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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for zbtb12.2

Z-value: 0.93

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Transcription factors associated with zbtb12.2

Gene Symbol Gene ID Gene Info
zbtb12.2
ENSDARG00000070658 zinc finger and BTB domain containing 12, tandem duplicate 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zbtb12.2dr11_v1_chr19_-_26964348_26964348-0.145.9e-01Click!

Activity profile of zbtb12.2 motif

Sorted Z-values of zbtb12.2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_17114852 3.82 ENSDART00000006549
pif1
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr2_-_17115256 3.59 ENSDART00000190488
pif1
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr19_-_27579805 2.97 ENSDART00000132980
ENSDART00000142263
si:dkeyp-46h3.3
si:dkeyp-46h3.3
chr5_+_25311309 1.81 ENSDART00000169638
wu:fa19b12
wu:fa19b12
chr15_+_38299563 1.73 ENSDART00000099375
si:dkey-24p1.6
si:dkey-24p1.6
chr14_-_6527010 1.73 ENSDART00000125058
nipsnap3a
nipsnap homolog 3A (C. elegans)
chr16_-_42175617 1.52 ENSDART00000084715
alkbh8
alkB homolog 8, tRNA methyltransferase
chr20_-_29532939 1.50 ENSDART00000049224
ENSDART00000062377
taf1b
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B
chr13_+_46941930 1.43 ENSDART00000056962
fbxo5
F-box protein 5
chr19_+_26640096 1.29 ENSDART00000067793
ints3
integrator complex subunit 3
chr3_+_43373867 1.25 ENSDART00000159455
ENSDART00000172425
zfand2a
zinc finger, AN1-type domain 2A
chr17_-_12249990 1.21 ENSDART00000177889
ENSDART00000155545
ahctf1
AT hook containing transcription factor 1
chr16_+_53526135 1.15 ENSDART00000083558
smpd5
sphingomyelin phosphodiesterase 5
chr19_-_24136233 1.15 ENSDART00000143365
thap7
THAP domain containing 7
chr24_-_7957581 1.06 ENSDART00000145815
txndc5
thioredoxin domain containing 5
chr24_-_28259127 1.04 ENSDART00000149589
prkag2a
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr20_+_38458084 1.02 ENSDART00000020153
ENSDART00000135912
coq8a
coenzyme Q8A
chr9_-_180334 0.99 ENSDART00000180339
zgc:158619
zgc:158619
chr3_+_43374571 0.96 ENSDART00000182497
zfand2a
zinc finger, AN1-type domain 2A
chr5_-_66823750 0.91 ENSDART00000041441
ENSDART00000112488
stip1
stress-induced phosphoprotein 1
chr21_+_1587722 0.86 ENSDART00000013581
wdr91
WD repeat domain 91
chr6_+_11397269 0.86 ENSDART00000114260
senp2
SUMO1/sentrin/SMT3 specific peptidase 2
chr6_+_12482599 0.83 ENSDART00000090316
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr19_+_3140313 0.82 ENSDART00000125504
zgc:86598
zgc:86598
chr1_+_58981985 0.81 ENSDART00000170646
ENSDART00000171055
thumpd1
THUMP domain containing 1
chr22_+_2048566 0.78 ENSDART00000169234
si:dkey-1b17.9
si:dkey-1b17.9
chr6_+_20954400 0.76 ENSDART00000143248
ENSDART00000165806
stk11ip
serine/threonine kinase 11 interacting protein
chr25_-_7649736 0.75 ENSDART00000149548
myo5ab
myosin VAb
chr12_-_48312647 0.73 ENSDART00000114415
ascc1
activating signal cointegrator 1 complex subunit 1
chr2_+_30547018 0.71 ENSDART00000193747
ankrd33bb
ankyrin repeat domain 33Bb
chr22_-_9861531 0.71 ENSDART00000193197
si:dkey-253d23.2
si:dkey-253d23.2
chr21_+_20386865 0.70 ENSDART00000144366
si:dkey-30k6.5
si:dkey-30k6.5
chr14_+_46342882 0.69 ENSDART00000193707
ENSDART00000060577
tmem33
transmembrane protein 33
chr1_+_218524 0.69 ENSDART00000109529
tmco3
transmembrane and coiled-coil domains 3
chr7_+_21768452 0.68 ENSDART00000127719
kdm6ba
lysine (K)-specific demethylase 6B, a
chr3_+_33300522 0.67 ENSDART00000114023
hspb9
heat shock protein, alpha-crystallin-related, 9
chr10_+_29849497 0.63 ENSDART00000099994
ENSDART00000132212
hspa8
heat shock protein 8
chr1_-_40341306 0.62 ENSDART00000190649
maml3
mastermind-like transcriptional coactivator 3
chr21_-_28737320 0.61 ENSDART00000098696
ENSDART00000124826
ENSDART00000125652
nrg2a
neuregulin 2a
chr6_-_46053300 0.59 ENSDART00000169722
ca16b
carbonic anhydrase XVI b
chr18_+_8402129 0.57 ENSDART00000081154
ENSDART00000171974
prpf18
PRP18 pre-mRNA processing factor 18 homolog (yeast)
chr3_-_36364903 0.57 ENSDART00000028883
gna13b
guanine nucleotide binding protein (G protein), alpha 13b
chr22_+_2512154 0.54 ENSDART00000097363
zgc:173726
zgc:173726
chr12_+_9849476 0.53 ENSDART00000110458
fam117ab
family with sequence similarity 117, member Ab
chr11_+_1551603 0.51 ENSDART00000185383
ENSDART00000121489
ENSDART00000040577
mybl2b
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr14_-_14607855 0.49 ENSDART00000162322
rab9b
RAB9B, member RAS oncogene family
chr5_-_42950963 0.47 ENSDART00000149868
grsf1
G-rich RNA sequence binding factor 1
chr19_-_42945965 0.46 ENSDART00000142858
dclk3
doublecortin-like kinase 3
chr6_+_2195625 0.45 ENSDART00000155659
acvr1bb
activin A receptor type 1Bb
chr11_+_2855430 0.43 ENSDART00000172837
kif21b
kinesin family member 21B
chr2_+_22602301 0.41 ENSDART00000038514
sept2
septin 2
chr21_+_43171013 0.38 ENSDART00000151362
zcchc10
zinc finger, CCHC domain containing 10
chr19_+_20793388 0.36 ENSDART00000142463
txnl4a
thioredoxin-like 4A
chr19_+_20793237 0.35 ENSDART00000014774
txnl4a
thioredoxin-like 4A
chr22_+_2686673 0.34 ENSDART00000161580
si:dkey-20i20.15
si:dkey-20i20.15
chr19_+_3215466 0.31 ENSDART00000181288
zgc:86598
zgc:86598
chr10_-_15048781 0.31 ENSDART00000038401
ENSDART00000155674
si:ch211-95j8.2
si:ch211-95j8.2
chr19_-_25519612 0.28 ENSDART00000133150
C1GALT1 (1 of many)
si:dkey-202e17.1
chr21_-_43171249 0.27 ENSDART00000021037
ENSDART00000148630
hspa4a
heat shock protein 4a
chr1_+_54194801 0.27 ENSDART00000186802
CABZ01067150.1

chr22_+_1837448 0.26 ENSDART00000160015
znf1183
zinc finger protein 1183
chr11_-_18254 0.25 ENSDART00000167814
prr13
proline rich 13
chr22_+_1734981 0.25 ENSDART00000158195
znf1159
zinc finger protein 1159
chr6_-_1566186 0.25 ENSDART00000156305
trim107
tripartite motif containing 107
chr8_+_24281512 0.24 ENSDART00000062845
mmp9
matrix metallopeptidase 9
chr22_+_1300587 0.22 ENSDART00000124161
si:ch73-138e16.5
si:ch73-138e16.5
chr8_+_22491947 0.21 ENSDART00000125805
si:ch211-261n11.8
si:ch211-261n11.8
chr4_+_16323970 0.21 ENSDART00000190651
BX322608.1

chr11_-_18449 0.21 ENSDART00000172050
prr13
proline rich 13
chr12_-_20120702 0.20 ENSDART00000153387
ENSDART00000158412
ENSDART00000112768
ubald1a
UBA-like domain containing 1a
chr1_+_16127825 0.19 ENSDART00000122503
tusc3
tumor suppressor candidate 3
chr2_-_20981907 0.18 ENSDART00000113384
lyrm4
LYR motif containing 4
chr19_+_8985230 0.17 ENSDART00000018973
scamp3
secretory carrier membrane protein 3
chr6_-_1566407 0.17 ENSDART00000112118
trim107
tripartite motif containing 107
chr8_-_50132860 0.16 ENSDART00000149964
antxr1a
anthrax toxin receptor 1a
chr3_-_2033105 0.16 ENSDART00000135249
si:dkey-88j15.3
si:dkey-88j15.3
chr8_-_50133064 0.15 ENSDART00000030064
antxr1a
anthrax toxin receptor 1a
chr22_+_9862466 0.15 ENSDART00000146864
si:dkey-253d23.3
si:dkey-253d23.3
chr8_+_43852743 0.14 ENSDART00000186485
AL808129.2

chr23_+_3553516 0.13 ENSDART00000181050
si:dkey-9l20.3
si:dkey-9l20.3
chr16_+_38659475 0.12 ENSDART00000023238
emc2
ER membrane protein complex subunit 2
chr1_-_45888608 0.12 ENSDART00000139219
pnpla6
patatin-like phospholipase domain containing 6
chr19_-_25519310 0.12 ENSDART00000089882
C1GALT1 (1 of many)
si:dkey-202e17.1
chr13_+_30055171 0.11 ENSDART00000143581
ENSDART00000132027
spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr5_+_31944270 0.10 ENSDART00000147850
ungb
uracil DNA glycosylase b
chr19_+_7864767 0.10 ENSDART00000137540
ENSDART00000151642
si:dkeyp-85e10.3
si:dkeyp-85e10.3
chr12_-_26430507 0.09 ENSDART00000153214
synpo2lb
synaptopodin 2-like b
chr23_+_34005792 0.08 ENSDART00000132668
si:ch211-207e14.4
si:ch211-207e14.4
chr22_+_9287929 0.07 ENSDART00000193522
si:ch211-250k18.7
si:ch211-250k18.7
chr9_-_22099536 0.07 ENSDART00000101923
CR391987.1

chr10_+_9595575 0.07 ENSDART00000091780
ENSDART00000184287
rc3h2
ring finger and CCCH-type domains 2
chr3_-_61345723 0.07 ENSDART00000156749
si:dkey-111k8.5
si:dkey-111k8.5
chr9_-_10357638 0.07 ENSDART00000132123
thsd7ba
thrombospondin, type I, domain containing 7Ba
chr22_+_2144278 0.05 ENSDART00000162173
ENSDART00000159914
ENSDART00000160192
znf1164
zinc finger protein 1164
chr7_-_58867188 0.05 ENSDART00000187006
CU681855.1

chr18_+_28106139 0.04 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr7_+_29024282 0.04 ENSDART00000076425
cog4
component of oligomeric golgi complex 4
chr16_-_10837245 0.04 ENSDART00000036891
rabac1
Rab acceptor 1 (prenylated)
chr16_-_44709832 0.04 ENSDART00000156784
si:ch211-151m7.6
si:ch211-151m7.6
chr5_-_29570141 0.03 ENSDART00000043259
entpd2a.2
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2
chr22_+_18469004 0.03 ENSDART00000061430
cilp2
cartilage intermediate layer protein 2
chr13_-_50446872 0.02 ENSDART00000083883
herc4
HECT and RLD domain containing E3 ubiquitin protein ligase 4
chr3_-_7129057 0.01 ENSDART00000125947
BX005085.1

chr3_-_136043 0.01 ENSDART00000160266
zgc:110249
zgc:110249
chr15_+_31426768 0.01 ENSDART00000014270
or103-1
odorant receptor, family C, subfamily 103, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of zbtb12.2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.4 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.4 1.4 GO:1904667 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.3 1.5 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 1.2 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 0.7 GO:0061383 trabecula morphogenesis(GO:0061383) heart trabecula morphogenesis(GO:0061384)
0.2 0.6 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 0.6 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 0.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 1.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.6 GO:1902946 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.1 0.6 GO:0060347 ventricular trabecula myocardium morphogenesis(GO:0003222) trabecula formation(GO:0060343) heart trabecula formation(GO:0060347) skin epidermis development(GO:0098773)
0.1 0.7 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
0.1 0.2 GO:0002544 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.1 1.3 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.1 0.9 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 1.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.9 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.7 GO:0061055 myotome development(GO:0061055)
0.0 0.3 GO:1901998 toxin transport(GO:1901998)
0.0 1.0 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 1.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.1 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.0 0.2 GO:2000406 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.0 0.9 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 1.1 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.1 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.0 0.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.8 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.8 GO:0006400 tRNA modification(GO:0006400)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.2 1.3 GO:0070876 SOSS complex(GO:0070876)
0.1 0.9 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 7.4 GO:0005657 replication fork(GO:0005657)
0.1 1.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 1.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.3 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.6 GO:0031526 brush border membrane(GO:0031526)
0.1 0.5 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.4 GO:0048179 activin receptor complex(GO:0048179)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 1.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.4 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0072546 ER membrane protein complex(GO:0072546)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.4 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.5 1.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.5 1.5 GO:0001164 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.2 0.6 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 1.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.1 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.4 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.7 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.9 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.0 GO:0016208 AMP binding(GO:0016208)
0.0 0.9 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0032977 membrane insertase activity(GO:0032977)
0.0 3.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.1 GO:0004620 phospholipase activity(GO:0004620)
0.0 0.1 GO:0035613 RNA stem-loop binding(GO:0035613)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.4 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.8 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.9 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions