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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for spi2+spic

Z-value: 0.46

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Transcription factors associated with spi2+spic

Gene Symbol Gene ID Gene Info
ENSDARG00000012435 Spi-C transcription factor (Spi-1/PU.1 related)
ENSDARG00000087438 Spi-2 proto-oncogene

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
spi2dr11_v1_chr4_-_17803784_17803784-0.653.4e-03Click!
spicdr11_v1_chr4_-_17812131_178121310.175.0e-01Click!

Activity profile of spi2+spic motif

Sorted Z-values of spi2+spic motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_39790388 1.14 ENSDART00000149488
ubiquitin protein ligase E3 component n-recognin 1
chr25_+_7532811 0.90 ENSDART00000161593
phosphatidylserine synthase 2
chr21_+_3244146 0.64 ENSDART00000127740
CBP80/20-dependent translation initiation factor
chr20_-_49889111 0.62 ENSDART00000058858
kinesin family member 13Bb
chr4_-_20108833 0.61 ENSDART00000100867
family with sequence similarity 3, member C
chr17_-_24587686 0.59 ENSDART00000143084
aftiphilin b
chr13_-_18695289 0.58 ENSDART00000176809
sideroflexin 3
chr3_-_36440705 0.56 ENSDART00000162875
rogdi homolog (Drosophila)
chr20_+_23947004 0.56 ENSDART00000144195
caspase 8 associated protein 2
chr19_+_43669122 0.54 ENSDART00000139151
si:ch211-193k19.1
chr11_-_6868287 0.54 ENSDART00000037824
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
chr21_+_7605803 0.53 ENSDART00000121813
WD repeat domain 41
chr4_-_3353595 0.53 ENSDART00000009076
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr8_-_32385989 0.53 ENSDART00000143716
ENSDART00000098850
lipase, endothelial
chr2_+_31942390 0.52 ENSDART00000138684
ENSDART00000146758
ENSDART00000137921
OTU deubiquitinase with linear linkage specificity b
chr8_-_30424182 0.51 ENSDART00000099021
dedicator of cytokinesis 8
chr7_-_50764714 0.51 ENSDART00000110283
IQ motif containing GTPase activating protein 1
chr1_+_12394205 0.50 ENSDART00000138622
ENSDART00000136421
ENSDART00000139440
ENSDART00000184296
ENSDART00000008127
zgc:77739
chr11_-_6868474 0.50 ENSDART00000168372
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
chr6_+_27090800 0.49 ENSDART00000121558
autophagy related 4B, cysteine peptidase
chr13_-_36050303 0.49 ENSDART00000134955
ENSDART00000139087
legumain
chr16_-_17345377 0.49 ENSDART00000143056
zyxin
chr1_+_494297 0.48 ENSDART00000108579
ENSDART00000146732
basic leucine zipper nuclear factor 1
chr24_-_24271629 0.48 ENSDART00000135060
ribosomal protein S6 kinase, polypeptide 3b
chr25_+_7532627 0.48 ENSDART00000187660
phosphatidylserine synthase 2
chr21_-_30168947 0.48 ENSDART00000130820
ENSDART00000193171
heparin-binding EGF-like growth factor b
chr13_+_11829072 0.48 ENSDART00000079356
ENSDART00000170160
suppressor of fused homolog (Drosophila)
chr20_+_27087539 0.47 ENSDART00000062094
transmembrane protein 251
chr2_-_1622641 0.47 ENSDART00000082143
protein kinase, cAMP-dependent, catalytic, beta b
chr17_-_24575893 0.46 ENSDART00000141914
aftiphilin b
chr2_-_32738535 0.46 ENSDART00000135293
nuclear receptor binding protein 2a
chr19_-_10915898 0.45 ENSDART00000163179
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a
chr12_-_33354409 0.45 ENSDART00000178515
solute carrier family 16 (monocarboxylate transporter), member 3
chr16_-_41488023 0.44 ENSDART00000169312
CKLF-like MARVEL transmembrane domain containing 6
chr19_+_11432330 0.44 ENSDART00000188065
PQ loop repeat containing 1
chr18_+_39487486 0.44 ENSDART00000126978
acyl-CoA dehydrogenase long chain
chr14_-_14687004 0.43 ENSDART00000169970
germ cell nuclear acidic peptidase
chr17_+_38295847 0.43 ENSDART00000008532
MAP3K12 binding inhibitory protein 1
chr19_-_43750389 0.43 ENSDART00000147328
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr2_+_35603637 0.43 ENSDART00000147278
polo-like kinase 3 (Drosophila)
chr8_-_50888806 0.43 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr11_+_34921492 0.43 ENSDART00000128070
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a
chr10_+_5954787 0.42 ENSDART00000161887
ENSDART00000160345
ENSDART00000190046
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr22_-_11829436 0.42 ENSDART00000126784
protein tyrosine phosphatase, non-receptor type 4b
chr9_+_27720428 0.42 ENSDART00000112415
leucine carboxyl methyltransferase 2
chr13_+_7665890 0.42 ENSDART00000046792
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr5_+_39099380 0.42 ENSDART00000166657
BMP2 inducible kinase
chr3_-_34561624 0.42 ENSDART00000129313
septin 9a
chr8_-_22531817 0.42 ENSDART00000140606
cold shock domain containing E1, RNA-binding
chr14_+_12178915 0.42 ENSDART00000054626
histone deacetylase 3
chr8_-_16725959 0.41 ENSDART00000183593
DEP domain containing 1a
chr14_-_48786708 0.41 ENSDART00000169730
si:ch211-199b20.3
chr4_-_17263210 0.41 ENSDART00000147853
lymphoid-restricted membrane protein
chr5_+_39099172 0.41 ENSDART00000006079
BMP2 inducible kinase
chr16_-_54919260 0.41 ENSDART00000156533
keratinocyte differentiation factor 1a
chr6_+_33537267 0.40 ENSDART00000040334
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
chr17_+_33415319 0.40 ENSDART00000140805
ENSDART00000025501
ENSDART00000146447
synaptosomal-associated protein 23.1
chr9_-_704667 0.40 ENSDART00000147092
CASP8 and FADD-like apoptosis regulator b
chr15_-_28262632 0.40 ENSDART00000134601
ENSDART00000175022
pre-mRNA processing factor 8
chr9_+_35843732 0.40 ENSDART00000020638
regulator of calcineurin 1a
chr13_+_31716820 0.40 ENSDART00000034745
protein kinase C, eta, a
chr15_-_2519640 0.40 ENSDART00000047013
signal recognition particle receptor, B subunit
chr2_+_24762567 0.40 ENSDART00000078866
interferon, gamma-inducible protein 30
chr16_-_17586883 0.39 ENSDART00000017142
mannose-6-phosphate receptor (cation dependent)
chr19_-_43750659 0.39 ENSDART00000151309
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr7_+_32901658 0.39 ENSDART00000115420
anoctamin 9b
chr12_-_4475890 0.39 ENSDART00000092492
si:ch211-173d10.1
chr1_-_55044256 0.39 ENSDART00000165505
ENSDART00000167536
ENSDART00000170001
vacuolar protein sorting 54 homolog (S. cerevisiae)
chr2_-_37462462 0.39 ENSDART00000145896
si:dkey-57k2.7
chr5_-_1999417 0.39 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
chr8_+_47677208 0.39 ENSDART00000123254
dipeptidyl-peptidase 9
chr17_+_33415542 0.38 ENSDART00000183169
synaptosomal-associated protein 23.1
chr1_+_6225493 0.38 ENSDART00000145378
FAST kinase domains 2
chr3_+_27664864 0.38 ENSDART00000126533
ENSDART00000180848
chloride channel 7
chr14_-_16810401 0.38 ENSDART00000158396
ENSDART00000170758
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b
chr9_+_24088062 0.38 ENSDART00000126198
leucine rich repeat (in FLII) interacting protein 1a
chr9_-_21238616 0.38 ENSDART00000191840
ENSDART00000189127
COX17 cytochrome c oxidase copper chaperone
chr1_+_26105141 0.38 ENSDART00000102379
ENSDART00000127154
topoisomerase I binding, arginine/serine-rich a
chr8_+_29636431 0.38 ENSDART00000133047
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 a
chr25_+_29688671 0.38 ENSDART00000073478
bromodomain containing 1b
chr13_+_30035253 0.38 ENSDART00000181303
ENSDART00000057525
ENSDART00000136622
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr17_-_29213710 0.38 ENSDART00000076481
EH-domain containing 4
chr25_+_16880990 0.38 ENSDART00000020259
zgc:77158
chr1_-_43712120 0.38 ENSDART00000074600
si:dkey-162b23.4
chr25_-_35664817 0.37 ENSDART00000148718
leucine-rich repeat kinase 2
chr15_+_25489406 0.37 ENSDART00000162482
zgc:152863
chr7_+_24023653 0.37 ENSDART00000141165
TERF1 (TRF1)-interacting nuclear factor 2
chr23_+_24989387 0.37 ENSDART00000172299
ENSDART00000145307
Rho GTPase activating protein 4a
chr1_+_2431956 0.37 ENSDART00000183832
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr5_-_51998708 0.36 ENSDART00000097194
serine incorporator 5
chr19_-_3821678 0.36 ENSDART00000169639
si:dkey-206d17.12
chr5_-_38248347 0.36 ENSDART00000084917
ENSDART00000139479
solute carrier family 12, member 9
chr5_+_25733774 0.36 ENSDART00000137088
ENSDART00000098467
abhydrolase domain containing 17B
chr10_+_5744941 0.35 ENSDART00000159769
ENSDART00000184734
peptidylglycine alpha-amidating monooxygenase
chr16_+_26439518 0.35 ENSDART00000041787
tripartite motif containing 35-28
chr14_-_16807206 0.35 ENSDART00000157957
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b
chr19_-_34063567 0.35 ENSDART00000157815
ENSDART00000183907
engulfment and cell motility 1 (ced-12 homolog, C. elegans)
chr3_-_40232615 0.35 ENSDART00000155969
flightless I actin binding protein
chr21_+_18907102 0.35 ENSDART00000160185
ENSDART00000190175
ENSDART00000017937
ENSDART00000191546
ENSDART00000130519
ENSDART00000137143
sphingomyelin phosphodiesterase 4
chr18_+_45862414 0.35 ENSDART00000024615
arginyl aminopeptidase like 1
chr14_+_31473866 0.34 ENSDART00000173088
coiled-coil domain containing 160
chr25_-_19655820 0.34 ENSDART00000149585
ENSDART00000104353
ATPase plasma membrane Ca2+ transporting 1b
chr3_+_27665160 0.34 ENSDART00000103660
chloride channel 7
chr13_-_17943135 0.34 ENSDART00000176027
membrane-associated ring finger (C3HC4) 8
chr7_+_57088920 0.33 ENSDART00000024076
secretory carrier membrane protein 2, like
chr22_+_10676981 0.33 ENSDART00000138016
hyaluronoglucosaminidase 2b
chr20_+_13141408 0.33 ENSDART00000034098
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr13_+_49727333 0.33 ENSDART00000168799
ENSDART00000037559
geranylgeranyl diphosphate synthase 1
chr10_+_29771256 0.33 ENSDART00000193195
hypoxia up-regulated 1
chr10_+_36439293 0.33 ENSDART00000043802
ubiquitin specific peptidase like 1
chr3_-_35865040 0.33 ENSDART00000102952
SUZ12 polycomb repressive complex 2a subunit
chr16_-_10261652 0.33 ENSDART00000163599
si:rp71-15i12.1
chr14_-_33859149 0.33 ENSDART00000163877
oculocerebrorenal syndrome of Lowe
chr7_+_26545502 0.33 ENSDART00000140528
tyrosine kinase, non-receptor, 1
chr5_-_24882357 0.32 ENSDART00000127773
ENSDART00000003998
ENSDART00000143851
EWS RNA-binding protein 1b
chr9_+_24936496 0.32 ENSDART00000157474
solute carrier family 39 (zinc transporter), member 10
chr6_-_39903393 0.32 ENSDART00000085945
Ts translation elongation factor, mitochondrial
chr4_+_20051478 0.32 ENSDART00000143642
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr5_-_69482891 0.32 ENSDART00000109487

chr7_+_26545911 0.32 ENSDART00000135313
tyrosine kinase, non-receptor, 1
chr16_+_5612547 0.32 ENSDART00000140226
ENSDART00000189352
si:dkey-283b15.4
chr23_+_41831224 0.32 ENSDART00000171885
sterol carrier protein 2b
chr24_-_23839647 0.31 ENSDART00000125190
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr18_+_3169579 0.31 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
p21 protein (Cdc42/Rac)-activated kinase 1
chr20_-_52928541 0.31 ENSDART00000162812
farnesyl-diphosphate farnesyltransferase 1
chr6_-_40768654 0.31 ENSDART00000184668
ENSDART00000146470
actin related protein 2/3 complex, subunit 4
chr21_-_12749501 0.31 ENSDART00000179724

chr19_-_31765615 0.31 ENSDART00000103636
si:dkeyp-120h9.1
chr22_-_10539180 0.30 ENSDART00000131217
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr9_-_12269847 0.30 ENSDART00000136558
ENSDART00000144734
ENSDART00000131766
ENSDART00000032344
nucleoporin 35
chr9_-_7287128 0.30 ENSDART00000176281
ENSDART00000065803
MIT, microtubule interacting and transport, domain containing 1
chr15_-_5901514 0.30 ENSDART00000155252
si:ch73-281n10.2
chr24_+_39034090 0.30 ENSDART00000185763
calpain 15
chr6_-_40713183 0.30 ENSDART00000157113
ENSDART00000154810
ENSDART00000153702
si:ch211-157b11.12
chr9_-_7287375 0.30 ENSDART00000128352
MIT, microtubule interacting and transport, domain containing 1
chr6_+_41555247 0.30 ENSDART00000084834
SLIT-ROBO Rho GTPase activating protein 3
chr1_+_15258641 0.30 ENSDART00000033018
phosphatidylinositol 4-kinase type 2 beta
chr9_-_16133263 0.30 ENSDART00000077187
myosin IB
chr20_-_35470891 0.29 ENSDART00000152993
ENSDART00000016090
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr17_-_28811747 0.29 ENSDART00000001444
G2/M-phase specific E3 ubiquitin protein ligase
chr25_-_36263115 0.29 ENSDART00000143046
ENSDART00000139002
dihydrouridine synthase 2
chr6_+_27992886 0.29 ENSDART00000160354
angiomotin like 2a
chr16_+_38119004 0.29 ENSDART00000132087
pogo transposable element derived with ZNF domain b
chr7_+_41887429 0.29 ENSDART00000115090
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr8_+_8643901 0.29 ENSDART00000142076
ENSDART00000075624
ubiquitin specific peptidase 11
chr6_+_29860776 0.29 ENSDART00000028406
discs, large homolog 1 (Drosophila)
chr8_+_16726386 0.29 ENSDART00000144621
small integral membrane protein 15
chr1_+_12301913 0.29 ENSDART00000165733
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr6_+_49722970 0.29 ENSDART00000155934
ENSDART00000154738
syntaxin 16
chr3_-_10425313 0.29 ENSDART00000111833
phosphatidylcholine transfer protein
chr12_-_17810543 0.28 ENSDART00000090484
tectonin beta-propeller repeat containing 1a
chr20_+_2642855 0.28 ENSDART00000058775
zgc:101562
chr1_+_6646529 0.28 ENSDART00000144641
ENSDART00000103701
ENSDART00000138919
ubiquitin-conjugating enzyme E2F (putative)
chr23_+_7710447 0.28 ENSDART00000168199
kinesin family member 3B
chr6_-_7123210 0.28 ENSDART00000041304
autophagy related 3
chr14_-_31862657 0.28 ENSDART00000172870
ENSDART00000007927
ENSDART00000134748
ENSDART00000128730
RNA binding motif protein, X-linked
chr6_+_49723289 0.28 ENSDART00000190452
syntaxin 16
chr16_-_41487589 0.28 ENSDART00000188115
CKLF-like MARVEL transmembrane domain containing 6
chr7_-_40578733 0.27 ENSDART00000173926
ENSDART00000010035
DnaJ (Hsp40) homolog, subfamily B, member 6b
chr19_-_2085027 0.27 ENSDART00000063615
sorting nexin 13
chr1_+_12177195 0.27 ENSDART00000146842
ENSDART00000142081
STRA6-like
chr3_-_36364903 0.27 ENSDART00000028883
guanine nucleotide binding protein (G protein), alpha 13b
chr6_+_29861288 0.27 ENSDART00000166782
discs, large homolog 1 (Drosophila)
chr18_+_3243292 0.27 ENSDART00000166580
p21 protein (Cdc42/Rac)-activated kinase 1
chr7_+_71764883 0.27 ENSDART00000166865
myosin, light chain 12, genome duplicate 1
chr23_-_36670369 0.27 ENSDART00000006881
zinc finger and BTB domain containing 39
chr6_+_112579 0.27 ENSDART00000034505
adaptor-related protein complex 1, mu 2 subunit
chr3_+_33367954 0.27 ENSDART00000103161
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr21_-_30181268 0.27 ENSDART00000167867
heterogeneous nuclear ribonucleoprotein H1, like
chr1_-_55888970 0.26 ENSDART00000064194
anti-silencing function 1Bb histone chaperone
chr16_+_13818500 0.26 ENSDART00000135245
folliculin
chr6_+_13046720 0.26 ENSDART00000165896
caspase 8, apoptosis-related cysteine peptidase
chr21_-_30181732 0.26 ENSDART00000015636
heterogeneous nuclear ribonucleoprotein H1, like
chr12_+_33361948 0.26 ENSDART00000124982
fatty acid synthase
chr16_+_5597600 0.26 ENSDART00000017307
zgc:91890
chr2_+_5406236 0.26 ENSDART00000154167
SFT2 domain containing 3
chr21_-_4793686 0.26 ENSDART00000158232
notch 1a
chr13_-_29980215 0.26 ENSDART00000042049
hypoxia inducible factor 1, alpha subunit inhibitor
chr7_-_49637278 0.26 ENSDART00000011456
tumor susceptibility 101b
chr18_+_46162204 0.25 ENSDART00000113545
ENSDART00000147556
zgc:113340
chr5_-_24008997 0.25 ENSDART00000066645
eukaryotic translation initiation factor 1A, X-linked, a
chr5_+_24086227 0.25 ENSDART00000051549
ENSDART00000177458
ENSDART00000135934
tumor protein p53
chr20_-_25878586 0.25 ENSDART00000153347
ENSDART00000063154
exocyst complex component 1
chr8_+_19977712 0.25 ENSDART00000134124
zinc finger protein 692
chr5_+_27137473 0.25 ENSDART00000181833
unc-5 netrin receptor Db
chr23_-_24253200 0.25 ENSDART00000114840
zinc finger and BTB domain containing 17
chr8_-_13735572 0.25 ENSDART00000139642
si:dkey-258f14.7
chr11_+_25560632 0.25 ENSDART00000033914
methyl-CpG binding domain protein 1b
chr13_+_15580758 0.25 ENSDART00000087194
ENSDART00000013525
MAP/microtubule affinity-regulating kinase 3a
chr8_+_49096486 0.24 ENSDART00000192998
zgc:56525
chr21_-_9769500 0.24 ENSDART00000170710
Rho GTPase activating protein 24
chr25_-_14087377 0.24 ENSDART00000124140
zgc:101566
chr23_-_36449111 0.24 ENSDART00000110478
zgc:174906
chr24_-_5691956 0.24 ENSDART00000189112
deleted in autism 1b
chr7_-_8961941 0.24 ENSDART00000111002
si:ch211-74f19.2
chr2_-_41620112 0.24 ENSDART00000138822
ENSDART00000004816
zgc:110158
chr5_-_24029228 0.24 ENSDART00000051546
ribosomal protein S6 kinase a, polypeptide 3a
chr3_-_42086577 0.24 ENSDART00000083111
ENSDART00000187312
tweety family member 3a
chr4_-_4261673 0.24 ENSDART00000150694
CD9 molecule b
chr7_+_71764665 0.24 ENSDART00000171996
myosin, light chain 12, genome duplicate 1

Network of associatons between targets according to the STRING database.

First level regulatory network of spi2+spic

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.4 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 1.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.4 GO:0035046 pronuclear migration(GO:0035046)
0.1 0.5 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.1 0.5 GO:0042306 regulation of protein import into nucleus(GO:0042306) negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) regulation of protein import(GO:1904589) negative regulation of protein import(GO:1904590)
0.1 0.4 GO:0048313 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.1 0.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.6 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.6 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 1.2 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.3 GO:0010662 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.1 0.4 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.3 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.4 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 0.3 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.1 0.5 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.3 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531)
0.1 0.3 GO:0043525 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.1 0.3 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.3 GO:0071869 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.1 0.4 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.1 0.3 GO:0052746 inositol phosphorylation(GO:0052746)
0.1 1.3 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.1 0.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 0.2 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.1 0.3 GO:1903405 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576) protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) protein localization to nucleoplasm(GO:1990173)
0.1 0.3 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.2 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1 0.3 GO:0032370 positive regulation of lipid transport(GO:0032370)
0.1 0.6 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.1 0.6 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 0.3 GO:0033238 regulation of cellular amino acid metabolic process(GO:0006521) regulation of cellular amine metabolic process(GO:0033238)
0.1 0.3 GO:0033119 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 0.3 GO:1903573 negative regulation of response to endoplasmic reticulum stress(GO:1903573)
0.1 0.3 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.1 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219) negative regulation of phospholipid metabolic process(GO:1903726)
0.1 0.5 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.1 0.7 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.3 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.1 0.3 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.2 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.1 0.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.2 GO:0015744 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 0.4 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.0 0.1 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.5 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.8 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.3 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.3 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.4 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.0 0.4 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.2 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.0 0.2 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.3 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
0.0 0.4 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.3 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.1 GO:0045730 respiratory burst(GO:0045730)
0.0 0.3 GO:0035909 establishment of cell polarity involved in ameboidal cell migration(GO:0003365) aorta morphogenesis(GO:0035909) dorsal aorta morphogenesis(GO:0035912)
0.0 0.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.3 GO:0043584 nose development(GO:0043584)
0.0 0.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 0.1 GO:0042908 xenobiotic transport(GO:0042908)
0.0 0.3 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.4 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.2 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0035678 neuromast hair cell morphogenesis(GO:0035678)
0.0 0.5 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.4 GO:0045116 protein neddylation(GO:0045116)
0.0 0.2 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.4 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.6 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.6 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.1 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.4 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.0 0.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.1 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 0.3 GO:0006999 NLS-bearing protein import into nucleus(GO:0006607) nuclear pore organization(GO:0006999)
0.0 0.1 GO:0031062 positive regulation of histone methylation(GO:0031062)
0.0 0.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.2 GO:0002931 response to ischemia(GO:0002931)
0.0 0.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.4 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.2 GO:0016137 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0 0.1 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:0019566 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.5 GO:0071218 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.0 0.8 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.6 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 0.5 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.2 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.1 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.2 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137) negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.2 GO:0051984 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of chromosome segregation(GO:0051984) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.3 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.4 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.1 GO:0042245 RNA repair(GO:0042245)
0.0 0.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0048855 adenohypophysis morphogenesis(GO:0048855)
0.0 0.2 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.0 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.3 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.1 GO:1902047 polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
0.0 0.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.3 GO:0007032 endosome organization(GO:0007032)
0.0 0.4 GO:0045047 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.3 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.4 GO:0071230 cellular response to amino acid stimulus(GO:0071230)
0.0 0.3 GO:2000404 regulation of T cell migration(GO:2000404)
0.0 0.1 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 0.2 GO:0008272 sulfate transport(GO:0008272)
0.0 0.3 GO:0090148 membrane fission(GO:0090148)
0.0 0.3 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.0 GO:0044878 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.2 GO:0032418 lysosome localization(GO:0032418)
0.0 0.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.4 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.4 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.1 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.1 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.0 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.4 GO:0003094 glomerular filtration(GO:0003094)
0.0 1.0 GO:0006821 chloride transport(GO:0006821)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.6 GO:0043291 RAVE complex(GO:0043291)
0.1 0.5 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.1 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.0 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.2 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.1 0.5 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.3 GO:0000938 GARP complex(GO:0000938)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.3 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)
0.0 0.3 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.7 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.3 GO:0031526 brush border membrane(GO:0031526)
0.0 0.3 GO:0005903 brush border(GO:0005903)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.5 GO:0015030 Cajal body(GO:0015030)
0.0 0.4 GO:0070187 telosome(GO:0070187)
0.0 0.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0070449 elongin complex(GO:0070449)
0.0 0.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 1.6 GO:0031201 SNARE complex(GO:0031201)
0.0 0.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.7 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:0035861 site of double-strand break(GO:0035861)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.7 GO:0032183 SUMO binding(GO:0032183)
0.1 0.4 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 0.4 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.3 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 0.7 GO:0030619 U1 snRNA binding(GO:0030619)
0.1 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.3 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 0.6 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.1 0.3 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.1 0.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.3 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 0.4 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.5 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.3 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 0.4 GO:0016531 copper chaperone activity(GO:0016531)
0.1 0.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.7 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 0.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.5 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.5 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.2 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.4 GO:0015157 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.3 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.2 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.1 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0008905 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
0.0 0.5 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.4 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 1.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.3 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.0 0.1 GO:0004557 alpha-galactosidase activity(GO:0004557)
0.0 0.3 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.1 GO:0033204 ribonuclease P RNA binding(GO:0033204)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.4 GO:0015377 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.3 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.4 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.1 GO:1990931 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.0 1.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 1.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900) translation regulator activity, nucleic acid binding(GO:0090079)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 0.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.7 PID ARF 3PATHWAY Arf1 pathway
0.0 0.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.8 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 0.6 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.4 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.4 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.3 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation