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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for tcf3a+tcf3b
Z-value: 0.99
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Transcription factors associated with tcf3a+tcf3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tcf3b | dr11_v1_chr22_-_20342260_20342260 | 0.39 | 1.1e-01 | Click! |
| tcf3a | dr11_v1_chr2_-_57379216_57379216 | -0.10 | 7.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_58751504 Show fit | 3.80 |
ENSDART00000024185
|
zgc:56231 |
|
| chr6_+_153146 Show fit | 3.20 |
ENSDART00000097468
|
zinc finger, GATA-like protein 1 |
|
| chr19_+_14109348 Show fit | 2.39 |
ENSDART00000159015
|
zgc:175136 |
|
| chr4_-_20177868 Show fit | 2.19 |
ENSDART00000003621
|
siaz-interacting nuclear protein |
|
| chr21_+_25777425 Show fit | 2.18 |
ENSDART00000021620
|
claudin d |
|
| chr19_-_27564458 Show fit | 2.17 |
ENSDART00000123155
|
si:dkeyp-46h3.6 |
|
| chr21_+_5192016 Show fit | 2.00 |
ENSDART00000139288
|
si:dkey-121h17.7 |
|
| chr10_-_8046764 Show fit | 1.98 |
ENSDART00000099031
|
zgc:136254 |
|
| chr19_+_7001170 Show fit | 1.97 |
ENSDART00000110366
|
zinc finger and BTB domain containing 22b |
|
| chr13_-_21672131 Show fit | 1.87 |
ENSDART00000067537
|
ELOVL family member 6, elongation of long chain fatty acids like |
Network of associatons between targets according to the STRING database.
First level regulatory network of tcf3a+tcf3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | GO:0006486 | protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413) |
| 0.0 | 3.5 | GO:0008285 | negative regulation of cell proliferation(GO:0008285) |
| 0.2 | 3.2 | GO:0060046 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.3 | 3.1 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.1 | 3.1 | GO:0048599 | oocyte development(GO:0048599) |
| 1.0 | 2.9 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.0 | 2.6 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.1 | 2.5 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.1 | 2.4 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 2.3 | GO:0032012 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 5.0 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 3.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 3.1 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 3.0 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.0 | 3.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 2.5 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 2.2 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 2.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 2.1 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.1 | 4.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.2 | 3.2 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.6 | 3.1 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.6 | 2.9 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.1 | 2.8 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 2.8 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.1 | 2.4 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.2 | 2.3 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 2.3 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 2.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 2.2 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 1.2 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.1 | 1.2 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.2 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 3.0 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.2 | 2.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 2.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 2.3 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 2.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 1.8 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 1.7 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 1.3 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |