168753
ENSDART00000165580
ENSDART00000164769
si:ch211-241j8.2
si:ch211-241j8.2
chr18_+_7611298 1.51 ENSDART00000062156
odf3b
outer dense fiber of sperm tails 3B
chr1_+_44003654 1.07 ENSDART00000131337
si:dkey-22i16.10
si:dkey-22i16.10
chr25_+_34915576 1.03 ENSDART00000073441
sntb2
syntrophin, beta 2
chr11_-_2838699 0.99 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr16_-_42894628 0.95 ENSDART00000045600
hfe2
hemochromatosis type 2
chr22_+_20720808 0.93 ENSDART00000171321
si:dkey-211f22.5
si:dkey-211f22.5
chr24_-_26328721 0.91 ENSDART00000125468
apodb
apolipoprotein Db
chr5_-_30715225 0.86 ENSDART00000016758
ftr82
finTRIM family, member 82
chr18_+_36914221 0.85 ENSDART00000147656
si:ch211-238g23.1
si:ch211-238g23.1
chr5_+_6954162 0.84 ENSDART00000086666
stpg2
sperm-tail PG-rich repeat containing 2
chr25_+_34915762 0.83 ENSDART00000191776
sntb2
syntrophin, beta 2
chr23_+_20689255 0.82 ENSDART00000182420
usp21
ubiquitin specific peptidase 21
chr16_-_27566552 0.63 ENSDART00000142102
zgc:153215
zgc:153215
chr13_+_27314795 0.58 ENSDART00000128726
eef1a1a
eukaryotic translation elongation factor 1 alpha 1a
chr20_+_36629173 0.58 ENSDART00000161241
ephx1
epoxide hydrolase 1, microsomal (xenobiotic)
chr20_+_27298783 0.58 ENSDART00000013861
ppp4r4
protein phosphatase 4, regulatory subunit 4
chr17_+_8212477 0.57 ENSDART00000064665
slc18b1
solute carrier family 18, subfamily B, member 1
chr8_-_18042089 0.55 ENSDART00000132596
dio1
iodothyronine deiodinase 1
chr5_+_13385837 0.53 ENSDART00000191190
ccl19a.1
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr15_-_17869115 0.51 ENSDART00000112838
atf5b
activating transcription factor 5b
chr1_+_54013457 0.49 ENSDART00000012104
ENSDART00000126339
dla
deltaA
chr12_-_35885349 0.47 ENSDART00000085662
cep131
centrosomal protein 131
chr21_-_20765338 0.46 ENSDART00000135940
ghrb
growth hormone receptor b
chr4_+_9669717 0.45 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr8_-_25074319 0.45 ENSDART00000134190
sort1b
sortilin 1b
chr21_-_13123176 0.44 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr22_-_34551568 0.43 ENSDART00000148147
rnf123
ring finger protein 123
chr4_+_57881965 0.42 ENSDART00000162234
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr22_-_15602593 0.42 ENSDART00000036075
tpm4a
tropomyosin 4a
chr4_+_7698862 0.39 ENSDART00000009909
elk3
ELK3, ETS-domain protein
chr12_-_19151708 0.35 ENSDART00000057124
tefa
thyrotrophic embryonic factor a
chr15_+_28685892 0.34 ENSDART00000155815
ENSDART00000060244
nova2
neuro-oncological ventral antigen 2
chr20_-_9095105 0.33 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr7_+_56577906 0.32 ENSDART00000184023
hp
haptoglobin
chr4_-_22338906 0.32 ENSDART00000131402
golgb1
golgin B1
chr22_+_13886821 0.31 ENSDART00000130585
ENSDART00000105711
sh3bp4a
SH3-domain binding protein 4a
chr20_+_41756996 0.29 ENSDART00000186393
fam184a
family with sequence similarity 184, member A
chr10_-_42131408 0.29 ENSDART00000076693
stambpa
STAM binding protein a
chr25_-_16818195 0.29 ENSDART00000185215
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr5_-_65158203 0.28 ENSDART00000171656
sh2d3cb
SH2 domain containing 3Cb
chr18_+_29950233 0.27 ENSDART00000146431
atmin
ATM interactor
chr10_-_11261565 0.25 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr25_+_28679672 0.24 ENSDART00000139965
ENSDART00000134072
cnot2
CCR4-NOT transcription complex, subunit 2
chr19_+_14573998 0.24 ENSDART00000022076
fam46bb
family with sequence similarity 46, member Bb
chr7_-_38658411 0.24 ENSDART00000109463
ENSDART00000017155
npsn
nephrosin
chr22_-_38480186 0.24 ENSDART00000171704
soul4
heme-binding protein soul4
chr3_-_34337969 0.23 ENSDART00000151634
tnrc6c1
trinucleotide repeat containing 6C1
chr17_-_51893123 0.23 ENSDART00000103350
ENSDART00000017329
numb
numb homolog (Drosophila)
chr18_+_2228737 0.23 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr10_-_17179415 0.23 ENSDART00000131751
depdc5
DEP domain containing 5
chr3_-_16055432 0.22 ENSDART00000123621
ENSDART00000023859
atp6v0ca
ATPase H+ transporting V0 subunit ca
chr25_+_24291156 0.22 ENSDART00000083407
b4galnt4a
beta-1,4-N-acetyl-galactosaminyl transferase 4a
chr10_-_11261386 0.22 ENSDART00000189946
ptbp3
polypyrimidine tract binding protein 3
chr7_+_42460302 0.22 ENSDART00000004120
adamts18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr16_-_41787421 0.21 ENSDART00000147210
si:dkey-199f5.8
si:dkey-199f5.8
chr21_+_9689103 0.21 ENSDART00000165132
mapk10
mitogen-activated protein kinase 10
chr1_+_44838706 0.21 ENSDART00000162779
ENSDART00000147357
kdm2aa
lysine (K)-specific demethylase 2Aa
chr14_-_25111496 0.21 ENSDART00000158108
si:rp71-1d10.8
si:rp71-1d10.8
chr21_+_13150937 0.21 ENSDART00000102251
sptan1
spectrin alpha, non-erythrocytic 1
chr5_+_32345187 0.20 ENSDART00000147132
c9
complement component 9
chr8_+_15254564 0.20 ENSDART00000024433
slc5a9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr23_+_24589633 0.20 ENSDART00000143694
mlh3
mutL homolog 3 (E. coli)
chr18_-_17399291 0.20 ENSDART00000192075
ENSDART00000060949
ENSDART00000188506
zfpm1
zinc finger protein, FOG family member 1
chr23_+_45200481 0.20 ENSDART00000004357
ENSDART00000111126
ENSDART00000193560
ENSDART00000190476
psip1b
PC4 and SFRS1 interacting protein 1b
chr8_+_18830759 0.20 ENSDART00000089079
mpnd
MPN domain containing
chr4_+_18804317 0.20 ENSDART00000101043
slc26a3.2
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr8_-_25569920 0.20 ENSDART00000136869
prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr3_+_40170216 0.19 ENSDART00000011568
syngr3a
synaptogyrin 3a
chr18_-_16181952 0.19 ENSDART00000157824
slc6a15
solute carrier family 6 (neutral amino acid transporter), member 15
chr10_+_42423318 0.18 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr13_+_45524475 0.16 ENSDART00000074567
ENSDART00000019113
maco1b
macoilin 1b
chr20_-_40755614 0.16 ENSDART00000061247
cx32.3
connexin 32.3
chr12_-_28848015 0.14 ENSDART00000153200
si:ch211-194k22.8
si:ch211-194k22.8
chr5_+_28830643 0.13 ENSDART00000051448
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr25_-_35599887 0.13 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr12_+_27061720 0.13 ENSDART00000153426
srcap
Snf2-related CREBBP activator protein
chr16_-_44127307 0.13 ENSDART00000104583
ENSDART00000151936
ENSDART00000058685
ENSDART00000190830
zfpm2a
zinc finger protein, FOG family member 2a
chr15_+_29472065 0.13 ENSDART00000154343
gdpd5b
glycerophosphodiester phosphodiesterase domain containing 5b
chr6_-_43283122 0.12 ENSDART00000186022
frmd4ba
FERM domain containing 4Ba
chr19_+_3056450 0.12 ENSDART00000141324
ENSDART00000082353
hsf1
heat shock transcription factor 1
chr15_-_17868870 0.11 ENSDART00000170950
atf5b
activating transcription factor 5b
chr5_+_28830388 0.11 ENSDART00000149150
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr17_-_30975707 0.10 ENSDART00000138346
evla
Enah/Vasp-like a
chr10_+_8690936 0.09 ENSDART00000144218
si:dkey-27b3.4
si:dkey-27b3.4
chr15_+_28685625 0.08 ENSDART00000188797
ENSDART00000166036
nova2
neuro-oncological ventral antigen 2
chr23_+_13375359 0.08 ENSDART00000151947
ZNF512B
si:dkey-256k13.2
chr4_-_5302866 0.08 ENSDART00000138590
SNAP91 (1 of many)
si:ch211-214j24.9
chr6_+_20647155 0.08 ENSDART00000193477
slc19a1
solute carrier family 19 (folate transporter), member 1
chr24_+_14713776 0.07 ENSDART00000134475
gdap1
ganglioside induced differentiation associated protein 1
chr25_-_3230187 0.07 ENSDART00000160545
cib1
calcium and integrin binding 1 (calmyrin)
chr25_+_18965430 0.06 ENSDART00000169742
tdg.1
thymine DNA glycosylase, tandem duplicate 1
chr22_-_24818066 0.06 ENSDART00000143443
vtg6
vitellogenin 6
chr17_+_2162916 0.06 ENSDART00000103775
pak6a
p21 protein (Cdc42/Rac)-activated kinase 6a
chr16_+_28383758 0.06 ENSDART00000059038
ENSDART00000141061
itga8
integrin, alpha 8
chr2_-_27609189 0.05 ENSDART00000040555
lyn
LYN proto-oncogene, Src family tyrosine kinase
chr6_+_30456788 0.04 ENSDART00000121492
FP236735.1

chr24_-_21470766 0.04 ENSDART00000178121
atp8a2
ATPase phospholipid transporting 8A2
chr7_-_20865005 0.03 ENSDART00000190752
fis1
fission, mitochondrial 1
chr20_-_40750953 0.02 ENSDART00000061256
cx28.9
connexin 28.9
chr1_+_22851261 0.02 ENSDART00000193925
gtf2e2
general transcription factor IIE, polypeptide 2, beta
chr5_+_9382301 0.02 ENSDART00000124017
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr7_+_4194306 0.02 ENSDART00000190454
si:dkey-28d5.5
si:dkey-28d5.5
chr4_-_20118468 0.02 ENSDART00000078587
si:dkey-159a18.1
si:dkey-159a18.1
chr17_-_7371564 0.02 ENSDART00000060336
rab32b
RAB32b, member RAS oncogene family
chr16_-_46645396 0.02 ENSDART00000131485
tmem176l.2
transmembrane protein 176l.2
chr4_-_32642681 0.02 ENSDART00000188695
ENSDART00000193974
si:dkey-265e7.1
si:dkey-265e7.1
chr7_-_17412559 0.01 ENSDART00000163020
nitr3a
novel immune-type receptor 3a
chr11_+_7432533 0.01 ENSDART00000180977
adgrl2a
adhesion G protein-coupled receptor L2a
chr22_+_19220459 0.00 ENSDART00000163070
si:dkey-21e2.7
si:dkey-21e2.7

Network of associatons between targets according to the STRING database.

First level regulatory network of zfhx3+zfhx3a+zfhx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.1 0.5 GO:0055016 hypochord development(GO:0055016)
0.1 0.5 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.1 0.3 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 0.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.5 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.2 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.1 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.3 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.2 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.5 GO:0060396 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.8 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.2 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.9 GO:0007568 aging(GO:0007568)
0.0 1.0 GO:0060122 detection of mechanical stimulus involved in sensory perception(GO:0050974) inner ear receptor stereocilium organization(GO:0060122)
0.0 0.1 GO:0098838 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.0 0.2 GO:0060036 notochord cell vacuolation(GO:0060036)
0.0 0.2 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 0.6 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.2 GO:0007530 sex determination(GO:0007530)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.4 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.5 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.3 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.3 GO:0070536 protein K63-linked deubiquitination(GO:0070536)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0000801 central element(GO:0000801)
0.1 0.5 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 1.9 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.1 0.2 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0033961 cis-stilbene-oxide hydrolase activity(GO:0033961)
0.1 0.5 GO:0004903 growth hormone receptor activity(GO:0004903)
0.0 0.2 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.0 0.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.5 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.1 GO:0015350 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing