ISMARA results: sp8a+sp8b_sp4_rsl1d1+sp3a

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Z-value: 1.39

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Transcription factors associated with sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Gene Symbol	Gene ID	Gene Info
sp8a NCBI UniProt	ENSDARG00000011870	sp8 transcription factor a
sp8b NCBI UniProt	ENSDARG00000056666	sp8 transcription factor b
sp4 NCBI UniProt	ENSDARG00000005186	sp4 transcription factor
sp3a NCBI UniProt	ENSDARG00000001549	sp3a transcription factor
rsl1d1 NCBI UniProt	ENSDARG00000005846	Sp5 transcription factor b
klf4 NCBI UniProt	ENSDARG00000079922	Kruppel-like factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sp8a	dr11_v1_chr19_-_2317558_2317558	0.88	1.2e-06	Click!
sp3a	dr11_v1_chr9_+_2762270_2762415	0.83	2.0e-05	Click!
klf4	dr11_v1_chr21_-_435466_435466	-0.76	2.3e-04	Click!
sp4	dr11_v1_chr19_+_2546775_2546775	0.75	3.4e-04	Click!
FO704755.1	dr11_v1_chr6_+_3809346_3809346	-0.38	1.2e-01	Click!
sp8b	dr11_v1_chr16_+_19536614_19536761	-0.27	2.9e-01	Click!

Activity profile of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Sorted Z-values of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_410728 Show fit	7.20	ENSDART00000151255	trim36 NCBI UniProt Show fit	tripartite motif containing 36
chr7_+_1473929 Show fit	6.02	ENSDART00000050687	lpcat4 NCBI UniProt Show fit	lysophosphatidylcholine acyltransferase 4
chr2_+_25658112 Show fit	5.69	ENSDART00000051234	tnika NCBI UniProt Show fit	TRAF2 and NCK interacting kinase a
chr22_+_835728 Show fit	5.31	ENSDART00000003325	dennd2db NCBI UniProt Show fit	DENN/MADD domain containing 2Db
chr10_-_34002185 Show fit	5.20	ENSDART00000046599	zar1l NCBI UniProt Show fit	zygote arrest 1-like
chr23_-_31645760 Show fit	5.11	ENSDART00000035031	sgk1 NCBI UniProt Show fit	serum/glucocorticoid regulated kinase 1
chr16_-_7793457 Show fit	5.09	ENSDART00000113483	trim71 NCBI UniProt Show fit	tripartite motif containing 71, E3 ubiquitin protein ligase
chr2_+_25657958 Show fit	4.97	ENSDART00000161407	tnika NCBI UniProt Show fit	TRAF2 and NCK interacting kinase a
chr19_+_26340736 Show fit	4.94	ENSDART00000013497	mylipa NCBI UniProt Show fit	myosin regulatory light chain interacting protein a
chr20_-_182841 Show fit	4.94	ENSDART00000064546	si:ch211-241j12.3 NCBI UniProt Show fit	si:ch211-241j12.3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.4	GO:0031098	stress-activated protein kinase signaling cascade(GO:0031098)
3.0	9.0	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.0	7.9	GO:0006644	phospholipid metabolic process(GO:0006644)
0.5	7.0	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.7	6.9	GO:0031272	pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
1.6	6.4	GO:0003228	atrial cardiac muscle tissue development(GO:0003228)
0.1	6.2	GO:0070830	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.4	5.4	GO:0055117	regulation of cardiac muscle contraction(GO:0055117)
0.3	5.4	GO:0019433	triglyceride catabolic process(GO:0019433)
1.0	5.1	GO:0010586	miRNA metabolic process(GO:0010586)

Showing 1 to 10 of 346 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.5	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0	10.2	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	9.1	GO:0005764	lysosome(GO:0005764)
0.1	6.9	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	6.1	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	5.4	GO:0005783	endoplasmic reticulum(GO:0005783)
0.0	5.2	GO:0016459	myosin complex(GO:0016459)
0.1	4.8	GO:0008023	transcription elongation factor complex(GO:0008023)
0.1	4.7	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.6	4.6	GO:0061700	GATOR2 complex(GO:0061700)

Showing 1 to 10 of 121 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	14.0	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.0	11.5	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.0	10.7	GO:0008270	zinc ion binding(GO:0008270)
0.5	7.5	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.1	6.7	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	6.5	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	6.2	GO:0051015	actin filament binding(GO:0051015)
0.2	5.9	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	5.7	GO:0042393	histone binding(GO:0042393)
0.3	5.4	GO:0045159	myosin II binding(GO:0045159)

Showing 1 to 10 of 240 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.8	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	9.1	PID MTOR 4PATHWAY	mTOR signaling pathway
0.2	4.9	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.3	4.7	PID EPHB FWD PATHWAY	EPHB forward signaling
0.3	3.7	PID NECTIN PATHWAY	Nectin adhesion pathway
0.1	3.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.5	2.7	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.1	2.7	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.1	2.5	PID IL3 PATHWAY	IL3-mediated signaling events
0.2	2.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions

Showing 1 to 10 of 49 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.3	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
1.2	5.9	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.3	5.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.6	5.6	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	4.6	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.3	4.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.1	4.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	3.5	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	3.5	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.4	3.4	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Showing 1 to 10 of 81 entries

Results for sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Z-value: 1.39

Motif logo

Transcription factors associated with sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Activity-expression correlation:

Activity profile of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Sorted Z-values of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: