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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for tfcp2+tfcp2l1+ubp1
Z-value: 0.82
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Transcription factors associated with tfcp2+tfcp2l1+ubp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ubp1 | dr11_v1_chr19_+_42806812_42806814 | 0.92 | 9.7e-08 | Click! |
| tfcp2 | dr11_v1_chr23_-_33679579_33679579 | 0.82 | 3.0e-05 | Click! |
| tfcp2l1 | dr11_v1_chr9_+_38292947_38292947 | -0.40 | 9.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_51743908 Show fit | 2.20 |
ENSDART00000149039
ENSDART00000148869 |
ornithine decarboxylase 1 |
|
| chr7_+_57088920 Show fit | 1.94 |
ENSDART00000024076
|
secretory carrier membrane protein 2, like |
|
| chr9_-_28939181 Show fit | 1.86 |
ENSDART00000101276
ENSDART00000135334 |
erythrocyte membrane protein band 4.1 like 5 |
|
| chr25_+_36292057 Show fit | 1.66 |
ENSDART00000152329
|
brambleberry |
|
| chr7_+_57089354 Show fit | 1.59 |
ENSDART00000140702
|
secretory carrier membrane protein 2, like |
|
| chr5_-_63065912 Show fit | 1.57 |
ENSDART00000161149
|
family with sequence similarity 57 member A |
|
| chr25_+_36292465 Show fit | 1.57 |
ENSDART00000152649
|
brambleberry |
|
| chr15_+_12429206 Show fit | 1.55 |
ENSDART00000168997
|
transmembrane protease, serine 4a |
|
| chr16_-_6424816 Show fit | 1.53 |
ENSDART00000164864
ENSDART00000141860 |
membrane bound O-acyltransferase domain containing 1 |
|
| chr25_+_7532627 Show fit | 1.51 |
ENSDART00000187660
|
phosphatidylserine synthase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tfcp2+tfcp2l1+ubp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.2 | GO:0007344 | karyogamy(GO:0000741) pronuclear fusion(GO:0007344) |
| 0.2 | 2.8 | GO:0061099 | negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.3 | 2.6 | GO:0021550 | medulla oblongata development(GO:0021550) dorsal motor nucleus of vagus nerve development(GO:0021744) |
| 0.2 | 2.2 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.0 | 2.0 | GO:0055088 | lipid homeostasis(GO:0055088) |
| 0.0 | 1.9 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
| 0.2 | 1.5 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.2 | 1.4 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.2 | 1.4 | GO:0045741 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273) |
| 0.3 | 1.2 | GO:1905067 | endodermal digestive tract morphogenesis(GO:0061031) Wnt signaling pathway involved in somitogenesis(GO:0090244) negative regulation of canonical Wnt signaling pathway involved in heart development(GO:1905067) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.2 | 3.5 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 3.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 1.2 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 1.2 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 1.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.2 | GO:0030117 | membrane coat(GO:0030117) coated membrane(GO:0048475) |
| 0.3 | 1.0 | GO:0005592 | collagen type XI trimer(GO:0005592) |
| 0.0 | 1.0 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.3 | 0.9 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210) |
| 0.2 | 2.2 | GO:0004586 | ornithine decarboxylase activity(GO:0004586) |
| 0.0 | 2.2 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 1.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 1.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 1.3 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.2 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 1.2 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.2 | 1.1 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.2 | 1.0 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 1.8 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 1.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.0 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 1.0 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.6 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 1.6 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 1.6 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.3 | 1.5 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 1.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 1.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 1.2 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 1.0 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 1.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 0.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |