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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for vsx1_shox_shox2_uncx4.1_lhx2a

Z-value: 1.15

Motif logo

Transcription factors associated with vsx1_shox_shox2_uncx4.1_lhx2a

Gene Symbol Gene ID Gene Info
ENSDARG00000056292 visual system homeobox 1 homolog, chx10-like
ENSDARG00000109766 visual system homeobox 1 homolog, chx10-like
ENSDARG00000025891 short stature homeobox
ENSDARG00000075713 short stature homeobox 2
ENSDARG00000037760 Unc4.1 homeobox (C. elegans)
ENSDARG00000037964 LIM homeobox 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx2adr11_v1_chr21_-_8422351_8422363-0.981.7e-12Click!
uncx4.1dr11_v1_chr1_+_9290103_92901030.872.3e-06Click!
shoxdr11_v1_chr9_+_34641237_34641237-0.865.6e-06Click!
vsx1dr11_v1_chr17_-_21066075_21066105-0.617.7e-03Click!
shox2dr11_v1_chr15_-_2188332_2188422-0.194.4e-01Click!

Activity profile of vsx1_shox_shox2_uncx4.1_lhx2a motif

Sorted Z-values of vsx1_shox_shox2_uncx4.1_lhx2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_21362071 10.19 ENSDART00000125167
avidin
chr10_-_21362320 9.54 ENSDART00000189789
avidin
chr18_-_40708537 9.27 ENSDART00000077577
si:ch211-132b12.8
chr21_+_25777425 9.20 ENSDART00000021620
claudin d
chr11_-_6452444 8.76 ENSDART00000137879
ENSDART00000134957
ENSDART00000004483
La ribonucleoprotein domain family, member 6b
chr8_+_45334255 7.14 ENSDART00000126848
ENSDART00000134161
ENSDART00000142322
ENSDART00000145011
ENSDART00000183560
poly(A) binding protein, cytoplasmic 1-like
chr16_+_29509133 7.11 ENSDART00000112116
cathepsin S, ortholog2, tandem duplicate 1
chr20_-_23426339 6.83 ENSDART00000004625
zygote arrest 1
chr9_-_35633827 6.75 ENSDART00000077745
zona pellucida glycoprotein 2, like 1
chr11_-_44801968 6.67 ENSDART00000161846
microtubule-associated protein 1 light chain 3 gamma
chr5_+_37903790 6.37 ENSDART00000162470
transmembrane protease, serine 4b
chr10_-_25217347 5.74 ENSDART00000036906
karyopherin alpha 7 (importin alpha 8)
chr10_-_34915886 5.10 ENSDART00000141201
ENSDART00000002166
cyclin A1
chr10_-_34916208 4.87 ENSDART00000187371
cyclin A1
chr10_-_34002185 4.47 ENSDART00000046599
zygote arrest 1-like
chr2_+_41526904 4.30 ENSDART00000127520
activin A receptor, type 1 like
chr2_+_6253246 4.29 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr1_-_18811517 4.28 ENSDART00000142026
si:dkey-167i21.2
chr11_-_1550709 4.27 ENSDART00000110097
si:ch73-303b9.1
chr1_-_55248496 4.17 ENSDART00000098615
nanos homolog 3
chr24_+_12835935 4.03 ENSDART00000114762
nanog homeobox
chr2_-_38284648 3.99 ENSDART00000148281
ENSDART00000132621
si:ch211-14a17.7
chr8_-_20230559 3.88 ENSDART00000193677
MLLT1, super elongation complex subunit a
chr14_+_34490445 3.86 ENSDART00000132193
ENSDART00000148044
wingless-type MMTV integration site family, member 8a
chr17_+_16046132 3.82 ENSDART00000155005
si:ch73-204p21.2
chr2_-_38287987 3.78 ENSDART00000185329
ENSDART00000061677
si:ch211-14a17.6
chr17_+_16046314 3.76 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
chr20_-_6532462 3.66 ENSDART00000054653
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like
chr11_+_18183220 3.65 ENSDART00000113468

chr8_+_11425048 3.38 ENSDART00000018739
tight junction protein 2b (zona occludens 2)
chr8_-_20230802 3.25 ENSDART00000063400
MLLT1, super elongation complex subunit a
chr7_-_48263516 3.18 ENSDART00000006619
ENSDART00000142370
ENSDART00000148273
ENSDART00000147968
RNA binding protein with multiple splicing 2b
chr16_+_39159752 3.10 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr2_-_15324837 3.02 ENSDART00000015655
trans-2,3-enoyl-CoA reductase-like 2b
chr16_-_17197546 2.85 ENSDART00000139939
ENSDART00000135146
ENSDART00000063800
ENSDART00000163606
glyceraldehyde-3-phosphate dehydrogenase
chr2_-_26596794 2.79 ENSDART00000134685
ENSDART00000056787
zgc:113691
chr4_+_9467049 2.77 ENSDART00000012659
zgc:55888
chr6_+_21001264 2.66 ENSDART00000044519
ENSDART00000151278
connexin 44.2
chr5_-_68333081 2.63 ENSDART00000168786
linker histone H1M
chr3_+_28860283 2.57 ENSDART00000077235
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr8_-_25034411 2.48 ENSDART00000135973
nuclear transcription factor Y, alpha, like
chr13_+_38817871 2.44 ENSDART00000187708
collagen, type XIX, alpha 1
chr5_+_60590796 2.43 ENSDART00000159859
transmembrane protein 132E
chr23_-_33709964 2.31 ENSDART00000143333
ENSDART00000130338
POU class 6 homeobox 1
chr21_+_34088110 2.22 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
myotubularin related protein 1b
chr1_+_35985813 2.18 ENSDART00000179634
ENSDART00000139636
ENSDART00000175902
zgc:152968
chr4_+_13586689 2.17 ENSDART00000067161
ENSDART00000138201
transportin 3
chr11_+_18873619 2.13 ENSDART00000176141
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr16_-_29387215 2.12 ENSDART00000148787
S100 calcium binding protein A1
chr14_+_35428152 2.01 ENSDART00000172597
synaptotagmin-like 4
chr6_+_40922572 1.97 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eukaryotic translation initiation factor 4E nuclear import factor 1
chr6_-_12172424 1.92 ENSDART00000109344
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a
chr20_-_45060241 1.92 ENSDART00000185227
kelch-like family member 29
chr23_+_2728095 1.89 ENSDART00000066086
zgc:114123
chr3_-_32337653 1.89 ENSDART00000156918
ENSDART00000156551
si:dkey-16p21.8
chr21_-_32060993 1.75 ENSDART00000131651
si:ch211-160j14.2
chr15_-_25099679 1.73 ENSDART00000154628
refilin B
chr12_+_22580579 1.72 ENSDART00000171725
ENSDART00000192290
capping protein (actin filament), gelsolin-like b
chr24_+_19415124 1.72 ENSDART00000186931
sulfatase 1
chr7_+_24023653 1.70 ENSDART00000141165
TERF1 (TRF1)-interacting nuclear factor 2
chr14_+_8940326 1.70 ENSDART00000159920
ribosomal protein S6 kinase a, like
chr24_-_25144441 1.70 ENSDART00000152104
pleckstrin homology-like domain, family B, member 2b
chr10_+_43039947 1.67 ENSDART00000193434
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr24_-_2450597 1.67 ENSDART00000188080
ENSDART00000093331
ras responsive element binding protein 1a
chr20_-_40758410 1.66 ENSDART00000183031
connexin 34.5
chr15_-_2519640 1.66 ENSDART00000047013
signal recognition particle receptor, B subunit
chr6_-_40922971 1.61 ENSDART00000155363
SFI1 centrin binding protein
chr13_-_25720876 1.59 ENSDART00000142404
ENSDART00000146487
si:dkey-192p21.6
chr10_-_21545091 1.58 ENSDART00000029122
ENSDART00000132207
zgc:165539
chr10_+_11261576 1.58 ENSDART00000155333
hydroxysteroid dehydrogenase like 2
chr8_+_11325310 1.57 ENSDART00000142577
frataxin
chr4_-_77125693 1.56 ENSDART00000174256

chr19_+_15441022 1.50 ENSDART00000098970
ENSDART00000140276
lin-28 homolog A (C. elegans)
chr17_-_30635298 1.50 ENSDART00000155478
SH3 and SYLF domain containing 1
chr17_-_41798856 1.46 ENSDART00000156031
ENSDART00000192801
ENSDART00000180172
ENSDART00000084745
ENSDART00000175577
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr20_+_32523576 1.45 ENSDART00000147319
Scm polycomb group protein like 4
chr20_+_29209926 1.45 ENSDART00000152949
ENSDART00000153016
katanin p80 subunit B-like 1
chr5_+_57924611 1.42 ENSDART00000050949
B-cell translocation gene 4
chr13_+_38814521 1.39 ENSDART00000110976
collagen, type XIX, alpha 1
chr3_-_26183699 1.39 ENSDART00000147517
ENSDART00000140731
si:ch211-11k18.4
chr20_+_29209767 1.38 ENSDART00000141252
katanin p80 subunit B-like 1
chr17_-_24575893 1.37 ENSDART00000141914
aftiphilin b
chr15_-_30857350 1.36 ENSDART00000138988
A kinase (PRKA) anchor protein 1b
chr20_-_37813863 1.35 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr11_+_18130300 1.33 ENSDART00000169146
zgc:175135
chr3_-_30488063 1.32 ENSDART00000055393
ENSDART00000151367
mediator complex subunit 25
chr8_-_23780334 1.30 ENSDART00000145179
ENSDART00000145894
zgc:195245
chr22_-_20924564 1.28 ENSDART00000100642
ENSDART00000032770
elongation factor RNA polymerase II
chr22_-_17653143 1.27 ENSDART00000089171
histocompatibility (minor) HA-1 b
chr19_+_15440841 1.26 ENSDART00000182329
lin-28 homolog A (C. elegans)
chr10_-_32494499 1.24 ENSDART00000129395
UV radiation resistance associated gene
chr21_+_34088377 1.24 ENSDART00000170070
myotubularin related protein 1b
chr11_+_18157260 1.22 ENSDART00000144659
zgc:173545
chr21_+_15592426 1.22 ENSDART00000138207
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr13_-_31017960 1.21 ENSDART00000145287
WDFY family member 4
chr17_+_37227936 1.21 ENSDART00000076009
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b
chr5_-_25733745 1.21 ENSDART00000051566
zgc:101016
chr23_-_17003533 1.20 ENSDART00000080545
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
chr4_-_77116266 1.19 ENSDART00000174249

chr14_-_33945692 1.18 ENSDART00000168546
ENSDART00000189778
zinc finger, DHHC-type containing 24
chr11_-_35171162 1.16 ENSDART00000017393
TRAF-interacting protein
chr4_-_77130289 1.14 ENSDART00000174380

chr1_-_40102836 1.12 ENSDART00000147317
ciliary neurotrophic factor
chr25_+_18475032 1.12 ENSDART00000073564
testis derived transcript (3 LIM domains)
chr25_-_3867990 1.10 ENSDART00000075663
calcium release activated channel regulator 2B
chr20_+_29209615 1.10 ENSDART00000062350
katanin p80 subunit B-like 1
chr5_+_25733774 1.08 ENSDART00000137088
ENSDART00000098467
abhydrolase domain containing 17B
chr20_-_28800999 1.06 ENSDART00000049462
RAB15, member RAS oncogene family
chr14_-_33481428 1.06 ENSDART00000147059
ENSDART00000140001
ENSDART00000124242
ENSDART00000164836
ENSDART00000190104
ENSDART00000186833
ENSDART00000180873
lysosomal-associated membrane protein 2
chr2_-_7246848 1.04 ENSDART00000146434
zgc:153115
chr8_-_15129573 1.04 ENSDART00000142358
BCAR3, NSP family adaptor protein
chr3_+_56366395 1.03 ENSDART00000154367
calcium channel, voltage-dependent, gamma subunit 5b
chr18_+_15644559 1.03 ENSDART00000061794
nuclear receptor subfamily 1, group H, member 4
chr19_+_21362553 1.03 ENSDART00000122002
teashirt zinc finger homeobox 1
chr3_-_26244256 1.01 ENSDART00000103741
protein phosphatase 4, catalytic subunit a
chr1_-_6028876 1.01 ENSDART00000168117
si:ch1073-345a8.1
chr8_+_18010568 1.01 ENSDART00000121984
single stranded DNA binding protein 3b
chr13_-_31008275 1.00 ENSDART00000139394
WDFY family member 4
chr2_-_38363017 0.99 ENSDART00000088026
protein arginine methyltransferase 5
chr10_-_32494304 0.99 ENSDART00000028161
UV radiation resistance associated gene
chr21_-_39177564 0.99 ENSDART00000065143
unc-119 homolog b (C. elegans)
chr15_+_17258246 0.96 ENSDART00000101707
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr8_-_32385989 0.95 ENSDART00000143716
ENSDART00000098850
lipase, endothelial
chr24_-_34680956 0.94 ENSDART00000171009
catenin (cadherin-associated protein), alpha 1
chr8_-_19467011 0.92 ENSDART00000162010
zgc:92140
chr24_-_30862168 0.92 ENSDART00000168540
polypyrimidine tract binding protein 2a
chr25_-_27621268 0.92 ENSDART00000146205
ENSDART00000073511
hyaluronoglucosaminidase 6
chr21_-_28640316 0.92 ENSDART00000128237
neuregulin 2a
chr10_-_8053753 0.91 ENSDART00000162289
si:ch211-251f6.7
chr13_+_2625150 0.91 ENSDART00000164177
phospholipid phosphatase 4
chr14_+_22113331 0.91 ENSDART00000109759
thioredoxin-related transmembrane protein 2a
chr9_-_50001606 0.91 ENSDART00000161648
ENSDART00000168514
sodium channel, voltage-gated, type I, alpha
chr17_-_11439815 0.89 ENSDART00000130105
proteasome subunit alpha 3
chr2_-_15318786 0.89 ENSDART00000135851
trans-2,3-enoyl-CoA reductase-like 2b
chr7_-_51773166 0.89 ENSDART00000054591
bone morphogenetic protein 15
chr2_-_49031303 0.89 ENSDART00000143471
cell division cycle 34 homolog (S. cerevisiae) b
chr3_-_26787430 0.88 ENSDART00000087047
RAB40c, member RAS oncogene family
chr17_-_49412313 0.88 ENSDART00000152100
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr12_-_26153101 0.87 ENSDART00000076051
opsin 4b
chr1_+_513986 0.86 ENSDART00000109083
ENSDART00000081945
thioredoxin-like 4B
chr20_-_52902693 0.86 ENSDART00000166115
ENSDART00000161050
cathepsin Bb
chr8_-_7232413 0.85 ENSDART00000092426
glutamate receptor interacting protein 2a
chr25_+_31405266 0.85 ENSDART00000103395
troponin T type 3a (skeletal, fast)
chr1_+_24387659 0.85 ENSDART00000130356
quinoid dihydropteridine reductase b2
chr15_-_26931541 0.85 ENSDART00000027563
coiled-coil domain containing 9
chr17_-_6613458 0.83 ENSDART00000175024
si:ch211-189e2.3
chr15_-_9272328 0.83 ENSDART00000172114
calmodulin 2a (phosphorylase kinase, delta)
chr8_-_25033681 0.83 ENSDART00000003493
nuclear transcription factor Y, alpha, like
chr24_+_26134209 0.82 ENSDART00000038824
teleost multiple tissue opsin b
chr20_-_9436521 0.79 ENSDART00000133000
zgc:101840
chr17_+_19630272 0.78 ENSDART00000104895
regulator of G protein signaling 7a
chr3_-_43356082 0.78 ENSDART00000171213
UNC homeobox
chr8_+_50953776 0.78 ENSDART00000013870
zgc:56596
chr15_-_18115540 0.76 ENSDART00000131639
ENSDART00000047902
archain 1b
chr11_+_31864921 0.76 ENSDART00000180252
diaphanous-related formin 3
chr13_-_36911118 0.76 ENSDART00000048739
tripartite motif containing 9
chr19_-_19871211 0.76 ENSDART00000170980
even-skipped homeobox 1
chr12_-_18577983 0.75 ENSDART00000193262
zinc finger, DHHC-type containing 4
chr15_+_12429206 0.75 ENSDART00000168997
transmembrane protease, serine 4a
chr7_+_24645186 0.75 ENSDART00000150118
ENSDART00000150233
ENSDART00000087691
glucosidase, beta (bile acid) 2
chr19_+_7549854 0.75 ENSDART00000138866
ENSDART00000151758
pre-B-cell leukemia homeobox interacting protein 1a
chr8_+_25034544 0.74 ENSDART00000123300
neugrin, neurite outgrowth associated
chr16_+_20161805 0.74 ENSDART00000192146
chromosome 16 C2orf66 homolog
chr2_+_37227011 0.74 ENSDART00000126587
ENSDART00000084958
sterile alpha motif domain containing 7
chr19_-_25119443 0.74 ENSDART00000148953
protein tyrosine phosphatase type IVA, member 3
chr18_+_50880096 0.73 ENSDART00000169782
si:ch1073-450f2.1
chr9_-_746317 0.72 ENSDART00000129632
ENSDART00000130720
ubiquitin specific peptidase 37
chr19_-_43750389 0.72 ENSDART00000147328
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr5_-_30074332 0.72 ENSDART00000147963
beta-carotene oxygenase 2a
chr10_-_13343831 0.72 ENSDART00000135941
interleukin 11 receptor, alpha
chr3_+_18807006 0.71 ENSDART00000180091
transportin 2 (importin 3, karyopherin beta 2b)
chr9_-_51436377 0.71 ENSDART00000006612
T-box, brain, 1b
chr22_+_17828267 0.71 ENSDART00000136016
hyaluronan and proteoglycan link protein 4
chr12_+_38563373 0.70 ENSDART00000134670
ENSDART00000193668
tweety family member 2
chr7_+_29167744 0.70 ENSDART00000076345
solute carrier family 38, member 8b
chr18_-_15551360 0.70 ENSDART00000159915
ENSDART00000172690
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr2_+_50608099 0.69 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr4_+_3980247 0.69 ENSDART00000049194
G protein-coupled receptor 37b
chr2_+_51783120 0.69 ENSDART00000177559
crystallin, gamma N1
chr13_-_8692860 0.68 ENSDART00000058107
multiple coagulation factor deficiency 2
chr12_+_48803098 0.67 ENSDART00000074768
peptidylprolyl isomerase Fb
chr20_+_28803977 0.67 ENSDART00000153351
ENSDART00000038149
farnesyltransferase, CAAX box, beta
chr7_+_28612671 0.66 ENSDART00000019991
solute carrier family 7, member 6 opposite strand
chr25_+_35891342 0.65 ENSDART00000147093
LSM14A mRNA processing body assembly factor a
chr9_+_50001746 0.64 ENSDART00000058892
solute carrier family 38, member 11
chr8_-_50888806 0.64 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr24_-_38110779 0.64 ENSDART00000147783
c-reactive protein, pentraxin-related
chr19_+_7152966 0.63 ENSDART00000080348
bromodomain containing 2a
chr13_+_38430466 0.63 ENSDART00000132691
adhesion G protein-coupled receptor B3
chr14_+_34492288 0.62 ENSDART00000144301
wingless-type MMTV integration site family, member 8a
chr25_-_2723682 0.62 ENSDART00000113382
ADP-dependent glucokinase
chr10_-_33297864 0.62 ENSDART00000163360
PR/SET domain 15
chr20_-_28642061 0.60 ENSDART00000135513
regulator of G protein signaling 6
chr2_-_57076687 0.60 ENSDART00000161523
solute carrier family 25, member 42
chr12_-_33817114 0.60 ENSDART00000161265
twinkle mtDNA helicase
chr16_+_25116827 0.59 ENSDART00000163244
si:ch211-261d7.6
chr22_-_20166660 0.59 ENSDART00000085913
ENSDART00000188241
BTB (POZ) domain containing 2a
chr16_-_54919260 0.58 ENSDART00000156533
keratinocyte differentiation factor 1a
chr10_+_17371356 0.58 ENSDART00000122663
signal peptide peptidase 3
chr14_+_30795559 0.58 ENSDART00000006132
cofilin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of vsx1_shox_shox2_uncx4.1_lhx2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 9.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
1.5 4.5 GO:0072111 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
1.1 4.3 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
1.0 4.2 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.8 3.1 GO:0060074 synapse maturation(GO:0060074)
0.7 12.4 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.6 3.2 GO:0051148 smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148)
0.6 1.7 GO:1900157 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.5 3.7 GO:1902292 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.5 5.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 6.6 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.3 1.7 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.2 0.7 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.2 1.0 GO:0034969 histone arginine methylation(GO:0034969)
0.2 1.2 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.2 1.9 GO:0033206 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.2 0.9 GO:0060283 negative regulation of oocyte development(GO:0060283)
0.2 1.7 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.2 1.3 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.2 0.6 GO:0030043 actin filament fragmentation(GO:0030043)
0.2 0.8 GO:0051645 Golgi localization(GO:0051645)
0.2 1.1 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.2 9.0 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.2 1.9 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.2 0.7 GO:0018343 protein farnesylation(GO:0018343)
0.2 2.0 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 3.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 2.6 GO:0016584 nucleosome positioning(GO:0016584)
0.1 4.5 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 0.9 GO:0003222 ventricular trabecula myocardium morphogenesis(GO:0003222) trabecula formation(GO:0060343) heart trabecula formation(GO:0060347) skin epidermis development(GO:0098773)
0.1 1.3 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 0.6 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.5 GO:0070285 pigment cell development(GO:0070285)
0.1 1.0 GO:2001287 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 1.7 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.1 0.6 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.1 1.0 GO:0006465 signal peptide processing(GO:0006465)
0.1 1.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 0.3 GO:0009085 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 0.7 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.5 GO:0006660 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 1.6 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 0.4 GO:0042182 ketone catabolic process(GO:0042182)
0.1 0.5 GO:0000012 single strand break repair(GO:0000012)
0.1 4.9 GO:0018198 peptidyl-cysteine modification(GO:0018198)
0.1 0.5 GO:0055071 manganese ion homeostasis(GO:0055071)
0.1 0.4 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 8.9 GO:0017148 negative regulation of translation(GO:0017148)
0.1 1.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.4 GO:0071422 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.1 0.8 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 0.8 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.1 1.7 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.7 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 0.7 GO:0016119 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 0.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 2.7 GO:0060968 regulation of gene silencing(GO:0060968)
0.1 0.3 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.1 1.7 GO:0072599 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.1 0.7 GO:0048532 anatomical structure arrangement(GO:0048532)
0.1 0.6 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 1.5 GO:0006825 copper ion transport(GO:0006825)
0.1 0.5 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.1 1.0 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.1 0.3 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.3 GO:0016246 RNA interference(GO:0016246)
0.1 1.7 GO:0051014 actin filament severing(GO:0051014)
0.1 0.7 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.1 1.0 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 0.9 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.3 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 1.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.4 GO:0033687 osteoblast proliferation(GO:0033687)
0.1 0.1 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 0.2 GO:1902260 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 0.4 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.1 4.3 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 0.9 GO:0008354 germ cell migration(GO:0008354)
0.0 0.5 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.0 2.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.4 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.0 0.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 1.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.6 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 2.7 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 1.7 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.9 GO:0033138 regulation of peptidyl-serine phosphorylation(GO:0033135) positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.2 GO:0071467 cellular response to pH(GO:0071467)
0.0 2.4 GO:0006497 protein lipidation(GO:0006497)
0.0 0.4 GO:0050909 sensory perception of taste(GO:0050909)
0.0 1.1 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.8 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.0 0.2 GO:0034505 tooth mineralization(GO:0034505)
0.0 0.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.6 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 0.7 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.5 GO:0050796 regulation of insulin secretion(GO:0050796)
0.0 0.3 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.2 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.8 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0043090 amino acid import(GO:0043090) L-amino acid import(GO:0043092)
0.0 0.1 GO:0048785 hatching gland development(GO:0048785)
0.0 1.2 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.5 GO:0060021 palate development(GO:0060021)
0.0 0.3 GO:0045471 response to ethanol(GO:0045471)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 0.1 GO:2000434 regulation of protein neddylation(GO:2000434)
0.0 1.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.5 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0043490 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:1900120 microglial cell activation(GO:0001774) regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.0 0.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0070254 mucus secretion(GO:0070254) regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.0 0.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.5 GO:0008016 regulation of heart contraction(GO:0008016)
0.0 0.4 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.2 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.5 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.0 0.1 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.3 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 0.0 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.0 0.2 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.5 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.4 GO:0071230 cellular response to amino acid stimulus(GO:0071230)
0.0 0.1 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.1 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.0 0.5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.8 GO:0030166 proteoglycan biosynthetic process(GO:0030166)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0036368 cone photoresponse recovery(GO:0036368)
0.0 1.7 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 1.2 GO:0048545 response to steroid hormone(GO:0048545)
0.0 0.0 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.2 GO:0051492 regulation of stress fiber assembly(GO:0051492)
0.0 0.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) synaptic vesicle budding(GO:0070142)
0.0 0.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 1.0 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.1 GO:0031060 regulation of histone methylation(GO:0031060)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 10.0 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
1.5 4.5 GO:0097189 apoptotic body(GO:0097189)
0.9 4.3 GO:0070724 BMP receptor complex(GO:0070724)
0.4 1.1 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.3 3.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.3 1.0 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.2 7.5 GO:0000421 autophagosome membrane(GO:0000421)
0.2 3.8 GO:0042555 MCM complex(GO:0042555)
0.2 1.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 0.7 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.2 5.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.2 GO:0035060 brahma complex(GO:0035060)
0.1 1.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.7 GO:0045180 basal cortex(GO:0045180)
0.1 0.8 GO:0071818 BAT3 complex(GO:0071818)
0.1 1.7 GO:0070187 telosome(GO:0070187)
0.1 14.1 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 0.6 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.4 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.4 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.3 GO:0044609 DBIRD complex(GO:0044609)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 1.7 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 2.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.8 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.9 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.0 1.9 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.3 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 3.1 GO:0001726 ruffle(GO:0001726)
0.0 0.2 GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e(GO:0071540)
0.0 1.8 GO:0016592 mediator complex(GO:0016592)
0.0 0.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.8 GO:0032432 actin filament bundle(GO:0032432)
0.0 2.8 GO:0005795 Golgi stack(GO:0005795)
0.0 2.8 GO:0000786 nucleosome(GO:0000786)
0.0 6.6 GO:0000323 lytic vacuole(GO:0000323)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 9.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.6 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.0 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0000974 Prp19 complex(GO:0000974)
0.0 1.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.5 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 3.5 GO:0005730 nucleolus(GO:0005730)
0.0 0.1 GO:0098888 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 19.7 GO:0009374 biotin binding(GO:0009374)
0.7 12.4 GO:0032190 acrosin binding(GO:0032190)
0.7 2.8 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.6 1.7 GO:0019777 Atg12 transferase activity(GO:0019777)
0.5 7.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 3.5 GO:0016530 metallochaperone activity(GO:0016530)
0.4 1.7 GO:0031005 filamin binding(GO:0031005)
0.4 1.2 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.4 6.4 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.4 4.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.3 3.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 1.0 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.2 0.8 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.2 0.6 GO:0080122 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.2 1.0 GO:0032052 bile acid binding(GO:0032052)
0.2 0.7 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 0.4 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.1 3.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.7 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 9.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 3.0 GO:0019894 kinesin binding(GO:0019894)
0.1 1.0 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.9 GO:0070698 type I activin receptor binding(GO:0070698)
0.1 0.9 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 2.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 2.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.3 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.1 0.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 4.3 GO:0005109 frizzled binding(GO:0005109)
0.1 1.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.4 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.1 0.5 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 2.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 6.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 0.7 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 0.3 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.1 1.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 5.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 2.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.8 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 1.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 1.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.1 0.3 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 0.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 3.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 15.7 GO:0042802 identical protein binding(GO:0042802)
0.1 1.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.7 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.6 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 4.1 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.1 0.8 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.1 0.4 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 1.0 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0030586 [methionine synthase] reductase activity(GO:0030586)
0.0 2.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.6 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 6.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.0 0.7 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.4 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 1.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 10.3 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.2 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.9 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 1.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.4 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.4 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 1.7 GO:0004527 exonuclease activity(GO:0004527)
0.0 0.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.4 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.0 GO:0030251 cyclase inhibitor activity(GO:0010852) guanylate cyclase inhibitor activity(GO:0030251)
0.0 0.4 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.3 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.1 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.1 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 2.0 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.5 NABA COLLAGENS Genes encoding collagen proteins
0.1 0.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 6.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 1.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 2.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 1.2 PID AURORA B PATHWAY Aurora B signaling
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 1.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 3.5 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.9 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 2.7 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 3.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 0.5 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.3 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.7 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.1 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.2 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.1 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.3 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 0.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.2 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.2 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 1.0 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions