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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for srebf2

Z-value: 0.59

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Transcription factors associated with srebf2

Gene Symbol Gene ID Gene Info
srebf2
ENSDARG00000063438 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
srebf2dr11_v1_chr3_+_1107102_11071020.851.0e-05Click!

Activity profile of srebf2 motif

Sorted Z-values of srebf2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr24_-_3477103 1.24 ENSDART00000143723
idi1
isopentenyl-diphosphate delta isomerase 1
chr14_-_21618005 0.86 ENSDART00000043162
reep2
receptor accessory protein 2
chr6_-_34958274 0.77 ENSDART00000113097
hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
chr18_+_50961953 0.73 ENSDART00000158768
ppfia1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chr3_+_1107102 0.62 ENSDART00000092690
srebf2
sterol regulatory element binding transcription factor 2
chr16_-_29164379 0.62 ENSDART00000132589
mef2d
myocyte enhancer factor 2d
chr13_+_30572172 0.53 ENSDART00000010052
ENSDART00000144417
ppifa
peptidylprolyl isomerase Fa
chr13_+_24671481 0.52 ENSDART00000001678
adam8a
ADAM metallopeptidase domain 8a
chr12_+_33395748 0.51 ENSDART00000129458
fasn
fatty acid synthase
chr1_+_44523516 0.48 ENSDART00000147702
zdhhc5a
zinc finger, DHHC-type containing 5a
chr18_-_39188664 0.46 ENSDART00000162983
mapk6
mitogen-activated protein kinase 6
chr5_+_40837539 0.42 ENSDART00000188279
si:dkey-3h3.3
si:dkey-3h3.3
chr24_-_37326236 0.42 ENSDART00000003789
pdpk1b
3-phosphoinositide dependent protein kinase 1b
chr4_+_646154 0.41 ENSDART00000171138
xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr1_-_9940494 0.39 ENSDART00000138726
tmem8a
transmembrane protein 8A
chr7_-_71486162 0.37 ENSDART00000045253
aco1
aconitase 1, soluble
chr2_-_34138400 0.36 ENSDART00000056667
cenpl
centromere protein L
chr18_+_8231138 0.36 ENSDART00000140193
arsa
arylsulfatase A
chr20_+_39223235 0.35 ENSDART00000132132
reps1
RALBP1 associated Eps domain containing 1
chr18_-_14337450 0.35 ENSDART00000061435
hsbp1b
heat shock factor binding protein 1b
chr14_-_26482096 0.34 ENSDART00000187280
smad5
SMAD family member 5
chr6_+_10094061 0.29 ENSDART00000150998
ENSDART00000162236
atp7b
ATPase copper transporting beta
chr1_+_12178215 0.28 ENSDART00000090380
stra6l
STRA6-like
chr10_-_28380919 0.27 ENSDART00000183409
ENSDART00000183105
ENSDART00000100207
ENSDART00000185392
ENSDART00000131220
btg3
B-cell translocation gene 3
chr19_-_25113660 0.26 ENSDART00000035538
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr7_+_22616212 0.26 ENSDART00000052844
cldn7a
claudin 7a
chr6_+_102506 0.26 ENSDART00000172678
ldlrb
low density lipoprotein receptor b
chr17_+_15041647 0.24 ENSDART00000108999
samd4a
sterile alpha motif domain containing 4A
chr18_-_21271373 0.24 ENSDART00000060001
pnp6
purine nucleoside phosphorylase 6
chr23_-_29878643 0.24 ENSDART00000058407
slc25a33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr7_-_30932094 0.20 ENSDART00000057677
terb2
telomere repeat binding bouquet formation protein 2
chr3_+_19299309 0.20 ENSDART00000046297
ENSDART00000146955
ldlra
low density lipoprotein receptor a
chr9_-_4075620 0.19 ENSDART00000046903
mylka
myosin, light chain kinase a
chr5_-_37989179 0.19 ENSDART00000139771
si:ch211-139a5.1
si:ch211-139a5.1
chr4_-_20511595 0.19 ENSDART00000185806
rassf8b
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8b
chr23_-_18057270 0.18 ENSDART00000173385
zgc:92287
zgc:92287
chr25_+_3008263 0.16 ENSDART00000160484
neo1b
neogenin 1b
chr11_+_21587950 0.16 ENSDART00000162251
FAM72B
zgc:101564
chr1_+_41690402 0.16 ENSDART00000177298
fbxo41
F-box protein 41
chr3_-_51109286 0.15 ENSDART00000172010
si:ch211-148f13.1
si:ch211-148f13.1
chr10_-_31782616 0.15 ENSDART00000128839
fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr5_+_37032038 0.15 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr7_+_29024282 0.14 ENSDART00000076425
cog4
component of oligomeric golgi complex 4
chr14_-_46117345 0.14 ENSDART00000172166
NDUFC1
si:ch211-235e9.6
chr3_+_26288981 0.14 ENSDART00000163500
rhot1a
ras homolog family member T1a
chr3_-_34296361 0.14 ENSDART00000181485
ENSDART00000113726
tnrc6c1
trinucleotide repeat containing 6C1
chr24_+_9590188 0.13 ENSDART00000137092
si:dkey-96n2.1
si:dkey-96n2.1
chr13_+_4409294 0.12 ENSDART00000146437
si:ch211-130h14.4
si:ch211-130h14.4
chr11_+_14333441 0.11 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr15_+_30157602 0.10 ENSDART00000047248
ENSDART00000123937
nlk2
nemo-like kinase, type 2
chr3_-_48612078 0.10 ENSDART00000169923
ndel1b
nudE neurodevelopment protein 1-like 1b
chr22_-_13165186 0.10 ENSDART00000105762
ahr2
aryl hydrocarbon receptor 2
chr16_+_41873708 0.09 ENSDART00000084631
ENSDART00000084639
ENSDART00000058611
scn1ba
sodium channel, voltage-gated, type I, beta a
chr18_+_14342326 0.09 ENSDART00000181013
ENSDART00000138372
si:dkey-246g23.2
si:dkey-246g23.2
chr5_-_36328688 0.08 ENSDART00000011399
efnb1
ephrin-B1
chr19_-_10196370 0.08 ENSDART00000091707
dbpa
D site albumin promoter binding protein a
chr14_-_29826659 0.06 ENSDART00000138413
sorbs2b
sorbin and SH3 domain containing 2b
chr24_-_40860603 0.06 ENSDART00000188032
CU633479.7

chr21_+_28445052 0.06 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr11_-_3334248 0.05 ENSDART00000154314
ENSDART00000121861
prph
peripherin
chr23_-_27694960 0.05 ENSDART00000135129
IKZF4
si:dkey-166n8.9
chr2_+_24203229 0.05 ENSDART00000138088
map4l
microtubule associated protein 4 like
chr6_-_15757867 0.04 ENSDART00000063665
ackr3b
atypical chemokine receptor 3b
chr8_+_4745340 0.04 ENSDART00000182894
ufd1l
ubiquitin recognition factor in ER associated degradation 1
chr5_-_29534748 0.04 ENSDART00000159587
AL831768.1

chr10_-_35220285 0.04 ENSDART00000180439
ypel2a
yippee-like 2a
chr7_+_39401388 0.03 ENSDART00000144750
tnni2b.1
troponin I type 2b (skeletal, fast), tandem duplicate 1
chr14_-_30390145 0.03 ENSDART00000045423
slc7a2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr25_-_34632050 0.03 ENSDART00000170671
megf8
multiple EGF-like-domains 8
chr4_+_48769555 0.03 ENSDART00000150725
znf1020
zinc finger protein 1020
chr23_-_20258490 0.02 ENSDART00000147326
lamb2
laminin, beta 2 (laminin S)
chr1_-_30689004 0.02 ENSDART00000018827
dachc
dachshund c
chr6_-_19351495 0.02 ENSDART00000164287
grb2a
growth factor receptor-bound protein 2a
chr22_-_6959769 0.02 ENSDART00000105866
si:ch73-213k20.5
si:ch73-213k20.5
chr17_-_48915427 0.01 ENSDART00000054781
lgals8b
galectin 8b
chr16_+_25761101 0.01 ENSDART00000110619
cblc
Cbl proto-oncogene C, E3 ubiquitin protein ligase
chr11_+_14281100 0.00 ENSDART00000193664
ENSDART00000161597
si:ch211-262i1.3
si:ch211-262i1.3

Network of associatons between targets according to the STRING database.

First level regulatory network of srebf2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.2 0.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.4 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.4 GO:0010039 response to iron ion(GO:0010039)
0.1 0.2 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 0.9 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.2 GO:0090220 telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 0.6 GO:0010885 regulation of cholesterol storage(GO:0010885)
0.1 0.3 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.3 GO:0071938 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.0 0.6 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.2 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.0 0.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.3 GO:2000223 regulation of BMP signaling pathway involved in heart jogging(GO:2000223)
0.0 0.1 GO:0052575 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.0 0.5 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.1 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.1 GO:0003404 optic vesicle morphogenesis(GO:0003404)
0.0 0.0 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.0 0.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.1 0.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.4 GO:0003994 aconitate hydratase activity(GO:0003994)
0.1 0.2 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1 0.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.2 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.0 0.5 GO:0002020 protease binding(GO:0002020)
0.0 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0008184 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.0 0.2 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis