ISMARA results: tbp

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tbp

Z-value: 1.29

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Transcription factors associated with tbp

Gene Symbol	Gene ID	Gene Info
tbp NCBI UniProt	ENSDARG00000014994	TATA box binding protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tbp	dr11_v1_chr13_-_24396199_24396199	-0.78	1.2e-04	Click!

Activity profile of tbp motif

Sorted Z-values of tbp motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_25085327 Show fit	4.62	ENSDART00000077661	prss1 NCBI UniProt Show fit	protease, serine 1
chr6_+_269204 Show fit	3.91	ENSDART00000191678	atf4a NCBI UniProt Show fit	activating transcription factor 4a
chr10_-_44924289 Show fit	3.68	ENSDART00000171267	tuba7l NCBI UniProt Show fit	tubulin, alpha 7 like
chr13_-_15702672 Show fit	3.45	ENSDART00000144445 ENSDART00000168950	ckba NCBI UniProt Show fit	creatine kinase, brain a
chr2_-_38000276 Show fit	3.11	ENSDART00000034790	pcp4l1 NCBI UniProt Show fit	Purkinje cell protein 4 like 1
chr5_+_37978501 Show fit	3.03	ENSDART00000012050	apoa1a NCBI UniProt Show fit	apolipoprotein A-Ia
chr9_-_1703761 Show fit	2.85	ENSDART00000144822 ENSDART00000137210 ENSDART00000135273	hnrnpa3 NCBI UniProt Show fit	heterogeneous nuclear ribonucleoprotein A3
chr5_-_71722257 Show fit	2.47	ENSDART00000013404	ak1 NCBI UniProt Show fit	adenylate kinase 1
chr2_+_55365727 Show fit	2.39	ENSDART00000162943	FP245456.1 NCBI UniProt Show fit
chr5_-_27867657 Show fit	2.28	ENSDART00000112495	tcima NCBI UniProt Show fit	transcriptional and immune response regulator a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.3	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.3	4.5	GO:0046314	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.5	4.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.4	3.9	GO:0070309	lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0	3.9	GO:0002088	lens development in camera-type eye(GO:0002088)
0.6	3.0	GO:0010873	regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.1	3.0	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.2	2.7	GO:0019731	antibacterial humoral response(GO:0019731)
0.4	2.5	GO:0009180	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.8	2.4	GO:0002792	negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)

Showing 1 to 10 of 105 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.1	GO:0005615	extracellular space(GO:0005615)
0.1	4.2	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.3	3.9	GO:1990589	ATF4-CREB1 transcription factor complex(GO:1990589)
0.2	3.7	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.1	3.1	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	2.1	GO:0030667	secretory granule membrane(GO:0030667)
0.0	1.9	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	1.9	GO:0000786	nucleosome(GO:0000786)
0.5	1.8	GO:0043073	germ cell nucleus(GO:0043073)
0.5	1.5	GO:0098556	cytoplasmic side of rough endoplasmic reticulum membrane(GO:0098556)

Showing 1 to 10 of 42 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	7.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.3	4.5	GO:0016775	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1	4.1	GO:0005212	structural constituent of eye lens(GO:0005212)
0.6	3.9	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	3.9	GO:0046982	protein heterodimerization activity(GO:0046982)
0.1	3.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.6	3.0	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2	2.5	GO:0004017	adenylate kinase activity(GO:0004017)
0.1	2.3	GO:0005112	Notch binding(GO:0005112)

Showing 1 to 10 of 89 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	1.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.9	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	0.4	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.3	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	0.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events

Showing 1 to 9 of 9 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.7	4.6	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	4.2	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	3.5	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	2.5	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	1.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.6	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.2	1.4	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	1.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	1.3	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis

Showing 1 to 10 of 30 entries

Results for tbp

Z-value: 1.29

Motif logo

Transcription factors associated with tbp

Activity-expression correlation:

Activity profile of tbp motif

Sorted Z-values of tbp motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: