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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tp63

Z-value: 0.47

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Transcription factors associated with tp63

Gene Symbol Gene ID Gene Info
ENSDARG00000044356 tumor protein p63
ENSDARG00000113627 tumor protein p63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp63dr11_v1_chr6_+_28796773_287967730.428.1e-02Click!

Activity profile of tp63 motif

Sorted Z-values of tp63 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_21672700 1.66 ENSDART00000187043
si:dkey-40g16.5
chr12_+_45200744 1.48 ENSDART00000098932
WW domain binding protein 2
chr15_+_44053244 1.43 ENSDART00000059550
leucine rich repeat containing 51
chr2_-_32501501 1.41 ENSDART00000181309
Fas apoptotic inhibitory molecule 2a
chr6_+_3280939 0.90 ENSDART00000151359
lysine (K)-specific demethylase 4A, genome duplicate a
chr10_+_39091353 0.80 ENSDART00000125986
si:ch73-1a9.4
chr17_+_53250802 0.72 ENSDART00000143819
vasohibin 1
chr20_-_1314537 0.70 ENSDART00000144288
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr22_-_24984733 0.64 ENSDART00000142147
ENSDART00000187284
dynein, axonemal, light chain 4b
chr25_+_34641536 0.63 ENSDART00000167033

chr2_-_26563978 0.63 ENSDART00000150016
GLIS family zinc finger 1a
chr10_+_25355308 0.61 ENSDART00000100415
map3k7 C-terminal like
chr1_+_52735484 0.61 ENSDART00000182076

chr20_+_36629173 0.60 ENSDART00000161241
epoxide hydrolase 1, microsomal (xenobiotic)
chr7_-_50914526 0.57 ENSDART00000160398
ankyrin repeat domain 46b
chr23_+_44307996 0.55 ENSDART00000042430
discs, large homolog 4b (Drosophila)
chr20_-_1314355 0.53 ENSDART00000152436
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr14_-_9522364 0.51 ENSDART00000054689
atonal bHLH transcription factor 8
chr17_-_7861219 0.48 ENSDART00000148604
spectrin repeat containing, nuclear envelope 1b
chr4_-_52165969 0.45 ENSDART00000171130
si:dkeyp-44b5.4
chr14_+_24241241 0.45 ENSDART00000022377
NK2 homeobox 5
chr24_+_35564668 0.42 ENSDART00000122734
CCAAT/enhancer binding protein (C/EBP), delta
chr25_+_4787431 0.40 ENSDART00000170640
myosin VC
chr10_+_5135842 0.37 ENSDART00000132627
ENSDART00000162434
zgc:113274
chr7_+_8324506 0.36 ENSDART00000168110
si:dkey-185m8.2
chr17_-_43466317 0.36 ENSDART00000155313
heat shock protein 4 like
chr17_-_14613711 0.35 ENSDART00000157345
serine dehydratase-like
chr23_-_1056808 0.33 ENSDART00000081961
zgc:113423
chr11_-_11518469 0.32 ENSDART00000104254
keratin 15
chr17_-_22324727 0.28 ENSDART00000160341

chr8_+_2487883 0.28 ENSDART00000101841
dynein, light chain, LC8-type 1
chr9_+_41103127 0.27 ENSDART00000000250
solute carrier family 40 (iron-regulated transporter), member 1
chr25_+_4787607 0.27 ENSDART00000159422
myosin VC
chr13_-_12581388 0.26 ENSDART00000079655
glutamyl aminopeptidase
chr18_+_17611627 0.24 ENSDART00000046891
cholesteryl ester transfer protein, plasma
chr8_-_4694458 0.23 ENSDART00000019828
zgc:63587
chr6_+_54538948 0.22 ENSDART00000149270
tubby like protein 1b
chr25_+_31912153 0.22 ENSDART00000153968
amyloid beta (A4) precursor protein-binding, family A, member 2a
chr17_-_32863250 0.21 ENSDART00000167292
prospero homeobox 1a
chr7_-_60156409 0.19 ENSDART00000006802
chaperonin containing TCP1, subunit 7 (eta)
chr25_+_22107643 0.18 ENSDART00000089680
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr7_+_69653981 0.18 ENSDART00000090165
Fras1 related extracellular matrix 1a
chr25_+_17871089 0.16 ENSDART00000133725
BTB (POZ) domain containing 10a
chr15_-_29387446 0.15 ENSDART00000145976
ENSDART00000035096
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr20_-_25436389 0.14 ENSDART00000153266
intersectin 2a
chr2_+_36691771 0.14 ENSDART00000131978
pentraxin 3, long b
chr16_+_20904754 0.14 ENSDART00000006043
homeobox A11b
chr20_-_27325258 0.13 ENSDART00000152917
ankyrin repeat and SOCS box containing 2a, tandem duplicate 1
chr7_-_56606752 0.12 ENSDART00000138714
sulfotransferase family 5A, member 1
chr10_-_10607118 0.11 ENSDART00000101089
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr23_-_19827411 0.11 ENSDART00000187964
HAUS augmin-like complex, subunit 7
chr18_-_17399291 0.10 ENSDART00000192075
ENSDART00000060949
ENSDART00000188506
zinc finger protein, FOG family member 1
chr13_-_41908583 0.09 ENSDART00000136515
inositol polyphosphate multikinase a
chr15_+_14378829 0.08 ENSDART00000160145
si:ch211-11n16.2
chr5_+_38913621 0.07 ENSDART00000137112
Fraser extracellular matrix complex subunit 1
chr13_+_25422009 0.06 ENSDART00000057686
calcium homeostasis modulator 2
chr22_+_21305682 0.05 ENSDART00000023521
outer dense fiber of sperm tails 3-like 2
chr22_+_569565 0.05 ENSDART00000037069
ubiquitin specific peptidase 49
chr16_+_48682309 0.04 ENSDART00000183957
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr23_-_17470146 0.03 ENSDART00000002398
tripartite motif containing 101
chr18_-_33080454 0.03 ENSDART00000191907
vomeronasal 2 receptor, a18
chr1_+_36651059 0.03 ENSDART00000187475
endothelin receptor type Aa
chr7_+_22702225 0.02 ENSDART00000173672
si:dkey-165a24.9
chr17_+_43623598 0.02 ENSDART00000154138
zinc finger protein 365
chr13_+_25421531 0.01 ENSDART00000158093
calcium homeostasis modulator 2
chr17_+_38724473 0.01 ENSDART00000075792
G protein-coupled receptor 68
chr17_+_45607580 0.01 ENSDART00000122583
si:ch211-202f3.4
chr17_+_30450163 0.00 ENSDART00000104257
lipin 1
chr8_-_38506339 0.00 ENSDART00000054558
ENSDART00000141623
forkhead box B2
chr21_-_45613564 0.00 ENSDART00000160324

Network of associatons between targets according to the STRING database.

First level regulatory network of tp63

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.2 0.5 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.2 0.9 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.4 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.1 0.4 GO:0009097 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.1 0.2 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
0.1 0.3 GO:0010039 response to iron ion(GO:0010039)
0.0 1.5 GO:0045815 positive regulation of gene expression, epigenetic(GO:0045815)
0.0 0.1 GO:0042421 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.0 0.1 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.5 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.6 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.7 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.2 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 0.0 GO:0019884 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.6 GO:0030286 dynein complex(GO:0030286)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.2 0.6 GO:0033961 cis-stilbene-oxide hydrolase activity(GO:0033961)
0.1 0.4 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.3 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.9 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 1.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID IL6 7 PATHWAY IL6-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport