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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for tgif1
Z-value: 1.24
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Transcription factors associated with tgif1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tgif1 | dr11_v1_chr24_-_9294134_9294134 | 0.76 | 2.6e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_+_39963599 Show fit | 1.69 |
ENSDART00000166539
|
FYVE and coiled-coil domain containing 1a |
|
| chr25_+_19238175 Show fit | 1.52 |
ENSDART00000110730
ENSDART00000193619 ENSDART00000154420 |
diphosphoinositol pentakisphosphate kinase 1b |
|
| chr6_-_11362871 Show fit | 1.27 |
ENSDART00000151125
|
pericentrin |
|
| chr2_+_23808640 Show fit | 1.27 |
ENSDART00000024619
|
golgi reassembly stacking protein 1a |
|
| chr13_+_47821524 Show fit | 1.13 |
ENSDART00000109978
|
zinc finger CCCH-type containing 6 |
|
| chr13_+_7575563 Show fit | 1.13 |
ENSDART00000146592
|
golgi brefeldin A resistant guanine nucleotide exchange factor 1 |
|
| chr25_+_418932 Show fit | 1.09 |
ENSDART00000059193
|
protogenin homolog b (Gallus gallus) |
|
| chr13_+_26703922 Show fit | 1.06 |
ENSDART00000020946
|
Fanconi anemia, complementation group L |
|
| chr23_-_10175898 Show fit | 1.06 |
ENSDART00000146185
|
keratin 5 |
|
| chr22_-_29640181 Show fit | 1.03 |
ENSDART00000059882
|
SHOC2 leucine-rich repeat scaffold protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of tgif1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0018231 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.1 | 2.0 | GO:0035278 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.0 | 1.8 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.3 | 1.7 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.0 | 1.7 | GO:0032012 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 1.7 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.3 | 1.6 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 1.5 | GO:0032272 | negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272) |
| 0.1 | 1.4 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 1.4 | GO:0045022 | early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 3.2 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 1.7 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 1.7 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.6 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 1.4 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 1.4 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 1.4 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.1 | 1.3 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 2.8 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 2.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.2 | 2.0 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 1.8 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 1.7 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 1.5 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 1.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.4 | 1.4 | GO:0033857 | inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.1 | 1.3 | GO:0043515 | kinetochore binding(GO:0043515) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.0 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.0 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.0 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 0.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 2.2 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 1.6 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 1.4 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 1.2 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.1 | 1.1 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 1.1 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.0 | 1.0 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 1.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 0.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |