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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for xbp1

Z-value: 1.77

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Transcription factors associated with xbp1

Gene Symbol Gene ID Gene Info
ENSDARG00000035622 X-box binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
xbp1dr11_v1_chr5_-_15948833_159489200.925.8e-08Click!

Activity profile of xbp1 motif

Sorted Z-values of xbp1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_10702031 4.25 ENSDART00000102304
lectin, mannose-binding, 1
chr21_+_10701834 4.18 ENSDART00000192473
lectin, mannose-binding, 1
chr12_-_990149 4.18 ENSDART00000054367
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2b
chr16_+_27224369 2.96 ENSDART00000136980
Sec61 translocon beta subunit
chr12_+_10116912 2.87 ENSDART00000189630
si:dkeyp-118b1.2
chr11_+_45286911 2.85 ENSDART00000181763
pyrroline-5-carboxylate reductase 1b
chr3_+_28860283 2.53 ENSDART00000077235
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr10_-_34915886 2.51 ENSDART00000141201
ENSDART00000002166
cyclin A1
chr11_-_6420917 2.40 ENSDART00000193717

chr24_+_14214831 2.36 ENSDART00000004664
translocation associated membrane protein 1
chr11_+_6431133 2.35 ENSDART00000190742

chr16_+_53603945 2.27 ENSDART00000083513
SAC1 like phosphatidylinositide phosphatase b
chr20_-_40758410 2.25 ENSDART00000183031
connexin 34.5
chr19_+_18903533 2.23 ENSDART00000157523
ENSDART00000166562
solute carrier family 39 (zinc transporter), member 7
chr20_-_438646 2.19 ENSDART00000009196
UFM1-specific ligase 1
chr8_+_47219107 2.18 ENSDART00000146018
ENSDART00000075068
methylenetetrahydrofolate reductase (NAD(P)H)
chr17_+_24446353 2.15 ENSDART00000140467
UDP-glucose pyrophosphorylase 2b
chr19_+_26640096 2.12 ENSDART00000067793
integrator complex subunit 3
chr17_+_24445818 2.11 ENSDART00000139963
UDP-glucose pyrophosphorylase 2b
chr14_+_9581896 2.11 ENSDART00000114563
transmembrane protein 129, E3 ubiquitin protein ligase
chr11_+_30647545 2.10 ENSDART00000114792
expressed sequence EH507706
chr25_+_34862225 2.10 ENSDART00000149782
zgc:194879
chr17_+_24446533 1.98 ENSDART00000131417
UDP-glucose pyrophosphorylase 2b
chr11_+_45287541 1.98 ENSDART00000165321
ENSDART00000173116
pyrroline-5-carboxylate reductase 1b
chr1_-_23308225 1.97 ENSDART00000137567
ENSDART00000008201
small integral membrane protein 14
chr17_+_24446705 1.93 ENSDART00000163221
UDP-glucose pyrophosphorylase 2b
chr22_-_11078988 1.91 ENSDART00000126664
ENSDART00000006927
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr6_-_42388608 1.86 ENSDART00000049425
Sec61 translocon alpha 1 subunit, like
chr1_-_9485939 1.83 ENSDART00000157814
mical-like 2b
chr25_+_3759553 1.83 ENSDART00000180601
ENSDART00000055845
ENSDART00000157050
ENSDART00000153905
THO complex 5
chr22_-_817479 1.82 ENSDART00000123487
zgc:153675
chr1_-_9486214 1.82 ENSDART00000137821
mical-like 2b
chr4_-_19693978 1.78 ENSDART00000100974
ENSDART00000040405
staphylococcal nuclease and tudor domain containing 1
chr5_+_69278089 1.76 ENSDART00000136656
selenoprotein M
chr23_-_18572685 1.66 ENSDART00000047175
signal sequence receptor, delta
chr6_+_13806466 1.65 ENSDART00000043522
transmembrane protein 198b
chr12_+_30788912 1.64 ENSDART00000160422
aldehyde dehydrogenase 18 family, member A1
chr25_-_3759322 1.63 ENSDART00000088077
zgc:158398
chr6_-_40071899 1.62 ENSDART00000034730
Sec61 translocon alpha 1 subunit
chr23_-_18572521 1.60 ENSDART00000138599
signal sequence receptor, delta
chr12_+_30789611 1.53 ENSDART00000181501
aldehyde dehydrogenase 18 family, member A1
chr25_-_4713461 1.51 ENSDART00000155302
dopamine receptor D4a
chr24_-_42090635 1.48 ENSDART00000166413
signal sequence receptor, alpha
chr2_+_37176814 1.48 ENSDART00000048277
ENSDART00000176827
coatomer protein complex, subunit alpha
chr5_-_40210447 1.47 ENSDART00000131323
si:dkey-193c22.1
chr3_+_34180835 1.47 ENSDART00000055252
translocase of inner mitochondrial membrane 29
chr25_+_5983430 1.45 ENSDART00000074814
peptidylprolyl isomerase B (cyclophilin B)
chr16_+_35918463 1.43 ENSDART00000160608
SH3 domain containing 21
chr3_+_33300522 1.41 ENSDART00000114023
heat shock protein, alpha-crystallin-related, 9
chr21_-_2958422 1.40 ENSDART00000174091
zgc:194215
chr18_-_34170918 1.33 ENSDART00000015079
solute carrier family 33 (acetyl-CoA transporter), member 1
chr4_-_13613148 1.33 ENSDART00000067164
ENSDART00000111247
interferon regulatory factor 5
chr15_-_18115540 1.32 ENSDART00000131639
ENSDART00000047902
archain 1b
chr4_-_5912951 1.30 ENSDART00000169439
ADP-ribosylation factor-like 1
chr11_+_7276983 1.29 ENSDART00000172407
ENSDART00000161176
ENSDART00000161041
ENSDART00000165536
si:ch73-238c9.1
chr2_-_1227221 1.29 ENSDART00000130897
ATP binding cassette subfamily F member 3
chr17_-_15029639 1.25 ENSDART00000142941
endoplasmic reticulum oxidoreductase alpha
chr11_+_7276824 1.24 ENSDART00000185992
si:ch73-238c9.1
chr10_+_16165533 1.23 ENSDART00000065045
proline-rich coiled-coil 1
chr15_-_16070731 1.23 ENSDART00000122099
dynein, light chain, LC8-type 2a
chr9_+_25840720 1.22 ENSDART00000024572
glycosyltransferase-like domain containing 1
chr1_-_53277187 1.22 ENSDART00000131520
zinc finger protein 330
chr8_-_24970790 1.22 ENSDART00000141267
si:ch211-199o1.2
chr22_+_1517318 1.21 ENSDART00000160406
si:ch211-255f4.5
chr8_+_11471350 1.20 ENSDART00000092355
ENSDART00000136184
tight junction protein 2b (zona occludens 2)
chr20_+_22799857 1.15 ENSDART00000058527
sec1 family domain containing 2
chr7_+_32693890 1.15 ENSDART00000121972
solute carrier family 39 (zinc transporter), member 13
chr10_-_26225548 1.14 ENSDART00000132019
ENSDART00000079194
ADP-ribosylation factor interacting protein 2b
chr12_+_31783066 1.14 ENSDART00000105584
leucine rich repeat containing 59
chr5_+_69868911 1.10 ENSDART00000014649
ENSDART00000188215
ENSDART00000167385
UDP glucuronosyltransferase 2 family, polypeptide A5
chr19_+_7549854 1.10 ENSDART00000138866
ENSDART00000151758
pre-B-cell leukemia homeobox interacting protein 1a
chr13_-_51247529 1.09 ENSDART00000191774
ENSDART00000083788

chr3_+_27770110 1.09 ENSDART00000017962
enoyl-CoA delta isomerase 1
chr14_+_20351 1.08 ENSDART00000051893
syntaxin 18
chr5_-_63644938 1.07 ENSDART00000050865
surfeit gene 4, like
chr19_-_11238620 1.07 ENSDART00000148697
ENSDART00000149169
signal sequence receptor, beta
chr5_+_20453874 1.06 ENSDART00000124545
ENSDART00000008402
squamous cell carcinoma antigen recognized by T cells 3
chr20_+_22799641 1.05 ENSDART00000131132
sec1 family domain containing 2
chr9_-_53899106 1.05 ENSDART00000171986
component of oligomeric golgi complex 3
chr4_+_77957611 1.04 ENSDART00000156692
ADP-ribosylation factor GTPase activating protein 3
chr23_-_24226533 1.04 ENSDART00000109134
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr1_-_53277413 1.03 ENSDART00000150579
zinc finger protein 330
chr18_-_34171280 1.03 ENSDART00000122321
solute carrier family 33 (acetyl-CoA transporter), member 1
chr6_-_23931442 1.03 ENSDART00000160547
SEC16 homolog B, endoplasmic reticulum export factor
chr17_+_22577472 1.01 ENSDART00000045099
Yip1 domain family, member 4
chr18_-_21746421 1.00 ENSDART00000188809
protein serine kinase H1
chr21_-_44003457 0.99 ENSDART00000190647
arylsulfatase family, member Ib
chr21_+_43882274 0.97 ENSDART00000075672
steroid receptor RNA activator 1
chr3_-_25377163 0.96 ENSDART00000055490
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr2_-_7757273 0.96 ENSDART00000136074
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5b
chr5_-_30516646 0.95 ENSDART00000014666
archain 1a
chr1_-_156375 0.95 ENSDART00000160221
PCI domain containing 2
chr18_-_7481036 0.93 ENSDART00000101292
si:dkey-238c7.16
chr14_+_8594367 0.92 ENSDART00000037749
syntaxin 5A
chr15_-_29326254 0.91 ENSDART00000114492
si:dkey-52l18.4
chr13_-_44808783 0.90 ENSDART00000099984
glyoxalase 1
chr16_+_813780 0.89 ENSDART00000162474
ENSDART00000161774
iroquois homeobox 1a
chr10_-_7472323 0.88 ENSDART00000163702
ENSDART00000167054
ENSDART00000167706
neuregulin 1
chr25_-_1687481 0.88 ENSDART00000163553
ENSDART00000179460
MON2 homolog, regulator of endosome-to-Golgi trafficking
chr17_-_24866727 0.88 ENSDART00000027957
3-hydroxymethyl-3-methylglutaryl-CoA lyase
chr12_-_16452200 0.87 ENSDART00000037601
ribonuclease P/MRP 30 subunit
chr3_-_34586403 0.86 ENSDART00000151515
septin 9a
chr18_+_6706140 0.85 ENSDART00000111343
lipase maturation factor 2a
chr5_+_65087226 0.85 ENSDART00000183187
peptidyl-tRNA hydrolase 1 homolog
chr17_+_15213496 0.84 ENSDART00000058351
ENSDART00000131663
glucosamine-phosphate N-acetyltransferase 1
chr18_-_18587745 0.82 ENSDART00000191973
splicing factor 3b, subunit 3
chr1_-_53277660 0.80 ENSDART00000014232
zinc finger protein 330
chr22_+_31059919 0.79 ENSDART00000077063
SEC13 homolog, nuclear pore and COPII coat complex component
chr6_+_23026714 0.79 ENSDART00000124948
signal recognition particle 68
chr9_+_54695981 0.78 ENSDART00000183605
RAB9A, member RAS oncogene family
chr17_-_24866964 0.77 ENSDART00000190601
ENSDART00000192547
3-hydroxymethyl-3-methylglutaryl-CoA lyase
chr17_+_6765621 0.77 ENSDART00000156637
ENSDART00000007622
AFG1 like ATPase a
chr6_+_3864040 0.76 ENSDART00000013743
golgi reassembly stacking protein 2
chr8_-_14554785 0.76 ENSDART00000057645
quiescin Q6 sulfhydryl oxidase 1
chr7_+_31339129 0.75 ENSDART00000173477
ENSDART00000114148
cancer susceptibility candidate 4
chr6_+_49723289 0.75 ENSDART00000190452
syntaxin 16
chr9_+_19623363 0.73 ENSDART00000142471
ENSDART00000147662
ENSDART00000136053
pyridoxal (pyridoxine, vitamin B6) kinase a
chr4_-_5913338 0.73 ENSDART00000183590
ADP-ribosylation factor-like 1
chr6_-_32087108 0.72 ENSDART00000150934
ENSDART00000130627
asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
chr10_-_22150419 0.72 ENSDART00000006173
claudin 7b
chr22_+_24214665 0.71 ENSDART00000163980
ENSDART00000167996
glutaredoxin 2
chr1_+_29798140 0.70 ENSDART00000019743
transmembrane 9 superfamily member 2
chr7_-_69352424 0.69 ENSDART00000170714
adaptor-related protein complex 1, gamma 1 subunit
chr5_+_65086668 0.69 ENSDART00000183746
peptidyl-tRNA hydrolase 1 homolog
chr16_-_54978981 0.67 ENSDART00000154023
WD and tetratricopeptide repeats 1
chr2_-_30912307 0.67 ENSDART00000188653
myosin, light chain 12, genome duplicate 2
chr10_-_3427589 0.67 ENSDART00000133452
ENSDART00000037183
transmembrane p24 trafficking protein 2
chr6_-_35052145 0.65 ENSDART00000073970
ENSDART00000185790
UDP-N-acetylglucosamine pyrophosphorylase 1
chr5_+_24543862 0.63 ENSDART00000029699
ATPase H+ transporting V0 subunit a2b
chr17_+_53156530 0.63 ENSDART00000126277
ENSDART00000156774
diphthamine biosynthesis 6
chr23_+_10396842 0.62 ENSDART00000167593
ENSDART00000125103
eukaryotic translation initiation factor 4Ba
chr17_+_23730089 0.62 ENSDART00000034913
zgc:91976
chr15_+_35933094 0.62 ENSDART00000019976
rhomboid domain containing 1
chr5_-_56964547 0.62 ENSDART00000074400
TIA1 cytotoxic granule-associated RNA binding protein
chr5_+_65086856 0.61 ENSDART00000169209
ENSDART00000162409
peptidyl-tRNA hydrolase 1 homolog
chr13_+_36595618 0.60 ENSDART00000022684
cornichon family AMPA receptor auxiliary protein 1
chr6_+_49722970 0.60 ENSDART00000155934
ENSDART00000154738
syntaxin 16
chr16_+_4078240 0.59 ENSDART00000160890
inositol polyphosphate-5-phosphatase B
chr14_-_26411918 0.58 ENSDART00000020582
transmembrane p24 trafficking protein 9
chr17_+_19630272 0.57 ENSDART00000104895
regulator of G protein signaling 7a
chr9_+_23825440 0.56 ENSDART00000138470
integrator complex subunit 6
chr22_+_31295791 0.56 ENSDART00000092447
glutamate receptor interacting protein 2b
chr5_+_22791686 0.56 ENSDART00000014806
neuronal PAS domain protein 2
chr14_+_31566517 0.55 ENSDART00000002684
integrator complex subunit 6 like
chr12_+_19362547 0.54 ENSDART00000180148
G1 to S phase transition 1
chr3_+_53773256 0.54 ENSDART00000170461
collagen, type V, alpha 3a
chr2_+_36608387 0.54 ENSDART00000159541
p21 protein (Cdc42/Rac)-activated kinase 2a
chr12_+_19362335 0.53 ENSDART00000041711
G1 to S phase transition 1
chr3_-_34180364 0.53 ENSDART00000151819
ENSDART00000003133
Yip1 domain family, member 2
chr22_+_24215007 0.52 ENSDART00000162227
glutaredoxin 2
chr20_-_1120056 0.52 ENSDART00000040680
RNA guanylyltransferase and 5'-phosphatase
chr8_+_5024468 0.51 ENSDART00000030938
adrenoceptor alpha 1Aa
chr1_-_45049603 0.51 ENSDART00000023336
ribosomal protein S6
chr25_-_23583101 0.51 ENSDART00000149107
ENSDART00000103704
ENSDART00000184903
nucleosome assembly protein 1-like 4a
chr21_+_17016337 0.51 ENSDART00000065755
GPN-loop GTPase 3
chr2_-_44971551 0.50 ENSDART00000018818
mitochondrial E3 ubiquitin protein ligase 1a
chr6_+_6779114 0.49 ENSDART00000163493
ENSDART00000143359
Sec23 homolog B, COPII coat complex component
chr3_-_33494163 0.49 ENSDART00000020342
small G protein signaling modulator 3
chr20_-_1191910 0.47 ENSDART00000043218
ubiquitin-conjugating enzyme E2, J1
chr20_+_4392687 0.47 ENSDART00000187271
im:7142702
chr3_+_29510818 0.47 ENSDART00000055407
ENSDART00000193743
ENSDART00000123619
Rac family small GTPase 2
chr1_-_19215336 0.46 ENSDART00000162949
ENSDART00000170680
protein tyrosine phosphatase, receptor type, D, b
chr19_-_3482138 0.46 ENSDART00000168139
human immunodeficiency virus type I enhancer binding protein 1
chr3_+_3610140 0.45 ENSDART00000104977
protein interacting with prkca 1
chr3_-_37588855 0.44 ENSDART00000149258
ADP-ribosylation factor 2a
chr24_+_42074143 0.42 ENSDART00000170514
DNA topoisomerase I mitochondrial
chr9_-_2594410 0.41 ENSDART00000188306
ENSDART00000164276
sp9 transcription factor
chr16_-_42750295 0.40 ENSDART00000176570
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr5_-_56943064 0.40 ENSDART00000146991
si:ch211-127d4.3
chr11_-_26832685 0.40 ENSDART00000153519
IQ motif and Sec7 domain 1b
chr15_-_14193659 0.40 ENSDART00000171197
polynucleotide kinase 3'-phosphatase
chr3_-_18384501 0.39 ENSDART00000027630
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2a
chr20_+_49787584 0.39 ENSDART00000193458
ENSDART00000181511
ENSDART00000185850
ENSDART00000185613
ENSDART00000191671

chr9_-_27748868 0.39 ENSDART00000190306
TBCC domain containing 1
chr6_-_35052388 0.38 ENSDART00000181000
ENSDART00000170116
UDP-N-acetylglucosamine pyrophosphorylase 1
chr6_+_59854224 0.38 ENSDART00000083499
lysine (K)-specific demethylase 6A, like
chr17_+_19630068 0.38 ENSDART00000182619
regulator of G protein signaling 7a
chr19_-_5103313 0.38 ENSDART00000037007
triosephosphate isomerase 1a
chr23_-_18057851 0.36 ENSDART00000173075
ENSDART00000173230
ENSDART00000173135
ENSDART00000173431
ENSDART00000173068
ENSDART00000172987
zgc:92287
chr20_+_29565906 0.36 ENSDART00000062383
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a
chr1_+_10018466 0.36 ENSDART00000113551
tripartite motif containing 2b
chr10_+_11265387 0.34 ENSDART00000038888
hydroxysteroid dehydrogenase like 2
chr9_-_56399699 0.33 ENSDART00000170281
RAB3 GTPase activating protein subunit 1
chr23_+_43638982 0.33 ENSDART00000168646
solute carrier family 10, member 7
chr23_-_18057553 0.33 ENSDART00000173102
ENSDART00000058742
zgc:92287
chr11_+_2699951 0.32 ENSDART00000082512
transmembrane protein 167B
chr12_+_1592146 0.31 ENSDART00000184575
ENSDART00000192902
solute carrier family 39 member 11
chr9_-_28867562 0.30 ENSDART00000189597
ENSDART00000060321
zgc:91818
chr25_-_18249751 0.30 ENSDART00000153950
si:dkey-106n21.1
chr12_-_2869565 0.29 ENSDART00000152772
zinc finger, DHHC-type containing 16b
chr25_+_35062353 0.27 ENSDART00000089844
zgc:113983
chr4_-_54100377 0.26 ENSDART00000188064
si:dkey-199m13.7
chr22_+_2844865 0.26 ENSDART00000139123
si:dkey-20i20.4
chr2_-_9527129 0.26 ENSDART00000157422
ENSDART00000004398
coatomer protein complex, subunit epsilon
chr2_-_56655769 0.25 ENSDART00000113589
glutathione peroxidase 4b
chr19_-_46219035 0.25 ENSDART00000170601
si:ch1073-228h2.2
chr15_-_10341048 0.25 ENSDART00000171013
teneurin transmembrane protein 4
chr9_-_23118350 0.24 ENSDART00000020884
LY6/PLAUR domain containing 6
chr16_-_36196700 0.24 ENSDART00000172324
calpain 7
chr7_-_71837213 0.24 ENSDART00000168645
ENSDART00000160512
calcium channel, voltage-dependent, beta 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of xbp1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 8.2 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.9 6.4 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.9 8.0 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.7 2.7 GO:0051645 Golgi localization(GO:0051645)
0.6 4.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.5 1.6 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.5 2.0 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.4 2.2 GO:1903573 IRE1-mediated unfolded protein response(GO:0036498) negative regulation of response to endoplasmic reticulum stress(GO:1903573) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.4 1.7 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.4 2.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.4 1.1 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.3 0.9 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.3 0.9 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.3 1.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.3 13.2 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.3 0.8 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.2 0.7 GO:0042823 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.2 1.1 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 1.0 GO:0070863 regulation of protein exit from endoplasmic reticulum(GO:0070861) positive regulation of protein exit from endoplasmic reticulum(GO:0070863) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 1.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 1.9 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.2 3.4 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.2 0.7 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.2 1.1 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 0.5 GO:2000389 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.1 2.2 GO:0009086 methionine biosynthetic process(GO:0009086) tetrahydrofolate interconversion(GO:0035999)
0.1 0.6 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 1.9 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 4.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.7 GO:0060876 semicircular canal formation(GO:0060876)
0.1 0.5 GO:0002090 regulation of receptor internalization(GO:0002090)
0.1 2.1 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.1 1.5 GO:0051481 spinal cord motor neuron cell fate specification(GO:0021520) negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.6 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.5 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.6 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.1 1.1 GO:1903729 regulation of plasma membrane organization(GO:1903729)
0.1 0.4 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.1 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.6 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 2.4 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.1 0.5 GO:0003321 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.1 0.2 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 0.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 3.6 GO:0036269 swimming behavior(GO:0036269)
0.1 1.2 GO:0060974 cell migration involved in heart formation(GO:0060974)
0.1 1.8 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.1 1.1 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 2.5 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0032289 central nervous system myelin formation(GO:0032289)
0.0 1.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.0 1.2 GO:0001757 somite specification(GO:0001757)
0.0 0.6 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.6 GO:0099638 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 2.3 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.1 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.2 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.0 0.1 GO:1901993 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.0 0.7 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 2.1 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.9 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 1.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 2.5 GO:0007030 Golgi organization(GO:0007030)
0.0 0.8 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.4 GO:0070972 protein localization to endoplasmic reticulum(GO:0070972)
0.0 1.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.1 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.0 1.2 GO:0051057 positive regulation of Ras protein signal transduction(GO:0046579) positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.0 0.9 GO:0048278 vesicle docking(GO:0048278)
0.0 0.9 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.0 0.2 GO:0072584 negative regulation of receptor-mediated endocytosis(GO:0048261) caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.5 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0099558 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.0 1.3 GO:0051607 defense response to virus(GO:0051607)
0.0 0.7 GO:0009648 photoperiodism(GO:0009648)
0.0 1.8 GO:0031047 gene silencing by RNA(GO:0031047)
0.0 1.4 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 0.1 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.0 0.5 GO:0051646 mitochondrion localization(GO:0051646)
0.0 0.1 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.2 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.4 GO:0005784 Sec61 translocon complex(GO:0005784)
0.8 2.5 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.6 8.4 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.5 1.5 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.4 2.1 GO:0070876 SOSS complex(GO:0070876)
0.3 1.8 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 1.8 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.2 0.9 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.2 1.1 GO:0018444 translation release factor complex(GO:0018444)
0.2 0.9 GO:0070390 transcription export complex 2(GO:0070390)
0.2 1.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 10.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.5 GO:0098842 postsynaptic early endosome(GO:0098842)
0.1 0.8 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.6 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.1 0.7 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.8 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.1 1.0 GO:0017119 Golgi transport complex(GO:0017119)
0.1 2.4 GO:0035861 site of double-strand break(GO:0035861)
0.1 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.1 GO:0015030 Cajal body(GO:0015030)
0.1 0.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 1.1 GO:0032039 integrator complex(GO:0032039)
0.0 4.4 GO:0031201 SNARE complex(GO:0031201)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.2 GO:0043186 P granule(GO:0043186)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 2.2 GO:0030141 secretory granule(GO:0030141)
0.0 0.9 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 8.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.2 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 8.2 GO:0051748 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
1.5 4.4 GO:0046923 ER retention sequence binding(GO:0046923)
1.0 4.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.8 2.3 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.7 2.2 GO:0071568 UFM1 transferase activity(GO:0071568)
0.6 8.4 GO:0005537 mannose binding(GO:0005537)
0.6 3.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.4 1.7 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.4 2.4 GO:0051185 coenzyme transporter activity(GO:0051185)
0.3 1.0 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.3 2.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.3 0.8 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.2 1.2 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.2 3.5 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.2 1.0 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.2 0.9 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.2 0.8 GO:0030620 U2 snRNA binding(GO:0030620)
0.2 0.8 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.2 1.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.6 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1 1.1 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.1 3.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.2 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.5 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 1.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.4 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.6 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 2.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 1.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.6 GO:0033592 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.1 2.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.9 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 5.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.5 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 1.0 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.1 0.6 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 0.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 1.0 GO:0019894 kinesin binding(GO:0019894)
0.0 0.7 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.6 GO:0051117 ATPase binding(GO:0051117)
0.0 0.2 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 2.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 1.0 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.7 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.4 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.8 GO:0048029 monosaccharide binding(GO:0048029)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0048038 quinone binding(GO:0048038)
0.0 0.2 GO:2001069 glycogen binding(GO:2001069)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.4 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.2 2.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 0.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 1.5 PID ARF 3PATHWAY Arf1 pathway
0.0 0.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 1.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 1.7 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.2 2.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 7.9 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.2 2.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.1 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 4.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 13.9 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 2.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 0.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.1 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 0.7 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.5 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.0 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.6 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins