ISMARA results: tfap2a+tfap2c

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tfap2a+tfap2c

Z-value: 0.85

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Transcription factors associated with tfap2a+tfap2c

Gene Symbol	Gene ID	Gene Info
tfap2c NCBI UniProt	ENSDARG00000040606	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
tfap2a NCBI UniProt	ENSDARG00000059279	transcription factor AP-2 alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tfap2c	dr11_v1_chr6_+_56141852_56141852	0.57	1.5e-02	Click!
tfap2a	dr11_v1_chr24_-_8732519_8732519	-0.12	6.4e-01	Click!

Activity profile of tfap2a+tfap2c motif

Sorted Z-values of tfap2a+tfap2c motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_54607166 Show fit	2.88	ENSDART00000021977	dnmt1 NCBI UniProt Show fit	DNA (cytosine-5-)-methyltransferase 1
chr24_-_21903588 Show fit	2.27	ENSDART00000180991	spata13 NCBI UniProt Show fit	spermatogenesis associated 13
chr24_-_21903360 Show fit	2.26	ENSDART00000091252	spata13 NCBI UniProt Show fit	spermatogenesis associated 13
chr15_+_6459847 Show fit	1.96	ENSDART00000157250 ENSDART00000065824	bace2 NCBI UniProt Show fit	beta-site APP-cleaving enzyme 2
chr5_+_25736979 Show fit	1.79	ENSDART00000175959	abhd17b NCBI UniProt Show fit	abhydrolase domain containing 17B
chr16_+_26846495 Show fit	1.76	ENSDART00000078124	trim35-29 NCBI UniProt Show fit	tripartite motif containing 35-29
chr2_+_1988036 Show fit	1.56	ENSDART00000155956	ssx2ipa NCBI UniProt Show fit	synovial sarcoma, X breakpoint 2 interacting protein a
chr3_-_26244256 Show fit	1.53	ENSDART00000103741	ppp4ca NCBI UniProt Show fit	protein phosphatase 4, catalytic subunit a
chr1_+_16548733 Show fit	1.52	ENSDART00000048855	mtus1b NCBI UniProt Show fit	microtubule associated tumor suppressor 1b
chr7_+_32693890 Show fit	1.50	ENSDART00000121972	slc39a13 NCBI UniProt Show fit	solute carrier family 39 (zinc transporter), member 13

Showing 1 to 10 of 89 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2a+tfap2c

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	2.9	GO:0032776	DNA methylation on cytosine(GO:0032776)
0.0	2.6	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	2.3	GO:0090630	activation of GTPase activity(GO:0090630)
0.3	2.0	GO:0006621	protein retention in ER lumen(GO:0006621)
0.2	2.0	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.1	1.8	GO:0002084	protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1	1.5	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.1	1.5	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.1	1.3	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0	1.3	GO:0050821	protein stabilization(GO:0050821)

Showing 1 to 10 of 32 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	GO:0031228	integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0	2.0	GO:0005802	trans-Golgi network(GO:0005802)
0.0	1.6	GO:0036064	ciliary basal body(GO:0036064)
0.1	1.3	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.1	1.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.1	1.1	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.2	0.9	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.9	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.7	GO:0031594	neuromuscular junction(GO:0031594)
0.0	0.7	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Showing 1 to 10 of 14 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.2	2.9	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	2.1	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.1	2.0	GO:0070001	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1	1.8	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1	1.5	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	1.3	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	1.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.2	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	1.2	GO:0031490	chromatin DNA binding(GO:0031490)

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.5	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	2.9	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	1.0	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.6	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	0.4	PID CERAMIDE PATHWAY	Ceramide signaling pathway

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	1.0	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	0.9	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.7	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.7	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.3	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Showing 1 to 6 of 6 entries

Results for tfap2a+tfap2c

Z-value: 0.85

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Transcription factors associated with tfap2a+tfap2c

Activity-expression correlation:

Activity profile of tfap2a+tfap2c motif

Sorted Z-values of tfap2a+tfap2c motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2a+tfap2c

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: