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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for tfap4
Z-value: 1.98
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Transcription factors associated with tfap4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tfap4 | dr11_v1_chr3_-_12227359_12227359 | 0.84 | 1.1e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_17947217 Show fit | 8.34 |
ENSDART00000101601
|
cysteine three histidine 1 |
|
| chr15_+_38299563 Show fit | 8.13 |
ENSDART00000099375
|
si:dkey-24p1.6 |
|
| chr12_+_20693743 Show fit | 7.34 |
ENSDART00000153023
ENSDART00000153370 |
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 2 |
|
| chr6_-_8360918 Show fit | 7.00 |
ENSDART00000004716
|
acid phosphatase 5a, tartrate resistant |
|
| chr5_+_37903790 Show fit | 6.95 |
ENSDART00000162470
|
transmembrane protease, serine 4b |
|
| chr19_-_42503143 Show fit | 5.32 |
ENSDART00000007642
|
zgc:110239 |
|
| chr14_-_34605607 Show fit | 5.00 |
ENSDART00000191608
|
actin filament associated protein 1-like 1a |
|
| chr15_+_38308421 Show fit | 4.86 |
ENSDART00000129941
|
si:dkey-24p1.6 |
|
| chr2_-_17114852 Show fit | 4.83 |
ENSDART00000006549
|
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) |
|
| chr3_+_51563695 Show fit | 4.68 |
ENSDART00000008607
|
tweety homolog 2, like |
Network of associatons between targets according to the STRING database.
First level regulatory network of tfap4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.8 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.0 | 7.4 | GO:0043413 | protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413) |
| 0.6 | 7.0 | GO:0045453 | bone resorption(GO:0045453) |
| 0.1 | 6.9 | GO:0060389 | pathway-restricted SMAD protein phosphorylation(GO:0060389) |
| 0.6 | 6.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.5 | 6.6 | GO:0003139 | secondary heart field specification(GO:0003139) |
| 1.5 | 6.0 | GO:0070987 | error-free translesion synthesis(GO:0070987) |
| 0.2 | 5.9 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 1.1 | 5.5 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) |
| 0.1 | 5.5 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.8 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.1 | 18.8 | GO:0005764 | lysosome(GO:0005764) |
| 0.0 | 13.7 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 9.6 | GO:0005657 | replication fork(GO:0005657) |
| 0.6 | 8.8 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 6.6 | GO:0016459 | myosin complex(GO:0016459) |
| 0.3 | 4.3 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 4.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 4.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 4.0 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.6 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 1.8 | 8.8 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.2 | 7.3 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 7.1 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.9 | 7.0 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.1 | 7.0 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 6.9 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 6.8 | GO:0003774 | motor activity(GO:0003774) |
| 0.9 | 6.6 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 6.4 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 4.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 4.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 4.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 4.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 3.5 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 3.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 2.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.7 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.5 | 6.6 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 5.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 3.9 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.2 | 3.8 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 3.5 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 3.1 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.2 | 3.0 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.4 | 2.9 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 2.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |