ISMARA results: tp53

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tp53

Z-value: 1.02

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Transcription factors associated with tp53

Gene Symbol	Gene ID	Gene Info
tp53 NCBI UniProt	ENSDARG00000035559	tumor protein p53
tp53 NCBI UniProt	ENSDARG00000115148	tumor protein p53

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tp53	dr11_v1_chr5_+_24087035_24087035	0.92	8.6e-08	Click!

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_22132896 Show fit	5.52	ENSDART00000138274	ccng1 NCBI UniProt Show fit	cyclin G1
chr5_+_57924611 Show fit	4.57	ENSDART00000050949	btg4 NCBI UniProt Show fit	B-cell translocation gene 4
chr25_+_36292465 Show fit	3.74	ENSDART00000152649	bmb NCBI UniProt Show fit	brambleberry
chr19_+_2835240 Show fit	2.85	ENSDART00000190838	CDCP1 NCBI UniProt Show fit	CUB domain containing protein 1
chr16_+_20496691 Show fit	2.74	ENSDART00000182737 ENSDART00000078984	cpvl NCBI UniProt Show fit	carboxypeptidase, vitellogenic-like
chr6_-_7109063 Show fit	2.56	ENSDART00000148548	nhej1 NCBI UniProt Show fit	nonhomologous end-joining factor 1
chr21_-_19919020 Show fit	2.27	ENSDART00000147396	ppp1r3b NCBI UniProt Show fit	protein phosphatase 1, regulatory subunit 3B
chr16_-_34195002 Show fit	2.26	ENSDART00000054026	rcc1 NCBI UniProt Show fit	regulator of chromosome condensation 1
chr5_+_27404946 Show fit	2.20	ENSDART00000121886 ENSDART00000005025	hdr NCBI UniProt Show fit	hematopoietic death receptor
chr5_-_1999417 Show fit	2.07	ENSDART00000155437 ENSDART00000145781	si:ch211-160e1.5 NCBI UniProt Show fit	si:ch211-160e1.5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.6	GO:0008285	negative regulation of cell proliferation(GO:0008285)
0.7	3.7	GO:0000741	karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.5	2.6	GO:0010719	photoreceptor cell morphogenesis(GO:0008594) negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.1	2.6	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.5	2.5	GO:1904036	negative regulation of epithelial cell apoptotic process(GO:1904036)
0.8	2.3	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.3	2.3	GO:1901673	regulation of mitotic spindle assembly(GO:1901673)
0.5	2.2	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.3	2.1	GO:0006083	acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.1	2.0	GO:0050892	intestinal absorption(GO:0050892)

Showing 1 to 10 of 59 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.8	GO:0031965	nuclear membrane(GO:0031965)
0.1	4.0	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	3.0	GO:0005730	nucleolus(GO:0005730)
0.5	2.6	GO:0032807	DNA ligase IV complex(GO:0032807)
0.1	2.6	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	2.5	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1	2.3	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	2.0	GO:0030027	lamellipodium(GO:0030027)
0.1	1.8	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.1	1.7	GO:0005689	U12-type spliceosomal complex(GO:0005689)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.3	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5	2.7	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.2	2.6	GO:0045159	myosin II binding(GO:0045159)
0.8	2.4	GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.2	2.3	GO:2001069	glycogen binding(GO:2001069)
0.0	2.2	GO:0004518	nuclease activity(GO:0004518)
0.3	2.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.1	1.7	GO:0008171	O-methyltransferase activity(GO:0008171)
0.5	1.6	GO:0016300	tRNA (uracil) methyltransferase activity(GO:0016300)
0.0	1.6	GO:0000146	microfilament motor activity(GO:0000146)

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.6	PID P53 REGULATION PATHWAY	p53 pathway
0.2	3.6	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1	3.4	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.1	3.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	2.6	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.1	2.1	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	1.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.8	PID FGF PATHWAY	FGF signaling pathway
0.0	0.7	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	0.7	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.3	REACTOME LATE PHASE OF HIV LIFE CYCLE	Genes involved in Late Phase of HIV Life Cycle
0.2	2.5	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.4	2.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	1.5	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.2	1.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	1.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.0	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	0.9	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.9	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1	0.5	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins

Showing 1 to 10 of 14 entries

Results for tp53

Z-value: 1.02

Motif logo

Transcription factors associated with tp53

Activity-expression correlation:

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: