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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for sp2
Z-value: 1.34
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Transcription factors associated with sp2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| sp2 | dr11_v1_chr11_-_12008001_12008001 | 0.13 | 6.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_-_127558 Show fit | 6.73 |
ENSDART00000149556
|
transient receptor potential cation channel, subfamily M, member 7 |
|
| chr23_+_2740741 Show fit | 4.73 |
ENSDART00000134938
|
zgc:114123 |
|
| chr10_+_1849874 Show fit | 4.73 |
ENSDART00000158897
ENSDART00000149956 |
adenomatous polyposis coli |
|
| chr15_+_25489406 Show fit | 4.36 |
ENSDART00000162482
|
zgc:152863 |
|
| chr19_+_26340736 Show fit | 4.28 |
ENSDART00000013497
|
myosin regulatory light chain interacting protein a |
|
| chr20_+_33987465 Show fit | 4.26 |
ENSDART00000061751
|
zona pellucida glycoprotein 3a, tandem duplicate 2 |
|
| chr18_-_127873 Show fit | 4.23 |
ENSDART00000148490
|
transient receptor potential cation channel, subfamily M, member 7 |
|
| chr3_+_51684963 Show fit | 4.18 |
ENSDART00000091180
ENSDART00000183711 ENSDART00000159493 |
BAI1-associated protein 2a |
|
| chr13_-_17860307 Show fit | 4.02 |
ENSDART00000135920
ENSDART00000054579 |
membrane-associated ring finger (C3HC4) 8 |
|
| chr20_+_33991801 Show fit | 3.96 |
ENSDART00000061744
|
zona pellucida glycoprotein 3a, tandem duplicate 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of sp2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 11.6 | GO:2000344 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 3.7 | 11.0 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.0 | 5.5 | GO:0031098 | stress-activated protein kinase signaling cascade(GO:0031098) activation of protein kinase activity(GO:0032147) |
| 1.2 | 4.7 | GO:0061031 | endodermal digestive tract morphogenesis(GO:0061031) Wnt signaling pathway involved in somitogenesis(GO:0090244) negative regulation of canonical Wnt signaling pathway involved in heart development(GO:1905067) |
| 0.6 | 4.7 | GO:0040038 | meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038) |
| 0.0 | 4.3 | GO:0030178 | negative regulation of Wnt signaling pathway(GO:0030178) |
| 0.5 | 4.2 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 1.0 | 4.0 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.8 | 3.8 | GO:0010586 | miRNA metabolic process(GO:0010586) |
| 0.7 | 3.7 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 5.5 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 5.1 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.7 | 4.7 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 4.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 4.0 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.9 | 3.5 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.6 | 2.5 | GO:0070319 | Golgi to plasma membrane transport vesicle(GO:0070319) |
| 0.2 | 2.5 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.3 | 2.0 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 11.6 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 11.4 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.7 | 10.4 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 0.1 | 5.2 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 4.9 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.3 | 4.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 4.0 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.4 | 3.8 | GO:0035198 | miRNA binding(GO:0035198) |
| 1.2 | 3.7 | GO:0008386 | cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713) |
| 0.2 | 3.3 | GO:0008143 | poly(A) binding(GO:0008143) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.7 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 3.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 2.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 1.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.3 | 1.7 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.1 | 1.6 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 1.2 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.2 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.6 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.7 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.6 | 3.2 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.2 | 3.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.3 | 2.8 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.6 | 2.5 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 2.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 2.2 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 2.0 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 1.8 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 1.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |