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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for vox

Z-value: 0.73

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Transcription factors associated with vox

Gene Symbol Gene ID Gene Info
ENSDARG00000099761 ventral homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
voxdr11_v1_chr13_-_50624173_506241730.973.5e-11Click!

Activity profile of vox motif

Sorted Z-values of vox motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_29671586 2.63 ENSDART00000098336
sperm acrosome associated 9
chr23_+_45966436 2.30 ENSDART00000172160

chr5_+_29671681 2.27 ENSDART00000043096
adenylate kinase 8
chr7_-_40110140 2.03 ENSDART00000173469
si:ch73-174h16.5
chr5_+_66353750 1.83 ENSDART00000143410
si:ch211-261c8.5
chr20_-_14925281 1.69 ENSDART00000152641
dynamin 3a
chr1_-_17715493 1.63 ENSDART00000133027
si:dkey-256e7.8
chr20_-_47188966 1.63 ENSDART00000152965
si:dkeyp-104f11.9
chr17_+_41992054 1.61 ENSDART00000182878
ENSDART00000111537
kizuna centrosomal protein
chr6_-_7720332 1.56 ENSDART00000135945
ribosomal protein SA
chr2_+_49799470 1.51 ENSDART00000146325
si:ch211-190k17.19
chr5_+_66353589 1.51 ENSDART00000138246
si:ch211-261c8.5
chr18_+_35173683 1.50 ENSDART00000192545
cilia and flagella associated protein 45
chr20_-_14924858 1.48 ENSDART00000047039
dynamin 3a
chr7_-_45999333 1.44 ENSDART00000158603
si:ch211-260e23.8
chr25_+_19149241 1.43 ENSDART00000184982
ENSDART00000067324
milk fat globule-EGF factor 8 protein b
chr12_+_7445595 1.38 ENSDART00000103536
ENSDART00000152524
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr25_+_5035343 1.25 ENSDART00000011751
parvin, beta
chr1_+_22691256 1.24 ENSDART00000017413
zinc finger, MYND-type containing 10
chr7_-_48667056 1.22 ENSDART00000006378
cyclin-dependent kinase inhibitor 1Ca
chr6_+_15762647 1.22 ENSDART00000127133
ENSDART00000128939
IQ motif containing with AAA domain 1
chr10_+_39091353 1.19 ENSDART00000125986
si:ch73-1a9.4
chr6_+_30091811 1.11 ENSDART00000088403
melanotransferrin
chr16_+_54263921 1.10 ENSDART00000002856
dopamine receptor D2 like
chr1_+_57311901 1.07 ENSDART00000149397
mycbp associated protein
chr5_+_7989210 1.04 ENSDART00000168071
glial cell derived neurotrophic factor b
chr5_+_19343880 1.03 ENSDART00000148130
acetyl-CoA carboxylase beta
chr21_+_6751405 0.98 ENSDART00000037265
ENSDART00000146371
olfactomedin 1b
chr14_+_30762131 0.96 ENSDART00000145039
si:ch211-145o7.3
chr2_+_33747509 0.94 ENSDART00000134187
si:dkey-31m5.5
chr25_+_31868268 0.93 ENSDART00000022325
poly (ADP-ribose) polymerase family, member 16
chr21_-_17296789 0.92 ENSDART00000192180
growth factor independent 1B transcription repressor
chr15_+_15856178 0.91 ENSDART00000080338
dual specificity phosphatase 14
chr19_+_23932259 0.90 ENSDART00000139040
si:dkey-222b8.1
chr10_-_5847655 0.87 ENSDART00000192773
ankyrin repeat domain 55
chr10_+_35257651 0.85 ENSDART00000028940
serine/threonine/tyrosine interacting-like 1
chr20_-_53435483 0.84 ENSDART00000135091
methyltransferase like 24
chr21_+_6751760 0.84 ENSDART00000135914
olfactomedin 1b
chr23_+_35713557 0.77 ENSDART00000123518
tubulin, alpha 1c
chr19_+_26718074 0.76 ENSDART00000134455
zgc:100906
chr7_+_6652967 0.71 ENSDART00000102681
purine nucleoside phosphorylase 5a
chr13_+_8677166 0.69 ENSDART00000181016
ENSDART00000135028
PROP paired-like homeobox 1
chr11_+_30057762 0.69 ENSDART00000164139
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr3_-_23643751 0.64 ENSDART00000078425
ENSDART00000140264
even-skipped-like1
chr2_-_23411368 0.64 ENSDART00000159495
si:ch73-129a22.11
chr2_-_48171441 0.63 ENSDART00000123040
phosphofructokinase, platelet b
chr5_-_64883082 0.62 ENSDART00000064983
ENSDART00000139066
keratin, type 1, gene c5
chr2_-_48171112 0.62 ENSDART00000156258
phosphofructokinase, platelet b
chr23_+_20110086 0.61 ENSDART00000054664
troponin C type 1b (slow)
chr4_+_35553514 0.57 ENSDART00000182938

chr10_+_42690374 0.56 ENSDART00000123496
Rho-related BTB domain containing 2b
chr7_+_50822465 0.50 ENSDART00000011082
period circadian clock 1b
chr21_-_32097908 0.50 ENSDART00000147387
si:ch211-160j14.3
chr25_-_4148719 0.49 ENSDART00000112880
ENSDART00000023278
fatty acid desaturase 2
chr22_+_6905210 0.48 ENSDART00000167530

chr6_-_30210378 0.45 ENSDART00000157359
ENSDART00000113924
leucine rich repeat containing 7
chr4_+_5506952 0.45 ENSDART00000032857
ENSDART00000160222
mitogen-activated protein kinase 11
chr14_-_33105434 0.45 ENSDART00000163795
discs, large homolog 3 (Drosophila)
chr15_+_41027466 0.44 ENSDART00000075940
melatonin receptor type 1Ba
chr13_+_33688474 0.44 ENSDART00000161465

chr11_+_16152316 0.43 ENSDART00000081054
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr3_-_15999501 0.42 ENSDART00000160668
NME/NM23 nucleoside diphosphate kinase 3
chr8_+_17078692 0.41 ENSDART00000023206
polo-like kinase 2b (Drosophila)
chr1_-_7582859 0.40 ENSDART00000110696
myxovirus (influenza) resistance B
chr10_-_40968095 0.39 ENSDART00000184104
neuropeptide FF receptor 1 like 1
chr18_+_48423973 0.37 ENSDART00000184233
ENSDART00000147074
Fli-1 proto-oncogene, ETS transcription factor a
chr5_+_66433287 0.37 ENSDART00000170757
kinetochore associated 1
chr8_+_52637507 0.35 ENSDART00000163830
si:dkey-90l8.3
chr16_-_7443388 0.35 ENSDART00000017445
PR domain containing 1a, with ZNF domain
chr25_-_18953322 0.34 ENSDART00000155927
si:ch211-68a17.7
chr7_+_48667081 0.32 ENSDART00000083473
transient receptor potential cation channel, subfamily M, member 5
chr11_-_29737088 0.32 ENSDART00000159828
si:ch211-218g23.6
chr3_-_15444396 0.31 ENSDART00000104361
si:dkey-56d12.4
chr15_-_15357178 0.29 ENSDART00000106120
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr23_-_35082494 0.29 ENSDART00000189809

chr9_-_52962521 0.29 ENSDART00000170419

chr4_-_7212875 0.29 ENSDART00000161297
leucine rich repeat neuronal 3b
chr15_+_5360407 0.29 ENSDART00000110420
odorant receptor, family A, subfamily 112, member 1
chr6_-_35401282 0.28 ENSDART00000127612
regulator of G protein signaling 5a
chr1_-_49250490 0.28 ENSDART00000150386
si:ch73-6k14.2
chr10_+_33744098 0.27 ENSDART00000147775
relaxin/insulin-like family peptide receptor 2a
chr4_-_55459037 0.27 ENSDART00000172184
zinc finger protein 569, like
chr2_-_22363460 0.26 ENSDART00000158486
selenoprotein F
chr10_+_21867307 0.26 ENSDART00000126629
cerebellin 17
chr17_+_33311784 0.25 ENSDART00000156229
si:ch211-132f19.7
chr8_-_19246342 0.24 ENSDART00000147172
abhydrolase domain containing 17Ab
chr19_+_7735157 0.24 ENSDART00000186717
tuftelin 1b
chr6_+_28051978 0.24 ENSDART00000143218
si:ch73-194h10.2
chr22_-_17474583 0.24 ENSDART00000148027
si:ch211-197g15.8
chr22_-_36530902 0.23 ENSDART00000056188
info polymerase (RNA) II (DNA directed) polypeptide H
chr10_+_3049636 0.22 ENSDART00000081794
ENSDART00000183167
ENSDART00000191634
ENSDART00000183514
Ras protein-specific guanine nucleotide-releasing factor 2a
chr2_+_35240764 0.22 ENSDART00000015827
tenascin R (restrictin, janusin)
chr2_-_10896745 0.21 ENSDART00000114609
CUB domain containing protein 2
chr11_+_2506516 0.20 ENSDART00000130886
ENSDART00000189767
si:ch73-190f16.2
chr18_+_8346920 0.19 ENSDART00000083421
carnitine palmitoyltransferase 1B (muscle)
chr6_-_39649504 0.18 ENSDART00000179960
ENSDART00000190951
La ribonucleoprotein domain family, member 4Ab
chr15_+_3790556 0.18 ENSDART00000181467
ring finger protein 14
chr10_+_37137464 0.18 ENSDART00000114909
CUE domain containing 1a
chr3_+_34919810 0.16 ENSDART00000055264
carbonic anhydrase Xb
chr6_-_39344259 0.15 ENSDART00000104074
zgc:158846
chr22_-_17474781 0.15 ENSDART00000186817
si:ch211-197g15.8
chr21_-_37790727 0.14 ENSDART00000162907
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr5_-_51484156 0.14 ENSDART00000162064

chr4_+_35594200 0.14 ENSDART00000193902
si:dkeyp-4c4.2
chr11_+_38280454 0.13 ENSDART00000171496
si:dkey-166c18.1
chr21_+_15713097 0.12 ENSDART00000015841
glutathione S-transferase theta 1b
chr4_+_57580303 0.12 ENSDART00000166492
ENSDART00000103025
ENSDART00000170786
interleukin 17 receptor A1b
interleukin 17 receptor A2
chr4_+_14727212 0.11 ENSDART00000158094
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr24_+_38301080 0.11 ENSDART00000105672
myosin binding protein C, fast type b
chr22_+_2198246 0.11 ENSDART00000165168
ENSDART00000157485
ENSDART00000168713
zinc finger protein 1157
zinc finger protein 1166
chr16_-_25829779 0.10 ENSDART00000086301
immunity-related GTPase family, e4
chr10_+_32104305 0.10 ENSDART00000099880
wingless-type MMTV integration site family, member 11, related
chr4_+_14727018 0.10 ENSDART00000124189
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr17_-_45525936 0.10 ENSDART00000084102
HHIP-like 2
chr8_-_22274222 0.09 ENSDART00000131805
nephronophthisis 4
chr19_-_10971230 0.09 ENSDART00000166196

chr4_-_41269844 0.08 ENSDART00000186177

chr3_-_38783951 0.08 ENSDART00000155518
zinc finger protein 281a
chr2_+_54798689 0.08 ENSDART00000183426
twisted gastrulation BMP signaling modulator 1a
chr11_+_24703108 0.07 ENSDART00000159173
G protein-coupled receptor 25
chr5_-_14373662 0.07 ENSDART00000183694
tet methylcytosine dioxygenase 3
chr4_+_49322310 0.06 ENSDART00000184154
ENSDART00000167162

chr19_+_10592778 0.06 ENSDART00000135488
ENSDART00000151624
si:dkey-211g8.5
chr5_+_56268436 0.05 ENSDART00000021159
LIM homeobox 1b
chr15_-_590787 0.05 ENSDART00000189367
si:ch73-144d13.5
chr6_-_52348562 0.05 ENSDART00000142565
ENSDART00000145369
ENSDART00000016890
eukaryotic translation initiation factor 6
chr22_-_7457247 0.05 ENSDART00000106081

chr2_-_33645411 0.05 ENSDART00000114663
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr20_+_37295006 0.04 ENSDART00000153137
connexin 23
chr3_+_22334012 0.04 ENSDART00000193526
interferon phi 3
chr4_-_49119557 0.03 ENSDART00000150263
zinc finger protein 1036
chr5_+_28160503 0.03 ENSDART00000051516
tachykinin receptor 1a
chr2_+_35421285 0.03 ENSDART00000143787
tenascin R (restrictin, janusin)
chr11_-_7380674 0.03 ENSDART00000014979
ENSDART00000103418
vitellogenin 3, phosvitinless
chr12_-_7157527 0.03 ENSDART00000152274
si:dkey-187i8.2
chr15_-_2493771 0.03 ENSDART00000184906
sialidase 4
chr15_-_2497568 0.02 ENSDART00000080398
sialidase 4
chr20_+_26966725 0.01 ENSDART00000029781
AHA1, activator of heat shock protein ATPase homolog 1a
chr23_-_7674902 0.00 ENSDART00000185612
ENSDART00000180524
pleiomorphic adenoma gene-like 2

Network of associatons between targets according to the STRING database.

First level regulatory network of vox

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.3 1.0 GO:0061213 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.3 1.0 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.2 0.8 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.2 3.6 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.2 1.2 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 1.2 GO:0006735 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.1 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 1.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.3 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.6 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
0.1 1.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.4 GO:0001709 cell fate determination(GO:0001709)
0.0 2.7 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.0 1.1 GO:0006826 iron ion transport(GO:0006826)
0.0 0.5 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.9 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.7 GO:0021984 adenohypophysis development(GO:0021984)
0.0 0.3 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.9 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 1.4 GO:0007338 single fertilization(GO:0007338)
0.0 0.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.2 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.0 GO:0042256 mature ribosome assembly(GO:0042256) assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.6 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.4 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 0.1 GO:0032656 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.0 1.6 GO:0007051 spindle organization(GO:0007051)
0.0 0.6 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 0.4 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.2 GO:0009437 carnitine metabolic process(GO:0009437)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 3.6 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 1.2 GO:0034451 centriolar satellite(GO:0034451)
0.1 1.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 0.9 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.1 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0045095 keratin filament(GO:0045095)
0.0 1.2 GO:0030018 Z disc(GO:0030018)
0.0 0.5 GO:0005861 troponin complex(GO:0005861)
0.0 1.1 GO:0055037 recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0004127 cytidylate kinase activity(GO:0004127)
0.3 1.0 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.3 1.0 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 1.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 0.7 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 1.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.4 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 1.6 GO:0043236 laminin binding(GO:0043236)
0.1 0.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.9 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0060182 apelin receptor activity(GO:0060182)
0.0 0.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0005227 calcium activated cation channel activity(GO:0005227)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 1.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.4 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.5 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.2 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation