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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for zbtb12.2
Z-value: 0.93
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Transcription factors associated with zbtb12.2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zbtb12.2 | dr11_v1_chr19_-_26964348_26964348 | -0.14 | 5.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_17114852 Show fit | 3.82 |
ENSDART00000006549
|
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) |
|
| chr2_-_17115256 Show fit | 3.59 |
ENSDART00000190488
|
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) |
|
| chr19_-_27579805 Show fit | 2.97 |
ENSDART00000132980
ENSDART00000142263 |
si:dkeyp-46h3.3 |
|
| chr5_+_25311309 Show fit | 1.81 |
ENSDART00000169638
|
wu:fa19b12 |
|
| chr15_+_38299563 Show fit | 1.73 |
ENSDART00000099375
|
si:dkey-24p1.6 |
|
| chr14_-_6527010 Show fit | 1.73 |
ENSDART00000125058
|
nipsnap homolog 3A (C. elegans) |
|
| chr16_-_42175617 Show fit | 1.52 |
ENSDART00000084715
|
alkB homolog 8, tRNA methyltransferase |
|
| chr20_-_29532939 Show fit | 1.50 |
ENSDART00000049224
ENSDART00000062377 |
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B |
|
| chr13_+_46941930 Show fit | 1.43 |
ENSDART00000056962
|
F-box protein 5 |
|
| chr19_+_26640096 Show fit | 1.29 |
ENSDART00000067793
|
integrator complex subunit 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of zbtb12.2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.4 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.3 | 1.5 | GO:0042790 | transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790) |
| 0.1 | 1.5 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 0.4 | 1.4 | GO:1904667 | negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667) |
| 0.1 | 1.3 | GO:0044818 | mitotic G2/M transition checkpoint(GO:0044818) |
| 0.2 | 1.2 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
| 0.1 | 1.2 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.0 | 1.1 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.0 | 1.0 | GO:0009395 | phospholipid catabolic process(GO:0009395) |
| 0.0 | 1.0 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.4 | GO:0005657 | replication fork(GO:0005657) |
| 0.5 | 1.5 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.2 | 1.3 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 1.3 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.0 | 1.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 0.1 | 1.1 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.0 | 1.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 1.0 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 0.9 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 0.7 | GO:0044666 | MLL3/4 complex(GO:0044666) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 7.4 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.0 | 3.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.5 | 1.5 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.5 | 1.5 | GO:0001164 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.1 | 1.2 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 1.1 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 1.1 | GO:0004620 | phospholipase activity(GO:0004620) |
| 0.0 | 1.0 | GO:0016208 | AMP binding(GO:0016208) |
| 0.1 | 0.9 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.1 | 0.9 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 1.5 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 1.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 1.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.9 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.7 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.1 | 0.6 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |