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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tbx20

Z-value: 0.56

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Transcription factors associated with tbx20

Gene Symbol Gene ID Gene Info
ENSDARG00000005150 T-box transcription factor 20

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tbx20dr11_v1_chr16_-_42523744_42523744-0.607.9e-03Click!

Activity profile of tbx20 motif

Sorted Z-values of tbx20 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_49537646 1.27 ENSDART00000180438

chr12_+_4920451 1.15 ENSDART00000171525
ENSDART00000159986
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr13_+_34690158 1.04 ENSDART00000182978
taspase, threonine aspartase, 1
chr12_+_48340133 1.00 ENSDART00000152899
ENSDART00000153335
ENSDART00000054788
DNA-damage-inducible transcript 4
chr23_-_29668286 0.96 ENSDART00000129248
calsyntenin 1
chr11_-_26832685 0.89 ENSDART00000153519
IQ motif and Sec7 domain 1b
chr21_-_5831413 0.89 ENSDART00000150914
wu:fj64h06
chr15_-_30867594 0.87 ENSDART00000154448
neurofibromin 1a
chr2_-_57076687 0.85 ENSDART00000161523
solute carrier family 25, member 42
chr7_+_40081630 0.84 ENSDART00000173559
zgc:112356
chr9_-_32912638 0.80 ENSDART00000110582
family with sequence similarity 160, member A2
chr8_-_42677086 0.77 ENSDART00000191173
si:ch73-138n13.1
chr13_+_34689663 0.77 ENSDART00000133661
taspase, threonine aspartase, 1
chr15_-_41689684 0.74 ENSDART00000143447
splA/ryanodine receptor domain and SOCS box containing 4b
chr11_+_45233348 0.70 ENSDART00000173150
transmembrane channel-like 6b
chr21_-_12749501 0.68 ENSDART00000179724

chr14_-_33858214 0.67 ENSDART00000112268
oculocerebrorenal syndrome of Lowe
chr15_-_47479119 0.67 ENSDART00000164957
inositol polyphosphate phosphatase-like 1a
chr25_+_18475032 0.66 ENSDART00000073564
testis derived transcript (3 LIM domains)
chr20_+_42246948 0.64 ENSDART00000061135
golgi-associated PDZ and coiled-coil motif containing
chr10_+_42589707 0.61 ENSDART00000075269
fibroblast growth factor receptor 1b
chr22_-_37796998 0.58 ENSDART00000124742
ENSDART00000191232
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr17_-_11357851 0.55 ENSDART00000153915
si:ch211-185a18.2
chr4_-_18840487 0.51 ENSDART00000066978
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr13_-_48431766 0.50 ENSDART00000159688
ENSDART00000171765
F-box protein 11a
chr6_-_18751696 0.49 ENSDART00000171537
trinucleotide repeat containing 6C2
chr7_-_40082053 0.49 ENSDART00000083719
ENSDART00000173687
sharpin and rbck1 related
chr21_+_1119046 0.44 ENSDART00000184678

chr4_-_18840919 0.39 ENSDART00000015834
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr12_+_1286642 0.39 ENSDART00000157467
phosphatidylethanolamine N-methyltransferase
chr20_+_32756763 0.38 ENSDART00000023006
family with sequence similarity 84, member A
chr2_-_37797577 0.38 ENSDART00000110781
nuclear factor of activated T cells 4
chr23_-_18381361 0.37 ENSDART00000016891
hydroxysteroid (17-beta) dehydrogenase 10
chr17_+_1496107 0.36 ENSDART00000187804

chr11_+_45299447 0.29 ENSDART00000172999
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr23_-_27479558 0.29 ENSDART00000013563
activating transcription factor 7a
chr24_-_41220538 0.26 ENSDART00000150207
activin A receptor type 2Ba
chr23_+_21380079 0.26 ENSDART00000089379
intermediate filament family orphan 2a
chr12_-_43428542 0.23 ENSDART00000192266
protein tyrosine phosphatase, receptor type, E, a
chr9_+_23900703 0.23 ENSDART00000127859
tripartite motif containing 63b
chr13_-_10620652 0.21 ENSDART00000135000
ENSDART00000191587
si:ch73-54n14.2
calmodulin-lysine N-methyltransferase
chr15_+_33696559 0.21 ENSDART00000188248
ENSDART00000161951
histone deacetylase 12
chr12_+_17933775 0.20 ENSDART00000186047
ENSDART00000160586
transformation/transcription domain-associated protein
chr5_+_30759232 0.18 ENSDART00000078018
RuvB-like AAA ATPase 2
chr12_+_15290800 0.17 ENSDART00000145656
mediator complex subunit 1
chr8_-_11112058 0.17 ENSDART00000042755
adenosine monophosphate deaminase 1 (isoform M)
chr15_-_31516558 0.13 ENSDART00000156427
ENSDART00000156072
ENSDART00000156047
high mobility group box 1b
chr25_-_7686201 0.11 ENSDART00000157267
ENSDART00000155094
si:ch211-286c4.6
chr3_-_47036951 0.11 ENSDART00000186971

chr24_+_42948 0.07 ENSDART00000122785
thioredoxin related transmembrane protein 3b
chr7_+_69449814 0.07 ENSDART00000109644
CTD nuclear envelope phosphatase 1b
chr17_+_26965351 0.06 ENSDART00000114215
ENSDART00000147192
grainyhead-like transcription factor 3
chr18_+_3572314 0.06 ENSDART00000169814
ENSDART00000157819
stress-associated endoplasmic reticulum protein 1
chr25_+_36152215 0.05 ENSDART00000036147
iroquois homeobox 5b
chr3_+_25857008 0.04 ENSDART00000154899
ENSDART00000193762
zgc:171844
chr3_-_8285123 0.04 ENSDART00000158699
ENSDART00000138588
tripartite motif containing 35-9
chr4_-_50207986 0.04 ENSDART00000150388
si:ch211-197e7.3
chr2_-_31301929 0.04 ENSDART00000191992
ENSDART00000190723
adenylate cyclase activating polypeptide 1b
chr12_-_48127985 0.04 ENSDART00000193805
neuropeptide FF receptor 1
chr4_-_75812937 0.03 ENSDART00000125096
si:ch211-203c5.3
chr15_+_1765988 0.03 ENSDART00000159032
cullin 3b
chr2_+_43469241 0.03 ENSDART00000142078
ENSDART00000098265
neuropilin 1b
chr20_-_31808779 0.02 ENSDART00000133788
syntaxin binding protein 5a (tomosyn)
chr17_+_33496067 0.02 ENSDART00000184724
parathyroid hormone 2
chr22_-_35385810 0.02 ENSDART00000111824
5-hydroxytryptamine receptor 3C
chr8_+_36416285 0.01 ENSDART00000158400
si:busm1-194e12.8
chr21_-_2273244 0.01 ENSDART00000171417
si:ch73-299h12.3
chr7_+_39389273 0.01 ENSDART00000191298
troponin I type 2b (skeletal, fast), tandem duplicate 2
chr25_+_19170500 0.01 ENSDART00000182572

chr4_+_35138928 0.01 ENSDART00000167934
ENSDART00000192116
ENSDART00000183689
si:dkey-279j5.1
chr16_+_6750756 0.01 ENSDART00000149720
zinc finger protein 236
chr13_-_293250 0.01 ENSDART00000138581
chitin synthase 1
chr6_+_7555614 0.00 ENSDART00000187590
myosin, heavy chain 10, non-muscle
chr7_-_5070794 0.00 ENSDART00000097877
leukotriene B4 receptor 2a
chr16_-_563732 0.00 ENSDART00000183394
iroquois homeobox 2a
chr3_-_7940522 0.00 ENSDART00000159710
ENSDART00000167201
tripartite motif containing 35-25

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx20

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 0.6 GO:2000008 regulation of protein localization to cell surface(GO:2000008) negative regulation of protein localization to cell surface(GO:2000009)
0.2 0.7 GO:0071871 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.1 0.9 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.1 0.5 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.7 GO:0090024 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.1 0.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.4 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.3 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.5 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.9 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.4 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.2 GO:0060420 box C/D snoRNP assembly(GO:0000492) regulation of heart growth(GO:0060420)
0.0 1.0 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.9 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.6 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.5 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.1 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.0 0.9 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.1 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 1.8 GO:0051604 protein maturation(GO:0051604)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0001650 fibrillar center(GO:0001650)
0.1 0.7 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.5 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0097255 R2TP complex(GO:0097255)
0.0 0.6 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.3 0.9 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.2 1.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.7 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.0 0.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.2 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.7 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.6 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.0 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.4 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage