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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for twist1a+twist1b+twist3

Z-value: 0.29

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Transcription factors associated with twist1a+twist1b+twist3

Gene Symbol Gene ID Gene Info
twist3
ENSDARG00000019646 twist3
twist1a
ENSDARG00000030402 twist family bHLH transcription factor 1a
twist1b
ENSDARG00000076010 twist family bHLH transcription factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
twist1bdr11_v1_chr16_+_19732543_19732543-0.951.0e-09Click!
twist1adr11_v1_chr19_-_2231146_22311880.513.1e-02Click!
twist3dr11_v1_chr23_+_2669_2669-0.174.9e-01Click!

Activity profile of twist1a+twist1b+twist3 motif

Sorted Z-values of twist1a+twist1b+twist3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_44574059 1.20 ENSDART00000123007
si:ch73-160p18.3
si:ch73-160p18.3
chr21_-_43666420 1.07 ENSDART00000139008
ENSDART00000183996
ENSDART00000183395
si:dkey-229d11.3
si:dkey-229d11.5
si:dkey-229d11.3
si:dkey-229d11.5
chr17_+_1360192 0.54 ENSDART00000184561
siva1
SIVA1, apoptosis-inducing factor
chr5_+_6670945 0.52 ENSDART00000185686
pxna
paxillin a
chr10_+_1052591 0.43 ENSDART00000123405
unc5c
unc-5 netrin receptor C
chr5_-_30080332 0.39 ENSDART00000140049
bco2a
beta-carotene oxygenase 2a
chr21_-_35325466 0.38 ENSDART00000134780
ENSDART00000145930
ENSDART00000076715
ENSDART00000065341
ENSDART00000162189
ublcp1
ubiquitin-like domain containing CTD phosphatase 1
chr3_+_58472305 0.37 ENSDART00000154122
si:ch211-165g14.1
si:ch211-165g14.1
chr5_-_23696926 0.34 ENSDART00000021462
rnf128a
ring finger protein 128a
chr14_-_31087830 0.34 ENSDART00000002250
hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr16_-_19568795 0.32 ENSDART00000185141
abcb5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr20_-_44575103 0.31 ENSDART00000192573
ubxn2a
UBX domain protein 2A
chr6_-_10728921 0.31 ENSDART00000151484
sp3b
Sp3b transcription factor
chr18_+_45666489 0.29 ENSDART00000180147
ENSDART00000151351
prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr11_-_34232906 0.29 ENSDART00000162150
lsg1
large 60S subunit nuclear export GTPase 1
chr5_-_32505109 0.29 ENSDART00000188219
ntmt1
N-terminal Xaa-Pro-Lys N-methyltransferase 1
chr6_-_55423220 0.28 ENSDART00000158929
ctsa
cathepsin A
chr16_-_31791165 0.28 ENSDART00000148389
chd4b
chromodomain helicase DNA binding protein 4b
chr6_-_10728057 0.27 ENSDART00000002247
sp3b
Sp3b transcription factor
chr23_+_2914577 0.25 ENSDART00000184897
DHX35
zgc:158828
chr4_+_26496489 0.23 ENSDART00000160652
iqsec3a
IQ motif and Sec7 domain 3a
chr3_+_16663373 0.22 ENSDART00000100961
zgc:55558
zgc:55558
chr1_+_45925150 0.20 ENSDART00000074689
eif5b
eukaryotic translation initiation factor 5B
chr1_+_45925365 0.19 ENSDART00000144245
eif5b
eukaryotic translation initiation factor 5B
chr17_-_40876680 0.19 ENSDART00000127200
supt7l
SPT7-like STAGA complex gamma subunit
chr5_-_11809404 0.18 ENSDART00000132564
nf2a
neurofibromin 2a (merlin)
chr7_-_9674073 0.17 ENSDART00000187902
lrrk1
leucine-rich repeat kinase 1
chr18_-_35842554 0.15 ENSDART00000088488
opa3
optic atrophy 3
chr1_-_55058795 0.14 ENSDART00000187293
peli1a
pellino E3 ubiquitin protein ligase 1a
chr8_+_20140321 0.14 ENSDART00000012120
acsbg2
acyl-CoA synthetase bubblegum family member 2
chr3_+_59411956 0.14 ENSDART00000166982
sec14l1
SEC14-like lipid binding 1
chr16_-_21047483 0.12 ENSDART00000136235
cbx3b
chromobox homolog 3b
chr6_+_42693114 0.11 ENSDART00000154353
si:ch211-207d10.2
si:ch211-207d10.2
chr20_-_22193190 0.11 ENSDART00000047624
tmem165
transmembrane protein 165
chr20_+_36623807 0.10 ENSDART00000149171
ENSDART00000062895
srp9
signal recognition particle 9
chr5_-_15321451 0.10 ENSDART00000139203
txnrd2.1
thioredoxin reductase 2, tandem duplicate 1
chr13_-_9119867 0.09 ENSDART00000137255
si:dkey-112g5.15
si:dkey-112g5.15
chr3_+_49021079 0.09 ENSDART00000162012
zgc:163083
zgc:163083
chr24_+_39660124 0.08 ENSDART00000066500
stub1
STIP1 homology and U-Box containing protein 1
chr2_+_38002717 0.06 ENSDART00000139564
dcaf8
DDB1 and CUL4 associated factor 8
chr6_+_42693288 0.05 ENSDART00000155010
si:ch211-207d10.2
si:ch211-207d10.2
chr22_-_26251563 0.05 ENSDART00000060888
ENSDART00000142821
ccdc130
coiled-coil domain containing 130
chr12_-_44180132 0.05 ENSDART00000165998
si:ch73-329n5.1
si:ch73-329n5.1
chr15_-_46736432 0.04 ENSDART00000124567
ilkap
integrin-linked kinase-associated serine/threonine phosphatase
chr11_-_40101246 0.04 ENSDART00000161083
tnfrsf9b
tumor necrosis factor receptor superfamily, member 9b
chr15_-_766015 0.04 ENSDART00000190648
si:dkey-7i4.15
si:dkey-7i4.15
chr18_-_21859019 0.03 ENSDART00000100885
nrn1la
neuritin 1-like a
chr7_+_17485782 0.03 ENSDART00000098083
CU179759.1
Danio rerio novel immune-type receptor 1d (nitr1d), mRNA.
chr5_-_65159258 0.03 ENSDART00000160429
sh2d3cb
SH2 domain containing 3Cb
chr4_-_36476889 0.03 ENSDART00000163956
si:ch211-263l8.1
si:ch211-263l8.1
chr16_-_21047872 0.02 ENSDART00000131582
cbx3b
chromobox homolog 3b
chr4_-_31700186 0.01 ENSDART00000183986
ENSDART00000180890
si:dkey-16p6.1
si:dkey-16p6.1
chr4_+_33830944 0.01 ENSDART00000170238
znf1026
zinc finger protein 1026
chr8_+_247163 0.01 ENSDART00000122378
cep120
centrosomal protein 120
chr9_-_327901 0.00 ENSDART00000159956
ndufa4l2a
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2a
chr4_+_1530287 0.00 ENSDART00000067446
slc38a4
solute carrier family 38, member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of twist1a+twist1b+twist3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050787 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.1 0.3 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.0 0.4 GO:0042214 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.0 0.5 GO:0061055 myotome development(GO:0061055)
0.0 0.1 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.0 0.3 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.3 GO:0000054 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0030914 STAGA complex(GO:0030914)
0.0 0.3 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.1 0.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.4 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.4 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.5 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.1 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling